| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Cirann. Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology. Current neuropharmacology. vol 4. issue 2. 2010-06-09. PMID:18615128. |
finally, the physiological meaning of neuromodulatory effects of 5-ht will be briefly discussed with respect to pathologies deriving from malfunctioning of serotonin system. |
2010-06-09 |
2023-08-12 |
Not clear |
| Andrew W Bismark, Francisco A Moreno, Jennifer L Stewart, David N Towers, James A Coan, Jennifer Oas, Robert P Erickson, John J B Alle. Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry. Biological psychology. vol 83. issue 2. 2010-05-20. PMID:20025927. |
polymorphic variations in genes related to serotonin synthesis, transport, recognition, or degradation may convey subtle changes in serotonin system architecture that may place an individual at risk for psychopathology when faced with life stressors. |
2010-05-20 |
2023-08-12 |
human |
| Lena C Quilty, Kathryn M Godfrey, Sidney H Kennedy, R Michael Bagb. Harm avoidance as a mediator of treatment response to antidepressant treatment of patients with major depression. Psychotherapy and psychosomatics. vol 79. issue 2. 2010-05-05. PMID:20090398. |
the temperament harm avoidance (ha) has consistently demonstrated an association with major depressive disorder (mdd), serotonin functioning and reduction in depression symptoms in response to antidepressant medications targeting the serotonin system. |
2010-05-05 |
2023-08-12 |
Not clear |
| Elizabeth M Haney, Stuart J Warden, M Michael Bliziote. Effects of selective serotonin reuptake inhibitors on bone health in adults: time for recommendations about screening, prevention and management? Bone. vol 46. issue 1. 2010-04-21. PMID:19664737. |
serotonin is involved in the pathophysiology of depression, and therefore studies of depression and antidepressant treatments (as modulators of the serotonin system) are relevant with regard to bone outcomes. |
2010-04-21 |
2023-08-12 |
Not clear |
| Lakshmi N Yatham, Peter F Liddle, Jonathan Erez, Marcia Kauer-Sant'Anna, Raymond W Lam, Miguel Imperial, Vesna Sossi, Thomas J Rut. Brain serotonin-2 receptors in acute mania. The British journal of psychiatry : the journal of mental science. vol 196. issue 1. 2010-04-15. PMID:20044660. |
although 5-hydroxytryptamine (5-ht) has been implicated in mania, the precise alterations in the 5-ht system remain elusive. |
2010-04-15 |
2023-08-12 |
Not clear |
| Scott F Stoltenberg, Joanna M Vandeve. Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19781560. |
because gender moderates the effect of genetic polymorphisms on serotonin function and because there are gender differences in decision-making, the present study examined potential gender moderation of associations between polymorphisms in important serotonin system candidate genes (serotonin transporter [slc6a4] and tryptophan hydroxylase-2 [tph2]) and performance on a decision-making task (iowa gambling task, igt) in healthy, adults (n = 188; 62% women). |
2010-04-13 |
2023-08-12 |
human |
| Marta Bosia, Simona Anselmetti, Adele Pirovano, Elena Ermoli, Elena Marino, Placido Bramanti, Enrico Smeraldi, Roberto Cavallar. HTTLPR functional polymorphism in schizophrenia: executive functions vs. sustained attention dissociation. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 1. 2010-04-07. PMID:19818823. |
recently attention has been addressed to the role of 5-ht in cognition and several experimental studies revealed that manipulations of the central 5-ht system can produce quite specific changes in cognitive functioning. |
2010-04-07 |
2023-08-12 |
Not clear |
| Ivan Skelin, Hiroki Sato, Mirko Diksi. Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats: an autoradiographic study. Brain research. vol 1310. 2010-03-30. PMID:19912994. |
d-fenfluramine is a 5-ht releasing drug, frequently used in the study of the responsivity of the 5-ht system in subjects with psychiatric disorders, including depression. |
2010-03-30 |
2023-08-12 |
human |
| Ivan Skelin, Hiroki Sato, Mirko Diksi. Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats: an autoradiographic study. Brain research. vol 1310. 2010-03-30. PMID:19912994. |
the results suggest the blunted capacity of the 5-ht system in obx rats to respond to the challenge by the 5-ht releasing compound, d-fenfluramine. |
2010-03-30 |
2023-08-12 |
human |
| Jocelien D A Olivier, Alexander R Cools, Peter M T Deen, Berend Olivier, Bart A Ellenbroe. Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20004658. |
the lack of the serotonin transporter in sert(-/-) rats might reflect humans with a life-long disturbed serotonin system, making this rat a good model to study possible changes in dopaminergic and noradrenergic systems in psychiatric disorders. |
2010-03-30 |
2023-08-12 |
rat |
| Pierre Blie. Altered function of the serotonin 1A autoreceptor and the antidepressant response. Neuron. vol 65. issue 1. 2010-03-23. PMID:20152106. |
report on a novel genetic approach to conditionally and specifically dampen the function of the 5-ht(1a) autoreceptor in mice to study its role on the 5-ht system and on the antidepressant-like effect of the selective serotonin reuptake inhibitor (ssri) fluoxetine. |
2010-03-23 |
2023-08-12 |
mouse |
| Baldwin M Way, Shelley E Taylo. Social influences on health: is serotonin a critical mediator? Psychosomatic medicine. vol 72. issue 2. 2010-03-15. PMID:20145277. |
building on recent studies of genetic variation in the serotonin system, particularly focusing on a polymorphism (5-httlpr) in the serotonin transporter gene, we provide evidence that activity within the serotonin system is critically involved in setting sensitivity to social experiences. |
2010-03-15 |
2023-08-12 |
Not clear |
| Janaina M Zanoveli, Milene C Carvalho, Joice M Cunha, Marcus L Brandã. Extracellular serotonin level in the basolateral nucleus of the amygdala and dorsal periaqueductal gray under unconditioned and conditioned fear states: an in vivo microdialysis study. Brain research. vol 1294. 2010-01-12. PMID:19646971. |
the present study showed that the 5-ht system was activated during conditioned fear, whereas it remained unchanged during unconditioned fear, supporting the hypothesis that 5-ht has distinct roles in conditioned and unconditioned fear (dual role of 5-ht in anxiety disorders). |
2010-01-12 |
2023-08-12 |
Not clear |
| N V Maluchenko, J V Schegolkova, M A Kulikova, M A Timofeeva, V A Shlepcova, O V Sysoeva, A G Tonevitsk. Gender effects on association of serotonin transporter gene polymorphism with symptoms of central fatigue. Bulletin of experimental biology and medicine. vol 147. issue 4. 2009-12-28. PMID:19704949. |
thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter. |
2009-12-28 |
2023-08-12 |
Not clear |
| Yvonne Kuepper, Nina Alexander, Roman Osinsky, Eva Mueller, Anja Schmitz, Petra Netter, Juergen Henni. Aggression--interactions of serotonin and testosterone in healthy men and women. Behavioural brain research. vol 206. issue 1. 2009-12-09. PMID:19747510. |
animal models implicate t to modulate 5-ht system activity, and furthermore have shown behaviorally relevant interactions of t and 5-ht with respect to aggression. |
2009-12-09 |
2023-08-12 |
human |
| Yvonne Kuepper, Nina Alexander, Roman Osinsky, Eva Mueller, Anja Schmitz, Petra Netter, Juergen Henni. Aggression--interactions of serotonin and testosterone in healthy men and women. Behavioural brain research. vol 206. issue 1. 2009-12-09. PMID:19747510. |
we tested for associations between habitual t-level and 5-ht system activity, as well as behaviorally relevant interactions of t and 5-ht with respect to trait aggression in 48 healthy male and female subjects. |
2009-12-09 |
2023-08-12 |
human |
| David S Paterson, Gerard Hilaire, Debra E Weese-Maye. Medullary serotonin defects and respiratory dysfunction in sudden infant death syndrome. Respiratory physiology & neurobiology. vol 168. issue 1-2. 2009-12-02. PMID:19481178. |
a subset of sids infants have several abnormalities in medullary markers of 5-ht function and genetic polymorphisms impacting the 5-ht system, informing the hypothesis that sids results from a defect in 5-ht brainstem-mediated control of respiratory (and autonomic) regulation. |
2009-12-02 |
2023-08-12 |
human |
| J Elizabeth Bolhuis, Esther D Ellen, Cornelis G Van Reenen, Johanna De Groot, Jan Ten Napel, Rudie E Koopmanschap, Ger De Vries Reilingh, Koen A Uitdehaag, Bas Kemp, T Bas Rodenbur. Effects of genetic group selection against mortality on behavior and peripheral serotonin in domestic laying hens with trimmed and intact beaks. Physiology & behavior. vol 97. issue 3-4. 2009-08-12. PMID:19341749. |
in addition, they displayed higher whole blood 5-ht concentrations and a lower platelet 5-ht uptake, indicating differences in functional activity of the 5-ht system. |
2009-08-12 |
2023-08-12 |
Not clear |
| Stephen J Kish, Paul S Fitzmaurice, Isabelle Boileau, Gregory A Schmunk, Lee-Cyn Ang, Yoshiaki Furukawa, Li-Jan Chang, Dennis J Wickham, Allan Sherwin, Junchao Ton. Brain serotonin transporter in human methamphetamine users. Psychopharmacology. vol 202. issue 4. 2009-08-11. PMID:18841348. |
as information on the brain serotonin system in human ma users is fragmentary, our objective was to determine whether protein levels of serotonin transporter (sert), a key marker of serotonin neurones, are decreased in brain of chronic ma users. |
2009-08-11 |
2023-08-12 |
human |
| Hideki Miura, Tetsuya Shirokawa, Kenichi Isobe, Norio Ozak. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress (Amsterdam, Netherlands). vol 12. issue 3. 2009-08-03. PMID:19006008. |
thus, isolation housing shifted the balance between the kyn and 5-ht pathways to the 5-ht pathway, whereas systemic administration of lps shifted it to the kyn pathway. |
2009-08-03 |
2023-08-12 |
mouse |