| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Hayashi, T Z Guo, M Maz. Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats. Anesthesia and analgesia. vol 83. issue 3. 1996-10-09. PMID:8780290. |
to better predict the clinical consequences of this combination, we studied the behavioral effects of dexmedetomidine, a highly selective alpha 2 agonist with analgesic and hypnotic properties, during the development of, and recovery from, morphine tolerance. |
1996-10-09 |
2023-08-12 |
rat |
| A J Rouch, L H Kud. Alpha 2-adrenergic-mediated inhibition of water and urea permeability in the rat IMCD. The American journal of physiology. vol 271. issue 1 Pt 2. 1996-10-08. PMID:8760256. |
these studies were conducted to determine whether the alpha 2-agonists epinephrine and dexmedetomidine inhibit osmotic water permeability (pf) and urea permeability (pu) in the rat inner medullary collecting duct (imcd). |
1996-10-08 |
2023-08-12 |
rat |
| A J Rouch, L H Kud. Alpha 2-adrenergic-mediated inhibition of water and urea permeability in the rat IMCD. The American journal of physiology. vol 271. issue 1 Pt 2. 1996-10-08. PMID:8760256. |
epinephrine or dexmedetomidine, both at 1 microm, was then added to the bath, and this period was followed by adding 1 microm atipamezole, a selective alpha 2-antagonist. |
1996-10-08 |
2023-08-12 |
rat |
| T Halonen, T Kotti, J Tuunanen, A Toppinen, R Miettinen, P J Riekkine. Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. Brain research. vol 693. issue 1-2. 1996-07-31. PMID:8653412. |
alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. |
1996-07-31 |
2023-08-12 |
rat |
| T Z Guo, J Y Jiang, A E Buttermann, M Maz. Dexmedetomidine injection into the locus ceruleus produces antinociception. Anesthesiology. vol 84. issue 4. 1996-07-11. PMID:8638842. |
alpha(2)-adrenergic agonists such as clonidine and dexmedetomidine are known to produce sedation and analgesia in humans. |
1996-07-11 |
2023-08-12 |
rat |
| M O Enkvist, H Hämäläinen, C C Jansson, J P Kukkonen, R Hautala, M J Courtney, K E Akerma. Coupling of astroglial alpha 2-adrenoreceptors to second messenger pathways. Journal of neurochemistry. vol 66. issue 6. 1996-07-01. PMID:8632162. |
the alpha 2 agonist dexmedetomidine inhibited forskolin-induced increases in cyclic amp both in treated and untreated cultures in a pertussis toxin-dependent manner. |
1996-07-01 |
2023-08-12 |
Not clear |
| M O Enkvist, H Hämäläinen, C C Jansson, J P Kukkonen, R Hautala, M J Courtney, K E Akerma. Coupling of astroglial alpha 2-adrenoreceptors to second messenger pathways. Journal of neurochemistry. vol 66. issue 6. 1996-07-01. PMID:8632162. |
selective alpha 2-receptor agonists dexmedetomidine, clonidine, and uk14,304 all increased intracellular calcium only in dbcamp-treated cells. |
1996-07-01 |
2023-08-12 |
Not clear |
| C J Lawrence, F W Prinzen, S de Lang. The effect of dexmedetomidine on the balance of myocardial energy requirement and oxygen supply and demand. Anesthesia and analgesia. vol 82. issue 3. 1996-06-14. PMID:8623959. |
the effect of the alpha(2)-adrenergic agonist dexmedetomidine on the balance between myocardial energy requirement and oxygen supply and demand was investigated in 16 open-chest dogs anesthetized with either chloralose/urethane (cu) or fentanyl/halothane (fh). |
1996-06-14 |
2023-08-12 |
Not clear |
| P Valtonen, A Haapalinna, P Riekkinen, T Halone. Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. European journal of pharmacology. vol 285. issue 3. 1996-03-14. PMID:8575509. |
effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. |
1996-03-14 |
2023-08-12 |
rat |
| P Valtonen, A Haapalinna, P Riekkinen, T Halone. Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. European journal of pharmacology. vol 285. issue 3. 1996-03-14. PMID:8575509. |
the effect of the alpha 2-adrenoceptor agonist dexmedetomidine (5 micrograms/kg, s.c.) and the alpha 2-adrenoceptor antagonist atipamezole (0.1 mg/kg and 1 mg/kg, s.c.) on the release of extracellular glutamate, aspartate and gamma-aminobutyric acid (gaba) was studied with microdialysis in the hippocampus of freely moving rats under basal and k(+)-evoked conditions. |
1996-03-14 |
2023-08-12 |
rat |
| T H Chiu, M J Chen, Y R Yang, J J Yang, F I Tan. Action of dexmedetomidine on rat locus coeruleus neurones: intracellular recording in vitro. European journal of pharmacology. vol 285. issue 3. 1996-03-14. PMID:8575512. |
in contrast, prazosin, the alpha 1-, alpha 2b- and alpha 2c-adrenoceptor subtype-preferring ligand, did not inhibit the dexmedetomidine effect. |
1996-03-14 |
2023-08-12 |
rat |
| T H Chiu, M J Chen, Y R Yang, J J Yang, F I Tan. Action of dexmedetomidine on rat locus coeruleus neurones: intracellular recording in vitro. European journal of pharmacology. vol 285. issue 3. 1996-03-14. PMID:8575512. |
these data therefore suggest that dexmedetomidine binds to alpha 2a-adrenoceptors on the cell membrane of neurones of the locus coeruleus and that this leads to opening of the inwardly rectifying k+ channels, resulting in the observed hyperpolarization of the membrane. |
1996-03-14 |
2023-08-12 |
rat |
| J Jalonen, L Halkola, K Kuttila, J Perttilä, A Rajalin, T Savunen, M Scheinin, M Valtone. Effects of dexmedetomidine on coronary hemodynamics and myocardial oxygen balance. Journal of cardiothoracic and vascular anesthesia. vol 9. issue 5. 1996-02-22. PMID:8547552. |
the hypothesis of the present study was that a rapid intravenous bolus of dexmedetomidine, a specific alpha 2-adrenergic agonist, will cause coronary vasoconstriction and accompanying myocardial ischemia in young pigs. |
1996-02-22 |
2023-08-12 |
Not clear |
| E MacDonald, M Scheini. Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 46. issue 3. 1996-01-26. PMID:8527807. |
dexmedetomidine) or antagonize alpha 2-receptors (e.g. |
1996-01-26 |
2023-08-12 |
Not clear |
| P Jaatinen, P Riihioja, A Haapalinna, E Heinonen, K Kiianmaa, A Hervone. Prevention of ethanol-induced sympathetic overactivity and degeneration by dexmedetomidine. Alcohol (Fayetteville, N.Y.). vol 12. issue 5. 1996-01-22. PMID:8519439. |
the effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on rat sympathetic neurons were studied during a 12-day, heavy ethanol exposure. |
1996-01-22 |
2023-08-12 |
rat |
| T Kamibayashi, T Mammoto, Y Hayashi, A Yamatodani, K Takada, S Sasaki, I Yoshiy. Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology. vol 83. issue 5. 1995-12-21. PMID:7486159. |
the authors previously reported that dexmedetomidine, a selective alpha 2 agonist, prevents the genesis of halothane-epinephrine dysrhythmias through a central mechanism. |
1995-12-21 |
2023-08-12 |
Not clear |
| T Kamibayashi, Y Hayashi, T Mammoto, A Yamatodani, K Sumikawa, I Yoshiy. Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology. vol 83. issue 5. 1995-12-21. PMID:7486186. |
dexmedetomidine, an alpha 2-adrenergic agonist, can prevent the genesis of halothane/epinephrine dysrhythmias through the central nervous system. |
1995-12-21 |
2023-08-12 |
Not clear |
| T Kamibayashi, Y Hayashi, T Mammoto, A Yamatodani, K Sumikawa, I Yoshiy. Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology. vol 83. issue 5. 1995-12-21. PMID:7486186. |
because stimulation of alpha 2 adrenoceptors in the central nervous system enhances vagal neural activity and vagal stimulation is known to inhibit digitalis-induced dysrhythmias, dexmedetomidine may exert the antidysrhythmic property through vagal stimulation. |
1995-12-21 |
2023-08-12 |
Not clear |
| Y Hayashi, B C Rabin, T Z Guo, M Maz. Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat. Anesthesiology. vol 83. issue 4. 1995-11-09. PMID:7574062. |
at this site, the hypnotic response to dexmedetomidine, an alpha 2 agonist, can be blocked by pretreatment with ptx. |
1995-11-09 |
2023-08-12 |
rat |
| Y Hayashi, B C Rabin, T Z Guo, M Maz. Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat. Anesthesiology. vol 83. issue 4. 1995-11-09. PMID:7574062. |
to address this question the effects of pretreatment with ptx administered intracerebroventricularly, intrathecally, or a combination of the two were examined on the mac for halothane, and the anesthetic-sparing and analgesic effects of a systemically administered alpha 2 agonist, dexmedetomidine. |
1995-11-09 |
2023-08-12 |
rat |