| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Velling, David W Dodick, Jesse J Mui. Sustained-release niacin for prevention of migraine headache. Mayo Clinic proceedings. vol 78. issue 6. 2003-08-27. PMID:12934790. |
however, low plasma levels of serotonin have been implicated in migraine pathogenesis, and niacin may act as a negative feedback regulator on the kynurenine pathway to shunt tryptophan into the serotonin pathway, thus increasing plasma serotonin levels. |
2003-08-27 |
2023-08-12 |
Not clear |
| Leo Sher, Maria A Oquendo, Shuhua Li, Steven Ellis, Beth S Brodsky, Kevin M Malone, Thomas B Cooper, J John Man. Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls. Psychoneuroendocrinology. vol 28. issue 4. 2003-07-17. PMID:12689612. |
the hormonal response to the serotonin releasing agent/uptake inhibitor fenfluramine has been used as an indicator of central serotonin system function. |
2003-07-17 |
2023-08-12 |
Not clear |
| D Rujescu, I Giegling, B Bondy, A Gietl, P Zill, H-J Mölle. Association of anger-related traits with SNPs in the TPH gene. Molecular psychiatry. vol 7. issue 9. 2003-04-30. PMID:12399958. |
tryptophan hydroxylase (tph) is the rate limiting biosynthetic enzyme in the serotonin pathway and regulates levels of serotonin. |
2003-04-30 |
2023-08-12 |
human |
| A Rasmussen, J Christensen, P M Clemmensen, N J Dalsgaard, H Dam, I Hindberg, M Lunde, P Plenge, E Melleru. Platelet serotonin transporter in stroke patients. Acta neurologica Scandinavica. vol 107. issue 2. 2003-04-15. PMID:12580867. |
post-stroke depression can be treated with serotonin transport inhibitors suggesting a role for the serotonin system in these patients. |
2003-04-15 |
2023-08-12 |
human |
| David J Nut. Tolerability and safety aspects of mirtazapine. Human psychopharmacology. vol 17 Suppl 1. 2003-01-13. PMID:12404669. |
the 5-ht(2) blocking effect contributes towards its anxiolytic effects and benefits on sleep, as well as preventing the sexual dysfunction that may occur with non-specific stimulation of the serotonin system by drugs such as the selective serotonin reuptake inhibitors (ssris). |
2003-01-13 |
2023-08-12 |
Not clear |
| Stéphanie Caillé, Emilio F Espejo, George F Koob, Luis Stinu. Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062589. |
to test the hypothesis that serotonin (5-ht) has a critical role in the development of opiate withdrawal, we have employed a near-total brain 5-ht system lesion technique (90% depletion) using 5,7-dihydroxytryptamine combined with induction of opiate dependence by implantation of morphine pellets or by repeated injections of increasing doses of morphine. |
2003-01-08 |
2023-08-12 |
rat |
| S Kuma. Aluminium-induced changes in the rat brain serotonin system. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 40. issue 12. 2002-12-24. PMID:12419702. |
significantly increased 5-ht levels observed in brain regions olb (60 days), hip (4,14 days), str (14 days), hyp (14, 60 days), mbr (4 and 14 days), pon (4 days), mob (4 days) and spi (4, 14 and 60 days) following al exposure may be due to al deactivating 5-ht system by decreased release and subsequent breakdown of 5-ht. |
2002-12-24 |
2023-08-12 |
rat |
| S Kuma. Aluminium-induced changes in the rat brain serotonin system. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 40. issue 12. 2002-12-24. PMID:12419702. |
decreased 5-ht levels observed in cerebral cor, hip (60 days) and in cbl after 4 and 60 days of exposure suggest an inhibitory effect of al on the 5-ht system due to withdrawal of cholinergic input in these brain regions. |
2002-12-24 |
2023-08-12 |
rat |
| Evelyne Chanut, Jeanine Nguyen-Legros, Benoît Labarthe, Jean-Hugues Trouvin, Claudine Versaux-Botter. Serotonin synthesis and its light-dark variation in the rat retina. Journal of neurochemistry. vol 83. issue 4. 2002-12-24. PMID:12421358. |
to demonstrate local synthesis of serotonin in the rat retina, substrates of tryptophan hydroxylase, the first limiting enzyme in the serotonin pathway, have been used. |
2002-12-24 |
2023-08-12 |
rat |
| Piyarat Govitrapong, Sujira Mukda, Wanpen Turakitwanakan, Hattaya Dumrongphol, Chittin Chindaduangratn, Yupin Sanvarind. Platelet serotonin transporter in schizophrenic patients with and without neuroleptic treatment. Neurochemistry international. vol 41. issue 4. 2002-10-24. PMID:12106771. |
to elucidate the role of the serotonin system in schizophrenia, the serotonin transporters on human platelets were examined in this study. |
2002-10-24 |
2023-08-12 |
human |
| V E Golimbet, M V Alfimova, T V Shcherbatykh, E I Rogae. [Allele polymorphism of the serotonin transporter gene and clinical heterogeneity of depressive disorders]. Genetika. vol 38. issue 5. 2002-08-13. PMID:12068552. |
their development is to a substantial extent underlain by dysfunction of the serotonin system, in particular, disturbed serotonin transport. |
2002-08-13 |
2023-08-12 |
Not clear |
| Gwenn S Smith, Yilong Ma, Vijay Dhawan, Handan Gunduz, Maren Carbon, Maggie Kirshner, Jennifer Larson, Thomas Chaly, Abdel Belakhleff, Elisse Kramer, Blaine Greenwald, John M Kane, Fouzia Laghrissi-Thode, Bruce G Pollock, David Eidelbe. Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112403. |
to develop a method to measure the dynamic response of the serotonin system in vivo, the effects of intravenously administered citalopram (the most selective of the serotonin reuptake inhibitors) on cerebral glucose metabolism were evaluated. |
2002-08-08 |
2023-08-12 |
human |
| E Sibille, R He. Combining genetic and genomic approaches to study mood disorders. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 6. 2002-07-03. PMID:11704418. |
the serotonin system, and the serotonin(1a) (5-ht(1a)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-ht(1a) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression. |
2002-07-03 |
2023-08-12 |
mouse |
| Mariko Yamano, Hiroo Ogura, Shigeru Okuyama, Hiroko Ohki-Hamazak. Modulation of 5-HT system in mice with a targeted disruption of neuromedin B receptor. Journal of neuroscience research. vol 68. issue 1. 2002-06-18. PMID:11933049. |
to assess the role of neuromedin b receptor (nmb-r) on the modulation of serotonergic (5-ht) system, the function of the 5-ht system was examined in mice lacking the nmb-r gene. |
2002-06-18 |
2023-08-12 |
mouse |
| Mariko Yamano, Hiroo Ogura, Shigeru Okuyama, Hiroko Ohki-Hamazak. Modulation of 5-HT system in mice with a targeted disruption of neuromedin B receptor. Journal of neuroscience research. vol 68. issue 1. 2002-06-18. PMID:11933049. |
although restraint stress enhanced 5-ht expression in these neurons in wild-type mice, this treatment did not affect 5-ht expression level in nmb-r-deficient mice, indicating the modulation of 5-ht system in the mutant mice. |
2002-06-18 |
2023-08-12 |
mouse |
| M Bianchi, C Moser, C Lazzarini, E Vecchiato, F Cresp. Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes. Experimental brain research. vol 143. issue 2. 2002-05-10. PMID:11880895. |
the present data showing that the levels of 5-ht in ips tend to return to control values 12 days after the beginning of chronic fluoxetine treatment suggest that 5-ht levels in ips (intracellular environment) mirror the influence of ssri treatment upon the central 5-ht system. |
2002-05-10 |
2023-08-12 |
rat |
| M Bianchi, C Moser, C Lazzarini, E Vecchiato, F Cresp. Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes. Experimental brain research. vol 143. issue 2. 2002-05-10. PMID:11880895. |
in particular, the present data support the idea that peripheral 5-ht platelet levels can reflect the state of the central 5-ht system in conditions of depression. |
2002-05-10 |
2023-08-12 |
rat |
| I S Chee, S W Lee, J L Kim, S K Wang, Y O Shin, S C Shin, Y H Lee, H M Hwang, M R Li. 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder. Psychiatric genetics. vol 11. issue 3. 2002-05-02. PMID:11702051. |
genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2a (5-ht2a) receptor gene promoter polymorphism -1438a/g has been reported. |
2002-05-02 |
2023-08-12 |
human |
| H Hermann, G Marsicano, B Lut. Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain. Neuroscience. vol 109. issue 3. 2002-04-15. PMID:11823058. |
together with overlapping expression patterns of dopamine and serotonin receptors this suggests a potential of cb1 to modulate the function of the dopamine and serotonin system. |
2002-04-15 |
2023-08-12 |
mouse |
| R J Thielen, D J Bare, W J McBride, L Lumeng, T-K L. Ethanol-stimulated serotonin release in the ventral hippocampus: an absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812514. |
these data suggest that ethanol may activate terminals of the median raphe 5-ht system in p rats because the vhip receives its 5-ht inputs primarily from the median raphe nucleus (mrn). |
2002-04-05 |
2023-08-12 |
rat |