| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Inoue, T Shimizu, T Saheki, T Noda, T Fukud. Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation. Biochemical medicine and metabolic biology. vol 42. issue 3. 1990-02-02. PMID:2597437. |
increased flux through the 5-ht pathway during hyperammonemia was indicated by a significant positive correlation between gln concentration and the ratio of 5-hiaa to 5-ht in the brain of spf mice taken after microwave irradiation to prevent postmortem changes in metabolites. |
1990-02-02 |
2023-08-11 |
mouse |
| A Romaniuk, M Strzelczuk, M Wieczore. Is it advisable to use sorbitans in the investigation of the brain mechanisms? Acta neurobiologiae experimentalis. vol 49. issue 5. 1989-12-28. PMID:2480057. |
the content of 5-hydroxyindoleacetic acid (5-hiaa) increased in the hypothalamus, midbrain and amygdala, which indicates the increase in serotonin (5-ht) turnover and the 5-ht system activity. |
1989-12-28 |
2023-08-11 |
cat |
| P Blier, C de Montigny, D Tardi. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.). vol 1. issue 3. 1989-02-21. PMID:2850622. |
in the first part of the present study, the effect of lithium on the function of terminal 5-ht autoreceptors was assessed by comparing in controls and lithium-treated rats the differential effect of two frequencies of stimulation (0.8 and 5 hz) and that of methiothepin, a terminal 5-ht autoreceptor antagonist, on the effectiveness of the electrical activation of the ascending 5-ht pathway in suppressing dorsal hippocampus pyramidal neuron firing activity. |
1989-02-21 |
2023-08-11 |
rat |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium treatment and serotoninergic function. Neuroendocrine and behavioral responses to intravenous tryptophan in affective disorder. Archives of general psychiatry. vol 46. issue 1. 1989-01-30. PMID:2910219. |
the present findings suggest that lithium treatment enhances 5-ht function, but that homeostatic responses of the 5-ht system to long-term lithium treatment may differ in patients with affective disorder and healthy subjects. |
1989-01-30 |
2023-08-11 |
human |
| P Blier, C de Montigny, Y Chapu. Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission. Clinical neuropharmacology. vol 11 Suppl 2. 1988-12-20. PMID:2846168. |
the acute administration of 5-ht reuptake blockers does not enhance the efficacy of the stimulation of the 5-ht pathway. |
1988-12-20 |
2023-08-11 |
rat |
| P Blier, C de Montigny, Y Chapu. Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission. Clinical neuropharmacology. vol 11 Suppl 2. 1988-12-20. PMID:2846168. |
the electrophysiological assessment of the effects of these different types of antidepressant treatments on the 5-ht system therefore revealed as a common effect an enhancement of 5-ht neurotransmission, albeit each one achieving this via a different mechanism. |
1988-12-20 |
2023-08-11 |
rat |
| J P Zak, J A Miller, D V Sheehan, B S Fanou. The potential role of serotonin reuptake inhibitors in the treatment of obsessive compulsive disorder. The Journal of clinical psychiatry. vol 49 Suppl. 1988-10-13. PMID:3045108. |
(5) are the effects of the serotonin reuptake inhibitors that are effective in treating ocd mediated via the serotonin system or via another mechanism? |
1988-10-13 |
2023-08-11 |
human |
| P Blier, Y Chaput, C de Montign. Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 3. 1988-08-22. PMID:3260661. |
the function of the terminal 5-ht autoreceptors was assessed by comparing the effectiveness of the electrical stimulation of the ascending 5-ht pathway on the firing activity of hippocampus pyramidal neurons prior to, and following, the administration of methiothepin, an antagonist of the terminal 5-ht autoreceptor, and, by determining the ratio of effectiveness of 0.8 hz (s1) and 5 hz (s2) stimulations. |
1988-08-22 |
2023-08-11 |
rat |
| Y Chaput, C de Montign. Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2839669. |
to assess whether endogenous 5-ht also could be antagonized, the response of pyramidal neurons to electrical activation of the 5-ht pathway was determined before and after i.v. |
1988-08-17 |
2023-08-11 |
rat |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
three parameters related to the 5-ht system were investigated: (i) the inhibition of [3h]5-ht uptake into rat brain synaptosomes, (ii) the inhibition of [3h]paroxetine binding to rat neuronal membranes and (iii) the effect of the compounds on the affinity of [3h]imipramine for the human platelet membrane binding site, measured as the dissociation rate of the [3h]imipramine human platelet membrane binding site complex. |
1988-02-26 |
2023-08-11 |
human |
| C Foresta, M Indino, C Scandellar. Role of gonadal steroids in the serotoninergic control of prolactin secretion in men. Clinical endocrinology. vol 26. issue 5. 1987-12-01. PMID:3665121. |
the physiological regulation of prl secretion seems to involve the central serotonin system, since plasma prl levels are enhanced by serotoninergic agonists and serotonin re-uptake blockers. |
1987-12-01 |
2023-08-11 |
Not clear |
| D G Morga. The dopamine and serotonin systems during aging in human and rodent brain. A brief review. Progress in neuro-psychopharmacology & biological psychiatry. vol 11. issue 2-3. 1987-10-15. PMID:2819950. |
in the serotonin system, the concentration of serotonin remains stable during nonpathological aging in both rodents and humans. |
1987-10-15 |
2023-08-11 |
mouse |
| B Costall, M E Kelly, R J Naylor, C C Tan, F D Tattersal. 5-Hydroxytryptamine M-receptor antagonism in the hypothalamus facilitates gastric emptying in the guinea-pig. Neuropharmacology. vol 25. issue 11. 1987-02-11. PMID:3099224. |
it is concluded that an endogenous hypothalamic 5-ht system may inhibit gastric emptying through a 5-ht m-receptor mechanism which may afford a site of action for 5-ht agonist and antagonist drugs to modify gastric emptying. |
1987-02-11 |
2023-08-11 |
Not clear |
| C G Gottfries, T Bartfai, A Carlsson, S Eckernäs, L Svennerhol. Multiple biochemical deficits in both gray and white matter of Alzheimer brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3797685. |
in the brains from the alzheimer patients a disturbance was found in the 5-ht system in the form of reduced levels of 5-ht and 5-hydroxyindolacetic acid (5-hiaa). |
1987-02-06 |
2023-08-11 |
cat |
| Y Chaput, C de Montigny, P Blie. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 333. issue 4. 1986-12-12. PMID:3022157. |
for 14 days, the suppression of firing activity of ca3 hippocampal pyramidal neurons produced by microiontophoretically-applied 5-ht and by the electrical activation of the ascending 5-ht pathway was measured. |
1986-12-12 |
2023-08-11 |
rat |
| L Antkiewicz-Michalu. The influence of chronic treatment with antidepressant neuroleptics on the central serotonin system. Polish journal of pharmacology and pharmacy. vol 38. issue 4. 1986-12-10. PMID:3774629. |
they also indicate that antidepressant neuroleptics, which are potent serotonin 5-ht2 and alpha 1-adrenergic blocking agents, after chronic administration affect the serotonin system in a manner similar to that produced by chronic treatment with classical antidepressant drugs. |
1986-12-10 |
2023-08-11 |
rat |
| Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 10. 1986-11-12. PMID:3020184. |
in a first series of experiments, the effect of the electrical activation of the ascending 5-ht pathway on the firing activity of ca3 hippocampal pyramidal neurons was measured before and after the intravenous administration of methiothepin, a terminal 5-ht autoreceptor antagonist. |
1986-11-12 |
2023-08-11 |
Not clear |
| Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 10. 1986-11-12. PMID:3020184. |
methiothepin significantly increased the duration of the suppression of firing activity of these neurons by the electrical stimulation of the 5-ht pathway, without modifying their responsiveness to microiontophoretically applied 5-ht. |
1986-11-12 |
2023-08-11 |
Not clear |
| Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 10. 1986-11-12. PMID:3020184. |
in a second series of experiments, further evidence for the activation of terminal 5-ht autoreceptors by 5-ht released by the electrical stimulation was sought by assessing the effectiveness of 2 series of stimulations of the ascending 5-ht pathway delivered at different frequencies while recording the same postsynaptic neuron. |
1986-11-12 |
2023-08-11 |
Not clear |
| L Brodin, J T Buchanan, T Hökfelt, S Grillner, A A Verhofsta. A spinal projection of 5-hydroxytryptamine neurons in the lamprey brainstem; evidence from combined retrograde tracing and immunohistochemistry. Neuroscience letters. vol 67. issue 1. 1986-08-13. PMID:3725200. |
these findings suggest that in addition to the well-described local intraspinal 5-ht system, there is also, as in higher vertebrates, a descending 5-ht projection from the brainstem which extends at least 20 segments into the spinal cord. |
1986-08-13 |
2023-08-11 |
Not clear |