| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Gregoretti, T Henderson, D A Parks, S Gelma. Haemodynamic changes and oxygen uptake during crossclamping of the thoracic aorta in dexmedetomidine pretreated dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie. vol 39. issue 7. 1992-10-29. PMID:1356647. |
this study was designed to test the hypothesis that the alpha 2 adrenergic agonist, dexmedetomidine (dex), decreases tissue oxygen demand thereby increasing tolerance to hypoxic insult. |
1992-10-29 |
2023-08-11 |
Not clear |
| A F Sullivan, E A Kalso, H J McQuay, A H Dickenso. The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. European journal of pharmacology. vol 215. issue 1. 1992-10-08. PMID:1355441. |
the actions of the selective alpha 2-adrenoceptor agonist dexmedetomidine were examined on the nociceptive c and innocuous a beta fibre-evoked responses of dorsal horn neurones to transcutaneous electrical stimulation in the intact anaesthetized rat. |
1992-10-08 |
2023-08-11 |
rat |
| A F Sullivan, E A Kalso, H J McQuay, A H Dickenso. The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. European journal of pharmacology. vol 215. issue 1. 1992-10-08. PMID:1355441. |
the antinociceptive effects of dexmedetomidine were reversed by the alpha 2-adrenoceptor antagonist atipamezole and the opioid antagonist naloxone. |
1992-10-08 |
2023-08-11 |
rat |
| L T Proctor, W T Schmeling, D C Warltie. Premedication with oral dexmedetomidine alters hemodynamic actions of intravenous anesthetic agents in chronically instrumented dogs. Anesthesiology. vol 77. issue 3. 1992-10-07. PMID:1355639. |
dexmedetomidine (the d-stereoisomer of medetomidine), a highly selective alpha 2-adrenoceptor agonist, has been demonstrated to produce analgesia and sedation and attenuate hemodynamic responses to emergence from inhalational anesthetics, which suggests a potential use for this drug as a premedicant for general anesthesia. |
1992-10-07 |
2023-08-11 |
Not clear |
| W E Flacke, J W Flacke, K D Blow, D F McIntee, B C Bloo. Effect of dexmedetomidine, an alpha 2-adrenergic agonist, in the isolated heart. Journal of cardiothoracic and vascular anesthesia. vol 6. issue 4. 1992-09-11. PMID:1353991. |
effect of dexmedetomidine, an alpha 2-adrenergic agonist, in the isolated heart. |
1992-09-11 |
2023-08-11 |
human |
| M H Zornow, M S Scheller, P B Sheehan, M A Strnat, M Matsumot. Intracranial pressure effects of dexmedetomidine in rabbits. Anesthesia and analgesia. vol 75. issue 2. 1992-08-14. PMID:1352950. |
the alpha 2-adrenergic receptor agonist dexmedetomidine produces an anesthetic state in a variety of species. |
1992-08-14 |
2023-08-11 |
Not clear |
| M L Jaakola, T Ali-Melkkilä, J Kanto, A Kallio, H Scheinin, M Scheini. Dexmedetomidine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery. British journal of anaesthesia. vol 68. issue 6. 1992-07-27. PMID:1351736. |
dose of dexmedetomidine, a highly selective and specific alpha 2 adrenoceptor agonist, on intraocular pressure (iop), haemodynamic and sympathoadrenal responses to laryngoscopy and tracheal intubation, and on anaesthetic requirements in ophthalmic surgery. |
1992-07-27 |
2023-08-11 |
Not clear |
| M Salonen, K Reid, M Maz. Synergistic interaction between alpha 2-adrenergic agonists and benzodiazepines in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350887. |
therefore, we investigated the nature of the interaction between dexmedetomidine, the highly-selective alpha 2-adrenergic agonist, and midazolam in a series of in vivo and in vitro studies in rats. |
1992-07-09 |
2023-08-11 |
rat |
| C Correa-Sales, B C Rabin, M Maz. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350889. |
a hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. |
1992-07-09 |
2023-08-11 |
rat |
| C Correa-Sales, B C Rabin, M Maz. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350889. |
dexmedetomidine, the highly selective alpha 2-adrenergic agonist, produces a dose-dependent hypnotic response in rats through a central mechanism. |
1992-07-09 |
2023-08-11 |
rat |
| C Correa-Sales, B C Rabin, M Maz. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350889. |
because the locus coeruleus (lc) contains pathways involved in the maintenance of vigilance and a high prevalence of alpha 2 adrenoceptors, we investigated the role of this brainstem nucleus in the hypnotic response to dexmedetomidine. |
1992-07-09 |
2023-08-11 |
rat |
| C Correa-Sales, B C Rabin, M Maz. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350889. |
atipamezole 0.07 micrograms-12 micrograms, a selective alpha 2-adrenergic antagonist, blocked the hypnotic response to dexmedetomidine 6.6 micrograms when both were administered into the lc. |
1992-07-09 |
2023-08-11 |
rat |
| C Correa-Sales, B C Rabin, M Maz. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350889. |
prazosin, an alpha 1-adrenergic antagonist, 4.2 micrograms into the lc or 1.0 mg.kg-1 ip, did not alter the hypnotic response to dexmedetomidine 6.6 micrograms into the lc. |
1992-07-09 |
2023-08-11 |
rat |
| C Correa-Sales, B C Rabin, M Maz. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. vol 76. issue 6. 1992-07-09. PMID:1350889. |
the present data suggest that alpha 2-adrenergic receptors in the lc appear to be a major site for the hypnotic action of dexmedetomidine. |
1992-07-09 |
2023-08-11 |
rat |
| G Horvàth, M Szikszay, G Benede. Calcium channels are involved in the hypnotic-anesthetic action of dexmedetomidine in rats. Anesthesia and analgesia. vol 74. issue 6. 1992-06-26. PMID:1375817. |
our study examined whether calcium channels are involved in the anesthetic action of dexmedetomidine (100-300 micrograms/kg), a highly selective alpha 2-adrenoceptor agonist. |
1992-06-26 |
2023-08-11 |
rat |
| J Vartiainen, E MacDonald, A Urtti, H Rouhiainen, R Virtane. Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. Investigative ophthalmology & visual science. vol 33. issue 6. 1992-06-16. PMID:1349879. |
the dextro-isomer, dexmedetomidine, is known from pharmacologic experiments to be a specific, potent, and selective full agonist at alpha 2-adrenoceptors, whereas the levo-enantiomer seems to be almost inactive. |
1992-06-16 |
2023-08-11 |
Not clear |
| J Vartiainen, E MacDonald, A Urtti, H Rouhiainen, R Virtane. Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. Investigative ophthalmology & visual science. vol 33. issue 6. 1992-06-16. PMID:1349879. |
these results indicate that the selective alpha 2-adrenoceptor agonist, dexmedetomidine, is a potent and effective drug for decreasing intraocular pressure in rabbits. |
1992-06-16 |
2023-08-11 |
Not clear |
| J Sirviö, P Riekkinen, T Ekonsalo, R Lammintausta, P J Riekkine. The effects of dexmedetomidine, an alpha 2 agonist, on learning and memory, assessed using passive avoidance and water maze tasks in rats. Neuropharmacology. vol 31. issue 2. 1992-04-28. PMID:1348113. |
the effects of dexmedetomidine, an alpha 2 agonist, on learning and memory, assessed using passive avoidance and water maze tasks in rats. |
1992-04-28 |
2023-08-11 |
rat |
| J Sirviö, P Riekkinen, T Ekonsalo, R Lammintausta, P J Riekkine. The effects of dexmedetomidine, an alpha 2 agonist, on learning and memory, assessed using passive avoidance and water maze tasks in rats. Neuropharmacology. vol 31. issue 2. 1992-04-28. PMID:1348113. |
the effects of dexmedetomidine, a specific and potent alpha 2 agonist, on the performance of rats in passive avoidance and water maze tasks were studied. |
1992-04-28 |
2023-08-11 |
rat |
| D Nguyen, I Abdul-Rasool, D Ward, J Hsieh, D Kobayashi, S Hadlock, F Singer, B Bloo. Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs. Anesthesiology. vol 76. issue 4. 1992-04-23. PMID:1347980. |
dexmedetomidine (dmed) is a novel alpha 2 adrenergic agonist that has been shown to have potent analgesic and anesthetic sparing effects. |
1992-04-23 |
2023-08-11 |
Not clear |