| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Blier, C de Montign. Clarifications on the effects of 5-HT1A agonists and selective 5-HT reuptake inhibitors on the 5-HT system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 2. 1996-12-26. PMID:8840358. |
clarifications on the effects of 5-ht1a agonists and selective 5-ht reuptake inhibitors on the 5-ht system. |
1996-12-26 |
2023-08-12 |
Not clear |
| D L Dow-Edward. Modification of acoustic startle reactivity by cocaine administration during the postnatal period: comparison with a specific serotonin reuptake inhibitor. Neurotoxicology and teratology. vol 18. issue 3. 1996-12-11. PMID:8725641. |
together these data indicate that, in males, whereas postnatal cocaine alters the development of the 5-ht system as evidenced by an altered startle response to 5-ht agonists, cocaine does not produce the same alteration as that produced by the administration of a specific 5-ht uptake inhibitor during the same period of development. |
1996-12-11 |
2023-08-12 |
human |
| G Piñeyro, C de Montigny, M Weiss, P Blie. Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822478. |
the 5-ht pathway was electrically stimulated at the level of the ventromedial tegmentum and the ensuing action potentials, recorded in the dorsal raphe, met all criteria for antidromic invasion of 5-ht neurons. |
1996-11-08 |
2023-08-12 |
rat |
| F G Graeff, F S Guimarães, T G De Andrade, J F Deaki. Role of 5-HT in stress, anxiety, and depression. Pharmacology, biochemistry, and behavior. vol 54. issue 1. 1996-10-23. PMID:8728550. |
to study the role of the drn 5-ht system in anxiety, we microinjected 8-oh-dpat into the drn to inhibit 5-ht release. |
1996-10-23 |
2023-08-12 |
human |
| U Fre. Cerebral metabolic effects of serotonin drugs and neurotoxins. Life sciences. vol 59. issue 11. 1996-10-21. PMID:8795699. |
dose, time from administration, receptor affinity, behavioral and neurochemical correlates, 5-ht system lesion and circulating glucocorticoid were all relevant factors in determining the rcmrglc effects of 5-ht drugs. |
1996-10-21 |
2023-08-12 |
human |
| D Zhou, G Huether, J Wiltfang, G Hajak, E Rüthe. Serotonin transporters in the rat frontal cortex: lack of circadian rhythmicity but down-regulation by food restriction. Journal of neurochemistry. vol 67. issue 2. 1996-09-19. PMID:8764592. |
because the duration and the radius of action of presynaptically released serotonin are governed by the efficiency of the reuptake mechanism, such adaptive changes of serotonin transporter density must be expected to cause long-term alterations of the modulatory impact of the central serotonin system on certain brain functions. |
1996-09-19 |
2023-08-12 |
human |
| E F Coccaro, R J Kavoussi, R L Hauge. Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. International clinical psychopharmacology. vol 10. issue 3. 1996-08-13. PMID:8675971. |
since none of these physiological indices of 5-ht system function were intercorrelated, it is possible that simultaneous assessment of these 5-ht indices may yield a more comprehensive assessment of the relationship between central 5-ht system function and aggressive behavior in humans. |
1996-08-13 |
2023-08-12 |
Not clear |
| N A Borisova, E V Proshlyakova, A Y Sapronova, M V Ugrumo. Androgen-dependent sex differences in the hypothalamic serotoninergic system. European journal of endocrinology. vol 134. issue 2. 1996-06-28. PMID:8630525. |
such integrative characteristics of the 5-ht system as 5-ht content and specific uptake were estimated and compared in the anterior and middle hypothalami in intact adult females and males, as well as in neonatally castrated adult males. |
1996-06-28 |
2023-08-12 |
rat |
| M H Lade. Tolerability and safety: essentials in antidepressant pharmacotherapy. The Journal of clinical psychiatry. vol 57 Suppl 2. 1996-06-25. PMID:8626362. |
it is different from other antidepressants because of its two actions in the serotonin system, moderate serotonin selective reuptake blocking properties and direct 5-ht2 antagonism, which also can enhance 5-ht1 neurotransmission. |
1996-06-25 |
2023-08-12 |
human |
| A Richter, W Lösche. Behavioural response to pharmacologic manipulation of serotonin receptors in the genetically dystonic hamster. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587901. |
because the serotonin (5-ht) system has been suggested to be involved in dystonia, we examined the functional responsiveness of the 5-ht system in dystonic hamsters by administering various 5-ht agonists and antagonists selective for different receptor subtypes and observing the effects on dystonic attacks as well as the behavioural responses associated with drug administration. |
1996-03-27 |
2023-08-12 |
Not clear |
| H Tohgi, T Abe, S Takahashi, M Saheki, M Kimur. Indoleamine concentrations in cerebrospinal fluid from patients with Alzheimer type and Binswanger type dementias before and after administration of citalopram, a synthetic serotonin uptake inhibitor. Journal of neural transmission. Parkinson's disease and dementia section. vol 9. issue 2-3. 1996-02-01. PMID:8526997. |
these results suggest that both the serotonin and kynurenine pathways are impaired in atd; whereas, the serotonin pathway alone is in vdbt, and that these impairments are ameliorated by the administration of citalopram. |
1996-02-01 |
2023-08-12 |
Not clear |
| M M Katz, J W Maas, A Frazer, S H Koslow, C L Bowden, N Berman, A C Swann, P E Stoke. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 2. 1995-03-07. PMID:7530963. |
results indicated the following: (1) drug-induced changes in the 5-ht system to be associated with mood aspects, notably anxiety, and depressed mood; changes in ne primarily with the psychomotor, secondarily with the mood components of the depressed state; (2) the pattern of relationships between changes in 5-ht and in mood in the unipolar was different than that in the bipolar subtype. |
1995-03-07 |
2023-08-12 |
Not clear |
| R Sandyk, G I Awerbuc. The co-occurrence of multiple sclerosis and migraine headache: the serotoninergic link. The International journal of neuroscience. vol 76. issue 3-4. 1994-12-02. PMID:7960481. |
as migraine has been linked to changes in serotonin (5-ht) functions, the emergence of migraine headaches coincident with the onset of relapse implicates dysregulation of the 5-ht system in the pathophysiology of ms. |
1994-12-02 |
2023-08-12 |
Not clear |
| R Sandy. Aggressive behavior in schizophrenia: relationship to age of onset and cortical atrophy. The International journal of neuroscience. vol 68. issue 1-2. 1994-09-19. PMID:8063505. |
specifically, since aggressive behavior has been linked to impairment of serotonergic (5-ht) functions, i propose that the timing of onset of schizophrenia may be partly associated with dysregulation of the 5-ht system. |
1994-09-19 |
2023-08-12 |
crow |
| J J López Costa, S Averill, J P Saavedra, J V Priestle. Serotonin innervation of enkephalin containing neurones in the rat spinal trigeminal nucleus. Neuroscience letters. vol 168. issue 1-2. 1994-08-08. PMID:8028772. |
5-ht axons are therefore in a position to exert a direct action on enkephalinergic interneurones and this may contribute to the analgesic actions of the 5-ht system. |
1994-08-08 |
2023-08-12 |
rat |
| D V Sheehan, B A Raj, R R Trehan, E L Knap. Serotonin in panic disorder and social phobia. International clinical psychopharmacology. vol 8 Suppl 2. 1994-07-07. PMID:7911142. |
(5) are serotonin selective uptake inhibitors (ssuis) effective in panic disorder via the serotonin system or some other mechanism? |
1994-07-07 |
2023-08-12 |
Not clear |
| F Molina-Holgado, E Molina-Holgado, M L Leret, M I González, T A Reade. Distribution of indoleamines and [3H]paroxetine binding in rat brain regions following acute or perinatal delta 9-tetrahydrocannabinol treatments. Neurochemical research. vol 18. issue 11. 1994-01-13. PMID:7504790. |
the present results show that acute and maternal exposure to delta 9-thc produced different effects on the central 5-ht system of the offspring, with a clear regional specificity, but with no changes in the densities of 5-ht uptake sites. |
1994-01-13 |
2023-08-12 |
rat |
| N H Chen, M E Reit. [3H]dopamine and [3H]serotonin release in vitro induced by electrical stimulation in A9 and A10 dopamine regions of rat brain: characterization and responsiveness to cocaine. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:8229765. |
the dual effects of cocaine on electrically induced [3h]da release from vm may be attributed to the complex 5-ht/da and 5-ht autoreceptor/cocaine interactions as well as the relative densities of 5-ht/da transporters in this region, indicating a possible involvement of the 5-ht system in cocaine's behavioral effects. |
1993-11-29 |
2023-08-12 |
rat |
| G A Ricaurte, A L Markowska, G L Wenk, G Hatzidimitriou, J Wlos, D S Olto. 3,4-Methylenedioxymethamphetamine, serotonin and memory. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8102642. |
these data suggest that selective damage to the 5-ht system, like that produced by mdma, is not sufficient to impair memory, but that combined damage to the 5-ht and norepinephrine systems can disrupt performance in tasks that require recent memory. |
1993-09-17 |
2023-08-12 |
rat |
| W K Goodman, C J McDougle, L C Barr, S C Aronson, L H Pric. Biological approaches to treatment-resistant obsessive compulsive disorder. The Journal of clinical psychiatry. vol 54 Suppl. 1993-08-18. PMID:8331098. |
the most commonly employed strategy involves combining a potent serotonin reuptake inhibitor (sri) (e.g., clomipramine or fluvoxamine) with another medication that may exert effects on the brain serotonin system. |
1993-08-18 |
2023-08-12 |
Not clear |