| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristian Saied-Santiago, Melissa Baxter, Jaffna Mathiaparanam, Michael Granat. Serotonin neuromodulation directs optic nerve regeneration. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185204. |
we find several serotonin type-1 receptor genes are expressed in rgc neurons during regeneration and that inhibiting 5- ht1 receptors or components of the 5-ht pathway selectively impedes on regeneration. |
2024-08-26 |
2024-08-28 |
zebrafish |
| Bartosz Bobula, Joanna Bąk, Agnieszka Kania, Marcin Siwiec, Michał Kiełbiński, Krzysztof Tokarski, Agnieszka Pałucha-Poniewiera, Grzegorz Hes. Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice. Pharmacology, biochemistry, and behavior. 2024-08-14. PMID:39142357. |
the consequences of ssri-induced excess of 5-ht during development for the brain neuromodulatory 5-ht system remain largely unexplored. |
2024-08-14 |
2024-08-17 |
mouse |
| Tianlong Ling, Zhanghan Dai, Houming Wang, Tran Trung Kien, Rong Cui, Tachung Yu, Jianjun Che. Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer. Cancer letters. 2024-08-03. PMID:39097134. |
collectively, this study sheds light on the serotonylation-dependent mechanisms of 5-ht in crc progression, offering insights into potential therapeutic strategies targeting the serotonin pathway for crc treatment. |
2024-08-03 |
2024-08-06 |
Not clear |
| Mouna Chajadine, Ludivine Laurans, Tobias Radecke, Nirmala Mouttoulingam, Rida Al-Rifai, Emilie Bacquer, Clara Delaroque, Héloïse Rytter, Marius Bredon, Camille Knosp, José Vilar, Coralie Fontaine, Nadine Suffee, Marie Vandestienne, Bruno Esposito, Julien Dairou, Jean Marie Launay, Jacques Callebert, Alain Tedgui, Hafid Ait-Oufella, Harry Sokol, Benoit Chassaing, Soraya Tale. Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice. Nature communications. vol 15. issue 1. 2024-07-30. PMID:39080345. |
this is associated with an increase in serotonin production and a decrease in indole metabolites, thus hijacking trp for the serotonin pathway. |
2024-07-30 |
2024-08-02 |
mouse |
| Hongfei Ji, Dian Chen, Christopher Fang-Ye. Segmentation-free measurement of locomotor frequency in Caenorhabditis elegans using image invariants. G3 (Bethesda, Md.). 2024-07-26. PMID:39056257. |
we demonstrate the system's capabilities by testing the effects of serotonin and serotonin pathway mutations on c. elegans locomotor frequency. |
2024-07-26 |
2024-07-28 |
human |
| Hongfei Ji, Dian Chen, Christopher Fang-Ye. Segmentation-free measurement of locomotor frequency in Caenorhabditis elegans using image invariants. bioRxiv : the preprint server for biology. 2024-06-25. PMID:38293059. |
we demonstrate the system's capabilities by testing the effects of serotonin and serotonin pathway mutations on c. elegans locomotor frequency. |
2024-06-25 |
2024-06-27 |
human |
| Tobias P Whelan, Eileen Daly, Nicolaas A Puts, Paula Smith, Carrie Allison, Simon Baron-Cohen, Ekaterina Malievskaia, Declan G M Murphy, Grainne M McAlona. The 'PSILAUT' protocol: an experimental medicine study of autistic differences in the function of brain serotonin targets of psilocybin. BMC psychiatry. vol 24. issue 1. 2024-04-25. PMID:38658877. |
the underlying neurobiology of the complex autism phenotype remains obscure, although accumulating evidence implicates the serotonin system and especially the 5ht |
2024-04-25 |
2024-04-28 |
Not clear |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| b' Paola Giuliano, Giuliana La Rosa, Serena Capozzi, Emanuele Cassano, Simona Damiano, Francesco Habetswallner, Rosa Iodice, Maurizio Marra, Luigi Michele Pavone, Mario Quarantelli, Giuseppe Vitelli, Mariarosaria Santillo, Roberto Patern\\xc3\\xb. A Blood Test for the Diagnosis of Multiple Sclerosis. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338973.' |
in this study, since there is evidence connecting the serotonin pathway to ms, we used an elisa (enzyme-linked immunosorbent assay) to detect serum ms-specific auto-antibodies (auto-ab) against the extracellular loop 1 (ecl-1) of the 5-hydroxytryptamine (5-ht) receptor subtype 2a (5-ht2a). |
2024-02-10 |
2024-02-12 |
Not clear |
| Koshiro Mitsui, Aki Takahash. Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-02-05. PMID:38314963. |
however, recent studies challenge this 5-ht deficiency model, revealing a more complex role for the drn 5-ht system in aggression. |
2024-02-05 |
2024-02-09 |
Not clear |
| Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng, Jian X. Interaction of 5-HTTLPR and SLE disease status on resting-state brain function. Arthritis research & therapy. vol 26. issue 1. 2024-01-31. PMID:38297395. |
serotonin transporter gene-linked polymorphic region (5-httlpr) is an essential element of the 5-ht system gene polymorphism and is directly related to the control of 5-hydroxytryptamine transporter (5-htt)gene expression. |
2024-01-31 |
2024-02-03 |
Not clear |
| Cheng Zhang, Yanyao Li, Haibo Yu, Tian Li, Limin Ye, Xiaotian Zhang, Chi Wang, Pengju Li, Hong Ji, Qinfeng Gao, Shuanglin Don. Co-exposure of nanoplastics and arsenic causes neurotoxicity in zebrafish (Danio rerio) through disrupting homeostasis of microbiota-intestine-brain axis. The Science of the total environment. 2023-12-22. PMID:38135083. |
intestine, the primary source of 5-ht, its impaired health (aggravation in oxidative stress, mitochondrial damage and histopathological alterations) induced the dysregulation in the 5-ht system, which may be induced by the increased accumulation of as in the intestine by the co-exposure. |
2023-12-22 |
2023-12-25 |
zebrafish |
| Sneha Sivaramakrishnan, Vettriselvi Venkatesan, Sampath Kumar Paranthaman, R Sathianathan, Swetha Raghavan, Priyadarshee Pradha. Impact of Serotonin Pathway Gene Polymorphisms and Serotonin Levels in Suicidal Behavior. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2023-09-17. PMID:37717578. |
impact of serotonin pathway gene polymorphisms and serotonin levels in suicidal behavior. |
2023-09-17 |
2023-10-07 |
Not clear |
| Gunild M Vulpius, Kristin Köhler-Forsberg, Brice Ozenne, Søren V Larsen, Arafat Nasser, Claus Svarer, Nic Gillings, Sune H Keller, Martin B Jørgensen, Gitte M Knudsen, Vibe G Frokjae. Stress hormone dynamics are coupled to brain serotonin 4 receptor availability in unmedicated patients with Major Depressive Disorder - a NeuroPharm study. The international journal of neuropsychopharmacology. 2023-08-05. PMID:37542733. |
an interesting feature of the cerebral serotonin system is the serotonin 4 receptor (5-ht4r), which is lower in depressed relative to healthy individuals, and also has been highlighted as a promising novel antidepressant target. |
2023-08-05 |
2023-08-14 |
Not clear |
| HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhan. The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia. Molecular neurobiology. 2023-07-29. PMID:37516665. |
our data showed that exogenous administration of 5-hydroxytryptophan (5-htp) and optogenetic activation of 5-ht neurons in the dorsal raphe nucleus (dr) could significantly shorten the emergence time of sevoflurane anesthesia in mice, suggesting that regulation of the 5-ht system using both endogenous and exogenous approaches could mediate delayed emergence. |
2023-07-29 |
2023-08-14 |
mouse |
| Alexander Ya Rodnyy, Elena M Kondaurova, Anton S Tsybko, Nina K Popova, Dmitry A Kudlay, Vladimir S Naumenk. The brain serotonin system in autism. Reviews in the neurosciences. 2023-07-07. PMID:37415576. |
in this review, we summarize existing data on the participation of all members of the brain 5-ht system, namely, 5-ht transporter, tryptophan hydroxylase 2, maoa, and 5-ht receptors, in autism in human and various animal models. |
2023-07-07 |
2023-08-14 |
human |
| Marcela Konjevod, Katherina B Sreter, Sanja Popovic-Grle, Marina Lampalo, Lucija Tudor, Irena Jukic, Gordana Nedic Erjavec, Jasna Bingulac-Popovic, Hana Safic Stanic, Matea Nikolac Perkovic, Jasenka Markeljevic, Miroslav Samarzija, Nela Pivac, Dubravka Svob Stra. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238670. |
platelet serotonin (5-ht) concentration, platelet monoamine oxidase b (mao-b) activity and the complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. |
2023-05-27 |
2023-08-14 |
Not clear |
| Julia Sacher, Rachel G Zsido, Claudia Barth, Franziska Zientek, Michael Rullmann, Julia Luthardt, Marianne Patt, Georg A Becker, Pablo Rusjan, A Veronica Witte, Ralf Regenthal, Abhay Koushik, Juergen Kratzsch, Beate Decker, Petra Jogschies, Arno Villringer, Swen Hesse, Osama Sabr. Increase in Serotonin Transporter Binding in Patients With Premenstrual Dysphoric Disorder Across the Menstrual Cycle: A Case-Control Longitudinal Neuroreceptor Ligand Positron Emission Tomography Imaging Study. Biological psychiatry. 2023-03-30. PMID:36997451. |
here, we tested whether a heightened sensitivity of the serotonin system to menstrual cycle phase underlies pmdd, assessing the relationship of serotonin transporter (5-htt) changes with symptom severity across the menstrual cycle. |
2023-03-30 |
2023-08-14 |
Not clear |
| Akihiro Mouri, Masaya Hasegawa, Kazuo Kunisawa, Kuniaki Saito, Toshitaka Nabeshim. [Diagnoses and new therapeutic strategy focused on physiological alteration of tryptophan metabolism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023-03-29. PMID:36990795. |
indoleamine 2,3-dioxygenase 1 (ido1) is the first metabolizing enzyme in the trp-kyn pathway which is inducible by pro-inflammatory cytokines, involved depression-like behavior via 5-ht depletion due to decreased level of trp in the 5-ht pathway. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ana Salomé Correia, Isabel Silva, Henrique Reguengo, José Carlos Oliveira, Francisco Vasques-Nóvoa, Armando Cardoso, Nuno Val. The Effect of the Stress Induced by Hydrogen Peroxide and Corticosterone on Tryptophan Metabolism, Using Human Neuroblastoma Cell Line (SH-SY5Y). International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901819. |
it is important in processes such as mood and stress response, the 5-ht pathway begins with the conversion of l-trp to 5-hydroxytryptophan (5-htp), that is metabolized into 5-ht, converted to melatonin or to 5-hydroxyindoleacetic acid (5-hiaa). |
2023-03-11 |
2023-08-14 |
human |