| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Faranak Vahid-Ansari, Paul R Alber. Rewiring of the Serotonin System in Major Depression. Frontiers in psychiatry. vol 12. 2022-01-03. PMID:34975594. |
chronic treatment with antidepressants that amplify 5-ht action, such as selective serotonin reuptake inhibitors (ssris), appears to accelerate the rewiring of the 5-ht system by mechanisms that may be critical to the behavioral and cognitive improvements induced in these models. |
2022-01-03 |
2023-08-13 |
Not clear |
| De-Wei Yang, Jie Su. [Correlation of lifelong premature ejaculation with 5-HT system gene polymorphism]. Zhonghua nan ke xue = National journal of andrology. vol 27. issue 8. 2021-12-16. PMID:34914250. |
the pathogenesis of lpe has not been clarified, but it is believed to be related to the regulation of 5-ht and the 5-ht1a and 5-ht2c receptors from the perspective of the theory of 5-ht system neurotransmitter disorder. |
2021-12-16 |
2023-08-13 |
Not clear |
| Nirupa Goel, Tristan J Philippe, Judy Chang, Maya E Koblanski, Victor Via. Cellular and serotonergic correlates of habituated neuroendocrine responses in male and female rats. Psychoneuroendocrinology. vol 136. 2021-12-10. PMID:34891046. |
serotonin staining in the dorsal raphe and terminal profiles in the forebrain continued to reflect a higher pre-synaptic capacity for the 5-ht system in females. |
2021-12-10 |
2023-08-13 |
rat |
| Rezvan Yaghoubfar, Ava Behrouzi, Ehsan Zare Banadkoki, Fatemeh Ashrafian, Arezou Lari, Farzam Vaziri, Seyed Ali Nojoumi, Abolfazl Fateh, Shohreh Khatami, Seyed Davar Siada. Effect of Akkermansia muciniphila, Faecalibacterium prausnitzii, and Their Extracellular Vesicles on the Serotonin System in Intestinal Epithelial Cells. Probiotics and antimicrobial proteins. vol 13. issue 6. 2021-12-09. PMID:33852147. |
our findings showed that a. muciniphila and f. prausnitzii along with their evs could modulate serotonin system-related genes; hence, they may be useful in microbiota modulation therapies to maintain the homeostasis of the serotonin system. |
2021-12-09 |
2023-08-13 |
human |
| Paul Andrews, Jay Amsterda. A hormetic approach to understanding antidepressant effectiveness and the development of antidepressant tolerance - A conceptual view. Psychiatria polska. vol 54. issue 6. 2021-09-29. PMID:33740797. |
specifically, the serotonin system adapts to ssris by suppressing the firing of serotonergic neurons, inhibiting the synthesis of serotonin, and reducing the overall content of serotonin in the brain. |
2021-09-29 |
2023-08-13 |
Not clear |
| Cláudia Teixeira, Pedro Rodrigues, Paula Serrão, Luís Figueira, Laura Guimarães, Luís Oliva Teles, Helena Peres, António Paulo Carvalh. Dietary tryptophan supplementation does not affect growth but increases brain serotonin level and modulates the expression of some liver genes in zebrafish (Danio rerio). Fish physiology and biochemistry. vol 47. issue 5. 2021-09-29. PMID:34370152. |
this study aimed at assessing the effects of the dietary tryptophan (trp) supplementation on growth and feed utilization, brain serotonin content, and expression of selected liver genes (involved in the liver serotonin pathway, protein synthesis degradation, and antioxidant activity) in zebrafish. |
2021-09-29 |
2023-08-13 |
zebrafish |
| Giuseppe Fanciulli, Rosaria M Ruggeri, Erika Grossrubatscher, Fabio Lo Calzo, Troy D Wood, Antongiulio Faggiano, Andrea Isidori, Annamaria Cola. Serotonin pathway in carcinoid syndrome: Clinical, diagnostic, prognostic and therapeutic implications. Reviews in endocrine & metabolic disorders. vol 21. issue 4. 2021-09-27. PMID:32152781. |
serotonin pathway is complex, resulting in production of biologically active molecules such as serotonin and melatonin, as well as of different intermediate molecules and final metabolites. |
2021-09-27 |
2023-08-13 |
Not clear |
| Pragathi Balakrishna, Sagila George, Hassan Hatoum, Sarbajit Mukherje. Serotonin Pathway in Cancer. International journal of molecular sciences. vol 22. issue 3. 2021-09-08. PMID:33525332. |
this review article describes serotonin's role in cancer pathogenesis and the utility of the serotonin pathway as a potential therapeutic target in cancer treatment. |
2021-09-08 |
2023-08-13 |
Not clear |
| S V Larsen, K Köhler-Forsberg, V H Dam, A S Poulsen, C Svarer, P S Jensen, G M Knudsen, P M Fisher, B Ozenne, V G Frokjae. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women. Acta psychiatrica Scandinavica. vol 142. issue 4. 2021-08-18. PMID:33314049. |
here, we investigate whether use of ocs in healthy women is associated with a marker of the serotonin system in terms of serotonin 4 receptor (5-ht4r) brain imaging. |
2021-08-18 |
2023-08-13 |
Not clear |
| Jun-Qi Yao, Chang Liu, Zeng-Liang Jin, Yan-Qin Liu, Yong-Yu Yin, Xin-Xin Fang, Yu-Hua Ran, Li-Ming Zhang, Yun-Feng L. Serotonergic transmission is required for the anxiolytic-like behavioral effects of YL-IPA08, a selective ligand targeting TSPO. Neuropharmacology. vol 178. 2021-08-12. PMID:32693005. |
since 5-ht is one of the most comprehensively studied neurotransmitter systems in the anxiety field, in the present study, we want to investigate whether 5-ht system is involved in the anxiolytic-like effects of yl-ipa08, a novel tspo ligand designed and synthesized at our institute. |
2021-08-12 |
2023-08-13 |
mouse |
| Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wan. Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism. Experimental brain research. vol 239. issue 8. 2021-08-12. PMID:34106297. |
in conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-ht[formula: see text] receptor is an important cause of the depressive behaviors in hypothyroidism. |
2021-08-12 |
2023-08-13 |
rat |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Mauricio Sepulveda, Elizabeth E Manning, Andrea Gogos, Matthew Hale, Maarten van den Buus. Long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: Role of brain-derived neurotrophic factor. Brain research. vol 1762. 2021-08-11. PMID:33737066. |
to assess the long-term effects of chronic adolescent methamphetamine (meth) treatment on the serotonin system in the brain, we used serotonin-1a receptor (5-ht |
2021-08-11 |
2023-08-13 |
mouse |
| Vinicius Kannen, Michael Bader, Juliana Y Sakita, Sergio A Uyemura, Jeremy A Squir. The Dual Role of Serotonin in Colorectal Cancer. Trends in endocrinology and metabolism: TEM. vol 31. issue 8. 2021-08-09. PMID:32439105. |
here, we review the diverse roles of 5-ht in intestinal homeostasis and in crc and discuss how improved understanding of the modulation of the 5-ht pathway could be helpful for the design of novel anticancer therapies. |
2021-08-09 |
2023-08-13 |
Not clear |
| Frederick S Barrett, Clifford I Workman, Haris I Sair, Alena V Savonenko, Michael A Kraut, Devin J Sodums, Jin J Joo, Najlla Nassery, Christopher M Marano, Cynthia A Munro, Jason Brandt, Yun Zhou, Dean F Wong, Gwenn S Smit. Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment. Human brain mapping. vol 38. issue 7. 2021-07-03. PMID:28379618. |
serotonin neurodegeneration has been observed in mci and ad and is associated with cognitive deficits and neuropsychiatric symptoms, but the role of the serotonin system in relation to brain network dysfunction has not been a major focus of investigation. |
2021-07-03 |
2023-08-13 |
human |
| Max Andersson, Ämma Tangen, Lars Farde, Sven Bölte, Christer Halldin, Jacqueline Borg, Johan Lundber. Serotonin transporter availability in adults with autism-a positron emission tomography study. Molecular psychiatry. vol 26. issue 5. 2021-06-11. PMID:32848204. |
reuptake through the 5-ht transporter (5-htt) is the main pathway decreasing extracellular 5-ht in the brain and a marker for the 5-ht system, but in vivo investigations of the 5-htt and the 5-ht system in asd are scarce and so far inconclusive. |
2021-06-11 |
2023-08-13 |
Not clear |
| Andrea Forero, Hsing-Ping Ku, Ana Belén Malpartida, Sina Wäldchen, Judit Alhama-Riba, Christina Kulka, Benjamin Aboagye, William H J Norton, Andrew M J Young, Yu-Qiang Ding, Robert Blum, Markus Sauer, Olga Rivero, Klaus-Peter Lesc. Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology. vol 168. 2021-05-27. PMID:32113967. |
serotonin (5-ht) neuron-specific inactivation of cadherin-13 impacts 5-ht system formation and cognitive function. |
2021-05-27 |
2023-08-13 |
mouse |
| Andrea Forero, Hsing-Ping Ku, Ana Belén Malpartida, Sina Wäldchen, Judit Alhama-Riba, Christina Kulka, Benjamin Aboagye, William H J Norton, Andrew M J Young, Yu-Qiang Ding, Robert Blum, Markus Sauer, Olga Rivero, Klaus-Peter Lesc. Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology. vol 168. 2021-05-27. PMID:32113967. |
here, we dissect the specific impact of cdh13 on 5-ht system development and function using a 5-ht neuron-specific cdh13 knockout mouse model (conditional cdh13 knockout, cdh13 cko). |
2021-05-27 |
2023-08-13 |
mouse |
| Yen-Chen Chiu, Bang-Hung Yang, Kai-Chin Yang, Mu-N Liu, Li-Yu Hu, Ying-Jay Liou, Li-Yi Chan, Yuan-Hwa Cho. A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder. Psychiatry research. Neuroimaging. vol 312. 2021-05-20. PMID:33945927. |
the serotonin system is mainly modulated by the serotonin transporter (sert) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. |
2021-05-20 |
2023-08-13 |
Not clear |
| Dan Wang, Hui-Ling Tian, Xia Cui, Qian Wang, Fan Guo, Wen Zhang, Qi-Sheng Tan. Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-13. PMID:32738135. |
conclusions jpzdd alleviated both tic and anxiety symptoms and the mechanism may be via reducing the expression of 5-ht2c mrna in the striatum, increasing the concentration of 5-ht, and enhancing the activity of the 5-ht system, which in turn exerts neuro-inhibition. |
2021-05-13 |
2023-08-13 |
rat |