| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard C Tenpenny, Kathryn G Common. What Gene Mutations Affect Serotonin in Mice? ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28418237. |
although serotonin neurotransmission has been implicated in several neurodevelopmental and psychological disorders, the factors that drive dysfunction of the serotonin system are poorly understood. |
2018-02-07 |
2023-08-13 |
mouse |
| Richard C Tenpenny, Kathryn G Common. What Gene Mutations Affect Serotonin in Mice? ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28418237. |
current research regarding the serotonin system revolves around its dysfunction in neuropsychiatric disorders, but there is no database collating genetic mutations that result in serotonin abnormalities. |
2018-02-07 |
2023-08-13 |
mouse |
| Juan P Ramirez-Mahaluf, Alexander Roxin, Helen S Mayberg, Albert Compt. A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 1. 2018-01-29. PMID:26514163. |
furthermore, growing evidence suggests a role for abnormal glutamate metabolism in the vacc, while serotonergic treatments (selective serotonin reuptake inhibitor, ssri) effective for many patients implicate the serotonin system. |
2018-01-29 |
2023-08-13 |
Not clear |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
early in gestation, before midbrain 5-ht projections have reached the cortex, peripheral sources supply 5-ht to the forebrain, suggesting that altered maternal or placenta 5-ht system function could impact the developing embryo. |
2018-01-05 |
2023-08-13 |
mouse |
| Sattar Ostadhadi, Nazgol-Sadat Haddadi, Arash Foroutan, Ehsan Azimi, Sarina Elmariah, Ahmad-Reza Dehpou. Development of resistance to serotonin-induced itch in bile duct ligated mice. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28316077. |
the serotonin system is implicated in cholestatic itch; however, the pruritogenic properties of serotonin have not been evaluated in cholestatic mice. |
2018-01-01 |
2023-08-13 |
mouse |
| P M Fisher, B Ozenne, C Svarer, D Adamsen, S Lehel, W F C Baaré, P S Jensen, G M Knudse. BDNF val66met association with serotonin transporter binding in healthy humans. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195567. |
the serotonin transporter (5-htt) is a key feature of the serotonin system, which is involved in behavior, cognition and personality and implicated in neuropsychiatric illnesses including depression. |
2017-11-16 |
2023-08-13 |
Not clear |
| Robbie Schepers, C Robert Marku. The interaction between 5-HTTLPR genotype and ruminative thinking on BMI. The British journal of nutrition. vol 118. issue 8. 2017-10-30. PMID:28969722. |
a short (s) allele polymorphism in the serotonin transporter gene (5-httlpr) is associated with a less efficient functioning brain serotonin system and therefore higher stress vulnerability. |
2017-10-30 |
2023-08-13 |
Not clear |
| Renata Ferreira, Marcus Lira Brandão, Manoel Jorge Nobr. 5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats. Hormones and behavior. vol 84. 2017-10-03. PMID:27328163. |
furthermore, we investigate the role of the 5-ht system of the prl, particularly the 5-ht1a receptors, as a possible modulator of estrous cycle influence on the expression of learned fear through intra-prl microinjections of 5-ht itself or the full 5-ht1a agonist 8-oh-dpat (8-hydroxy-2-(di-n-propylamine)tetralin). |
2017-10-03 |
2023-08-13 |
human |
| Meredith Sorenson Whitney, Ashley M Shemery, Alexandra M Yaw, Lauren J Donovan, J David Glass, Evan S Deneri. Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656022. |
here, we have developed a genetic approach that reproducibly achieves near-complete elimination of 5-ht synthesis from the adult ascending 5-ht system by stereotaxic injection of an adeno-associated virus expressing cre recombinase (aav-cre) into the midbrain/pons of mice carrying a loxp-conditional tryptophan hydroxylase 2 (tph2) allele. |
2017-08-17 |
2023-08-13 |
mouse |
| Dong-Fang He, Yan-Ping Ren, Mei-Yan Li. Effects of Ginseng Fruit Saponins on Serotonin System in Sprague-Dawley Rats with Myocardial Infarction, Depression, and Myocardial Infarction Complicated with Depression. Chinese medical journal. vol 129. issue 24. 2017-03-13. PMID:27958222. |
our previous studies have demonstrated that the levels of 5-hydroxytryptamine (5-ht) and 5-ht 2a receptor (5-ht2ar) in serum and platelet were associated with depression and myocardial infarction (mi), and pretreatment with ginseng fruit saponins (gfs) before mi and depression had an effect on the 5-ht system. |
2017-03-13 |
2023-08-13 |
rat |
| Wenjuan Wang, Guangxia Cui, Biao Jin, Ke Wang, Xing Chen, Yu Sun, Lihua Qin, Wenpei Ba. Estradiol Valerate and Remifemin ameliorate ovariectomy-induced decrease in a serotonin dorsal raphe-preoptic hypothalamus pathway in rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 208. 2017-02-07. PMID:27562857. |
we conclude that serotonin pathway is changed after ovariectomy, including the serotonin synthesis in dr and serotonin fibers in po/ah, both e and remifemin have an equivalent therapeutic effect on it. |
2017-02-07 |
2023-08-13 |
rat |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
the 5-ht system in the brain is carefully controlled by a combined process of regulating 5-ht neuron firing through 5-ht autoreceptors, neurotransmitter release, enzymatic degradation, and reuptake by transporters. |
2016-12-14 |
2023-08-13 |
mouse |
| Inbar Zohar, Shai Shoham, Marta Weinstoc. Perinatal citalopram does not prevent the effect of prenatal stress on anxiety, depressive-like behaviour and serotonergic transmission in adult rat offspring. The European journal of neuroscience. vol 43. issue 4. 2016-12-13. PMID:26669896. |
it had adverse behavioural effects in the offspring of control rats, which, together with the lack of any change in prenatally-stressed rats, may be due to inhibition of the foetal serotonin transporter thereby preventing normal development of the serotonin system. |
2016-12-13 |
2023-08-13 |
rat |
| Koen Hogenelst, Anastasios Sarampalis, N Pontus Leander, Barbara C N Müller, Robert A Schoevers, Marije aan het Ro. The effects of acute tryptophan depletion on speech and behavioural mimicry in individuals at familial risk for depression. Journal of psychopharmacology (Oxford, England). vol 30. issue 3. 2016-12-13. PMID:26755543. |
mdd has also been associated with disturbances in the brain serotonin system, but the extent to which serotonin regulates speech and behavioural mimicry remains unclear. |
2016-12-13 |
2023-08-13 |
human |
| Wanhong Zuo, Yong Zhang, Guiqin Xie, Danielle Gregor, Alex Bekker, Jiang-Hong Y. Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels. Neuropharmacology. vol 101. 2016-10-05. PMID:26471419. |
these results demonstrate that the reciprocal connection between the lhb and the 5-ht system highlights a key role for 5-ht stimulation of lhb neurons that may be important in the pathogenesis of depression. |
2016-10-05 |
2023-08-13 |
rat |
| Daan van Rooij, Catharina A Hartman, Marjolein M J van Donkelaar, Janita Bralten, Daniel von Rhein, Marina Hakobjan, Barbara Franke, Dirk J Heslenfeld, Jaap Oosterlaan, Nanda Rommelse, Jan K Buitelaar, Pieter J Hoekstr. Variation in serotonin neurotransmission genes affects neural activation during response inhibition in adolescents and young adults with ADHD and healthy controls. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 16. issue 8. 2016-09-21. PMID:26428549. |
given the role of serotonin in adhd and impulsivity, we postulated that genetic variants within the serotonin pathway might influence response inhibition. |
2016-09-21 |
2023-08-13 |
Not clear |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
it is well established that the brain 5-ht system is under autoregulatory control by its principal transmitter 5-ht via its effects on activity and expression of 5-ht system-related proteins. |
2016-08-26 |
2023-08-13 |
mouse |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
brain serotonin (5-hydroxytryptamine, 5-ht) levels increase following exercise, and the 5-ht system has been suggested to have an important role in these exercise-induced neuronal effects. |
2016-08-02 |
2023-08-13 |
mouse |
| Luis Rodrigo Cataldo, Víctor Antonio Cortés, José Eduardo Galgani, Pablo Roberto Olmos, José Luis Santo. [Role of peripheral serotonin in the insulin secretion and glucose homeostasis]. Nutricion hospitalaria. vol 30. issue 3. 2016-07-28. PMID:25238823. |
additionally, other tissues such as the endocrine pancreas, particularly β-cells, have its own serotonin system able to synthesize, secrete and respond to extracellular 5ht through cell surface receptors subtypes that have been grouped in 7 families (htr1-7). |
2016-07-28 |
2023-08-13 |
Not clear |
| Xiaoxia Zhu, Linlin Jing, Chun Chen, Meng Shao, Qin Fan, Jianxin Diao, Yuanliang Liu, Zhiping Lv, Xuegang Su. Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase. Journal of ethnopharmacology. vol 160. 2016-05-23. PMID:25435286. |
this study is aimed to investigate the hypothesis that dxs treats depressive-like behavior by shifting the balance of the kynurenine (kyn)/serotonin (5-ht) pathway toward the 5-ht pathway through the downregulation of hippocampal indoleamine 2,3-dioxygenase (ido). |
2016-05-23 |
2023-08-13 |
Not clear |