| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Scott F Stoltenber. Epistasis among presynaptic serotonergic system components. Behavior genetics. vol 35. issue 2. 2005-04-14. PMID:15685432. |
epistasis among presynaptic components appears to be important in the 5-ht system's regulation of extracellular 5-ht levels, but not of firing rates. |
2005-04-14 |
2023-08-12 |
Not clear |
| Kristen M Davidge, Leslie Atkinson, Lori Douglas, Vivien Lee, Solomon Shapiro, James L Kennedy, Joseph H Beitchma. Association of the serotonin transporter and 5HT1Dbeta receptor genes with extreme, persistent and pervasive aggressive behaviour in children. Psychiatric genetics. vol 14. issue 3. 2005-03-07. PMID:15318027. |
the present study sought to investigate the relationship between childhood aggression and polymorphisms of two serotonin system genes: the 5ht1dbeta receptor gene and the serotonin transporter (5htt) gene. |
2005-03-07 |
2023-08-12 |
human |
| Elizabeth Scarr, Geoffrey Pavey, David Copolov, Brian Dea. Hippocampal 5-hydroxytryptamine receptors: abnormalities in postmortem brain from schizophrenic subjects. Schizophrenia research. vol 71. issue 2-3. 2005-03-01. PMID:15474910. |
there is strong evidence that hippocampal 5-hydroxytryptamine (5-ht) systems are affected in schizophrenia and hence we have studied a number of markers of the 5-ht system in hippocampi from subjects with schizophrenia. |
2005-03-01 |
2023-08-12 |
human |
| Gwenn S Smith, Francis E Lotrich, Anil K Malhotra, Annette T Lee, Yilong Ma, Elisse Kramer, Peter K Gregersen, David Eidelberg, Bruce G Polloc. Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 12. 2005-02-14. PMID:15354180. |
the goal of the present study was to evaluate the association between the 5-httlpr and the functional response of the serotonin system as measured by the neuroendocrine and cerebral metabolic response to intravenous administration of the selective serotonin reuptake inhibitor citalopram in normal control subjects. |
2005-02-14 |
2023-08-12 |
human |
| Muragundla Anjaneyulu, Kanwaljit Chopr. Fluoxetine attenuates thermal hyperalgesia through 5-HT1/2 receptors in streptozotocin-induced diabetic mice. European journal of pharmacology. vol 497. issue 3. 2005-01-14. PMID:15336946. |
these results suggest that fluoxetine-induced antinociception primarily involves serotonin pathway modulation through 5-ht(1) and 5-ht(2) receptors, but not through 5-ht(3) receptors, in the chronic pain associated with streptozotocin-induced diabetic neuropathy. |
2005-01-14 |
2023-08-12 |
mouse |
| Eduard Maron, Gunnar Tasa, Innar Tõru, Aavo Lang, Veiko Vasar, Jakov Shli. Association between serotonin-related genetic polymorphisms and CCK-4-induced panic attacks with or without 5-hydroxytryptophan pretreatment in healthy volunteers. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 5. issue 3. 2005-01-10. PMID:15346539. |
these data suggest that functional genetic polymorphisms of the 5-ht system may influence the vulnerability to panic attacks and add to the growing evidence of inhibitory function of 5-ht in the neuronal circuitry of panic. |
2005-01-10 |
2023-08-12 |
human |
| Damiaan Denys, Joseph Zohar, Herman G M Westenber. The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. The Journal of clinical psychiatry. vol 65 Suppl 14. 2005-01-06. PMID:15554783. |
obsessive-compulsive disorder (ocd) is a frequent and chronic psychiatric disorder that has been linked closely to the serotonin system mainly because of the antiobsessional efficacy of selective serotonin reuptake inhibitors (ssris). |
2005-01-06 |
2023-08-12 |
Not clear |
| Thomas I F H Cremers, Marco Giorgetti, Fokko J Bosker, Sandra Hogg, Jørn Arnt, Arne Mørk, Gerard Honig, Klaus-Peter Bøgesø, Ben H C Westerink, Hans den Boer, Håkan V Wikstrom, Laurence H Tecot. Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15138437. |
the enhancement of central serotonin system function underlies the therapeutic effects of selective serotonin reuptake inhibitors (ssris), which have become the most commonly used class of antidepressant agents. |
2004-11-22 |
2023-08-12 |
mouse |
| Sherie Novotny, Eric Hollander, Ann Phillips, Andrea Allen, Stacey Wasserman, Rupa Iyenga. Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders. The international journal of neuropsychopharmacology. vol 7. issue 3. 2004-10-27. PMID:15132762. |
this study provides further evidence for altered 5-ht sensitivity in individuals with autism spectrum disorders, as well as a possible relationship between repetitive behaviours in autism spectrum disorders and abnormalities in the 5-ht system. |
2004-10-27 |
2023-08-12 |
human |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Satoshi Kat. Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 4. 2004-10-18. PMID:15276688. |
the present study was undertaken to demonstrate that nervous systems other than the 5-ht system also participate in the pathophysiology of 5-ht syndrome. |
2004-10-18 |
2023-08-12 |
Not clear |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Satoshi Kat. Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 4. 2004-10-18. PMID:15276688. |
these findings suggest that not only hyperactivity of the 5-ht system, but also hyperactivity of the da system, are present in 5-ht syndrome, and that the glutamatergic system is influenced in some 5-ht syndrome cases in which the da concentration markedly increases. |
2004-10-18 |
2023-08-12 |
Not clear |
| Shoichi Mizuno, Hidemi Ito, Nobuyuki Hamajima, Akiko Tamakoshi, Kaoru Hirose, Kazuo Tajim. Association between smoking habits and tryptophan hydroxylase gene C218A polymorphism among the Japanese population. Journal of epidemiology. vol 14. issue 3. 2004-08-27. PMID:15242065. |
genes in serotonin system are one of the candidates because of serotonin's role in mood regulation. |
2004-08-27 |
2023-08-12 |
Not clear |
| Joëlle Adrie. [Implication of serotonin in the control of vigilance states as revealed by knockout-mouse studies]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146953. |
genetic manipulation of the 5-ht system leads to alterations of 5-ht neurotransmission and provides new opportunities to investigate the role of 5-ht in sleep regulations. |
2004-07-19 |
2023-08-12 |
mouse |
| Olivier Lepage, Inmaculada Molina Vílchez, Tom G Pottinger, Svante Winber. Time-course of the effect of dietary L-tryptophan on plasma cortisol levels in rainbow trout Oncorhynchus mykiss. The Journal of experimental biology. vol 206. issue Pt 20. 2004-06-28. PMID:12966050. |
the amino acid trp is the precursor of the monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-ht) and the brain 5-ht system is known to be involved in the control of the hypothalamic-pituitary-interrenal (hpi) axis. |
2004-06-28 |
2023-08-12 |
Not clear |
| M Jansson, M Gatz, S Berg, B Johansson, B Malmberg, G E McClearn, M Schalling, N L Pederse. Association between depressed mood in the elderly and a 5-HTR2A gene variant. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 120B. issue 1. 2004-02-19. PMID:12815744. |
the aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate snps in the serotonin system: one in the 5-htr2a gene promotor (-1438 g/a) and one in the 5-ht transporter gene (-925 c/a). |
2004-02-19 |
2023-08-12 |
Not clear |
| Yasser Khazaal, Daniele Fabio Zullin. Depersonalization-derealization syndrome induced by reboxetine. Swiss medical weekly. vol 133. issue 27-28. 2004-01-06. PMID:12947529. |
previous data having indicated a role of the serotonin system in the pathophysiology of the phenomenon, a noradrenaline induced serotonin liberation of raphe neurons is suggested as possible underlying mechanism. |
2004-01-06 |
2023-08-12 |
Not clear |
| Patricia Gaspar, Olivier Cases, Luc Maroteau. The developmental role of serotonin: news from mouse molecular genetics. Nature reviews. Neuroscience. vol 4. issue 12. 2004-01-05. PMID:14618156. |
new genetic models that target the serotonin system show that transient alterations in serotonin homeostasis cause permanent changes to adult behaviour and modify the fine wiring of brain connections. |
2004-01-05 |
2023-08-12 |
mouse |
| Leping Cheng, Chih-Li Chen, Ping Luo, Min Tan, Mengsheng Qiu, Randy Johnson, Qiufu M. Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 31. 2003-12-02. PMID:14602809. |
here we show that the lim class homeobox gene lmx1b is required for proper formation of the entire 5-ht system in the hindbrain, as indicated by the loss of expression of genes necessary for serotonin synthesis and transport in lmx1b null mice. |
2003-12-02 |
2023-08-12 |
mouse |
| Yasushi Inada, Hiroshi Yoneda, Jun Koh, Jun Sakai, Akio Himei, Yoko Kinoshita, Kazuyo Akabame, Yayoi Hiraoka, Toshiaki Saka. Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. Psychiatry research. vol 118. issue 1. 2003-10-03. PMID:12759158. |
assuming that genes regulating the serotonin system are involved in the pathogenesis of panic disorder, the authors searched for a genetic association of panic disorder with the serotonin 1a (htr1a), 2a (htr2a), and 2c (htr2c) receptor genes. |
2003-10-03 |
2023-08-12 |
human |
| Lígia Moreiras Sena, Cíntia Bueno, Roger L H Pobbe, Telma G C S Andrade, Hélio Zangrossi, Milena B Vian. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behavioural brain research. vol 142. issue 1-2. 2003-09-30. PMID:12798273. |
it has been proposed that the ascending dorsal raphe (dr)-serotonergic (5-ht) pathway facilitates conditioned avoidance responses to potential or distal threat, while the dr-periventricular 5-ht pathway inhibits unconditioned flight reactions to proximal danger. |
2003-09-30 |
2023-08-12 |
rat |