| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R J Thielen, D J Bare, W J McBride, L Lumeng, T-K L. Ethanol-stimulated serotonin release in the ventral hippocampus: an absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812514. |
in addition, the data suggest that the 5-ht system in the vhip of np rats may be relatively insensitive to the stimulating effect of acute ethanol of 5-ht release. |
2002-04-05 |
2023-08-12 |
rat |
| M M Bliziotes, A J Eshleman, X W Zhang, K M Wire. Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake. Bone. vol 29. issue 5. 2002-03-01. PMID:11704501. |
these results demonstrate that osteoblastic cells express a functional serotonin system, with mechanisms for responding to and regulating uptake of 5-ht. |
2002-03-01 |
2023-08-12 |
human |
| G Apelqvist, C Wikell, B Carlsson, S Hjorth, P B Bergqvist, J Ahlner, F Bengtsso. Dynamic and kinetic effects of chronic citalopram treatment in experimental hepatic encephalopathy. Clinical neuropharmacology. vol 23. issue 6. 2002-01-30. PMID:11575864. |
for the 5-ht system, this change was further evidenced by outspoken elevation in 5-ht output after kci-depolarizing challenges. |
2002-01-30 |
2023-08-12 |
human |
| K A Miczek, S C Maxson, E W Fish, S Faccidom. Aggressive behavioral phenotypes in mice. Behavioural brain research. vol 125. issue 1-2. 2002-01-22. PMID:11682108. |
a potentially common mechanism may be some components of the serotonin system, since alterations in 5-ht neurotransmission have been found in several of the ko mice that display unusual aggressive behavior. |
2002-01-22 |
2023-08-12 |
mouse |
| T A Reader, C Hébert, A R Ase, N Le Mare. Distribution of serotonin, its metabolites and 5-HT transporters in the neostriatum of Lurcher and weaver mutant mice. Neurochemistry international. vol 39. issue 3. 2001-11-01. PMID:11434974. |
this reorganization of the 5-ht system in the neostriatum was more obvious in the wv/wv and is compatible with the hypothesis that the postnatal dopaminergic deficiencies that characterize weaver mutants lead to a sprouting of fibers and thus constitute a genetic model of dopaminergic denervation that leads to a 5-ht hyperinnervation. |
2001-11-01 |
2023-08-12 |
mouse |
| C Lerman, N E Caporaso, A Bush, Y L Zheng, J Audrain, D Main, P G Shield. Tryptophan hydroxylase gene variant and smoking behavior. American journal of medical genetics. vol 105. issue 6. 2001-09-06. PMID:11496367. |
genes in the serotonin system are plausible candidates because of serotonin's role in mood regulation. |
2001-09-06 |
2023-08-12 |
human |
| I A Khan, P Thoma. Lead and Aroclor 1254 disrupt reproductive neuroendocrine function in Atlantic croaker. Marine environmental research. vol 50. issue 1-5. 2001-08-30. PMID:11460677. |
in the present study we investigated whether impairment of the hypothalamic 5-ht pathway involves alterations in tryptophan hydroxylase (tph), the rate-limiting enzyme in 5-ht biosynthesis, or monoamine oxidase (mao), the catabolic enzyme. |
2001-08-30 |
2023-08-12 |
Not clear |
| S B Turkel, J G Nadala, M Z Winco. Possible serotonin syndrome in association with 5-HT(3) antagonist agents. Psychosomatics. vol 42. issue 3. 2001-08-09. PMID:11351116. |
it occurs with selective serotonin reuptake inhibitors (ssris), opioids, and other serotonergic agents when the serotonin system has been modulated by another serotonergic agent or compromised by illness. |
2001-08-09 |
2023-08-12 |
Not clear |
| V Di Matteo, A De Blasi, C Di Giulio, E Esposit. Role of 5-HT(2C) receptors in the control of central dopamine function. Trends in pharmacological sciences. vol 22. issue 5. 2001-08-02. PMID:11339973. |
substantial evidence suggests that the functional status of the mesocorticolimbic dopamine (da) system originating in the ventral tegmental area is under a phasic and tonic inhibitory control by the 5-ht system that acts by stimulating 5-ht(2c) receptor subtypes. |
2001-08-02 |
2023-08-12 |
Not clear |
| A Menese. Could the 5-HT1B receptor inverse agonism affect learning consolidation? Neuroscience and biobehavioral reviews. vol 25. issue 2. 2001-07-05. PMID:11323083. |
diverse evidence indicates that, the 5-ht system might play a role in learning and memory, since it occurs in brain areas mediating such processes and 5-ht drugs modulate them. |
2001-07-05 |
2023-08-12 |
Not clear |
| K P Lesc. Serotonergic gene expression and depression: implications for developing novel antidepressants. Journal of affective disorders. vol 62. issue 1-2. 2001-06-14. PMID:11172874. |
given the fact that the 5-ht system continues to be an important target for drug development and production, novel strategies aiming toward the modification of 5-ht function at the level of gene expression are likely to be exploited by enterprises participating actively in the introduction of alternative therapeutic approaches. |
2001-06-14 |
2023-08-12 |
Not clear |
| Y Sari, T Powrozek, F C Zho. Alcohol deters the outgrowth of serotonergic neurons at midgestation. Journal of biomedical science. vol 8. issue 1. 2001-05-31. PMID:11173985. |
in light of the importance of the 5-ht system in brain development, alcohol may affect the growth of the forebrain through its effect on 5-ht signaling. |
2001-05-31 |
2023-08-12 |
mouse |
| P Blier, F V Abbot. Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain. Journal of psychiatry & neuroscience : JPN. vol 26. issue 1. 2001-03-15. PMID:11212592. |
these observations emphasize the notion that the 5-ht system is endowed with different adaptive properties in various parts of the body, which, in addition to the multiplicity of 5-ht receptors, makes this chemospecific network important in many disorders. |
2001-03-15 |
2023-08-12 |
Not clear |
| J Evans, B Reeves, H Platt, A Leibenau, D Goldman, K Jefferson, D Nut. Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH). Psychological medicine. vol 30. issue 6. 2001-02-22. PMID:11097073. |
serotonin function has been linked to impulsive and suicidal behaviour and genetic polymorphisms have been identified within the serotonin system that could account for this link. |
2001-02-22 |
2023-08-12 |
Not clear |
| J F Quist, C L Barr, R Schachar, W Roberts, M Malone, R Tannock, V S Basile, J Beitchman, J L Kenned. Evidence for the serotonin HTR2A receptor gene as a susceptibility factor in attention deficit hyperactivity disorder (ADHD). Molecular psychiatry. vol 5. issue 5. 2001-02-01. PMID:11032388. |
defects in serotonin system genes, therefore, may disrupt normal brain serotonin function causing an imbalance between these neurotransmitter systems leading to the development of attention deficit hyperactivity disorder (adhd). |
2001-02-01 |
2023-08-12 |
mouse |
| B A Heidenreich, T C Napie. Effects of serotonergic 5-HT1A and 5-HT1B ligands on ventral pallidal neuronal activity. Neuroreport. vol 11. issue 13. 2001-01-25. PMID:11006953. |
to clarify the role of the 5-ht system in limbic outputs, the present study compared the effects of the 5-ht1a agonist 8-oh-dpat and the 5-ht1b agonist cp-94253 with the non-selective 5-ht agonist tfmpp on the firing rate of ventral pallidal (vp) neurons recorded in chloral hydrate-anesthetized rats. |
2001-01-25 |
2023-08-12 |
rat |
| A Siddiqui, K Kotecha, A M Salicioni, V Kalia, J F Murray, C A Wilso. Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. Neuroendocrinology. vol 72. issue 5. 2001-01-25. PMID:11124584. |
previous findings show that there is an inverse relationship between serotonin (5-ht) activity in the zi and plasma luteinizing hormone (lh) levels, indicating that the 5-ht system in this area has an inhibitory effect on lh release. |
2001-01-25 |
2023-08-12 |
rat |
| L Uphous. Female gonadal hormones, serotonin, and sexual receptivity. Brain research. Brain research reviews. vol 33. issue 2-3. 2001-01-08. PMID:11011068. |
the effect of estrogen and progesterone on the lordosis response to 5-ht receptor-selective compounds is reviewed and potential mechanisms for hormonal modulation of the 5-ht system are suggested. |
2001-01-08 |
2023-08-12 |
rat |
| P Moore, H P Landolt, E Seifritz, C Clark, T Bhatti, J Kelsoe, M Rapaport, J C Gilli. Clinical and physiological consequences of rapid tryptophan depletion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 6. 2001-01-04. PMID:11063917. |
rtd has been used over the past decade to deplete serotonin (5-hydroxy-tryptamine, or 5-ht) in humans and to probe the role of the central serotonin system in a variety of psychiatric conditions. |
2001-01-04 |
2023-08-12 |
Not clear |
| D E Pongratz, M Siever. Fibromyalgia-symptom or diagnosis: a definition of the position. Scandinavian journal of rheumatology. Supplement. vol 113. 2000-11-03. PMID:11028823. |
initial reports on some allelic abnormalities in the serotonin system seem to highlight the important role of serotonin already presumed earlier. |
2000-11-03 |
2023-08-12 |
Not clear |