| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Scheinin, L Lindgren, T Randell, H Scheinin, M Scheini. Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl. British journal of anaesthesia. vol 68. issue 2. 1992-04-06. PMID:1347229. |
the effects of the new, highly selective alpha 2-adrenergic agonist, dexmedetomidine, were studied in a randomized, placebo-controlled, double-blind trial in 24 asa i patients. |
1992-04-06 |
2023-08-11 |
Not clear |
| O Pelkonen, J Puurunen, P Arvela, R Lammintaust. Comparative effects of medetomidine enantiomers on in vitro and in vivo microsomal drug metabolism. Pharmacology & toxicology. vol 69. issue 3. 1992-04-06. PMID:1686651. |
the effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, and its levo enantiomer (mpv-1441), on in vitro microsomal p450-dependent drug-metabolizing activities as well as on in vivo aminopyrine elimination and hexobarbital sleeping time were studied. |
1992-04-06 |
2023-08-11 |
human |
| A F Sullivan, E A Kalso, H J McQuay, A H Dickenso. FLFQPQRF-amide modulates alpha 2-adrenergic antinociception in the rat dorsal horn in vivo. Brain research. vol 562. issue 2. 1992-03-03. PMID:1685347. |
the inhibition of c fibre-evoked neuronal responses by the selective alpha 2-adrenergic agonist dexmedetomidine was significantly reduced by intrathecal flfqpqrfamide pretreatment. |
1992-03-03 |
2023-08-11 |
rat |
| M H Zorno. Ventilatory, hemodynamic and sedative effects of the alpha 2 adrenergic agonist, dexmedetomidine. Neuropharmacology. vol 30. issue 10. 1992-02-04. PMID:1684646. |
ventilatory, hemodynamic and sedative effects of the alpha 2 adrenergic agonist, dexmedetomidine. |
1992-02-04 |
2023-08-11 |
rat |
| M H Zorno. Ventilatory, hemodynamic and sedative effects of the alpha 2 adrenergic agonist, dexmedetomidine. Neuropharmacology. vol 30. issue 10. 1992-02-04. PMID:1684646. |
to examine the ability of an alpha 2 adrenergic antagonist to reverse the effects of dexmedetomidine, 5 rabbits initially received 320 micrograms/kg of dexmedetomidine as described above. |
1992-02-04 |
2023-08-11 |
rat |
| Marja-Leena Jaakola, Markku Salonen, Risto Lehtinen, Harry Scheini. The analgesic action of dexmedetomidine--a novel alpha 2-adrenoceptor agonist--in healthy volunteers. Pain. vol 46. issue 3. 1992-02-03. PMID:1684653. |
the analgesic action of dexmedetomidine--a novel alpha 2-adrenoceptor agonist--in healthy volunteers. |
1992-02-03 |
2023-08-11 |
human |
| Marja-Leena Jaakola, Markku Salonen, Risto Lehtinen, Harry Scheini. The analgesic action of dexmedetomidine--a novel alpha 2-adrenoceptor agonist--in healthy volunteers. Pain. vol 46. issue 3. 1992-02-03. PMID:1684653. |
the analgesic efficacy of dexmedetomidine (dex)--a novel alpha 2-adrenoceptor agonist--was studied in man. |
1992-02-03 |
2023-08-11 |
human |
| M J Mattila, M E Mattila, K T Olkkola, H Scheini. Effect of dexmedetomidine and midazolam on human performance and mood. European journal of clinical pharmacology. vol 41. issue 3. 1992-01-22. PMID:1684154. |
the effects of dexmedetomidine (dxm), a novel alpha 2-adrenoceptor agonist, on human performance and mood were studied in a double-blind randomized crossover study in 12 healthy student volunteers. |
1992-01-22 |
2023-08-11 |
human |
| J S Salone. Tissue-specificity of hydroxylation and N-methylation of arylalkylimidazoles. Pharmacology & toxicology. vol 69. issue 1. 1991-12-23. PMID:1946187. |
hydroxylation and n-methylation of three potent alpha 2-adrenoceptor agonists detomidine, medetomidine and dexmedetomidine by rat brain, kidney, liver and lung were studied in vitro. |
1991-12-23 |
2023-08-11 |
rat |
| R Aanta. Assessment of the sedative effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, with analysis of saccadic eye movements. Pharmacology & toxicology. vol 68. issue 5. 1991-12-17. PMID:1682907. |
assessment of the sedative effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, with analysis of saccadic eye movements. |
1991-12-17 |
2023-08-11 |
human |
| R Aanta. Assessment of the sedative effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, with analysis of saccadic eye movements. Pharmacology & toxicology. vol 68. issue 5. 1991-12-17. PMID:1682907. |
single intravenous doses (0.5 microgram/kg and 1.0 microgram kg) of dexmedetomidine (4(5)-(1-(2,3-dimethylphenyl)ethyl)imidazole), a selective alpha 2-adrenoceptor agonist, and saline placebo were administered to six healthy volunteers (4 males and 2 females) in a double-blind, placebo-controlled cross-over study. |
1991-12-17 |
2023-08-11 |
human |
| R Aantaa, M L Jaakola, A Kallio, J Kanto, M Scheinin, J Vuorine. A comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. premedication for minor gynaecological surgery. British journal of anaesthesia. vol 67. issue 4. 1991-12-16. PMID:1681840. |
a comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. |
1991-12-16 |
2023-08-11 |
Not clear |
| R Aantaa, M L Jaakola, A Kallio, J Kanto, M Scheinin, J Vuorine. A comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. premedication for minor gynaecological surgery. British journal of anaesthesia. vol 67. issue 4. 1991-12-16. PMID:1681840. |
dexmedetomidine 1.0 micrograms kg-1, a new alpha 2-adrenoceptor agonist, were compared with those of i.m. |
1991-12-16 |
2023-08-11 |
Not clear |
| T Z Guo, B Maze, M Maz. Attenuation of central alpha 2 adrenergic action in diabetic rats. Pharmacology, biochemistry, and behavior. vol 39. issue 2. 1991-11-26. PMID:1682948. |
to investigate whether the alpha 2 adrenergic receptor-effector mechanism is functionally altered by insulin deficiency, we determined the hypnotic response to dexmedetomidine [(+)4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole, a highly-selective alpha 2 agonist, in streptozotocin-induced diabetic rats. |
1991-11-26 |
2023-08-11 |
rat |
| E D Kharasch, H F Hill, A C Edd. Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism. Anesthesiology. vol 75. issue 3. 1991-10-10. PMID:1679616. |
the new highly selective alpha 2 agonist dexmedetomidine (d-medetomidine) is a substituted imidazole and thus may inhibit hepatic drug biotransformation. |
1991-10-10 |
2023-08-11 |
human |
| M K Savola, S J Woodley, M Maze, J J Kendi. Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Anesthesiology. vol 75. issue 3. 1991-10-10. PMID:1716080. |
alpha 2-adrenoceptor agonists such as clonidine and dexmedetomidine are effective analgesics at the spinal level, and furthermore, they reduce the volatile anesthetic requirement. |
1991-10-10 |
2023-08-11 |
rat |
| L Jacobsson, N Grundström, R G Andersso. Influence of some alpha 2-receptor agonists and antagonists on the excitatory non-adrenergic, non-cholinergic neurotransmission in the airways of guinea-pigs in vivo. Acta physiologica Scandinavica. vol 142. issue 1. 1991-09-23. PMID:1678910. |
the aim of the present study was to investigate the dose-dependence of the selective alpha 2-receptor agonists uk 14,304, dexmedetomidine and clonidine on these alpha 2-adrenoceptors in the airway of guinea-pigs in vivo. |
1991-09-23 |
2023-08-11 |
Not clear |
| J M Savola, R Virtane. Central alpha 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. European journal of pharmacology. vol 195. issue 2. 1991-09-20. PMID:1678707. |
central alpha 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. |
1991-09-20 |
2023-08-11 |
mouse |
| M K Savola, M B MacIver, V A Doze, J J Kendig, M Maz. The alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Brain research. vol 548. issue 1-2. 1991-09-19. PMID:1678296. |
the alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. |
1991-09-19 |
2023-08-11 |
rat |
| M K Savola, M B MacIver, V A Doze, J J Kendig, M Maz. The alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Brain research. vol 548. issue 1-2. 1991-09-19. PMID:1678296. |
this study was performed to quantitate the effect of dexmedetomidine, a novel alpha 2-adrenoceptor agonist, on the action of the volatile anesthetic agent isoflurane in rats in vivo. |
1991-09-19 |
2023-08-11 |
rat |