| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Li, Chuanyuan Kang, Yufeng Wang, Rulun Zhou, Bing Wang, Lili Guan, Li Yang, Stephen V Faraon. Contribution of 5-HT2A receptor gene -1438A>G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 5. 2006-08-16. PMID:16741915. |
the current study examined the association between adolescent outcome in adhd and serotonin system genes, including the -1438a>g polymorphism of the serotonin 2a receptor gene (htr2a) and the -759c>t polymorphism of the serotonin 2c receptor gene (htr2c). |
2006-08-16 |
2023-08-12 |
Not clear |
| Małgorzata Filip, Małgorzata Frankowska, Magdalena Zaniewska, Anna Gołda, Edmund Przegalińsk. The serotonergic system and its role in cocaine addiction. Pharmacological reports : PR. vol 57. issue 6. 2006-07-21. PMID:16382187. |
the present state of knowledge of 5-ht neurotransmission justifies the opinion that pharmacological manipulation in the 5-ht system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse. |
2006-07-21 |
2023-08-12 |
Not clear |
| Howard Steiger, Lise Gauvin, Marla J Engelberg, N M K Ng Ying Kin, Mimi Israel, Stephen A Wonderlich, Jodie Richardso. Mood- and restraint-based antecedents to binge episodes in bulimia nervosa: possible influences of the serotonin system. Psychological medicine. vol 35. issue 11. 2006-06-09. PMID:16219113. |
however, as central serotonin (5-hydroxytryptamine: 5-ht) mechanisms regulate appetite and mood, the 5-ht system could be implicated in diet- and mood-based binge antecedents. |
2006-06-09 |
2023-08-12 |
Not clear |
| Klaus-Peter Lesc. Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link? European journal of pharmacology. vol 526. issue 1-3. 2006-05-25. PMID:16288736. |
although variations in many of the genes that encode receptors, enzymes, and transporters of the 5-ht system have been tested as risk factors for alcohol dependence, genetic analyses of 5-ht signaling in alcohol dependence have mainly been focused on the 5-ht transporter (5-htt) gene. |
2006-05-25 |
2023-08-12 |
Not clear |
| Christian P Müller, Joseph P Husto. Determining the region-specific contributions of 5-HT receptors to the psychostimulant effects of cocaine. Trends in pharmacological sciences. vol 27. issue 2. 2006-04-04. PMID:16406129. |
the 5-ht system comprises several subtypes of 5-ht receptors, which contribute differentially to the various behavioural effects of cocaine. |
2006-04-04 |
2023-08-12 |
Not clear |
| Mary M Niblock, Catherine J Luce, Richard A Belliveau, David S Paterson, Michelle L Kelly, Lynn A Sleeper, James J Filiano, Hannah C Kinne. Comparative anatomical assessment of the piglet as a model for the developing human medullary serotonergic system. Brain research. Brain research reviews. vol 50. issue 1. 2006-03-30. PMID:16043226. |
each species shows evidence of age-related changes in the 5-ht system, but the changes are different in nature; in the human infant, statistically significant age-related changes are observed in the proportional distribution of medullary 5-ht cells, while in the piglet, statistically significant age-related changes are observed in the levels of 5-ht receptor binding in certain medullary nuclei. |
2006-03-30 |
2023-08-12 |
human |
| Heidi M Rivera, Lisa A Ecke. The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats. Physiology & behavior. vol 86. issue 3. 2006-02-21. PMID:16139852. |
although the inhibition of food intake by fenfluramine is largely attributed to its ability to increase synaptic levels of 5-ht, additional research involving selective 5-ht receptor agonists and antagonists is necessary to determine whether estradiol interacts with the endogenous 5-ht system to control food intake in the female rat. |
2006-02-21 |
2023-08-12 |
rat |
| David S Paterson, Eric G Thompson, Richard A Belliveau, Bobbie A Antalffy, Felicia L Trachtenberg, Dawna D Armstrong, Hannah C Kinne. Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. Journal of neuropathology and experimental neurology. vol 64. issue 11. 2005-12-15. PMID:16254496. |
we analyzed selected parameters of the 5-ht system of the medulla in autopsied patients with rett syndrome because of the role of bdnf in 5-ht cell development and because 5-ht plays a key role in modulating autonomic control. |
2005-12-15 |
2023-08-12 |
mouse |
| Alessandro Serretti, Francesco Benedetti, Raffaella Zanardi, Enrico Smerald. The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15939518. |
the influence of serotonin transporter promoter polymorphism (sertpr) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. |
2005-10-27 |
2023-08-12 |
Not clear |
| Alessandro Serretti, Francesco Benedetti, Raffaella Zanardi, Enrico Smerald. The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15939518. |
among these, gene variants in sequences of serotonin pathway proteins were candidate, both for the well known evidence of its involvement in the development of depressive symptomathology and for the wide-world use of selective serotonin reuptake inhibitors as first choice treatment of depression. |
2005-10-27 |
2023-08-12 |
Not clear |
| Hannah C Kinney, Michael M Myers, Richard A Belliveau, Leslie L Randall, Felicia L Trachtenberg, Sherri Ten Fingers, Mitzi Youngman, Donald Habbe, William P Fife. Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report. Journal of neuropathology and experimental neurology. vol 64. issue 8. 2005-10-19. PMID:16106217. |
the medullary 5-ht system is composed of 5-ht neurons in the raphé, extra-raphé, and arcuate nucleus at the ventral surface. |
2005-10-19 |
2023-08-12 |
Not clear |
| Hannah C Kinney, Michael M Myers, Richard A Belliveau, Leslie L Randall, Felicia L Trachtenberg, Sherri Ten Fingers, Mitzi Youngman, Donald Habbe, William P Fife. Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report. Journal of neuropathology and experimental neurology. vol 64. issue 8. 2005-10-19. PMID:16106217. |
at autopsy, arcuate nucleus hypoplasia and 5-ht receptor-binding abnormalities in the arcuate nucleus and other components of the medullary 5-ht system were found. |
2005-10-19 |
2023-08-12 |
Not clear |
| Ewa Tatarczyńska, Lucyna Antkiewicz-Michaluk, Aleksandra Kłodzińska, Katarzyna Stachowicz, Ewa Chojnacka-Wójci. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. European journal of pharmacology. vol 516. issue 1. 2005-08-29. PMID:15913599. |
the anti-immobility effect of cp 94253 was wholly blocked by the selective 5-ht(1b) receptor antagonist n-[3-(2-dimethylamino)ethoxy-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide (sb 216641, 5 mg/kg), the dopamine d2-like receptor antagonist sulpiride (50 mg/kg) and the alpha(2)-adrenoceptor antagonist idazoxan (2 mg/kg), but was not modified in animals with a lesion of the 5-ht system produced by p-chlorophenylalanine (p-cpa, 3 x 300 mg/kg). |
2005-08-29 |
2023-08-12 |
mouse |
| Holger Rosenbrock, Anita Bloching, Carmen Weiss, Franco Borsin. Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test. Pharmacology, biochemistry, and behavior. vol 80. issue 4. 2005-07-27. PMID:15820524. |
recently, it was shown in adult animals that antidepressants which influence 5-ht levels increase hippocampal progenitor cell proliferation, suggesting an important role of the 5-ht system in the regulation of adult neurogenesis. |
2005-07-27 |
2023-08-12 |
rat |
| Renee F Ren-Patterson, Lauren W Cochran, Andrew Holmes, Suzanne Sherrill, Su-Jan Huang, Teresa Tolliver, Klaus-Peter Lesch, Bai Lu, Dennis L Murph. Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15672416. |
to study the neurochemical and behavioral effects of altered brain-derived neurotrophic factor (bdnf) expression on a brain serotonin system with diminished serotonin transport capability, a double-mutant mouse model was developed by interbreeding serotonin transporter (sert) knockout mice with bdnf heterozygous knockout mice (bdnf +/-), producing sert -/- x bdnf +/- (sb) mice. |
2005-07-15 |
2023-08-12 |
mouse |
| Takahiro Fukumoto, Ido P Kema, Michael Levi. Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Current biology : CB. vol 15. issue 9. 2005-07-11. PMID:15886096. |
we tested the hypothesis that lr patterning required prenervous serotonin signaling and characterized the 5-ht pathway in chick and frog embryos. |
2005-07-11 |
2023-08-12 |
chicken |
| Hilary Coon, Diane Dunn, Janet Lainhart, Judith Miller, Cindy Hamil, Agatino Battaglia, Raffaella Tancredi, Mark F Leppert, Robert Weiss, William McMaho. Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 135B. issue 1. 2005-05-31. PMID:15768392. |
the well-replicated involvement of the serotonin neurotransmitter system in autism has stimulated interest in many genes in the serotonin pathway as possible candidates for mutations leading to autism susceptibility. |
2005-05-31 |
2023-08-12 |
mouse |
| Jacob Geday, Flemming Hermansen, Raben Rosenberg, Donald F Smit. Serotonin modulation of cerebral blood flow measured with positron emission tomography (PET) in humans. Synapse (New York, N.Y.). vol 55. issue 4. 2005-05-26. PMID:15668991. |
to develop a method to measure the dynamic response of the serotonin system in vivo, the effects of intravenously administered citalopram (the most selective of the serotonin reuptake inhibitors) or clomipramine on cerebral blood flow (cbf) were evaluated. |
2005-05-26 |
2023-08-12 |
human |
| Maartje M L de Win, Jan B A Habraken, Liesbeth Reneman, Wim van den Brink, Gerard J den Heeten, Jan Booi. Validation of [(123)I]beta-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 5. 2005-05-12. PMID:15770240. |
the 5-ht system can be studied in vivo by measuring 5-ht transporter (sert) densities using (123)iodine-labeled 2beta-carbomethoxy-3beta(4-iodophenyl)tropane ([(123)i]beta-cit) and single photon emission computed tomography (spect). |
2005-05-12 |
2023-08-12 |
human |
| M Bliziotes, M Gunness, A Eshleman, K Wire. The role of dopamine and serotonin in regulating bone mass and strength: studies on dopamine and serotonin transporter null mice. Journal of musculoskeletal & neuronal interactions. vol 2. issue 3. 2005-05-09. PMID:15758457. |
these results demonstrate that osteoblastic cells express a functional serotonin system, with mechanisms for responding to and regulating uptake of 5-ht, and disruption of the 5-htt gene may cause osteopenia. |
2005-05-09 |
2023-08-12 |
human |