| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C F Phelix, D M Adai, C Cantu, H Chen, M J Wayne. Immunohistochemical demonstration of serotonin-containing axons in the hypothalamus of the white-footed mouse, Peromyscus leucopus. Brain research. vol 808. issue 2. 1998-12-11. PMID:9767166. |
although neurochemical analyses of hypothalamic serotonin and its receptors have been reported for this species, the relevant neuroanatomy of the serotonin system within mouse hypothalamus has not been studied. |
1998-12-11 |
2023-08-12 |
mouse |
| H K Kramer, J C Poblete, E C Azmiti. Characterization of the translocation of protein kinase C (PKC) by 3,4-methylenedioxymethamphetamine (MDMA/ecstasy) in synaptosomes: evidence for a presynaptic localization involving the serotonin transporter (SERT). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 4. 1998-11-25. PMID:9718590. |
3, 4-methylenedioxymethamphetamine (mdma or ecstasy) is a substituted amphetamine whose acute and long-term effects on the serotonin system are dependent on an interaction with the 5-ht uptake transporter (sert). |
1998-11-25 |
2023-08-12 |
Not clear |
| H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
alterations in the activity of the central 5-ht system are important in understanding the pathophysiology of depression, and therefore, we examined whether this model was associated with changes in the expression of 5-ht1a receptor, 5-ht1b receptor, and 5-ht transporter mrna in the dorsal raphe nucleus and the hippocampus. |
1998-11-04 |
2023-08-12 |
rat |
| V Pérez, N Bel, P Celada, J Ortiz, E Alvarez, F Artiga. Relationship between blood serotonergic variables, melancholic traits, and response to antidepressant treatments. Journal of clinical psychopharmacology. vol 18. issue 3. 1998-09-03. PMID:9617981. |
the inverse relationship between the pretreatment platelet 5-ht content and clinical response may be useful in the investigation of the relationship between the 5-ht system and antidepressant response. |
1998-09-03 |
2023-08-12 |
Not clear |
| L H Price, R T Malison, C J McDougle, G H Pelton, G R Heninge. The neurobiology of tryptophan depletion in depression: effects of intravenous tryptophan infusion. Biological psychiatry. vol 43. issue 5. 1998-05-05. PMID:9513749. |
previous work has suggested that acute depletion of the serotonin (5-ht) precursor tryptophan (trp) causes transient compensatory changes in the 5-ht system that might be exploited for their antidepressant effects. |
1998-05-05 |
2023-08-12 |
Not clear |
| A Srikiatkhachorn, S Maneesri, P Govitrapong, V Kasantiku. Derangement of serotonin system in migrainous patients with analgesic abuse headache: clues from platelets. Headache. vol 38. issue 1. 1998-04-21. PMID:9505003. |
based on this platelet model, we suggest that excessive use of analgesics alters the central 5-ht system by depleting 5-ht from its storage sites and results in the hyposerotonergic state. |
1998-04-21 |
2023-08-12 |
Not clear |
| H H Hansen, C Sánchez, E Meie. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9400008. |
the present study was carried out with a selective serotonin reuptake inhibitor (ssri) to investigate whether the serotonin system, in particular, is involved in the neonatal animal model. |
1998-01-15 |
2023-08-12 |
human |
| L Imeri, S Bianchi, M Manci. Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis. The American journal of physiology. vol 273. issue 5. 1997-12-16. PMID:9374807. |
these results suggest that 1) mdp effects on both sleep-wake activity and brain cortical temperature are mediated by the serotonergic system; 2) the mechanisms mediating the first and the second phases of il-1-induced sws excess are different: 5-ht could be involved in the first phase, but not in the second one; and 3) the 5-ht system does not appear to be involved in il-1-induced fever. |
1997-12-16 |
2023-08-12 |
rat |
| K Muneoka, T Ogawa, K Kamei, S Muraoka, R Tomiyoshi, Y Mimura, H Kato, M R Suzuki, M Takigaw. Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations. Brain research. Developmental brain research. vol 102. issue 1. 1997-11-19. PMID:9298240. |
in addition, the 5-ht system was also affected by prenatal nicotine, and reductions of 5-ht turnover in the m + p - m at pd15 and in the forebrain and the cerebellum at pd22 were found. |
1997-11-19 |
2023-08-12 |
rat |
| E V Gurevich, J N Joyc. Alterations in the cortical serotonergic system in schizophrenia: a postmortem study. Biological psychiatry. vol 42. issue 7. 1997-11-10. PMID:9376449. |
previous studies have suggested a disturbance in the cortical serotonergic (5-ht) system in schizophrenia; however, these studies have been confounded by suicide in the patients groups, which in itself is associated with alterations in the 5-ht system. |
1997-11-10 |
2023-08-12 |
human |
| E F Coccaro, R J Kavoussi, R L Hauge. Serotonin function and antiaggressive response to fluoxetine: a pilot study. Biological psychiatry. vol 42. issue 7. 1997-11-10. PMID:9376450. |
although evidence for this hypothesis is emerging, the relationship between baseline central 5-ht system function and antiaggressive responses to treatment with 5-ht agents has not yet been examined in human subjects. |
1997-11-10 |
2023-08-12 |
human |
| A Mosner, G Kuhlman, C Roehm, W H Voge. Serotonergic receptors modify the voluntary intake of alcohol and morphine but not of cocaine and nicotine by rats. Pharmacology. vol 54. issue 4. 1997-09-03. PMID:9211564. |
these results suggest: (1) selective stimulation of 5-ht1a receptors reduces alcohol preference, (2) stimulation of all 5-ht receptors has no effect on alcohol intake, indicating the presence of inhibitory receptors, (3) stimulation of the serotonergic system in general stimulates morphine preference, (4) the serotonin system does not affect nicotine or cocaine preference and (5) the serotonergic system is not involved in the voluntary consumption of all, but-only of some drugs/chemicals of abuse. |
1997-09-03 |
2023-08-12 |
rat |
| W A Fogel, A Kruk, M Kozlowska, K Sasiak, W Andrzejewski, C Maslinsk. Liver regeneration attenuates increased voluntary alcohol intake evoked by the liver damage. Alcoholism, clinical and experimental research. vol 21. issue 4. 1997-08-20. PMID:9194932. |
the brain serotonin system was activated in portocaval anastomosis rats and unchanged in thioacetamide-treated rats, thus suggesting that serotonin is not likely to be implicated in the mechanism(s) underlying development of alcohol preference in these rats. |
1997-08-20 |
2023-08-12 |
rat |
| D Zhou, M Schreinert, J Pilz, G Huethe. Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 12. 1997-05-15. PMID:9029405. |
substituted amphetamines are known to selectively destroy serotonin (5-ht) nerve endings in distant projection fields of the dorsal raphe nuclei and the systemic administration of these drugs is widely used in investigations of the role of the central 5-ht system and of the mechanisms involved in their toxicity. |
1997-05-15 |
2023-08-12 |
rat |
| N Haddjeri, C de Montigny, P Blie. Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5-hydroxtryptamine system. British journal of pharmacology. vol 120. issue 5. 1997-05-02. PMID:9138693. |
these data support the notion that the 5-ht system tonically modulates na neurotransmission since the lesion of 5-ht neurones enhanced the lc na neurones firing activity and the suppressant effect of way 100635 on the firing activity of na neurones was abolished by this lesion. |
1997-05-02 |
2023-08-12 |
rat |
| C K Farren, T G Dina. Elevated tryptophan levels in post-withdrawal alcoholics. Acta psychiatrica Scandinavica. vol 94. issue 6. 1997-04-30. PMID:9021001. |
these findings indicate a disturbance in serotonin precursor availability in post-withdrawal alcoholics, and contribute to the evidence for involvement of the serotonin system in alcoholism. |
1997-04-30 |
2023-08-12 |
human |
| P W Burnet, C P Chen, S McGowan, M Franklin, P J Harriso. The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience. vol 73. issue 2. 1997-03-11. PMID:8783268. |
we injected rats for 14 days with clozapine (25 mg/kg/day) or haloperidol (2 mg/kg/day), and measured three aspects of the serotonin system in forebrain regions: abundance of serotonin-2a, -2c and -1a receptor messenger rnas by in situ hybridization histochemistry; serotonin-2a and -1a binding sites using receptor autoradiography, and levels of serotonin and 5-hydroxyindoleacetic acid with high-performance liquid chromatography. |
1997-03-11 |
2023-08-12 |
rat |
| E H Cook, B L Leventha. The serotonin system in autism. Current opinion in pediatrics. vol 8. issue 4. 1997-03-07. PMID:9053096. |
the serotonin system has been implicated as a factor in some cases of autism since the finding in 1961 of elevated serotonin (5-hydroxytryptamine) levels in the blood of patients with autism. |
1997-03-07 |
2023-08-12 |
human |
| N T Mathew, G E Tietjen, C Lucke. Serotonin syndrome complicating migraine pharmacotherapy. Cephalalgia : an international journal of headache. vol 16. issue 5. 1997-02-19. PMID:8869767. |
serotonin syndrome has been reported exclusively in patients on medications for psychiatric illness and parkinsonism, despite the fact that the putative action of many antimigraine agents also involves the serotonin system. |
1997-02-19 |
2023-08-12 |
Not clear |
| T Y Kao, M T Li. Brain serotonin depletion attenuates heatstroke-induced cerebral ischemia and cell death in rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 80. issue 2. 1997-02-06. PMID:8929615. |
however, when the cerebral serotonin system was destroyed by 5,7-dihydroxytryptamine, the heatstroke-induced arterial hypotension, intracranial hypertension, ischemic damage to the brain, and elevated cerebral serotonin release were reduced. |
1997-02-06 |
2023-08-12 |
rat |