| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F M Benes, J B Taylor, M C Cunningha. Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology. Cerebral cortex (New York, N.Y. : 1991). vol 10. issue 10. 2000-10-25. PMID:11007552. |
this finding suggests that lesions of the serotonin system induce plasticity of the cortical dopamine system; however, it is not known whether this inferred suppressive effect of serotonin fibers occurs at brainstem levels or within the mpfcx itself. |
2000-10-25 |
2023-08-12 |
rat |
| A R Ase, C Strazielle, C Hébert, M I Botez, R LaLonde, L Descarries, T A Reade. Central serotonin system in Dystonia musculorum mutant mice: biochemical, autoradiographic and immunocytochemical data. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881040. |
to investigate possible changes in the central serotonin system of these mice, hplc measurements of 5-hydroxytryptophan, 5-hydroxy-tryptamine (serotonin; 5-ht), and 5-ht metabolites were obtained from 22 brain regions and the spinal cord of wild type and dt(j)/dt(j) mutant mice. |
2000-10-06 |
2023-08-12 |
mouse |
| A R Ase, C Strazielle, C Hébert, M I Botez, R LaLonde, L Descarries, T A Reade. Central serotonin system in Dystonia musculorum mutant mice: biochemical, autoradiographic and immunocytochemical data. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881040. |
the bulk of these results indicates a relative sparing of the central 5-ht system in the dt(j)/dt(j) mice, even though alterations in 5-ht transporters could justify attempts at improving the sensorimotor dysfunction by administration of serotoninergic agents in these mice. |
2000-10-06 |
2023-08-12 |
mouse |
| C L Tsai, L H Wang, C F Chang, C C Ka. Effects of gonadal steroids on brain serotonergic and aromatase activity during the critical period of sexual differentiation in tilapia, Oreochromis mossambicus. Journal of neuroendocrinology. vol 12. issue 9. 2000-10-02. PMID:10971814. |
since the 5-ht system may influence sexual differentiation, we examined the effects of para-chlorophenylalanine (p-cpa), a 5-ht synthesis inhibitor. |
2000-10-02 |
2023-08-12 |
Not clear |
| C L Tsai, L H Wang, C F Chang, C C Ka. Effects of gonadal steroids on brain serotonergic and aromatase activity during the critical period of sexual differentiation in tilapia, Oreochromis mossambicus. Journal of neuroendocrinology. vol 12. issue 9. 2000-10-02. PMID:10971814. |
in tilapia treated between days 7 and 10, the brain 5-ht content was lowered by e2 to an extent similar to that seen with p-cpa, which is consistent with the suggestion that the effect of e2 on sexual differentiation may be mediated by the 5-ht system. |
2000-10-02 |
2023-08-12 |
Not clear |
| C P Chen, S L Eastwood, T Hope, B McDonald, P T Francis, M M Esir. Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes. Neuropathology and applied neurobiology. vol 26. issue 4. 2000-09-19. PMID:10931368. |
it was concluded from these findings that the raphe nuclei are significantly affected by the pathology of ad and that plasticity in the 5-ht system is the probable reason for the lack of correlation of reduced 5-ht neurone density and clinical disease parameters. |
2000-09-19 |
2023-08-12 |
Not clear |
| V Di Matteo, G Di Giovanni, M Di Mascio, E Esposit. Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814735. |
taken together, these data confirm that central 5-ht system exerts an inhibitory control on the mesolimbic da system and that 5-ht(2c) receptors are involved in this effect. |
2000-07-21 |
2023-08-12 |
Not clear |
| K Hatanaka, S Yatsugi, T Yamaguch. Effect of acute treatment with YM992 on extracellular norepinephrine levels in the rat frontal cortex. European journal of pharmacology. vol 395. issue 1. 2000-06-22. PMID:10781670. |
ym992 enhances the neurotransmission of not only 5-ht system but also norepinephrine, and as such may have a preclinical profile different from that of a selective serotonin reuptake inhibitor. |
2000-06-22 |
2023-08-12 |
rat |
| A S New, A Woo-Ming, V Mitropoulou, J Silverman, D Reynolds, F Schopick, R L Trestman, L J Sieve. Serotonin and the prediction of response time to fluoxetine in patients with mild depression. Psychiatry research. vol 88. issue 2. 2000-02-08. PMID:10622345. |
pharmacologic manipulation of the serotonin system with a selective serotonin reuptake inhibitor (ssri) is effective in the treatment of depression. |
2000-02-08 |
2023-08-12 |
Not clear |
| N F Tajuddin, M J Drus. In utero ethanol exposure decreased the density of serotonin neurons. Maternal ipsapirone treatment exerted a protective effect. Brain research. Developmental brain research. vol 117. issue 1. 1999-12-28. PMID:10536236. |
these investigations also found that maternal treatment with a 5-ht(1a) agonist, buspirone, prevented most of the ethanol-associated damage to the developing 5-ht system. |
1999-12-28 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. In utero ethanol exposure decreased the density of serotonin neurons. Maternal ipsapirone treatment exerted a protective effect. Brain research. Developmental brain research. vol 117. issue 1. 1999-12-28. PMID:10536236. |
in the present investigation, we investigated whether the ethanol-associated changes in the 5-ht system are due to a reduction of 5-ht neurons and whether any changes in the density of 5-ht neurons can be prevented by maternal treatment with another 5-ht(1a) agonist, ipsapirone. |
1999-12-28 |
2023-08-12 |
rat |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
at the postsynaptic level, long-term treatment with flesinoxan (5 mg/kg/day x 14 days) did not modify the responsiveness of dorsal hippocampus ca3 pyramidal neurons to microiontophoretic applications of 5-ht and flesinoxan nor to endogenous 5-ht released by the electrical stimulation of the ascending 5-ht pathway, indicating an unchanged sensitivity of postsynaptic 5-ht1a receptors. |
1999-11-22 |
2023-08-12 |
rat |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
in conclusion, as for selective 5-ht re-uptake inhibitors, monoamine oxidase inhibitors and 5-ht1a receptor agonists, flesinoxan produced most of the adaptive changes exerted by these antidepressant drugs on the 5-ht system. |
1999-11-22 |
2023-08-12 |
rat |
| A Abouesh, A Clayto. Compulsive voyeurism and exhibitionism: a clinical response to paroxetine. Archives of sexual behavior. vol 28. issue 1. 1999-07-16. PMID:10097802. |
the discussion addresses the need for further comparative studies investigating the role of the serotonin system in the pathogenesis of sexual paraphilias and ocd as well as the effect of serotonin reuptake inhibitors in comparison to other pharmacologic modalities used in the treatment of paraphilias. |
1999-07-16 |
2023-08-12 |
Not clear |
| J D Coplan, H Tamir, D Calaprice, M DeJesus, M de la Nuez, D Pine, L A Papp, D F Klein, J M Gorma. Plasma anti-serotonin and serotonin anti-idiotypic antibodies are elevated in panic disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088140. |
in line with our interest in dysregulated 5-ht systems in panic disorder (pd), we wished to assess if antibodies directed at the 5-ht system were elevated in patients with pd in comparison to healthy volunteers. |
1999-06-03 |
2023-08-12 |
human |
| G Gerra, A Zaimovic, G Giucastro, D Maestri, C Monica, R Sartori, R Caccavari, R Delsignor. Serotonergic function after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans. International clinical psychopharmacology. vol 13. issue 1. 1999-04-02. PMID:9988361. |
these data suggest an association between serotonin system impairment and mdma use in humans; in interpretation of these results, the possibility that serotonin deficit in mdma individuals was partially related to a premorbid condition, in relationship with novelty-seeking behaviour and mood disorders, can not be excluded. |
1999-04-02 |
2023-08-12 |
Not clear |
| S O Ogren, I Misan. Animal models for studying serotonin (5-HT) receptor subtypes: relationship to 5-HT system pathologies. Nuclear medicine and biology. vol 25. issue 8. 1999-03-23. PMID:9863561. |
animal models for studying serotonin (5-ht) receptor subtypes: relationship to 5-ht system pathologies. |
1999-03-23 |
2023-08-12 |
rat |
| N Le Marec, C Hébert, F Amdiss, M I Botez, T A Reade. Regional distribution of 5-HT transporters in the brain of wild type and 'Purkinje cell degeneration' mutant mice: a quantitative autoradiographic study with [3H]citalopram. Journal of chemical neuroanatomy. vol 15. issue 3. 1999-01-08. PMID:9797073. |
this suggests that in progressive cerebellar degeneration, as found in the pcd mutant, the modified 5-ht system may still participate in motor functions by exerting an overall modulation of excitatory amino acid neurotransmission, but the availability of 5-ht may be altered in defined brain targets, as is the case for other spontaneous cerebellar mutants, in particular for the 'lurcher' mutant mouse, a model of human olivopontocerebellar atrophy. |
1999-01-08 |
2023-08-12 |
mouse |
| D J Bare, J H McKinzie, W J McBrid. Development of rapid tolerance to ethanol-stimulated serotonin release in the ventral hippocampus. Alcoholism, clinical and experimental research. vol 22. issue 6. 1999-01-04. PMID:9756042. |
because the vhip receives a major 5ht input from the median raphe nucleus (mrn), the results suggest that acute ethanol activates the mrn 5-ht system projecting to the vhip and that rapid tolerance develops to the activating effects of alcohol on this pathway. |
1999-01-04 |
2023-08-12 |
rat |
| A Hayashi, M Nagaoka, K Yamada, Y Ichitani, Y Miake, N Okad. Maternal stress induces synaptic loss and developmental disabilities of offspring. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 3-4. 1998-12-23. PMID:9785117. |
together with data in our previous studies, that have shown 5-ht to facilitate synapse formation and maintenance in the central nervous system, synaptic loss is suggested to occur in relation to changes of 5-ht system in the hippocampus of prenatally stressed offspring. |
1998-12-23 |
2023-08-12 |
rat |