| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Minegishi, R Fukumori, T Satoh, H Kitagawa, S Yanaur. Interaction of lithium and disulfiram in hexobarbital hypnosis: possible role of the 5-HT system. The Journal of pharmacology and experimental therapeutics. vol 218. issue 2. 1981-09-25. PMID:6166742. |
these results suggest that lithium and disulfiram exert their synergistic effect on hx hypnosis by acting on the 5-ht system and that an accumulation of 5-hydroxyindoleacetaldehyde, an active metabolite of 5-ht, may be responsible for the increase in the brain sensitivity to barbiturates caused by these drugs. |
1981-09-25 |
2023-08-12 |
rat |
| I I Lobacheva, N K Popov. [Interstrain differences in the serotonin and 5-hydroxyindoleacetic acid levels in the postnatal ontogeny of C57BL/6J and BALB/cLac strain mice]. Ontogenez. vol 12. issue 3. 1981-09-25. PMID:6166915. |
the characteristic dynamics of serotonin and its metabolite content related to the age was found in different brain regions and proved to be similar in both the strains, but the rate of serotonin system development in c57bl/6j mice was higher than in balb/c lac mice. |
1981-09-25 |
2023-08-12 |
mouse |
| I I Lobacheva, N K Popov. [Interstrain differences in the serotonin and 5-hydroxyindoleacetic acid levels in the postnatal ontogeny of C57BL/6J and BALB/cLac strain mice]. Ontogenez. vol 12. issue 3. 1981-09-25. PMID:6166915. |
sex differences in the rate of serotonin system maturation and serotonin and 5-hiaa content were shown for 12--16 days old mice: 12 days old males were characterized by more intensive metabolism than females while 16 days old males had less serotonin than females. |
1981-09-25 |
2023-08-12 |
mouse |
| H Fujiwara, M Uemoto, C Tanak. Stimulation of the rat dorsal raphe in vivo releases labeled serotonin from the parietal cortex. Brain research. vol 216. issue 2. 1981-09-25. PMID:7248780. |
these findings are a direct demonstration of the in vivo release of [3h]5-ht from the parietal cortex with stimulation of the dorsal raphe, particularly the rostral two-thirds of the nucleus and provide the neurochemical evidence for the dorsal raphe-cortical 5-ht pathway via the lateral 5-ht bundle. |
1981-09-25 |
2023-08-12 |
rat |
| Z Roliński, M Herbu. The role of the serotonergic system in foot shock-induced behavior in mice. Psychopharmacology. vol 73. issue 3. 1981-08-10. PMID:6454158. |
stimulation of the brain 5-hydroxytryptamine (5-ht) neurons with different serotonergic agents, such as l-tryptophan, 5-hydroxytryptophan, imipramine, fluoxetine, 5-methoxy-tryptamine, quipazine, and fenfluramine, showed the inhibiting role of the 5-ht system in fsif. |
1981-08-10 |
2023-08-12 |
mouse |
| Y Sakai, Y Matsu. [Neurochemical and electroencephalographical studies on the central actions of mianserin (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 76. issue 6. 1981-05-28. PMID:7203282. |
these results suggest that mianserin activated both the ne and 5-ht metabolic systems, imp activated the ne system in general, but activated the 5-ht system only at low doses and tended to suppress the formation of 5-ht, in high doses; cip had no effect on the ne system and suppressed 5-ht system, in high doses. |
1981-05-28 |
2023-08-12 |
mouse |
| T Yamamoto, S Uek. The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs. Pharmacology, biochemistry, and behavior. vol 14. issue 1. 1981-04-24. PMID:6258178. |
these results suggest that 5-ht receptors innervated with the ascending 5-ht pathway originating in the m-r play a vital role in the manifestation of hallucinogen-induced head-twitch. |
1981-04-24 |
2023-08-12 |
Not clear |
| J Z Nowak, B Bielkiewicz, U Lebrecht, A Kordecka, C Maslinsk. Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system. Agents and actions. vol 10. issue 1 Pt 2. 1980-08-28. PMID:6155770. |
dimaprit had negligible effect on the serotonin system while 4-methylhistamine and histamine decreased serotonin and simultaneously increased 5-hydroxyindolcacetic acid. |
1980-08-28 |
2023-08-12 |
rat |
| R Y Wang, C de Montigny, B I Gold, R H Roth, G K Aghajania. Denervation supersensitivity to serotonin in rat forebrain: single cell studies. Brain research. vol 178. issue 2-3. 1980-02-15. PMID:509215. |
5-ht projections to the vlgn and the amyg were destroyed by 5,7-dihydroxytryptamine (5,7-dht, a relatively selective toxin for 5-ht neurons) injected directly into the lateral ventricle or the ascending 5-ht pathway in the ventromedial tegmentum area. |
1980-02-15 |
2023-08-11 |
rat |
| B Fjallan. Neuroleptic influence on hyperthermia induced by 5-hydroxytryptophan and p-methoxy-amphetamine in MAOI-pretreated rabbits. Psychopharmacology. vol 63. issue 2. 1979-10-24. PMID:38473. |
it is concluded that both 5-ht and catecholamine (dopamine) receptor blockade is required to antagonize 5-htp hyperthermia and that antagonism of p-ma induced hyperthermia is primarily a result of influence on the 5-ht system. |
1979-10-24 |
2023-08-11 |
Not clear |
| J Maj, W Palider, Rawłó. Trazodone, a central serotonin antagonist and agonist. Journal of neural transmission. vol 44. issue 3. 1979-07-16. PMID:438809. |
our findings indicate that tr has a double effect on the central 5-ht system: at low doses it acts as a 5-ht antagonist, whereas at higher ones--as a 5-ht agonist. |
1979-07-16 |
2023-08-11 |
rat |
| M O Carruba, G Nisticò, G Gargiul. Effect of central nervous system-acting drugs after selective destruction by neurotoxins of 5-hydroxytryptamine fibers in the brain. Annals of the New York Academy of Sciences. vol 305. 1978-12-27. PMID:309299. |
these data indicate a modulatory role of the 5-ht system in the hyperthermic response to dopaminergic agonists, such as d-amphetamine and apomorphine, and rule out 5-ht involvement in the hyperpyrexia induced by pyrogen. |
1978-12-27 |
2023-08-11 |
Not clear |
| C T Giambalvo, S R Snodgras. Biochemical and behavioral effects of serotonin neurotoxins on the nigrostriatal dopamine system: comparison of injection sites. Brain research. vol 152. issue 3. 1978-11-18. PMID:308384. |
unilateral injections of the serotonin neurotoxin, 5,7-dihydroxytryptamine (dht), at various points along the 5-ht pathway to the forebrain produce a turning syndrome associated with alterations of dopamine synthesis in the ipsilateral striatum. |
1978-11-18 |
2023-08-11 |
rat |
| R Y Wang, G K Aghajania. Inhibiton of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway. Brain research. vol 120. issue 1. 1977-03-15. PMID:137766. |
the evidence may be briefly summarized as follows:(1) on the same amygdaloid cells, both iontophoresis of serotonin (5-ht) and electrical stimulation of the drn markedly inhibited spontaneous single unit activities; (2) the latency of drn-induced inhibition was relatively short and is compatible with the conduction velocities (which were determined by antidromic activation of the 5-ht pathway) of unmyelinated 5-ht fibers; (3) destruction of 5-ht projections by 5,7-dihydroxytryptamine (5,7-dht) or pharmacological depletion of 5-ht by parachlorophenylalanine (pcpa) prevented the inhibitory responsed to drn stimulation in the great majority of cells studied; (4) in pcpa-pretreated animals, injection of 5-hydroxytryptophan (5-htp) reversed the pcpa effect, restoring the responses of amygdaloid cells to drn stimulation. |
1977-03-15 |
2023-08-11 |
Not clear |
| D M Lawson, R R Gal. The interaction of dopaminergic and serotonergic drugs on plasma prolactin in ovariectomized, estrogen-treated rats. Endocrinology. vol 98. issue 1. 1976-04-10. PMID:1248448. |
the serotonin antagonists sq 10,631 and methysergide reduced the pimozide-induced elevation in prolactin levels, suggesting that part of the increase in prolactin following dopaminergic blockage may result from the action of a tonically stimulatory serotonin system that is normally masked by the intense tonic inhibition by the dopaminergic system. |
1976-04-10 |
2023-08-11 |
rat |