| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuai Zhang, Xiujing Feng, Guiyan Yang, Haoyang Tan, Xin Cheng, Qichao Tang, Haotian Yang, Yuan Zhao, Xuanpan Ding, Siyao Li, Xinyi Dou, Junfeng Li, Huijie Kang, Xingxing Li, Yaxin Ji, Qingdian Hou, Qiuyue An, Hao Fang, Honggang Fa. Dexmedetomidine ameliorates acute kidney injury by regulating mitochondrial dynamics via the α2-AR/SIRT1/PGC-1α pathway activation in rats. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-10-26. PMID:39455916. |
dexmedetomidine (dex) is an alpha 2 adrenal receptor agonist with antioxidant and anti-apoptotic effects. |
2024-10-26 |
2024-10-29 |
rat |
| Taichi Nakamura, Hidenori Iwasaki, Hanae Miyazawa, Shinichiro Mizutomi, Yoko Imi, Kunio Ohta, Taizo Wad. Usefulness of deep sedation with intravenous dexmedetomidine and midazolam in cardiac catheterization procedures for pediatric patients. Frontiers in pediatrics. vol 12. 2024-08-30. PMID:39210981. |
dexmedetomidine (dex) is a highly selective alpha 2 receptor agonist that has the advantage of causing less respiratory depression than other sedative agents. |
2024-08-30 |
2024-09-04 |
Not clear |
| Akash Doshi, Nitin Bhola, Anchal Agarwa. Comparing the efficacy of adrenaline, clonidine, and dexmedetomidine in enhancing local anesthesia for impacted third molar extraction: a randomized controlled trial. Journal of dental anesthesia and pain medicine. vol 24. issue 4. 2024-08-09. PMID:39118811. |
when combined with lignocaine, the alpha agonists dexmedetomidine and clonidine can extend the duration of anesthesia, thereby reducing the need for additional pain-relieving medications. |
2024-08-09 |
2024-08-12 |
human |
| Hyoeun Ahn, Yun Jeong Chae, Gyu Bin Choi, Min Gyu Lee, Ji Young Yo. Determining the Optimal Dosage of Dexmedetomidine for Smooth Emergence in Older Patients Undergoing Spinal Surgery: A Study of 44 Cases. Medical science monitor : international medical journal of experimental and clinical research. vol 30. 2024-06-09. PMID:38851875. |
dexmedetomidine is an alpha agonist that has sedative, anxiolytic, analgesic, and sympatholytic activities and is used as a continuous infusion to prevent emergence agitation. |
2024-06-09 |
2024-06-11 |
Not clear |
| Puja Saxena, Ravneet Kaur Gill, Richa Saroa, Bharti Sidhu, John Alen, Parul Soo. Comparison of nebulized ropivacaine (0.75%) with nebulized dexmedetomidine on the hemodynamic response on intubation in patients undergoing surgery under general anesthesia: A comparative randomized double-blind placebo-controlled study. Saudi journal of anaesthesia. vol 18. issue 1. 2024-02-05. PMID:38313724. |
we compared local anesthetic ropivacaine 0.75% with alpha agonist dexmedetomidine through ultrasonic nebulization for direct local action of the drug in the airway. |
2024-02-05 |
2024-02-07 |
Not clear |
| Melis Yavuz, Pelin İyiköşker, Nursima Mutlu, Serra Kiliçparlar, Öykü Hazal Şalci, Gökçen Dolu, Elif Nur Kaymakçilar, Serdar Akkol, Filiz Ona. Dexmedetomidine, an alpha 2A receptor agonist, triggers seizures unilaterally in GAERS during the pre-epileptic phase: does the onset of spike-and-wave discharges occur in a focal manner? Frontiers in neurology. vol 14. 2023-12-26. PMID:38146441. |
dexmedetomidine, an alpha 2a receptor agonist, triggers seizures unilaterally in gaers during the pre-epileptic phase: does the onset of spike-and-wave discharges occur in a focal manner? |
2023-12-26 |
2023-12-28 |
rat |
| Timothy Simon Walsh, Leanne M Aitken, Cathrine A McKenzie, Julia Boyd, Alix Macdonald, Annabel Giddings, David Hope, John Norrie, Christopher Weir, Richard Anthony Parker, Nazir I Lone, Lydia Emerson, Kalliopi Kydonaki, Benedict Creagh-Brown, Stephen Morris, Daniel Francis McAuley, Paul Dark, Matt P Wise, Anthony C Gordon, Gavin Perkins, Michael Reade, Bronagh Blackwood, Alasdair MacLullich, Robert Glen, Valerie J Pag. Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK. BMJ open. vol 13. issue 12. 2023-12-10. PMID:38072483. |
the alpha 2 agonists for sedation to produce better outcomes from critical illness (a2b) trial aims to determine whether clonidine or dexmedetomidine (or both) are clinically and cost-effective in mv icu patients compared with usual care. |
2023-12-10 |
2023-12-17 |
Not clear |
| Nicole Verhaar, Veronika Kopp, Christiane Pfarrer, Stephan Neudeck, Kathrin König, Karl Rohn, Sabine Kästne. Alpha Animals : an open access journal from MDPI. vol 13. issue 17. 2023-09-09. PMID:37685019. |
alpha pharmacological preconditioning with dexmedetomidine has been shown to ameliorate intestinal ischaemia reperfusion injury in different species, including horses. |
2023-09-09 |
2023-10-07 |
Not clear |
| M M Haque, D Banik, A K Akhtaruzzaman, D K Bhowmick, M A Kader, R Reza, M M Morshed, M Hasanuzzaman, A K Azad, M L Mariom, M S Hossain, M Masud, N Sultan. Dexmedetomidine as an Adjuvant to Bupivacaine in Caudal Analgesia in Children Undergoing Infra-Umbilical Surgery. Mymensingh medical journal : MMJ. vol 32. issue 3. 2023-07-01. PMID:37391982. |
dexmedetomidine, an alpha 2 agonistsare extensively used in neuraxial blocks and peripheral nerve blocks to prolong the action of bupivacaine. |
2023-07-01 |
2023-08-14 |
Not clear |
| Mrudula Mulay, Amit Mahajan, Navin Shah, Rakesh Shah, Saurabh Chandalia, Dharang Son. Comparative Evaluation of Intranasal Dexmedetomidine Spray Versus Intranasal Normal Saline Spray in Patients Undergoing Transalveolar Extractions for Anxiety Reduction: A Randomized Control Study. Journal of maxillofacial and oral surgery. 2023-06-26. PMID:37362875. |
dexmedetomidine has dose-dependent selectivity for alpha 2 adrenoceptors. |
2023-06-26 |
2023-08-14 |
Not clear |
| Justin Faden, Meghan Musselman, Leslie Citrom. Sublingual Dexmedetomidine: Repurposing an Anesthetic as an Anti-Agitation Agent. Expert review of neurotherapeutics. 2023-01-27. PMID:36707066. |
dexmedetomidine is a selective alpha 2-adrenergic receptor agonist, and a sublingual formulation has been approved in the us for the treatment of agitation associated with schizophrenia and bipolar disorder in adults. |
2023-01-27 |
2023-08-14 |
Not clear |
| Xiaojin Ye, Huailiang Xu, Yuan X. Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis. Folia histochemica et cytobiologica. 2022-12-12. PMID:36504132. |
dexmedetomidine (dex) is a selective alpha 2-adrenergic receptor agonist commonly used for analgesia and sedation in intensive care units. |
2022-12-12 |
2023-08-14 |
mouse |
| John P R Moore, Yahya Shehabi, Michael C Reade, Michael Bailey, John F Fraser, Lauren Murray, Christopher Anstey, Mervyn Singe. Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients. Critical care (London, England). vol 26. issue 1. 2022-11-24. PMID:36419197. |
dexmedetomidine is a sympatholytic alpha |
2022-11-24 |
2023-08-14 |
Not clear |
| Jonathan Birabaharan, Raymond E West, Thomas D Nolin, Chani Traube, Michael J Bell, Philip E Empe. Simultaneous detection of a panel of nine sedatives and metabolites in plasma from critically ill pediatric patients via UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. vol 218. 2022-06-06. PMID:35659658. |
the goal of this project was to develop a sensitive and selective assay for the simultaneous quantification of a panel of sedatives comprised of midazolam (mdz), alpha hydroxymidazolam (1- oh mdz), dexmedetomidine (dex), morphine (mor), morphine-3-glucuronide (m3g), morphine-6-glucuronide (m6g), fentanyl (fen), norfentanyl (nf), and hydromorphone (hm) in small volume pediatric plasma samples. |
2022-06-06 |
2023-08-14 |
Not clear |
| Jinxu Wang, Yueyang Xin, Tiantian Chu, Cheng Liu, Aijun X. Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1/RAGE/NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-29. PMID:35486975. |
dexmedetomidine (dex) is an alpha (α)-2 adrenoceptor agonist that is widely used in the perioperative period. |
2022-04-29 |
2023-08-13 |
rat |
| Leslie L Citrome, Sheldon H Preskorn, Lavanya Rajachandran, Robert Risinge. Dexmedetomidine Orally Dissolving Film for Acute Agitation Associated with Schizophrenia or Bipolar Disorder: SERENITY I and SERENITY II Trials. CNS spectrums. vol 27. issue 2. 2022-04-28. PMID:35477628. |
dexmedetomidine odf is a highly selective agonist of alpha 2 adrenergic receptors that modulate norepinephrine release from the locus coeruleus. |
2022-04-28 |
2023-08-13 |
human |
| Ping An, Xiao-Chun Zhao, Man-Jia Liu, Yu-Qing You, Jing-Ya Li, He-Song Gon. Dexmedetomidine Alleviates Intracerebral Hemorrhage-Induced Anxiety-Like Behaviors in Mice Through the Inhibition of TRPV4 Opening. Frontiers in pharmacology. vol 13. 2022-04-18. PMID:35431940. |
dexmedetomidine (dex), a highly selective alpha 2 adrenal receptor (α2-ar) agonist, was recently found to exert an excellent protective effect against mental disorders including anxiety. |
2022-04-18 |
2023-08-13 |
mouse |
| Vijay Pratap Kalaskar, Dipakkumar Hiralal Ruparel, Rohini Pradip Wakod. Effects of Dexmedetomidine Infusion in Low Dose on Dose Reduction of Propofol, Intraoperative Hemodynamics, and Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy. Anesthesia, essays and researches. vol 15. issue 4. 2022-04-15. PMID:35422554. |
dexmedetomidine, alpha 2 agonist, with its anxiolytic, sympatholytic and sedative property can be good adjuvant in anesthesia by modifying stress response to various stimuli during laparoscopic cholecystectomy including laryngoscopy, intubation, pneumoperitoneum, and extubation. |
2022-04-15 |
2023-08-13 |
Not clear |
| Li-Hui Yue, Li-Na Wang, Xi-Chun Zhu, Yan-Hui Pen. The promotion of liver regeneration in mice after a partial hepatectomy as a result of the modulation of macrophage activation by dexmedetomidine. Transplant immunology. 2022-03-10. PMID:35272011. |
this study investigates the effect of dexmedetomidine (dex), a highly selective agonist of alpha 2-adrenergic receptors (α2-ars), on the regulation of hepatic macrophage activation in liver regeneration. |
2022-03-10 |
2023-08-13 |
mouse |
| Shruti Kabi, Reetu Verma, Dinesh Singh, Premraj Singh, Jyotsna Agarwal, Brij Bihari Kushwaha, Ajay K Chaudhary, Nisha Sing. A Comparison Between Dexmedetomidine and Clonidine as Adjuvants to Levobupivacaine in Labour Analgesia. Cureus. vol 13. issue 12. 2022-01-10. PMID:35004052. |
dexmedetomidine and clonidine are selective alpha 2 agonists with analgesic properties and have been used via the neuraxial route with local anesthetics for the same without the side effects of fentanyl. |
2022-01-10 |
2023-08-13 |
Not clear |