| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Karhuvaara, A Kallio, M Salonen, J Tuominen, M Scheini. Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers. British journal of clinical pharmacology. vol 31. issue 2. 1991-07-24. PMID:1675577. |
the ability of atipamezole, a specific and selective alpha 2-adrenoceptor antagonist, to reverse the pharmacological effects induced by the alpha 2-adrenoceptor agonist dexmedetomidine was studied in six healthy male volunteers. |
1991-07-24 |
2023-08-11 |
human |
| S Karhuvaara, A Kallio, M Salonen, J Tuominen, M Scheini. Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers. British journal of clinical pharmacology. vol 31. issue 2. 1991-07-24. PMID:1675577. |
bradycardia was very modest after dexmedetomidine in this study, and thus no reversal of alpha 2-adrenoceptor agonist-induced bradycardia could be demonstrated. |
1991-07-24 |
2023-08-11 |
human |
| M Scheinin, S Karhuvaara, P Ojala-Karlsson, A Kallio, M Koul. Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers. Life sciences. vol 49. issue 1. 1991-07-23. PMID:1646924. |
the potent alpha 2-adrenoceptor agonist, dexmedetomidine, induced only about 15% maximal reductions in the metabolite concentrations, in spite of almost total inhibition of neuronal ne release, as evidenced by 90% reductions in plasma ne concentrations. |
1991-07-23 |
2023-08-11 |
human |
| B Fisher, M H Zornow, T L Yaksh, B M Peterso. Antinociceptive properties of intrathecal dexmedetomidine in rats. European journal of pharmacology. vol 192. issue 2. 1991-06-26. PMID:1674472. |
dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist. |
1991-06-26 |
2023-08-11 |
rat |
| B Fisher, M H Zornow, T L Yaksh, B M Peterso. Antinociceptive properties of intrathecal dexmedetomidine in rats. European journal of pharmacology. vol 192. issue 2. 1991-06-26. PMID:1674472. |
the intrathecal administration of the alpha 2-adrenoceptor antagonist, idazoxan, ablated all measurable antinociception produced by the prior injection of 10 micrograms of dexmedetomidine. |
1991-06-26 |
2023-08-11 |
rat |
| J J Kendig, M K Savola, S J Woodley, M Maz. Alpha 2-adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord. European journal of pharmacology. vol 192. issue 2. 1991-06-26. PMID:1674474. |
the present study explored the actions of the alpha 2-adrenoceptor agonists dexmedetomidine and clonidine on a nociceptive response in isolated neonatal rat spinal cord. |
1991-06-26 |
2023-08-11 |
rat |
| J D Weitz, S D Foster, W R Waugaman, R L Katz, B C Bloo. Anesthetic and hemodynamic effects of dexmedetomidine during isoflurane anesthesia in a canine model. Nurse anesthesia. vol 2. issue 1. 1991-05-31. PMID:1673630. |
dexmedetomidine, an alpha 2-adrenergic agonist, was administered during isoflurane anesthesia to investigate its anesthetic sparing and hemodynamic effects in the canine model. |
1991-05-31 |
2023-08-11 |
Not clear |
| J W Flacke, W E Flacke, B C Bloor, D F McInte. Hemodynamic effects of dexmedetomidine, an alpha 2-adrenergic agonist, in autonomically denervated dogs. Journal of cardiovascular pharmacology. vol 16. issue 4. 1991-04-26. PMID:1706803. |
hemodynamic effects of dexmedetomidine, an alpha 2-adrenergic agonist, in autonomically denervated dogs. |
1991-04-26 |
2023-08-11 |
Not clear |
| J W Flacke, W E Flacke, B C Bloor, D F McInte. Hemodynamic effects of dexmedetomidine, an alpha 2-adrenergic agonist, in autonomically denervated dogs. Journal of cardiovascular pharmacology. vol 16. issue 4. 1991-04-26. PMID:1706803. |
the hemodynamic effects of the alpha 2-adrenergic agonist, dexmedetomidine (dm), were studied in eight anesthetized, autonomically denervated dogs. |
1991-04-26 |
2023-08-11 |
Not clear |
| P R Housman. Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium. Anesthesiology. vol 73. issue 5. 1990-12-11. PMID:1978616. |
the effects of the highly selective alpha 2-adrenoceptor agonist dexmedetomidine on contractility, relaxation, and the intracellular ca2+ transients of isolated ventricular myocardium were studied in isolated right ventricular papillary muscles obtained from reserpinized ferrets. |
1990-12-11 |
2023-08-11 |
Not clear |
| R Aantaa, J Kanto, M Scheinin, A Kallio, H Scheini. Dexmedetomidine, an alpha 2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. Anesthesiology. vol 73. issue 2. 1990-09-13. PMID:1974394. |
dexmedetomidine, an alpha 2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. |
1990-09-13 |
2023-08-11 |
Not clear |
| R Aantaa, J Kanto, M Scheinin, A Kallio, H Scheini. Dexmedetomidine, an alpha 2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. Anesthesiology. vol 73. issue 2. 1990-09-13. PMID:1974394. |
the effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, on vigilance, thiopental anesthetic requirements, and the hemodynamic, catecholamine, and hormonal responses to surgery were investigated in healthy (asa physical status 1) women scheduled for dilatation and curettage (d & c) of the uterus. |
1990-09-13 |
2023-08-11 |
Not clear |
| B R Karlsson, M Forsman, O K Roald, M S Heier, P A Stee. Effect of dexmedetomidine, a selective and potent alpha 2-agonist, on cerebral blood flow and oxygen consumption during halothane anesthesia in dogs. Anesthesia and analgesia. vol 71. issue 2. 1990-08-28. PMID:1973880. |
effect of dexmedetomidine, a selective and potent alpha 2-agonist, on cerebral blood flow and oxygen consumption during halothane anesthesia in dogs. |
1990-08-28 |
2023-08-11 |
Not clear |
| B R Karlsson, M Forsman, O K Roald, M S Heier, P A Stee. Effect of dexmedetomidine, a selective and potent alpha 2-agonist, on cerebral blood flow and oxygen consumption during halothane anesthesia in dogs. Anesthesia and analgesia. vol 71. issue 2. 1990-08-28. PMID:1973880. |
the effect of the alpha 2-agonist dexmedetomidine on the cerebral blood flow (cbf) and the metabolic rate for oxygen was studied by a sagittal sinus outflow technique in dogs during halothane anesthesia. |
1990-08-28 |
2023-08-11 |
Not clear |
| S Karhuvaara, A Kallio, M Koulu, H Scheinin, M Scheini. No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men. Psychoneuroendocrinology. vol 15. issue 2. 1990-08-02. PMID:1972797. |
in the first experiment, 50 micrograms dexmedetomidine (mpv-1440), a selective alpha 2-adrenoceptor agonist, and saline placebo were infused (iv) in five subjects. |
1990-08-02 |
2023-08-11 |
human |
| M H Zornow, J E Fleischer, M S Scheller, K Nakakimura, J C Drummon. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. Anesthesia and analgesia. vol 70. issue 6. 1990-06-27. PMID:1971500. |
dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. |
1990-06-27 |
2023-08-11 |
dog |
| M H Zornow, J E Fleischer, M S Scheller, K Nakakimura, J C Drummon. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. Anesthesia and analgesia. vol 70. issue 6. 1990-06-27. PMID:1971500. |
the purpose of this study was to examine the effects of dexmedetomidine, an alpha 2-adrenergic agonist, on cerebral blood flow and metabolic rate in dogs anesthetized with 0.64% isoflurane. |
1990-06-27 |
2023-08-11 |
dog |
| M H Zornow, J E Fleischer, M S Scheller, K Nakakimura, J C Drummon. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. Anesthesia and analgesia. vol 70. issue 6. 1990-06-27. PMID:1971500. |
measurements of cerebral blood flow (cbf), cerebral metabolic rate for oxygen (cmro2), mean arterial pressure, cardiac output, and blood gas tensions were made at various levels of isoflurane anesthesia (0.64%, 1.9%, and 2.8%), after the administration of 10 micrograms/kg of dexmedetomidine (a dose that has been shown to reduce anesthetic requirements in dogs by greater than 90%) and finally after 0.3 micrograms/kg of the alpha 2-adrenergic antagonist idazoxan. |
1990-06-27 |
2023-08-11 |
dog |
| S R Furst, M B Weinge. Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Anesthesiology. vol 72. issue 5. 1990-06-19. PMID:1971163. |
dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. |
1990-06-19 |
2023-08-11 |
rat |
| S R Furst, M B Weinge. Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Anesthesiology. vol 72. issue 5. 1990-06-19. PMID:1971163. |
the authors examined the cardiovascular and respiratory effects of the highly selective alpha 2-adrenergic agonist dexmedetomidine, both alone and in combination with the synthetic opiate alfentanil. |
1990-06-19 |
2023-08-11 |
rat |