| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Furst, M B Weinge. Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Anesthesiology. vol 72. issue 5. 1990-06-19. PMID:1971163. |
spontaneously ventilating rats (n = 28) were pretreated with dexmedetomidine, 10 or 30 micrograms/kg; dexmedetomidine, 30 micrograms/kg in combination with the central-acting alpha 2-antagonist idazoxan, 10 mg/kg; or vehicle. |
1990-06-19 |
2023-08-11 |
rat |
| S R Furst, M B Weinge. Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Anesthesiology. vol 72. issue 5. 1990-06-19. PMID:1971163. |
these data show that addition of the alpha 2-agonist dexmedetomidine will not worsen the cardiovascular and respiratory depression associated with high-dose opiates in the spontaneously ventilating rat. |
1990-06-19 |
2023-08-11 |
rat |
| M Koulu, U Pesonen, R Virtane. Chronic dexmedetomidine, a selective alpha 2-agonist, decreases serotonin but not noradrenaline turnover in rat brainstem nuclei. European journal of pharmacology. vol 176. issue 2. 1990-04-26. PMID:1690141. |
chronic dexmedetomidine, a selective alpha 2-agonist, decreases serotonin but not noradrenaline turnover in rat brainstem nuclei. |
1990-04-26 |
2023-08-11 |
rat |
| M Koulu, U Pesonen, R Virtane. Chronic dexmedetomidine, a selective alpha 2-agonist, decreases serotonin but not noradrenaline turnover in rat brainstem nuclei. European journal of pharmacology. vol 176. issue 2. 1990-04-26. PMID:1690141. |
the effects of a chronic treatment with dexmedetomidine, the active d-isomer of a selective alpha 2-agonist, medetomidine, on the metabolism and turnover of catecholamines and indoleamines in discrete rat brain stem and mesencephalic nuclei were investigated. |
1990-04-26 |
2023-08-11 |
rat |
| R E Aantaa, J H Kanto, M Scheinin, A M Kallio, H Scheini. Dexmedetomidine premedication for minor gynecologic surgery. Anesthesia and analgesia. vol 70. issue 4. 1990-04-26. PMID:1969252. |
the effects of four different doses (0.167, 0.33, 0.67, and 1.0 microgram/kg) of dexmedetomidine, a novel alpha 2-adrenoceptor agonist, on anesthetic requirements, hemodynamics, and plasma catecholamine levels were investigated in a single-blind fashion in 20 healthy (asa physical status i) women scheduled for uterine dilatation and curettage. |
1990-04-26 |
2023-08-11 |
Not clear |
| R Virtane. Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571275. |
the alpha 2-adrenoceptor activity of medetomidine resides predominantly in its d-enantiomer (dexmedetomidine). |
1989-10-19 |
2023-08-11 |
mouse |
| I S Segal, R G Vickery, M Maz. Dexmedetomidine decreases halothane anesthetic requirements in rats. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571278. |
to determine whether alpha 2-adrenoreceptors mediated the mac-sparing effect of dexmedetomidine (d-medetomidine), cohorts of rats (n = 6 for each dose) were pretreated with idazoxan, 10 mg/kg i.p., the highly selective alpha 2-antagonist. |
1989-10-19 |
2023-08-11 |
rat |
| V Doze, B X Chen, Z Li, M Maz. Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571279. |
the centrally-active alpha 2-receptor antagonists, atipamezole (mpv-1248) and idazoxan, dose-dependently decreased the hypnotic action of dexmedetomidine. |
1989-10-19 |
2023-08-11 |
rat |
| V Doze, B X Chen, Z Li, M Maz. Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571279. |
the stereospecificity of dexmedetomidine's hypnotic action and its dose-dependent attenuation by alpha 2-antagonists confirmed the involvement of alpha 2-receptors in this effect. |
1989-10-19 |
2023-08-11 |
rat |
| V Doze, B X Chen, Z Li, M Maz. Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571279. |
the finding that only alpha 2-antagonists with central activity attenuate the hypnotic action of dexmedetomidine, suggests that the mediating alpha 2-receptor is located in the central nervous system. |
1989-10-19 |
2023-08-11 |
rat |
| V Doze, B X Chen, Z Li, M Maz. Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571279. |
in summary, this study suggests that dexmedetomidine induces hypnosis in rats by activating central alpha 2-adrenergic receptors. |
1989-10-19 |
2023-08-11 |
rat |
| V Doze, B X Chen, Z Li, M Maz. Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta veterinaria Scandinavica. Supplementum. vol 85. 1989-10-19. PMID:2571279. |
this study also suggests that alpha 2-antagonists can be used to reverse the hypnotic effects of dexmedetomidine. |
1989-10-19 |
2023-08-11 |
rat |
| A Kallio, M Scheinin, M Koulu, R Ponkilainen, H Ruskoaho, O Viinamäki, H Scheini. Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms. Clinical pharmacology and therapeutics. vol 46. issue 1. 1989-08-17. PMID:2568211. |
effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms. |
1989-08-17 |
2023-08-11 |
human |
| A Kallio, M Scheinin, M Koulu, R Ponkilainen, H Ruskoaho, O Viinamäki, H Scheini. Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms. Clinical pharmacology and therapeutics. vol 46. issue 1. 1989-08-17. PMID:2568211. |
dexmedetomidine, a selective alpha 2-adrenoceptor agonist, was administered to five healthy male volunteers in single intravenous doses of 12.5, 25, 50, and 75 micrograms as part of a placebo-controlled study. |
1989-08-17 |
2023-08-11 |
human |
| A Kallio, M Scheinin, M Koulu, R Ponkilainen, H Ruskoaho, O Viinamäki, H Scheini. Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms. Clinical pharmacology and therapeutics. vol 46. issue 1. 1989-08-17. PMID:2568211. |
dexmedetomidine is a potentially useful tool for studies of the physiology and pharmacology of alpha 2-adrenoceptors in human beings and may have therapeutic applications in clinical conditions in which sedative and sympatholytic effects are considered beneficial, such as premedication for anesthesia and surgery. |
1989-08-17 |
2023-08-11 |
human |
| I S Segal, R G Vickery, J K Walton, V A Doze, M Maz. Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology. vol 69. issue 6. 1989-01-05. PMID:2848424. |
dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. |
1989-01-05 |
2023-08-11 |
rat |
| I S Segal, R G Vickery, J K Walton, V A Doze, M Maz. Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology. vol 69. issue 6. 1989-01-05. PMID:2848424. |
to determine whether alpha 2 adrenoreceptors mediated this effect of dexmedetomidine on mac, cohorts of rats were pretreated with idazoxan, 10 mg/kg ip, a highly selective alpha 2 antagonist. |
1989-01-05 |
2023-08-11 |
rat |