| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurent Bardi. The complex role of serotonin and 5-HT receptors in chronic pain. Behavioural pharmacology. vol 22. issue 5-6. 2011-12-13. PMID:21808193. |
we discuss the inhibitory or facilitatory influences exerted by 5-ht, through the descending 5-ht pathway, on spinal processing of nociceptive information in pathological pain states. |
2011-12-13 |
2023-08-12 |
Not clear |
| Paul R Albert, Brice Le François, Anne M Milla. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Molecular brain. vol 4. 2011-11-30. PMID:21619616. |
the serotonin-1a (5-ht1a) receptor is among the most abundant and widely distributed 5-ht receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire serotonin system. |
2011-11-30 |
2023-08-12 |
Not clear |
| Sonny K H Tan, Henrike Hartung, Trevor Sharp, Yasin Teme. Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus? Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21251918. |
it is well established that the 5-ht system is markedly affected in the parkinsonian brain, with evidence including pathological loss of markers of 5-ht axons as well as cell bodies in the dorsal and median raphe nuclei of the midbrain. |
2011-10-14 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, David S Paterson, Richard A Belliveau, Felicia L Trachtenberg, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hannah C Kinne. Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome. Journal of neuropathology and experimental neurology. vol 70. issue 9. 2011-10-14. PMID:21865888. |
previously, we reported abnormalities in multiple 5-ht markers in the medullary 5-ht system of infants dying from sudden infant death syndrome (sids), suggesting that 5-ht dysfunction is involved in its pathogenesis. |
2011-10-14 |
2023-08-12 |
Not clear |
| Zhiyang Song, Björn A Meyerson, Bengt Linderot. Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy. Pain. vol 152. issue 7. 2011-10-13. PMID:21514998. |
recently, we demonstrated that the pain-relieving effect of scs appears to involve the spinal serotonin system, and the present study aimed at identifying the types of the spinal serotonin receptors involved. |
2011-10-13 |
2023-08-12 |
rat |
| Youssef Sari, Verity R Johnson, Jason M Weedma. Role of the serotonergic system in alcohol dependence: from animal models to clinics. Progress in molecular biology and translational science. vol 98. 2011-07-27. PMID:21199778. |
we emphasize the serotonin transporter and its possible role in alcoholism, then present several serotonergic receptors and discuss their contribution to alcoholism, and finally assess the serotonin system as a target for pharmacotherapy, with an emphasis on current and potential treatments. |
2011-07-27 |
2023-08-12 |
Not clear |
| Charles D Nichol. Serotonin 5-HT(2A) Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases. Cardiovascular psychiatry and neurology. vol 2009. 2011-07-14. PMID:20029624. |
it is hypothesized that one component of the serotonin system, the 5-ht(2a) receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders. |
2011-07-14 |
2023-08-12 |
Not clear |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
however, an acute depletion of serotonin in healthy individuals does not induce depressive symptoms suggesting that depression does not correlate with the serotonin system only. |
2011-07-14 |
2023-08-12 |
rat |
| Karine Madsen, David Erritzoe, Erik Lykke Mortensen, Anders Gade, Jacob Madsen, William Baaré, Gitte M Knudsen, Steen G Hasselbalc. Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20623110. |
the serotonin transporter (sert) protein is a key regulator in the serotonin system. |
2011-05-24 |
2023-08-12 |
human |
| N K Popova, V S Naumenko, A S Cybko, D V Bazovkin. Receptor-genes cross-talk: effect of chronic 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20423722. |
receptor-genes cross-talk: effect of chronic 5-ht(1a) agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior. |
2011-03-04 |
2023-08-12 |
mouse |
| N K Popova, V S Naumenko, A S Cybko, D V Bazovkin. Receptor-genes cross-talk: effect of chronic 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20423722. |
here, we investigated whether interaction exists between 5-ht(1a) receptor and genes encoding key members in brain 5-ht system. |
2011-03-04 |
2023-08-12 |
mouse |
| Matthew S Milak, Alin J Severance, Jaya Prabhakaran, J S Dileep Kumar, Vattoly J Majo, R Todd Ogden, J John Mann, Ramin V Parse. In vivo serotonin-sensitive binding of [11C]CUMI-101: a serotonin 1A receptor agonist positron emission tomography radiotracer. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20571518. |
these modest changes in bp(f) may make it unlikely that this ligand will detect changes in intrasynaptic 5-ht under physiologic conditions; future work will focus on evaluating its utility in measuring the responsiveness of the 5-ht system to pharmacological challenges. |
2011-02-03 |
2023-08-12 |
Not clear |
| b' Beata Kazek, Ma\\xc5\\x82gorzata Huzarska, Urszula Grzybowska-Chlebowczyk, Maciej Kajor, Monika Ciupi\\xc5\\x84ska-Kajor, Halina Wo\\xc5\\x9b, Elzbieta Marsza\\xc5\\x8. Platelet and intestinal 5-HT2A receptor mRNA in autistic spectrum disorders - results of a pilot study. Acta neurobiologiae experimentalis. vol 70. issue 2. 2010-12-27. PMID:20628446.' |
the analyses reveal a significantly higher level of 5-ht(2a)r mrna in platelets of the study group patients, which could suggest serotonin system dysregulation. |
2010-12-27 |
2023-08-12 |
Not clear |
| V S Naumenko, D V Osipova, A S Tsybk. [On the role of selective silencer Freud-1 in the regulation of the brain 5-HT(1A) receptor gene expression]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090244. |
these data allow us to conclude that the selective silencer of 5-ht(1a) receptor, freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-ht(1a) receptor transcriptional regulation. |
2010-12-17 |
2023-08-12 |
mouse |
| B M Ruf, Z Bhagwaga. The 5-HT1B receptor: a novel target for the pathophysiology of depression. Current drug targets. vol 10. issue 11. 2010-09-27. PMID:19702551. |
although the 5-ht system is a popular target for drug therapy in mdd the role that serotonin plays in mdd is not clearly understood. |
2010-09-27 |
2023-08-12 |
rat |
| Masaki Fumoto, Tsutomu Oshima, Kiyoshi Kamiya, Hiromi Kikuchi, Yoshinari Seki, Yasushi Nakatani, Xinjun Yu, Tamami Sekiyama, Ikuko Sato-Suzuki, Hideho Arit. Ventral prefrontal cortex and serotonergic system activation during pedaling exercise induces negative mood improvement and increased alpha band in EEG. Behavioural brain research. vol 213. issue 1. 2010-09-13. PMID:20412817. |
because cortical attenuation would be caused by the 5-ht-induced inhibition of the basal forebrain, we hypothesized that the observed eeg changes are linked with the increased blood 5-ht level or an augmentation of the 5-ht system in the brainstem. |
2010-09-13 |
2023-08-12 |
human |
| Yong Kee Choi, Taylor Moran-Gates, Matthew P Gardner, Frank I Taraz. Effects of repeated risperidone exposure on serotonin receptor subtypes in developing rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 3. 2010-08-31. PMID:19875272. |
these findings indicate that there are differential effects of risperidone on 5-ht(1a) and 5-ht(2a) receptors in juvenile animals, and that the 5-ht system in developing animals is more sensitive than adults to the long-term effects of risperidone. |
2010-08-31 |
2023-08-12 |
rat |
| Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xin. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain research. vol 1330. 2010-08-02. PMID:20230801. |
although much evidence indicates that the potentiation of descending facilitatory 5-ht pathways may contribute to the development of chronic pain, the inhibition of descending inhibitory 5-ht system may be functionally more important to the development of central sensitization and neuropathic pain. |
2010-08-02 |
2023-08-12 |
rat |
| W I Khan, J E Ghi. Gut hormones: emerging role in immune activation and inflammation. Clinical and experimental immunology. vol 161. issue 1. 2010-08-02. PMID:20408856. |
the studies reviewed in this paper demonstrate that 5-ht activates the immune cells to produce proinflammatory mediators and by manipulating the 5-ht system it is possible to modulate gut inflammation. |
2010-08-02 |
2023-08-12 |
Not clear |
| Gerard K H The, Gijs Bleijenberg, Jan K Buitelaar, Jos W M van der Mee. The effect of ondansetron, a 5-HT3 receptor antagonist, in chronic fatigue syndrome: a randomized controlled trial. The Journal of clinical psychiatry. vol 71. issue 5. 2010-06-11. PMID:20122367. |
neuropharmacologic studies point to a hyperactive 5-ht system, and open-label treatment studies with 5-ht(3) receptor antagonists have shown promising results. |
2010-06-11 |
2023-08-12 |
Not clear |