| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debra E Weese-Mayer, Michael J Ackerman, Mary L Marazita, Elizabeth M Berry-Kravi. Sudden Infant Death Syndrome: review of implicated genetic factors. American journal of medical genetics. Part A. vol 143A. issue 8. 2007-05-16. PMID:17340630. |
genetic studies in sudden infant death syndrome (sids) have been motivated by clinical, epidemiological, and/or neuropathological observations in sids victims, with subsequent pursuit of candidate genes in five categories: (1) genes for ion channel proteins based on electrocardiographic evidence of prolonged qt intervals in sids victims, (2) gene for serotonin transporter based on decreased serotonergic receptor binding in brainstems of sids victims, (3) genes pertinent to the early embryology of the autonomic nervous system (ans) (and with a link to the 5-ht system) based on reports of ans dysregulation in sids victims, (4) genes for nicotine metabolizing enzymes based on evidence of cigarette smoking as a modifiable risk factor for sids, and (5) genes regulating inflammation, energy production, hypoglycemia, and thermal regulation based on reports of postnatal infection, low birth weight, and/or overheating in sids victims. |
2007-05-16 |
2023-08-12 |
Not clear |
| Christian P Müller, Robert J Carey, Joseph P Huston, Maria A De Souza Silv. Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors. Progress in neurobiology. vol 81. issue 3. 2007-05-10. PMID:17316955. |
serotonin(1a)-receptors (5-ht(1a)-rs) are important components of the 5-ht system in the brain. |
2007-05-10 |
2023-08-12 |
Not clear |
| Jens O Drachmann Bukh, Camilla Bock, Niels Peter Ole Mors, Lars Vedel Kessin. [The influence of genetic variations on the effect of selective serotonin reuptake inhibitors]. Ugeskrift for laeger. vol 169. issue 16. 2007-05-10. PMID:17484840. |
we summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. |
2007-05-10 |
2023-08-12 |
Not clear |
| Candace E Hofmann, Linda Ellis, Wayne K Yu, Joanne Weinber. Hypothalamic-pituitary-adrenal responses to 5-HT1A and 5-HT2A/C agonists are differentially altered in female and male rats prenatally exposed to ethanol. Alcoholism, clinical and experimental research. vol 31. issue 2. 2007-03-08. PMID:17250628. |
as there are extensive interactions between the hpa axis and the 5-ht system, the present study tested the hypothesis that prenatal ethanol exposure would alter 5-ht(1a) and 5-ht(2a/c) receptor-mediated hpa function. |
2007-03-08 |
2023-08-12 |
rat |
| Julia C Lemos, Yu-Zhen Pan, Xiaohong Ma, Christophe Lamy, Adaure C Akanwa, Sheryl G Bec. Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe. The European journal of neuroscience. vol 24. issue 12. 2007-03-06. PMID:17229091. |
this finding, in concert with its previously described function as an autoreceptor, suggests that 5-ht(1b) receptors influence the ascending 5-ht system through multiple mechanisms. |
2007-03-06 |
2023-08-12 |
rat |
| Ana Paula M Guimarães, Cristian Zeni, Guilherme V Polanczyk, Julia P Genro, Tatiana Roman, Luis A Rohde, Mara H Hut. Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 1. 2007-02-27. PMID:16958038. |
low serotonin activity has been associated in both animal and human studies with measures of impulsivity, aggression, and disinhibited behaviors, which make genes from the serotonin system reasonable candidates for adhd susceptibility. |
2007-02-27 |
2023-08-12 |
human |
| Yukio Ago, Shigeo Nakamura, Aiko Hayashi, Soichi Itoh, Akemichi Baba, Toshio Matsud. Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16962650. |
previous studies using serotonin (5-ht) receptor ligands show that the 5-ht system is involved in cocaine-induced behavioral sensitization in rats, but the role of the 5-ht system has not been studied in mice. |
2007-02-23 |
2023-08-12 |
mouse |
| Carol A Tamming. The neurobiology of cognition in schizophrenia. The Journal of clinical psychiatry. vol 67. issue 9. 2007-02-23. PMID:17081078. |
several putative molecular targets for treating cognition in schizophrenia show promise, such as treatments that act on the d(1) receptor of the dopamine system; the 5ht(1a), 5ht(2a), and 5ht(6), receptors of the serotonin system; and ampakines, glycine/d-cycloserine, d-serine, and mglur 2/3 agonists of the glutamatergic system. |
2007-02-23 |
2023-08-12 |
Not clear |
| Wiesław Jerzy Cubała, Jerzy Landowsk. [Serotoninergic system and limbic-hypothalamic-pituitary-adrenal axis (LHPA axis) in depression]. Psychiatria polska. vol 40. issue 3. 2007-02-08. PMID:17037809. |
in depression, the 5-ht system exhibits impaired presynaptic activity of 5-ht neurones, an increased activity of central postsynaptic 5-ht2a receptors, decreased activity of postsynaptic 5-ht1a receptors and altered synaptic 5-ht uptake. |
2007-02-08 |
2023-08-12 |
Not clear |
| Barry V O'Neill, Rodney J Croft, Sumie Leung, Valérie Guille, Matthew Galloway, K Luan Phan, Pradeep J Natha. Dopamine receptor stimulation does not modulate the loudness dependence of the auditory evoked potential in humans. Psychopharmacology. vol 188. issue 1. 2006-12-22. PMID:16896953. |
the loudness dependence of the auditory evoked potential (ldaep) has been suggested as a reliable measure of central serotonin function in humans; however, its specificity for the serotonin system remains a topic of debate, with possible modulation of this purported serotonin marker by other neurotransmitters, including dopamine. |
2006-12-22 |
2023-08-12 |
Not clear |
| Kereshmeh Taravosh-Lahn, Christel Bastida, Yvon Delvill. Differential responsiveness to fluoxetine during puberty. Behavioral neuroscience. vol 120. issue 5. 2006-12-15. PMID:17014259. |
as serotonin inhibits offensive responses in adult hamsters, it is hypothesized that the serotonin system becomes upregulated in the hypothalamus during puberty. |
2006-12-15 |
2023-08-12 |
Not clear |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
because evidence suggests that bdnf is an important determinant of the function of the 5-hydroxytryptamine (5-ht) system, we also quantified tissue levels of 5-ht and its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa), to investigate if changes in bdnf mrna and protein paralleled changes in the 5-ht system. |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
additionally, as inferred from the alterations in tissue levels of 5-ht and 5-hiaa, chronic corticosterone may influence the function of the 5-ht system. |
2006-12-06 |
2023-08-12 |
rat |
| Brian George Dias, David Crew. Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens. Hormones and behavior. vol 50. issue 3. 2006-10-24. PMID:16793042. |
our data suggest that serotonin is inhibitory to male-like pseudosexual behavior in c. uniparens but more importantly that the hormonal environment modulates the serotonin system at the level of the preoptic area, with the serotonergic system then establishing behavioral thresholds that allow for this behavior to be "gated". |
2006-10-24 |
2023-08-12 |
Not clear |
| Richard G Ruddell, Fiona Oakley, Ziafat Hussain, Irene Yeung, Lesley J Bryan-Lluka, Grant A Ramm, Derek A Man. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. The American journal of pathology. vol 169. issue 3. 2006-10-24. PMID:16936262. |
we conclude that hscs express key regulatory components of the 5-ht system enabling them to store and release 5-ht and to respond to the neurotransmitter in a profibrogenic manner. |
2006-10-24 |
2023-08-12 |
human |
| Pierre Brown, Charles R Gerfe. Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 map kinase pathway. The Journal of comparative neurology. vol 498. issue 3. 2006-10-03. PMID:16871540. |
however, the striatal 5-hydroxytryptamine (5-ht) innervation remains intact after 6-ohda lesions, suggesting that the 5-ht system may contribute to the lesion-induced dysfunction, or alternatively, it may adapt and compensate for the dopamine deficit. |
2006-10-03 |
2023-08-12 |
Not clear |
| Pierre Brown, Charles R Gerfe. Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 map kinase pathway. The Journal of comparative neurology. vol 498. issue 3. 2006-10-03. PMID:16871540. |
neonatal 6-ohda lesions actually give rise to a 5-ht axonal hyperinnervation within the dorsal striatum, further reinforcing the idea that the 5-ht system plays a central role in striatal function after dopamine depletion. |
2006-10-03 |
2023-08-12 |
Not clear |
| Taku Sato, Eiji Suzuki, Masamoto Yokoyama, Jun'ichi Semba, Shigeru Watanabe, Hitoshi Miyaok. Chronic intraperitoneal injection of interferon-alpha reduces serotonin levels in various regions of rat brain, but does not change levels of serotonin transporter mRNA, nitrite or nitrate. Psychiatry and clinical neurosciences. vol 60. issue 4. 2006-09-20. PMID:16884454. |
further investigation is needed to determine exactly how this cytokine affects the central serotonin system and to assess whether a central serotonin abnormality is involved in interferon-induced depression. |
2006-09-20 |
2023-08-12 |
rat |
| Erin L Kinnally, Heather A Jensen, Jennifer H Ewing, Jeffrey A Frenc. Serotonin function is associated with behavioral response to a novel conspecific in marmosets. American journal of primatology. vol 68. issue 8. 2006-09-18. PMID:16847970. |
in the second study we first characterized the parameters of the marmoset peripheral 5-ht system and further assessed the relationship between natural variation in peripheral 5-ht and 5-hiaa levels with behavioral inhibition in response to a novel conspecific (n=14). |
2006-09-18 |
2023-08-12 |
marmoset |
| Esther Berrocoso, Juan Antonio Micó, Luisa Uged. In vivo effect of tramadol on locus coeruleus neurons is mediated by alpha2-adrenoceptors and modulated by serotonin. Neuropharmacology. vol 51. issue 1. 2006-09-11. PMID:16730359. |
moreover, this effect is modulated by the 5-ht system and particularly by 5-ht(1a) receptors. |
2006-09-11 |
2023-08-12 |
Not clear |