| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Markus Wöhr, Marcel M van Gaalen, Rainer K W Schwartin. Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26221830. |
consequently, the 5-ht system is implicated in various neuropsychiatric disorders, such as anxiety disorders and depression or autism spectrum disorders (asd), with selective 5-ht reuptake inhibitors being the frontline medication. |
2016-05-05 |
2023-08-13 |
mouse |
| Markus Wöhr, Marcel M van Gaalen, Rainer K W Schwartin. Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26221830. |
so far, little is known about the role of 5-ht in the production of interaction-induced usv in mice and appetitive 50-khz usv in rats, although recent findings also suggest a modulatory effect of the 5-ht system. |
2016-05-05 |
2023-08-13 |
mouse |
| Terrell Holloway, Javier González-Maes. Epigenetic Mechanisms of Serotonin Signaling. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25734378. |
the cardinal signal transduction mechanisms via serotonin and its receptors are well established, but fundamental questions regarding complex interactions between the serotonin system and heritable epigenetic modifications that exert control on gene function remain a topic of intense research and debate. |
2016-04-19 |
2023-08-13 |
Not clear |
| N K Popova, E G Ponimaskin, V S Naumenk. [CROSS-TALK BETWEEN 5-HT1A AND 5-HT7 RECEPTORS: ROLE IN THE AUTOREGULATION OF THE BRAIN SEROTONIN SYSTEM AND IN MECHANISM OF ANTIDEPRESSANTS ACTION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 101. issue 11. 2016-04-08. PMID:26995955. |
the results described in the present review indicate that: i) dimerization and formation of mobile receptor complexes is a common feature for the members of g-protein coupled receptor superfamily; ii) 5-ht7 receptor appears to be a modulator for 5-ht1a receptor - the key autoregulator of the brain serotonin system; iii) 5-ht1a/5-ht7 receptor complexes formation is one of the mechanisms for inactivation and desensitization of the 5-htia receptors in the brain; iv) differences in the 5-ht7 receptor and 5-htia/5-ht7 heterodimers density define different sensitivity of pre- and postsynaptic 5-htla receptors to chronic treatment with selective serotonin reuptake inhibitors. |
2016-04-08 |
2023-08-13 |
Not clear |
| H G Westenber. Biological concepts of anxiety disorders. Acta neuropsychiatrica. vol 9. issue 2. 2016-03-14. PMID:26972132. |
the complexity of the 5-ht system in terms of receptor heterogeneity offers a dazzling opportunity to the development of new drugs affecting selective 5-ht functions, but it also precludes that firm conclusions can be drawn when less selective agents are being used. |
2016-03-14 |
2023-08-13 |
human |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clinical and experimental pharmacology & physiology. vol 42. issue 6. 2016-02-29. PMID:25854421. |
this study aimed to investigate whether, behind the predominant serotonergic vasoconstrictor action, the 5-ht system may exert renal vasodilator actions, and, if so, characterize the 5-ht receptors and possible indirect pathways. |
2016-02-29 |
2023-08-13 |
rat |
| Michiel Alexander de Raaf, Yvet Kroeze, Anthonieke Middelman, Frances S de Man, Helma de Jong, Anton Vonk-Noordegraaf, Chris de Korte, Norbert F Voelkel, Judith Homberg, Harm Jan Bogaar. Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 10. 2016-02-25. PMID:26386116. |
an intact serotonin system, which critically depends on a normal function of the serotonin transporter (sert), is required for the development of experimental pulmonary hypertension in rodents exposed to hypoxia or monocrotaline. |
2016-02-25 |
2023-08-13 |
human |
| Haritha Durairaj, Michael D Steury, Narayanan Parameswara. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25744603. |
to determine if the effects of paroxetine are mediated via modulation of the 5-ht system, we treated macrophages with 5-ht or 5-ht receptor antagonist (ly215840) in the presence of lps and/or paroxetine. |
2016-01-04 |
2023-08-13 |
mouse |
| Emili Banerjee, Krishnadas Nandagopa. Does serotonin deficit mediate susceptibility to ADHD? Neurochemistry international. vol 82. 2015-12-15. PMID:25684070. |
selective serotonin re-uptake inhibitors, as also non-stimulant drugs acting on the 5-ht system are, however, clinically effective. |
2015-12-15 |
2023-08-13 |
Not clear |
| Andreas Frick, Fredrik Åhs, Jonas Engman, My Jonasson, Iman Alaie, Johannes Björkstrand, Örjan Frans, Vanda Faria, Clas Linnman, Lieuwe Appel, Kurt Wahlstedt, Mark Lubberink, Mats Fredrikson, Tomas Furmar. Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study. JAMA psychiatry. vol 72. issue 8. 2015-10-30. PMID:26083190. |
serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (sad), are characterized by an overactive or underactive serotonin system has not been established. |
2015-10-30 |
2023-08-13 |
Not clear |
| Adrian G Fischer, Tanja Endrass, Martin Reuter, Christian Kubisch, Markus Ullsperge. Serotonin reuptake inhibitors and serotonin transporter genotype modulate performance monitoring functions but not their electrophysiological correlates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019334. |
thus, pharmacogenetic evidence suggests that increased 5-ht levels lead to behavioral inhibition in the context of internal aversive events, but electrophysiological correlates of performance monitoring appear unrelated to the 5-ht system. |
2015-08-20 |
2023-08-13 |
human |
| Linda Booij, Richard E Tremblay, Moshe Szyf, Chawki Benkelfa. Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology. Journal of psychiatry & neuroscience : JPN. vol 40. issue 1. 2015-08-10. PMID:25285876. |
we review developmental milestones of the 5-ht system, how genetic and environmental 5-ht disturbances could affect brain development and the potential role of dna methylation in 5-ht genes for brain development. |
2015-08-10 |
2023-08-13 |
Not clear |
| J Markeljevic, H Sarac, N Bozina, N Henigsberg, M Simic, L Cicin Sai. Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's syndrome. Journal of neuroimmunology. vol 282. 2015-06-30. PMID:25903736. |
reduced psl in pss patients is in line with hypothesis of association between chronic immunoinflammation and 5-ht system dysregulation, identifying additional mechanisms such as altered 5-ht transport as potential genetic factor contributing to psl depletion. |
2015-06-30 |
2023-08-13 |
human |
| Matthew O Parker, Leonette V Annan, Alexandros H Kanellopoulos, Alistair J Brock, Fraser J Combe, Matteo Baiamonte, Muy-Teck Teh, Caroline H Brenna. The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Progress in neuro-psychopharmacology & biological psychiatry. vol 55. 2015-06-16. PMID:24690524. |
furthermore, it proposes a putative developmental mechanism characterized by ethanol-induced ot inhibition leading to suppression of 5-ht and up-regulation of 5-ht1a, which leads, in turn, to possible homeostatic up-regulation of 5-htt at 72hpf and subsequent imbalance of the 5-ht system. |
2015-06-16 |
2023-08-13 |
zebrafish |
| Milena R Shattuck, Jessica Satkoski-Trask, Amos Deinard, Raul Y Tito, David G Smith, Don J Melnick, Ripan S Malh. Patterns of genetic variation and the role of selection in HTR1A and HTR1B in macaques (Macaca). BMC genetics. vol 15. 2015-06-02. PMID:25376878. |
in addition, many genetic features of the macaque serotonin system are similar to those of humans, and as common models in biomedical research, knowledge of the genetic variation and evolution of serotonin functioning in macaques are particularly relevant for studies of human evolution. |
2015-06-02 |
2023-08-13 |
human |
| Milena R Shattuck, Jessica Satkoski-Trask, Amos Deinard, Raul Y Tito, David G Smith, Don J Melnick, Ripan S Malh. Patterns of genetic variation and the role of selection in HTR1A and HTR1B in macaques (Macaca). BMC genetics. vol 15. 2015-06-02. PMID:25376878. |
here, we examine the role of selection in the macaque serotonin system by comparing patterns of genetic variation for two genes that code for two types of serotonin receptors - htr1a and htr1b - across five species of macaques. |
2015-06-02 |
2023-08-13 |
human |
| Lauren D Garfield, David Dixon, Petra Nowotny, Francis E Lotrich, Bruce G Pollock, Sean D Kristjansson, Peter M Doré, Eric J Lenz. Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 22. issue 10. 2015-05-28. PMID:24021217. |
we investigated the association between antidepressant side effects and genetic variation in the serotonin system in anxious, older adults participating in a randomized, placebo-controlled trial of the selective serotonin reuptake inhibitor (ssri) escitalopram. |
2015-05-28 |
2023-08-12 |
Not clear |
| Feng Wei, Ming Gu, Yu-Xia Ch. New tricks for an old slug: descending serotonergic system in pain. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 5. 2015-05-16. PMID:23090493. |
although these studies shed more light on several aspects of descending 5-ht and spinal 5-ht receptors functioning in descending modulation in pain perception, the current knowledge about the specific role of descending 5-ht system in the induction and maintenance of persistent pain remains fragmentary. |
2015-05-16 |
2023-08-12 |
human |
| Dietmar Hestermann, Yasin Temel, Arjan Blokland, Lee Wei Li. Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation. Behavioural brain research. vol 273. 2015-05-11. PMID:25043730. |
although the hpa axis and the 5-ht system are well investigated, the relationship between the stress hormones induced by 5-ht drug treatment and the pag neural correlates of the behavior remain largely unknown. |
2015-05-11 |
2023-08-13 |
Not clear |
| Dietmar Hestermann, Yasin Temel, Arjan Blokland, Lee Wei Li. Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation. Behavioural brain research. vol 273. 2015-05-11. PMID:25043730. |
these correlation studies suggest that the regulation of 5-ht system was probably disrupted by acute 5-ht treatment. |
2015-05-11 |
2023-08-13 |
Not clear |