| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng C Zhou, Youssef Sari, Ting-Kai Li, Charles Goodlett, Efrain C Azmiti. Deviations in brain early serotonergic development as a result of fetal alcohol exposure. Neurotoxicity research. vol 4. issue 4. 2019-11-20. PMID:12829423. |
since 5-ht is a signal for development of many forebrain neurons, the deviation of 5-ht in early life may have consequences on brain development that extend beyond those seen in the 5-ht system. |
2019-11-20 |
2023-08-12 |
mouse |
| Elyse C Dankoski, Susan Carroll, Robert Mark Wightma. Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release. Journal of neurochemistry. vol 136. issue 6. 2019-11-20. PMID:26749030. |
the onset of antidepressant effects also coincides with desensitization of somatodendritic serotonin autoreceptors in the dorsal raphe nucleus (drn), suggesting that disrupting inhibitory feedback within the serotonin system may contribute to the therapeutic effects of ssris. |
2019-11-20 |
2023-08-13 |
mouse |
| Ayesha Sengupta, Andrew Holme. A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory. Neuron. vol 103. issue 3. 2019-10-31. PMID:31204082. |
although fear recruits 5-ht and vglut3 co-expressing drn neurons, the fear-potentiating influence of the drn→ba 5-ht pathway requires signaling at ba 5-ht1a/2a receptors. |
2019-10-31 |
2023-08-13 |
Not clear |
| Sahel Kumar, Zsofia Gal, Xenia Gonda, Robin J Huse, Gabriella Juhasz, Gyorgy Bagdy, Peter Petschne. Transcriptomic changes following chronic administration of selective serotonin reuptake inhibitors: a review of animal studies. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 21. issue 1. 2019-04-26. PMID:30962407. |
in spite of some measurable changes in serotonin system mrna expression, serotonin transporter levels remained mostly unaltered following various treatment protocols. |
2019-04-26 |
2023-08-13 |
Not clear |
| Danilo De Gregorio, Justine P Enns, Nicolas A Nuñez, Luca Posa, Gabriella Gobb. d-Lysergic acid diethylamide, psilocybin, and other classic hallucinogens: Mechanism of action and potential therapeutic applications in mood disorders. Progress in brain research. vol 242. 2019-03-29. PMID:30471683. |
lsd, belonging to the category of "classic halluginogens," interacts with the 5-ht system through 5ht |
2019-03-29 |
2023-08-13 |
Not clear |
| Agnete Overgaard, Stephanie E Lieblich, Robin Richardson, Liisa A M Galea, Vibe G Frokjae. Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression. Psychoneuroendocrinology. vol 89. 2018-12-31. PMID:29146408. |
the serotonin system is sensitive to such hormone fluctuations, and serotonin reuptake inhibitors (ssris) are used to treat pnd, although treatment is suboptimal and it is not known at which peripartum time-point ssri treatment may be most efficacious. |
2018-12-31 |
2023-08-13 |
rat |
| Wenrui Ye, Michael Duffy Pitlock, Martin A Javors, Brent J Thompson, James D Lechleiter, Julie G Hensle. The long-term effect of maternal dietary protein restriction on 5-HT Behavioural brain research. vol 349. 2018-11-26. PMID:29660440. |
we focused specifically on the serotonin system, the 5-ht |
2018-11-26 |
2023-08-13 |
Not clear |
| Ann-Katrin Holik, Verena Stöger, Kathrin Hölz, Mark M Somoza, Veronika Somoz. Impact of free N Food & function. vol 9. issue 7. 2018-10-29. PMID:29972203. |
n-epsilon-carboxymethyllysine (cml), one of the chemically diverse compounds formed in the reaction between reducing carbohydrates and amines, is often used as a marker of advanced glycation, and has been shown to stimulate serotonin release from cells representing the central (sh-sy5y cells) and the peripheral (caco-2 cells) serotonin system in vitro. |
2018-10-29 |
2023-08-13 |
human |
| Diva Eensoo, Marika Paaver, Mariliis Vaht, Helle-Mai Loit, Jaanus Harr. Risky driving and the persistent effect of a randomized intervention focusing on impulsivity: The role of the serotonin transporter promoter polymorphism. Accident; analysis and prevention. vol 113. 2018-08-06. PMID:29407665. |
prev., 2013; 50, 430-437), and have now addressed the question of whether does the impact of the intervention last for a few years, and whether traffic behaviour and the intervention effect are associated with the serotonin transporter polymorphism (5-httlpr) genotype as the central serotonin system is strongly associated with impulse control. |
2018-08-06 |
2023-08-13 |
human |
| Vanessa M Sinopoli, Christie L Burton, Sefi Kronenberg, Paul D Arnol. A review of the role of serotonin system genes in obsessive-compulsive disorder. Neuroscience and biobehavioral reviews. vol 80. 2018-07-03. PMID:28576508. |
based on efficacy of serotonin reuptake inhibitors (sris) in treating ocd, serotonin system genes have been a dominant focus in ocd candidate gene studies. |
2018-07-03 |
2023-08-13 |
Not clear |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
this study aimed to investigate the effects of baldrinal of valeriana jatamansi on the expression of corticotropin releasing factor (crf) and tryptophan hydroxylase 1 (tph1) mrna and levels of 5-hydroxytryptamine (5-ht) in colon of rats with irritable bowel syndrome (ibs), and to explain its therapeutic mechanism on ibs through 5-ht pathway. |
2018-05-31 |
2023-08-13 |
rat |
| Daniel G Ehlinger, Kathryn G Common. Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities. The European journal of neuroscience. vol 46. issue 8. 2018-05-23. PMID:28921675. |
given an emerging role for serotonin in the etiology of autism spectrum disorders (asd), we investigate the relationship between cav1.2 and the ascending serotonin system in the timothy syndrome type 2 (ts2-neo) mouse, which displays behavioral features consistent with the core triad of asd. |
2018-05-23 |
2023-08-13 |
mouse |
| Daniel G Ehlinger, Kathryn G Common. Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities. The European journal of neuroscience. vol 46. issue 8. 2018-05-23. PMID:28921675. |
collectively, these results suggest that the global gain-of-function cav1.2 mutation associated with timothy syndrome has pleiotropic effects on the ascending serotonin system including neuroanatomical changes, regional differences in forebrain serotonin metabolism and feedback regulatory control mechanisms within the dorsal raphe. |
2018-05-23 |
2023-08-13 |
mouse |
| Daniel G Ehlinger, Kathryn G Common. Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities. The European journal of neuroscience. vol 46. issue 8. 2018-05-23. PMID:28921675. |
altered activity of the ascending serotonin system continues to emerge as a common neural signature across several asd mouse models, and the capacity for cav1.2 l-type calcium channels to impact both serotonin structure and function has important implications for several neuropsychiatric conditions. |
2018-05-23 |
2023-08-13 |
mouse |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
the serotonin system may represent an important target for prevention and treatment of mci, particularly the post-synaptic receptors (5-ht4 and 5-ht6), which may not be as severely affected as presynaptic aspects of the serotonin system, as indicated by the observation of lower serotonin transporters in mci relative to healthy controls. |
2018-04-18 |
2023-08-13 |
human |
| Sally A Abuelezz, Nevien Hendawy, Yosra Magd. Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 2. 2018-03-02. PMID:27730347. |
this could be attributed to its ability to reduce ido-1 leading to shift the balance of the kynurenine/ serotonin toward the serotonin pathway. |
2018-03-02 |
2023-08-13 |
rat |
| Luka R Srejic, Kevin M Wood, Anisa Zeqja, Parastoo Hashemi, William D Hutchiso. Modulation of serotonin dynamics in the dorsal raphe nucleus via high frequency medial prefrontal cortex stimulation. Neurobiology of disease. vol 94. 2018-02-27. PMID:27326670. |
because modulation of the 5-ht system is the most common pharmacological means of treating depression, we sought to establish 5-ht's role in the mpfc-dr projection. |
2018-02-27 |
2023-08-13 |
mouse |
| Cynthia L Bethea, Arubala P Reddy, Fernanda Lima Christia. How Studies of the Serotonin System in Macaque Models of Menopause Relate to Alzheimer's Disease1. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27662311. |
serotonin plays a key role in mood or affect, and dysfunction of the serotonin system has been linked to depression in humans and animal models. |
2018-02-23 |
2023-08-13 |
monkey |
| Mirko Manchia, Bernardo Carpiniello, Flavia Valtorta, Stefano Coma. Serotonin Dysfunction, Aggressive Behavior, and Mental Illness: Exploring the Link Using a Dimensional Approach. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28378993. |
consistently, psychopharmacological interventions aimed at boosting the 5-ht system (e.g., with selective serotonin reuptake inhibitors) have demonstrated therapeutic efficacy in a high percentage of patients with either or both pathological conditions. |
2018-02-07 |
2023-08-13 |
Not clear |
| Mirko Manchia, Bernardo Carpiniello, Flavia Valtorta, Stefano Coma. Serotonin Dysfunction, Aggressive Behavior, and Mental Illness: Exploring the Link Using a Dimensional Approach. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28378993. |
in this review, we employ a dimensional approach to discuss the trivariate relationship among the 5-ht system, aggressive behavior, and mental illness, focusing our attention on 5-ht levels, 5-ht receptors, metabolic enzymes, and their genes. |
2018-02-07 |
2023-08-13 |
Not clear |