| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makiko Yamada, Yukie Kawahara, Fumi Kaneko, Yuki Kishikawa, Naoki Sotogaku, Wilfred J Poppinga, Joost H A Folgering, Eliyahu Dremencov, Hiroshi Kawahara, Akinori Nish. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology. vol 72. 2014-02-11. PMID:23643754. |
to evaluate the drn-pfc 5-ht system in wky rats, we examined the effects of escitalopram (escit) on the extracellular 5-ht level in comparison with wistar rats using dual-probe microdialysis. |
2014-02-11 |
2023-08-12 |
rat |
| Makiko Yamada, Yukie Kawahara, Fumi Kaneko, Yuki Kishikawa, Naoki Sotogaku, Wilfred J Poppinga, Joost H A Folgering, Eliyahu Dremencov, Hiroshi Kawahara, Akinori Nish. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology. vol 72. 2014-02-11. PMID:23643754. |
chronic escit induced upregulation of the drn-pfc 5-ht system in wky rats, with increases in basal 5-ht in the drn, responsiveness to escit in the drn and pfc, and feedback inhibition, whereas downregulation of these effects was induced in wistar rats. |
2014-02-11 |
2023-08-12 |
rat |
| Makiko Yamada, Yukie Kawahara, Fumi Kaneko, Yuki Kishikawa, Naoki Sotogaku, Wilfred J Poppinga, Joost H A Folgering, Eliyahu Dremencov, Hiroshi Kawahara, Akinori Nish. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology. vol 72. 2014-02-11. PMID:23643754. |
the finding that chronic escit upregulates the 5-ht system in hyposerotonergic wky rats may contribute to improved understanding of mechanisms of action of antidepressants, especially in depression with 5-ht deficiency. |
2014-02-11 |
2023-08-12 |
rat |
| Shao-Ju Weng, Chyng-Yann Shiue, Wen-Sheng Huang, Cheng-Yi Cheng, San-Yuan Huang, I-Hsun Li, Chih-Chieh Tao, Ta-Kai Chou, Mei-Hsiu Liao, Yung-Ping Chang, Kuo-Hsing M. PET imaging of serotonin transporters with 4-[18F]-ADAM in a Parkinsonian rat model. Cell transplantation. vol 22. issue 7. 2014-01-22. PMID:23127756. |
this study was undertaken to address the effects of fetal mesencephalic tissue transplantation on the serotonin system in a rat model of parkinson's disease (pd) while also investigating the usefulness of 4-[18f]-adam (a serotonin transporter imaging agent) coupled with micro-pet for imaging serotonin transporters (serts). |
2014-01-22 |
2023-08-12 |
rat |
| Daniel Keszthelyi, Freddy J Troost, Daisy M Jonkers, Joanna W Kruimel, Carsten Leue, Ad A M Mascle. Decreased levels of kynurenic acid in the intestinal mucosa of IBS patients: relation to serotonin and psychological state. Journal of psychosomatic research. vol 74. issue 6. 2014-01-16. PMID:23731747. |
this pathway may also be involved in the pathogenesis of ibs by virtue of deviating tryptophan from the 5-ht pathway resulting in 5-ht deficiency. |
2014-01-16 |
2023-08-12 |
Not clear |
| F Camicia, M Herz, L C Prada, L Kamenetzky, S H Simonetta, M A Cucher, J I Bianchi, C Fernández, K Brehm, M C Rosenzvi. The nervous and prenervous roles of serotonin in Echinococcus spp. International journal for parasitology. vol 43. issue 8. 2013-12-09. PMID:23639266. |
taking into account the important roles of 5-ht in parasite biology and the divergence of 5-ht pathway genes with respect to human counterparts, the serotoninergic system could be considered as an amenable drug target against hydatid disease. |
2013-12-09 |
2023-08-12 |
human |
| Matthew Thomas, Loredana Ciuclan, Martin J Hussey, Neil J Pres. Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension. Pharmacology & therapeutics. vol 138. issue 3. 2013-11-01. PMID:23416102. |
clinical experience with antagonists targeting the various elements of the serotonin pathway has been unsatisfactory, yet perhaps this is less than surprising given our expanding knowledge around serotonin production and signaling biology, which indicate opportunities for novel therapeutic options. |
2013-11-01 |
2023-08-12 |
Not clear |
| I Heitland, J L Kenemans, R S Oosting, J M P Baas, K B E Böcke. Auditory event-related potentials (P3a, P3b) and genetic variants within the dopamine and serotonin system in healthy females. Behavioural brain research. vol 249. 2013-10-21. PMID:23619133. |
in all subjects, genetic polymorphisms within the dopamine system (dopamine transporter [dat1], catecholamine-o-methyltransferase val158met [comt val158met]) and the serotonin system (serotonin transporter [5httlpr]) were assessed. |
2013-10-21 |
2023-08-12 |
human |
| Linda Booij, Dongsha Wang, Mélissa L Lévesque, Richard E Tremblay, Moshe Szy. Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 368. issue 1615. 2013-09-12. PMID:23440465. |
we discuss specific examples of genes in the 5-ht system (serotonin transporter) and hpa axis (glucocorticoid receptor and arginine vasopressin enhancer) whose dna methylation state is associated with early life experience and may potentially lead to depression vulnerability. |
2013-09-12 |
2023-08-12 |
human |
| Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor as a key player in the brain 5-HT system. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23492554. |
specifically, it describes the (1) functional interactions between 5-ht1a, 5-ht2a, 5-ht3, and 5-ht7 receptors; (2) cross-talk between 5-ht1a receptor and genes encoding key members of the brain 5-ht system; (3) implication of the 5-ht1a receptor in natural hibernation and genetic predisposition to different kinds of defensive behavior; and (4) role of 5-ht1a autoreceptors and heteroreceptors in anxiety, depression, and suicide, and in the antidepressant effect of serotonin reuptake inhibitors. |
2013-08-21 |
2023-08-12 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor as a key player in the brain 5-HT system. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23492554. |
this review provides converging lines of evidence that the 5-ht1a receptor contributes to the action of other 5-ht receptors, modulating their effect on behavior, and describes new data on the unique role of the 5-ht1a receptor in the indirect regulation of gene expression and in the autoregulation of the brain 5-ht system. |
2013-08-21 |
2023-08-12 |
Not clear |
| José Julio Rodríguez, Harun N Noristani, Alexei Verkhratsk. The serotonergic system in ageing and Alzheimer's disease. Progress in neurobiology. vol 99. issue 1. 2013-07-10. PMID:22766041. |
numerous studies have confirmed the pathophysiological role of the 5-ht system in ad and that several drugs enhancing 5-ht neurotransmission are effective in treating the ad-related cognitive and behavioural deficits. |
2013-07-10 |
2023-08-12 |
Not clear |
| Simon Bulley, Yufei Liu, Harris Ripps, Wen She. Taurine activates delayed rectifier Kv channels via a metabotropic pathway in retinal neurons. The Journal of physiology. vol 591. issue 1. 2013-06-13. PMID:23045337. |
in sum, this study provides new evidence that taurine activates a serotonin system, apparently via 5-ht(2a) receptors and related intracellular pathways. |
2013-06-13 |
2023-08-12 |
human |
| Li Li, Guozhen Qiu, Shengyuan Ding, Fu-Ming Zho. Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Brain research. vol 1491. 2013-05-31. PMID:23159831. |
the striatum receives serotonin (5-hydroxytryptamine, 5-ht) innervation and expresses 5-ht2a receptors (5-ht2ars) and other 5-ht receptors, raising the possibility that the striatal 5-ht system may undergo adaptive changes after chronic severe dopamine (da) loss and contribute to the function and dysfunction of the striatum. |
2013-05-31 |
2023-08-12 |
mouse |
| Eduard Maron, David Nutt, Jakov Shli. Neuroimaging of serotonin system in anxiety disorders. Current pharmaceutical design. vol 18. issue 35. 2013-05-28. PMID:22632475. |
although these studies shed more light on several aspects of the 5-ht functioning in patients with anxiety disorders, the current knowledge about the specific role of the 5-ht system in particular anxiety phenotypes remains fragmentary. |
2013-05-28 |
2023-08-12 |
human |
| Eduard Maron, David Nutt, Jakov Shli. Neuroimaging of serotonin system in anxiety disorders. Current pharmaceutical design. vol 18. issue 35. 2013-05-28. PMID:22632475. |
in this paper, we review the available data from spect and pet imaging studies of the 5-ht system in anxiety disorders, attempt to dissect the involvement of the 5-ht in neural circuits of anxiety and discuss some issues that need to be considered for further research in this area. |
2013-05-28 |
2023-08-12 |
human |
| Louise M Paterson, Birgitte R Kornum, David J Nutt, Victor W Pike, Gitte M Knudse. 5-HT radioligands for human brain imaging with PET and SPECT. Medicinal research reviews. vol 33. issue 1. 2013-05-14. PMID:21674551. |
currently available radioligands for in vivo brain imaging of the 5-ht system in humans include antagonists for the 5-ht(1a), 5-ht(1b), 5-ht(2a), and 5-ht(4) receptors, and for sert. |
2013-05-14 |
2023-08-12 |
human |
| Jue Wang, Roh-Yu Shen, Samir Haj-Dahman. Endocannabinoids mediate the glucocorticoid-induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons. The Journal of physiology. vol 590. issue 22. 2013-05-01. PMID:22946098. |
together, these findings unravel a novel mechanism by which glucocorticoids control the excitability of dr 5-ht neurons and provide new insight into the rapid effects of stress hormones on the function of the 5-ht system. |
2013-05-01 |
2023-08-12 |
Not clear |
| V S Naumenko, E M Kondaurova, D V Bazovkina, A S Tsybko, M A Tikhonova, A V Kulikov, N K Popov. Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains. Neuroscience. vol 214. 2013-04-29. PMID:22531372. |
increased tryptophan hydroxylase-2 (tph-2) and 5-ht(2a) receptor genes expression accompanied by 5-ht(2a) receptor sensitization was shown in bdnf-treated asc but not in cba mouse strain, suggesting bdnf-induced increase of the brain 5-ht system functional activity and activation of neurogenesis in "depressive" asc mice. |
2013-04-29 |
2023-08-12 |
mouse |
| Ivan Skelin, Tomislav Kovačević, Hiroki Sato, Mirko Diksi. The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression. Brain research bulletin. vol 88. issue 5. 2013-04-25. PMID:22542420. |
the shift in the direction of the treatment effect from acute to chronic, using the 5-ht(1b) agonist, cp-94253, on 5-ht synthesis in the fsl model of depression, with an opposite effect on the control frl rats, suggests the differential adaptation of the 5-ht system in the fsl and frl rats to chronic stimulation of 5-ht(1b) receptors. |
2013-04-25 |
2023-08-12 |
rat |