| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ha Young Kim, Mi Hyun Park, Hyun Koo Yoon, Ki Ok Ha. The changes in plasma serotonin levels after hormone therapy and their relationship with estrogen responsiveness on bone in postmenopausal women. The Journal of clinical endocrinology and metabolism. vol 97. issue 6. 2012-08-15. PMID:22442273. |
it has been suggested that circulating serotonin is an important regulatory factor and that estrogen may regulate bone metabolism through the serotonin pathway. |
2012-08-15 |
2023-08-12 |
Not clear |
| Melissa A Munn-Chernoff, Matthew B McQueen, Gary L Stetler, Brett C Haberstick, Soo Hyun Rhee, Laura E Sobik, Robin P Corley, Andrew Smolen, John K Hewitt, Michael C Stalling. Examining associations between disordered eating and serotonin transporter gene polymorphisms. The International journal of eating disorders. vol 45. issue 4. 2012-08-10. PMID:22271047. |
the serotonin system has been implicated in mood and appetite regulation, and the serotonin transporter gene (slc6a4) is a commonly studied candidate gene for eating pathology. |
2012-08-10 |
2023-08-12 |
Not clear |
| Stephanie R Fox, Evan S Deneri. Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674259. |
together, our findings reveal complex intrinsic functions for en in maturing 5-ht neurons, hence necessitating a reinterpretation of their roles in 5-ht system development. |
2012-08-09 |
2023-08-12 |
mouse |
| Simon Trent, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22189290. |
significant correlations between hippocampal 5-ht levels and pr performance, and between striatal 5-ht levels and locomotor activity strongly implicate regionally-specific perturbations of the 5-ht system as a neurobiological candidate for behavioral differences between 40,xy and 39,x(y)*o mice. |
2012-07-20 |
2023-08-12 |
mouse |
| A S M Hung, T Y M Tsui, J C Y Lam, M S M Wai, W M Chan, D T Ye. Serotonin and its receptors in the human CNS with new findings - a mini review. Current medicinal chemistry. vol 18. issue 34. 2012-06-28. PMID:22087825. |
as any detrimental changes in the 5-ht system is believed to alter emotion in human, different drugs including serotonin reuptake inhibitors (ssris) are nowadays commonly used as anti- depressives. |
2012-06-28 |
2023-08-12 |
human |
| Mushtaq A Margoob, Dhuha Mushta. Serotonin transporter gene polymorphism and psychiatric disorders: is there a link? Indian journal of psychiatry. vol 53. issue 4. 2012-05-21. PMID:22303036. |
among a large number of existing neurotransmitter systems, the serotonin system dysfunction has been implicated in many psychiatric disorders and therapeutic efficacy of many drugs is also thought to be based on modulation of serotonin. |
2012-05-21 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
previously we reported a deficiency of serotonin (5-ht) and its key biosynthetic enzyme, tryptophan hydroxylase (tph2), in sids infants in the medullary 5-ht system that modulates homeostatic responses during sleep. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
we first performed a discovery proteomic analysis of the gigantocellularis of the medullary 5-ht system in the same data set with deficiencies of tph2 and 5-ht levels. |
2012-05-01 |
2023-08-12 |
Not clear |
| Jacobus J Dudok, Alexander J A Groffen, Ruud F T Toonen, Matthijs Verhag. Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140524. |
deletion of munc18-1 in 5-ht neurons results in rapid degeneration of the 5-ht system and early postnatal lethality. |
2012-04-09 |
2023-08-12 |
mouse |
| Jacobus J Dudok, Alexander J A Groffen, Ruud F T Toonen, Matthijs Verhag. Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140524. |
to specifically ablate the 5-ht system we generated mutant mice carrying a floxed munc18-1 gene and cre recombinase driven by the 5-ht-specific serotonin reuptake transporter (sert) promoter. |
2012-04-09 |
2023-08-12 |
mouse |
| Jacobus J Dudok, Alexander J A Groffen, Ruud F T Toonen, Matthijs Verhag. Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140524. |
these data show that deletion of munc18-1 in 5-ht neurons results in rapid degeneration of the 5-ht system and suggests that the 5-ht system is important for postnatal survival. |
2012-04-09 |
2023-08-12 |
mouse |
| Jessica L Oliva, Sumie Leung, Rodney J Croft, Barry V O'Neill, Julie C Stout, Pradeep J Natha. Evidence for sex differences in the loudness dependence of the auditory evoked potential in humans. Human psychopharmacology. vol 26. issue 2. 2012-03-30. PMID:21455974. |
the loudness dependence of the auditory evoked potential (ldaep) has been suggested as a marker of the serotonin system, although studies directly examining the relationship between acute changes in serotonin and the ldaep have been inconsistent. |
2012-03-30 |
2023-08-12 |
Not clear |
| Sharonda S Harris, Dorota Maciag, Kimberly L Simpson, Rick C S Lin, Ian A Pau. Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat. Brain research. vol 1429. 2012-03-20. PMID:22079319. |
although perturbation of the serotonin system during neonatal life has been implicated in the long-term behavioral effects of neonatal antidepressant exposure, dose-response studies were necessary to confirm that inhibition of the serotonin transporter during the neonatal period is sufficient to produce impairments in sexual behavior. |
2012-03-20 |
2023-08-12 |
rat |
| Kristen A Horner, Yamiece E Gilbert, Erika S Nobl. Differential regulation of 5-HT2A receptor mRNA expression following withdrawal from a chronic escalating dose regimen of D-amphetamine. Brain research. vol 1390. 2012-03-07. PMID:21420940. |
these data indicate that region-specific changes in 5-ht(2a) receptor mrna expression occur in limbic system and associated areas following chronic d-amph treatment, supporting the notion that alterations in the 5-ht system may contribute to the negative emotional aspects of psychostimulant withdrawal. |
2012-03-07 |
2023-08-12 |
rat |
| Michael L Huynh, Elena Rivkin, Ryan Mui, Sabine P Corde. A tryptophan hydroxlyase 1 reporter that directs Cre recombinase extinguishable placental alkaline phosphatase expression in serotonergic (5-HT) neurons and peripheral tissues. Genesis (New York, N.Y. : 2000). vol 49. issue 11. 2012-02-24. PMID:21438125. |
thus, the tph1-loxp-plap reporter revealed a dosage sensitive role of the anx mutation in the early 5-ht system and later cortical layer-specific differences in 5-ht process distribution in anx/anx mice. |
2012-02-24 |
2023-08-12 |
mouse |
| Hannah C Kinney, Kevin G Broadbelt, Robin L Haynes, Ingvar J Rognum, David S Paterso. The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21640183. |
we define anatomically the caudal 5-ht system in the human medulla as 5-ht neuronal cell bodies located in the raphé (raphé obscurus, raphé magnus, and raphé pallidus), extra-raphé (gigantocellularis, paragigantocellularis lateralis, intermediate reticular zone, lateral reticular nucleus, and nucleus subtrigeminalis), and ventral surface (arcuate nucleus). |
2012-02-22 |
2023-08-12 |
human |
| Cynthia L Bethea, Fernanda B Lima, Maria L Centeno, Karin V Weissheimer, Olga Senashova, Arubala P Reddy, Judy L Camero. Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21683135. |
examination of the serotonin system revealed that ss monkeys had significantly lower fev (fifth ewing variant, rodent pet1), tph2 (tryptophan hydroxylase 2), 5ht1a autoreceptor and sert (serotonin reuptake transporter) expression in the dorsal raphe than sr monkeys. |
2012-02-22 |
2023-08-12 |
monkey |
| Efrain C Azmitia, Jorawer S Singh, Patricia M Whitaker-Azmiti. Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21329710. |
imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. |
2012-01-18 |
2023-08-12 |
Not clear |
| O Johnson, J Becnel, C D Nichol. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. vol 192. 2012-01-18. PMID:21749913. |
our data highlight the importance of the serotonin system and individual serotonin receptors to influence olfactory learning and memory in the fly, and position the fly as a model system to study the role of serotonin in cognitive processes relevant to mammalian cns function. |
2012-01-18 |
2023-08-12 |
drosophila_melanogaster |
| Charlotte Keating, Alan Tilbrook, Jayashri Kulkarn. Oestrogen: an overlooked mediator in the neuropsychopharmacology of treatment response? The international journal of neuropsychopharmacology. vol 14. issue 4. 2011-12-16. PMID:20860875. |
first-line approach to treatment for md involves modulation of the 5-ht system using selective serotonin reuptake inhibitors (ssris). |
2011-12-16 |
2023-08-12 |
Not clear |