| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takayuki Matsumoto, Shun Watanabe, Kumiko Taguchi, Tsuneo Kobayash. Mechanisms underlying increased serotonin-induced contraction in carotid arteries from chronic type 2 diabetic Goto-Kakizaki rats. Pharmacological research. vol 87. 2015-04-13. PMID:25034165. |
serotonin (5-hydroxytryptamine; 5-ht) plays important roles in the cardiovascular system; however, the relationship between 5-ht-induced vasocontraction and the arterial 5-ht system including metabolism and signal transduction, in the presence of chronic type 2 diabetes (t2d) remains unclear. |
2015-04-13 |
2023-08-13 |
rat |
| Vladimir S Naumenko, Elena M Kondaurova, Daria V Bazovkina, Anton S Tsybko, Tatyana V Il'chibaeva, Nina K Popov. On the role of 5-HT(1A) receptor gene in behavioral effect of brain-derived neurotrophic factor. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24706292. |
the data indicate that a small genetic variation altered the response to bdnf and show an important role of 5-ht(1a) receptor gene in the 5-ht system response to bdnf treatment and in behavioral effects of bdnf. |
2015-02-21 |
2023-08-13 |
mouse |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Maude Beaudoin-Gobert, Véronique Sgambato-Faur. Serotonergic pharmacology in animal models: from behavioral disorders to dyskinesia. Neuropharmacology. vol 81. 2014-12-15. PMID:24486710. |
animal models have been useful to investigate more precisely to what extent 5-ht is involved and whether drugs targeting the 5-ht system can counteract the symptoms exhibited. |
2014-12-15 |
2023-08-12 |
human |
| Donatella Marazziti, Stefano Baroni, Lionella Palego, Laura Betti, Gino Giannaccini, Maura Castagna, Antonio G Naccarato, Antonio Luccachini, Mario Catena-Dell'Osso, Liliana Dell'Oss. Clozapine effects on adenylyl cyclase activity and serotonin type 1A receptors in human brain post-mortem. Journal of psychopharmacology (Oxford, England). vol 28. issue 4. 2014-11-24. PMID:24429224. |
in particular, much interest is focused on the understanding of clozapine activity on serotonin (5-ht) neurotransmission, particularly on 5-ht receptor of type 1a (5-ht(1a)) that seems to play a pivotal role in the control of the 5-ht system. |
2014-11-24 |
2023-08-12 |
human |
| Jia Luo, Tao Wang, Shan Liang, Xu Hu, Wei Li, Feng Ji. Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat. Science China. Life sciences. vol 57. issue 3. 2014-11-21. PMID:24554471. |
5-ht system activity was evaluated by measuring 5-ht and its metabolite, 5-hiaa, and the 5-ht precursor, tryptophan. |
2014-11-21 |
2023-08-12 |
rat |
| Aaron M Marshall, Laura L Hernandez, Nelson D Horsema. Serotonin and serotonin transport in the regulation of lactation. Journal of mammary gland biology and neoplasia. vol 19. issue 1. 2014-11-11. PMID:24136337. |
the conventional components of a classic 5-ht system are found within the mammary gland; synthetic enzymes (tryptophan hydroxylase i, aromatic amino acid decarboxylase), several 5-ht receptors and the 5-ht reuptake transporter (sert). |
2014-11-11 |
2023-08-12 |
Not clear |
| Joanna H Sliwowska, Hyun Jung Song, Tamara Bodnar, Joanne Weinber. Prenatal alcohol exposure results in long-term serotonin neuron deficits in female rats: modulatory role of ovarian steroids. Alcoholism, clinical and experimental research. vol 38. issue 1. 2014-10-09. PMID:23915273. |
in light of known sex differences in responsiveness of the 5-ht system and known effects of estrogen (e2 ) and progesterone (p4 ) in the brain, we hypothesized that sex steroids will modulate the adverse effects of pae on 5-ht neurons in adult females. |
2014-10-09 |
2023-08-12 |
rat |
| Andrea Varrone, Per Svenningsson, Anton Forsberg, Katarina Varnäs, Mikael Tiger, Ryuji Nakao, Christer Halldin, Lars-Göran Nilsson, Lars Fard. Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease. Neurobiology of aging. vol 35. issue 4. 2014-09-29. PMID:24126162. |
the lower regional 5-ht(1b)-receptor availability is in line with previous studies showing a decrease of serotonin imaging markers in pd and corroborates a role of the serotonin system in the pathophysiology of pd. |
2014-09-29 |
2023-08-12 |
human |
| N Nevalainen, S Af Bjerkén, G A Gerhardt, I Strömber. Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia. Neuroscience. vol 260. 2014-09-25. PMID:24361918. |
nevertheless, knowledge of l-dopa-induced events that could lead to development of dyskinesias are limited and therefore the present work has evaluated (i) the role of the 5-ht system in l-dopa-derived dopamine synthesis when dopamine neurons are present, (ii) l-dopa-induced effects on striatal dopamine release and clearance, and on 5-ht nerve fiber density, and (iii) the behavioral outcome of altered 5-ht transmission in dyskinetic rats. |
2014-09-25 |
2023-08-12 |
rat |
| N Nevalainen, S Af Bjerkén, G A Gerhardt, I Strömber. Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia. Neuroscience. vol 260. 2014-09-25. PMID:24361918. |
taken together, the results indicate a central role for the 5-ht system in l-dopa-derived dopamine synthesis and in dyskinesia, and therefore potential l-dopa-induced deterioration of 5-ht function might reduce l-dopa efficacy as well as promote the upcoming of motor side effects. |
2014-09-25 |
2023-08-12 |
rat |
| José A Terró. Novel insights into the potential involvement of 5-HT7 receptors in endocrine dysregulation in stress-related disorders. Reviews in the neurosciences. vol 25. issue 3. 2014-09-25. PMID:24663228. |
glucocorticoids and stress profoundly affect the 5-ht system so it is possible that alterations of endocrine 5-ht mechanisms may underlie hpa axis overdrive in stress-related diseases. |
2014-09-25 |
2023-08-12 |
Not clear |
| Bo Xiang, Zhenxing Yang, Yin Lin, Lijie Guan, Xuan Li, Wei Deng, Zeyu Jiang, Guohui Lao, Qiang Wang, Xiaoyu Hao, Xiang Liu, Yingcheng Wang, Liansheng Zhao, Xiaohong Ma, Tao Li, Liping Cao, Xun H. Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population. Neuroscience bulletin. vol 30. issue 1. 2014-09-19. PMID:24136241. |
serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar i disorder (bp-i), a mood disorder, is not clear. |
2014-09-19 |
2023-08-12 |
Not clear |
| Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Benjamin R Berr. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904340. |
a major focus was to outline pathophysiological mechanisms whereby the serotonin system becomes impervious to the desired enhancement of serotonin neurotransmission by ssris. |
2014-06-24 |
2023-08-13 |
Not clear |
| Paul R Albert, Faranak Vahid-Ansari, Christine Luckhar. Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24936175. |
a key component of serotonin circuitry is the 5-ht1a autoreceptor, which functions as the major somatodendritic autoreceptor to negatively regulate the "gain" of the serotonin system. |
2014-06-24 |
2023-08-13 |
mouse |
| Manfred Göther. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part I. General background and discovery of serotonin as a basis for 5-HT receptor identification. Pharmacological reports : PR. vol 65. issue 4. 2014-06-13. PMID:24145072. |
this review contains background information on the serotonin system, furthermore the suggestion to introduce the term contemporary witness report (cwr) for a novel type of review and, as the main part, an overview over the history of serotonin discovery as a basis for the identification of its receptor heterogeneity and the increase in complexity by genetic and allosteric variation. |
2014-06-13 |
2023-08-12 |
dog |
| Tamami Sekiyama, Yasushi Nakatani, Xinjun Yu, Yoshinari Seki, Ikuko Sato-Suzuki, Hideho Arit. Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women. Psychiatry research. vol 209. issue 3. 2014-05-30. PMID:23541877. |
5-ht concentrations correlated with tension/anxiety in the third trimester and late postpartum, indicating an important role for the 5-ht system in the regulation of tension/anxiety in healthy postpartum women. |
2014-05-30 |
2023-08-12 |
Not clear |
| Jiafeng Geng, Aimin Li. Heme-dependent dioxygenases in tryptophan oxidation. Archives of biochemistry and biophysics. vol 544. 2014-04-02. PMID:24295960. |
it is utilized not only for protein synthesis but also for the biosynthesis of serotonin and melatonin by the serotonin pathway as well as nicotinamide adenine dinucleotide by the kynurenine pathway. |
2014-04-02 |
2023-08-12 |
Not clear |
| Stephanie M Groman, J David Jentsc. Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates. Current opinion in neurobiology. vol 23. issue 4. 2014-02-27. PMID:23528268. |
further, recent data has demonstrated an involvement of the serotonin system in addiction-related behaviors and neurobiology, suggesting that the relationship between dopamine and serotonin systems may be altered in addiction. |
2014-02-27 |
2023-08-12 |
human |
| Yukio Ago, Ryota Araki, Tatsunori Tanaka, Asuka Sasaga, Saki Nishiyama, Kazuhiro Takuma, Toshio Matsud. Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal behaviors of isolation-reared mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23426384. |
these findings suggest that the prefrontal da and 5-ht systems are activated by encounter stimulation in male isolation-reared mice, and the encounter-induced activation of 5-ht system triggers the induction of some abnormal behaviors in male isolation-reared mice. |
2014-02-13 |
2023-08-12 |
mouse |