| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher Bishop, Jessica A George, William Buchta, Adam A Goldenberg, Mohamed Mohamed, Sando O Dickinson, Satie Eissa, Karen L Eskow Jaunaraj. Serotonin transporter inhibition attenuates l-DOPA-induced dyskinesia without compromising l-DOPA efficacy in hemi-parkinsonian rats. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22762478. |
the present results support targeting serotonin transporters to improve parkinson's disease treatment and provide further evidence for the role of the serotonin system in l-dopa's effects. |
2013-01-09 |
2023-08-12 |
rat |
| Dongsha Wang, Moshe Szyf, Chawki Benkelfat, Nadine Provençal, Gustavo Turecki, Doretta Caramaschi, Sylvana M Côté, Frank Vitaro, Richard E Tremblay, Linda Booi. Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745770. |
here we hypothesized that 5-ht alterations associated with childhood aggression were linked to differential dna methylation of critical genes in the 5-ht pathway and these changes were also detectable in peripheral white blood cells. |
2012-11-30 |
2023-08-12 |
human |
| F M Farias, C S Passos, M D Arbo, D M Barros, C Gottfried, V M Steffen, A T Henrique. Strictosidinic acid, isolated from Psychotria myriantha Mull. Arg. (Rubiaceae), decreases serotonin levels in rat hippocampus. Fitoterapia. vol 83. issue 6. 2012-11-29. PMID:22546150. |
the results indicate that strictosidinic acid seems to act on 5-ht system in rat hippocampus, possibly inhibiting precursor enzymes of 5-ht biosynthesis. |
2012-11-29 |
2023-08-12 |
rat |
| Eunju Shin, Joanna Garcia, Christian Winkler, Anders Björklund, Manolo Cart. Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22579773. |
in addition, activation of 5-ht(1a) and 5-ht(1b) receptors by 8-oh-dpat and cp 94253, known to inhibit the activity of 5-ht neurons, significantly reduced gid, whereas induction of neurotransmitter release by fenfluramine administration significantly increased gid, indicating an involvement of the 5-ht system in the modulation of gid. |
2012-11-29 |
2023-08-12 |
rat |
| Eunju Shin, Joanna Garcia, Christian Winkler, Anders Björklund, Manolo Cart. Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22579773. |
to investigate the involvement of the host 5-ht system in gid, the endogenous 5-ht terminals were removed by intracerebral injection of 5,7-dihydroxytryptamine, but this treatment did not affect gid expression. |
2012-11-29 |
2023-08-12 |
rat |
| Sergio Domínguez-López, Rebecca Howell, Gabriella Gobb. Characterization of serotonin neurotransmission in knockout mice: implications for major depression. Reviews in the neurosciences. vol 23. issue 4. 2012-11-13. PMID:23089640. |
preclinical and clinical studies have established that a dysfunction of serotonin (5-ht) neurotransmission is a common hallmark in major depression and drugs acting on the 5-ht system have antidepressant properties. |
2012-11-13 |
2023-08-12 |
mouse |
| Elena M Kondaurova, Vladimir S Naumenko, Nina K Popov. Effect of chronic activation of 5-HT3 receptors on 5-HT3, 5-HT(1A) and 5-HT(2A) receptors functional activity and expression of key genes of the brain serotonin system. Neuroscience letters. vol 522. issue 1. 2012-11-09. PMID:22705909. |
effect of chronic activation of 5-ht3 receptors on 5-ht3, 5-ht(1a) and 5-ht(2a) receptors functional activity and expression of key genes of the brain serotonin system. |
2012-11-09 |
2023-08-12 |
mouse |
| Elena M Kondaurova, Vladimir S Naumenko, Nina K Popov. Effect of chronic activation of 5-HT3 receptors on 5-HT3, 5-HT(1A) and 5-HT(2A) receptors functional activity and expression of key genes of the brain serotonin system. Neuroscience letters. vol 522. issue 1. 2012-11-09. PMID:22705909. |
little is known about the interaction between the 5-ht(3) receptor and other 5-ht receptors and influence of 5-ht(3) chronic activation on other 5-ht receptors and the expression of key genes of 5-ht system. |
2012-11-09 |
2023-08-12 |
mouse |
| Elena M Kondaurova, Vladimir S Naumenko, Nina K Popov. Effect of chronic activation of 5-HT3 receptors on 5-HT3, 5-HT(1A) and 5-HT(2A) receptors functional activity and expression of key genes of the brain serotonin system. Neuroscience letters. vol 522. issue 1. 2012-11-09. PMID:22705909. |
chronic activation of 5-ht(3) receptor produced no considerable effect on the expression on 5-ht(3), 5-ht(1a), and 5-ht transporter (5-htt) and tryptophan hydroxylase-2 (tph-2) genes - the key genes of brain 5-ht system, in the midbrain, frontal cortex and hippocampus. |
2012-11-09 |
2023-08-12 |
mouse |
| Elena M Kondaurova, Vladimir S Naumenko, Nina K Popov. Effect of chronic activation of 5-HT3 receptors on 5-HT3, 5-HT(1A) and 5-HT(2A) receptors functional activity and expression of key genes of the brain serotonin system. Neuroscience letters. vol 522. issue 1. 2012-11-09. PMID:22705909. |
in conclusion, chronic activation of ionotropic 5-ht(3) receptor produced significant desensitization of 5-ht(3) and postsynaptic 5-ht(1a) receptors but caused no considerable changes in the expression of key genes of the brain 5-ht system. |
2012-11-09 |
2023-08-12 |
mouse |
| Sylvia Navailles, Manolo Carta, Martin Guthrie, Philippe De Deurwaerdèr. L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease. Central nervous system agents in medicinal chemistry. vol 11. issue 4. 2012-11-08. PMID:22117594. |
overall, the fact that 5-ht neurons release the newly synthesised da from l-dopa in multiple brain regions beyond the striatum gives new insight into the large impact of l-dopa in the parkinsonian brain and strengthens therapeutic perspectives targeting the 5-ht system to reduce both motor and non-motor complications of l-dopa medication. |
2012-11-08 |
2023-08-12 |
Not clear |
| Guadalupe M Flores-Cruz, Alfonso Escoba. Reduction of serotonergic neurons in the dorsal raphe due to chronic prenatal administration of a tryptophan-free diet. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 2. 2012-11-06. PMID:22244887. |
the appearance of 5-ht system early in ontogeny suggests the hypothesis that 5-ht plays a regulatory role in neurodevelopment. |
2012-11-06 |
2023-08-12 |
rat |
| Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Shih-Heng Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, Chen-Lin Wang, I Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru-Band L. Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism. Behavioral and brain functions : BBF. vol 8. 2012-10-25. PMID:22550993. |
several studies have hypothesized that genes regulating the components of the serotonin system, including serotonin transporter (5-httlpr) and serotonin 1 b receptor (5-ht1b), may be associated with alcoholism, but their results are contradictory because of alcoholism's heterogeneity. |
2012-10-25 |
2023-08-12 |
Not clear |
| Olga Senashova, Arubala P Reddy, Judy L Cameron, Cynthia L Bethe. The effect of citalopram on midbrain CRF receptors 1 and 2 in a primate model of stress-induced amenorrhea. Reproductive sciences (Thousand Oaks, Calif.). vol 19. issue 6. 2012-10-22. PMID:22412189. |
dysfunction of the serotonin system in ss monkeys suggested that administration of a selective serotonin reuptake inhibitor (ssri) might correct fha. |
2012-10-22 |
2023-08-12 |
monkey |
| Chikako Kiyohara, Kouichi Yoshimas. Molecular epidemiology of major depressive disorder. Environmental health and preventive medicine. vol 14. issue 2. 2012-10-02. PMID:19568851. |
the serotonin system provides a logical source of susceptibility genes for depression, because this system is the target of selective serotonin reuptake-inhibitor drugs that are effective in treating depression. |
2012-10-02 |
2023-08-12 |
Not clear |
| D Heal. 5-HT and physical illness. Journal of psychopharmacology (Oxford, England). vol 7. issue 1. 2012-10-02. PMID:22289661. |
from the widespread distribution of 5-ht in bodily systems and the range of effects and side effects reported, it is concluded that these and other drugs active on the 5-ht system are likely to have beneficial effects on a range of other physical conditions coincident and co-morbid with the affective disorders. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lisbeth Marner, Vibe G Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F C Baaré, Gitte M Knudsen, Steen G Hasselbalc. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20510480. |
to establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-ht(2a) receptor and the serotonin transporter binding, the latter as a measure of serotonergic projections and neurons. |
2012-09-28 |
2023-08-12 |
human |
| T Watanabe, H Aonum. Identification and expression analyses of a novel serotonin receptor gene, 5-HT2β, in the field cricket, Gryllus bimaculatus. Acta biologica Hungarica. vol 63 Suppl 2. 2012-09-17. PMID:22776473. |
in our previous report, in order to elucidate the molecular basis of the cricket 5-ht system, we identified three genes involved in 5-ht biosynthesis, as well as four 5-ht receptor genes (5-ht1a, 5-ht1b, 5-ht2α, and 5-ht7) expressed in the brain of the field cricket gryllus bimaculatus degeer [7]. |
2012-09-17 |
2023-08-12 |
cricket |
| Kanji Yoshimoto, Yoshihisa Watanabe, Masaki Tanaka, Minoru Kimur. Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior. The European journal of neuroscience. vol 35. issue 8. 2012-08-27. PMID:22512261. |
these results suggest that adaptations of the 5-ht system, especially the upregulation of 5-ht(2c) receptors in the acc(s) , are involved in the development of enhanced voluntary alcohol-drinking behavior. |
2012-08-27 |
2023-08-12 |
mouse |
| Sarah K Williams, Jean M Lauder, Josephine M John. Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure. Current neuropharmacology. vol 9. issue 3. 2012-08-23. PMID:22379462. |
cocaine, a competitive antagonist of the serotonin transporter, similar to selective serotonin reuptake inhibitors (ssris), also blocks dopamine and norepinephrine transporters, leaving the direct mechanism through which cocaine disrupts the developing serotonin system unclear. |
2012-08-23 |
2023-08-12 |
Not clear |