| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Z Guo, J Tinklenberg, R Oliker, M Maz. Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677547. |
central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. |
1991-08-23 |
2023-08-11 |
rat |
| T Z Guo, J Tinklenberg, R Oliker, M Maz. Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677547. |
previously, we demonstrated that dexmedetomidine, an alpha 2 agonist, produces a hypnotic-anesthetic response in rats via activation of central alpha 2 adrenoceptors and that this response could be enhanced by the alpha 1 antagonist prazosin. |
1991-08-23 |
2023-08-11 |
rat |
| T Z Guo, J Tinklenberg, R Oliker, M Maz. Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677547. |
cirazoline, an alpha 1 adrenoceptor agonist that partitions into the central nervous system, attenuated dexmedetomidine's hypnotic response whether administered systemically (0.3-1 mg.kg-1 intraperitoneally [ip]) or centrally (0.1 mg.kg-1 intracerebroventricularly). |
1991-08-23 |
2023-08-11 |
rat |
| T Z Guo, J Tinklenberg, R Oliker, M Maz. Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677547. |
administration of phenylephrine, 0.3-3 mg.kg-1 ip, an alpha 1 adrenoceptor agonist that does not penetrate into the brain, did not attenuate dexmedetomidine's hypnotic effect. |
1991-08-23 |
2023-08-11 |
rat |
| W E Hoffman, E Kochs, C Werner, C Thomas, R F Albrech. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677549. |
dexmedetomidine is an alpha 2-adrenergic agonist that decreases central sympathetic activity and reduces the anesthetic requirement for halothane. |
1991-08-23 |
2023-08-11 |
rat |
| W E Hoffman, E Kochs, C Werner, C Thomas, R F Albrech. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677549. |
four ischemic groups were tested: group 1 (n = 15) received an intraperitoneal (ip) saline injection (control); group 2 (n = 10) received an ip injection of 10 micrograms/kg dexmedetomidine 30 min before ischemia; group 3 (n = 10) received 100 micrograms/kg dexmedetomidine; and group 4 (n = 10) received 100 micrograms/kg dexmedetomidine plus 1 mg/kg atipamezole (an alpha 2-adrenergic antagonist). |
1991-08-23 |
2023-08-11 |
rat |
| W E Hoffman, E Kochs, C Werner, C Thomas, R F Albrech. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1677549. |
atipamezole abolished the decrease in catecholamines and the improvement in outcome seen with dexmedetomidine, confirming that these effects were mediated by alpha 2-adrenergic receptors. |
1991-08-23 |
2023-08-11 |
rat |
| E A Kalso, R Pöyhiä, P H Rosenber. Spinal antinociception by dexmedetomidine, a highly selective alpha 2-adrenergic agonist. Pharmacology & toxicology. vol 68. issue 2. 1991-08-22. PMID:1677190. |
spinal antinociception by dexmedetomidine, a highly selective alpha 2-adrenergic agonist. |
1991-08-22 |
2023-08-11 |
rat |
| E A Kalso, R Pöyhiä, P H Rosenber. Spinal antinociception by dexmedetomidine, a highly selective alpha 2-adrenergic agonist. Pharmacology & toxicology. vol 68. issue 2. 1991-08-22. PMID:1677190. |
the antinociceptive effects of dexmedetomidine, a highly selective new alpha 2-adrenoceptor agonist, were evaluated in rats after intrathecal, intraperitoneal and subcutaneous administration. |
1991-08-22 |
2023-08-11 |
rat |
| E A Kalso, R Pöyhiä, P H Rosenber. Spinal antinociception by dexmedetomidine, a highly selective alpha 2-adrenergic agonist. Pharmacology & toxicology. vol 68. issue 2. 1991-08-22. PMID:1677190. |
subcutaneous atipamezole, a specific alpha 2-adrenergic antagonist completely abolished the antinociception produced by intrathecal dexmedetomidine. |
1991-08-22 |
2023-08-11 |
rat |
| R Aantaa, J Kanto, M Scheini. Intramuscular dexmedetomidine, a novel alpha 2-adrenoceptor agonist, as premedication for minor gynaecological surgery. Acta anaesthesiologica Scandinavica. vol 35. issue 4. 1991-08-22. PMID:1677229. |
intramuscular dexmedetomidine, a novel alpha 2-adrenoceptor agonist, as premedication for minor gynaecological surgery. |
1991-08-22 |
2023-08-11 |
Not clear |
| R Aantaa, J Kanto, M Scheini. Intramuscular dexmedetomidine, a novel alpha 2-adrenoceptor agonist, as premedication for minor gynaecological surgery. Acta anaesthesiologica Scandinavica. vol 35. issue 4. 1991-08-22. PMID:1677229. |
the effects of three different doses (0.5, 1.0 and 1.5 micrograms/kg) of dexmedetomidine, a novel alpha 2-adrenoceptor agonist, on vigilance, anaesthetic requirements, haemodynamics, and plasma catecholamine levels were investigated in a double-blind placebo-controlled study in 20 healthy (asa physical status i-ii) women scheduled for uterine dilatation and curettage (ud&c). |
1991-08-22 |
2023-08-11 |
Not clear |
| Y Hayashi, K Sumikawa, M Maze, A Yamatodani, T Kamibayashi, M Kuro, I Yoshiy. Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. vol 75. issue 1. 1991-08-02. PMID:1676567. |
dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. |
1991-08-02 |
2023-08-11 |
Not clear |
| Y Hayashi, K Sumikawa, M Maze, A Yamatodani, T Kamibayashi, M Kuro, I Yoshiy. Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. vol 75. issue 1. 1991-08-02. PMID:1676567. |
the arrhythmogenic threshold for epinephrine was determined during halothane anesthesia in the presence of dexmedetomidine, a selective alpha 2 agonist, and l-medetomidine, a stereoisomer of medetomidine that lacks alpha 2-agonist activity. |
1991-08-02 |
2023-08-11 |
Not clear |
| Y Hayashi, K Sumikawa, M Maze, A Yamatodani, T Kamibayashi, M Kuro, I Yoshiy. Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. vol 75. issue 1. 1991-08-02. PMID:1676567. |
atipamezole, a central alpha 2 antagonist that crossed the blood-brain barrier, blocked the antiarrhythmic action of dexmedetomidine. |
1991-08-02 |
2023-08-11 |
Not clear |
| Y Hayashi, K Sumikawa, M Maze, A Yamatodani, T Kamibayashi, M Kuro, I Yoshiy. Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. vol 75. issue 1. 1991-08-02. PMID:1676567. |
l-659,066 a peripheral alpha 2 antagonist that does not penetrate the blood-brain barrier, did not affect the antiarrhythmic action of dexmedetomidine. |
1991-08-02 |
2023-08-11 |
Not clear |
| Y Hayashi, K Sumikawa, M Maze, A Yamatodani, T Kamibayashi, M Kuro, I Yoshiy. Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. vol 75. issue 1. 1991-08-02. PMID:1676567. |
thus, dexmedetomidine's antiarrhythmic effect on epinephrine-induced arrhythmias during halothane anesthesia appears to be mediated at least in part by stimulation of central alpha 2 adrenoceptors. |
1991-08-02 |
2023-08-11 |
Not clear |
| M Maze, J W Rega. Role of signal transduction in anesthetic action. Alpha 2 adrenergic agonists. Annals of the New York Academy of Sciences. vol 625. 1991-08-01. PMID:1711813. |
studies with the superselective alpha 2 agonist dexmedetomidine confirmed this, as the alpha 2 agonist could still reduce the mac for halothane in rats depleted of their central norepinephrine stores. |
1991-08-01 |
2023-08-11 |
rat |
| M Maze, J W Rega. Role of signal transduction in anesthetic action. Alpha 2 adrenergic agonists. Annals of the New York Academy of Sciences. vol 625. 1991-08-01. PMID:1711813. |
the profound reduction in anesthetic requirements with dexmedetomidine raised the possibility that alpha 2 adrenergic agonists may be considered an anesthetic hypnotic agent by itself. |
1991-08-01 |
2023-08-11 |
rat |
| S Karhuvaara, A Kallio, M Salonen, J Tuominen, M Scheini. Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers. British journal of clinical pharmacology. vol 31. issue 2. 1991-07-24. PMID:1675577. |
the ability of atipamezole, a specific and selective alpha 2-adrenoceptor antagonist, to reverse the pharmacological effects induced by the alpha 2-adrenoceptor agonist dexmedetomidine was studied in six healthy male volunteers. |
1991-07-24 |
2023-08-11 |
human |