| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fangfang Xia, Zhousheng Jin, Tingting Lin, Xixi Cai, Linmin Pan, Shi Wang, Yaoyao Cai, Hongfei Che. Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved. BMC pharmacology & toxicology. vol 20. issue 1. 2020-03-30. PMID:31753018. |
this study was designed to investigate the direct effects of dexmedetomidine on cardiotoxicity induced by bupivacaine on langendorff rat heart preparation and the role of alpha 2 adrenoceptors in this process was explored. |
2020-03-30 |
2023-08-13 |
rat |
| Ioannis Dardalas, Eleni Stamoula, Panagiotis Rigopoulos, Faye Malliou, Georgia Tsaousi, Zoi Aidoni, Vasileios Grosomanidis, Antonios Milonas, Georgios Papazisis, Dimitrios Kouvelas, Chryssa Pourzitak. Dexmedetomidine effects in different experimental sepsis in vivo models. European journal of pharmacology. vol 856. 2020-01-13. PMID:31108055. |
dexmedetomidine (dex), an <alpha> |
2020-01-13 |
2023-08-13 |
Not clear |
| b' Huotari, Kukkonen, Liikka, Potasev, Raasmaja, M\\xc3\\xa4nnist\\xc3\\xb. Effects of histamine H(3)-ligands on the levodopa-induced turning behavior of hemiparkinsonian rats. Parkinsonism & related disorders. vol 6. issue 3. 2019-11-20. PMID:10817955.' |
the effects of h(3)-ligands (an agonist, r-alpha-methylhistamine and an antagonist, thioperamide) on levodopa-induced turning behavior in a rat model of parkinson's disease were quite similar to those seen with alpha(2)-adrenoceptor ligands (dexmedetomidine and atipamezole). |
2019-11-20 |
2023-08-12 |
rat |
| Zyad J Carr, Theodore J Cios, Kenneth F Potter, John T Swic. Does Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature. Current neurology and neuroscience reports. vol 18. issue 10. 2019-09-16. PMID:30083844. |
this brief review discusses select evidence suggesting an association between neuroinflammation and pocd and whether the use of dexmedetomidine, a short-acting alpha 2 agonist, may ameliorate the incidence of pocd. |
2019-09-16 |
2023-08-13 |
Not clear |
| Yi Huang, Shite Hu, Yongliang Li, Dan Xue, Xiuguo W. Dexmedetomidine, an Alpha 2a Adrenergic Receptor Agonist, Mitigates Experimental Autoimmune Encephalomyelitis by Desensitization of CXCR7 in Microglia. Biochemistry. vol 57. issue 28. 2019-04-03. PMID:29897736. |
dexmedetomidine, an alpha 2a adrenergic receptor agonist, mitigates experimental autoimmune encephalomyelitis by desensitization of cxcr7 in microglia. |
2019-04-03 |
2023-08-13 |
Not clear |
| Yi Huang, Shite Hu, Yongliang Li, Dan Xue, Xiuguo W. Dexmedetomidine, an Alpha 2a Adrenergic Receptor Agonist, Mitigates Experimental Autoimmune Encephalomyelitis by Desensitization of CXCR7 in Microglia. Biochemistry. vol 57. issue 28. 2019-04-03. PMID:29897736. |
in this study, we report that dexmedetomidine, an alpha 2a adrenergic receptor agonist, attenuates the clinical severity of eae with less infiltration of microglia. |
2019-04-03 |
2023-08-13 |
Not clear |
| Chunhua Xi, Shiyue Sun, Chuxiong Pan, Fang Ji, Xu Cui, Tianzuo L. Different effects of propofol and dexmedetomidine sedation on electroencephalogram patterns: Wakefulness, moderate sedation, deep sedation and recovery. PloS one. vol 13. issue 6. 2018-12-26. PMID:29920532. |
during moderate sedation, both dexmedetomidine and propofol induced increased spindle power; however, dexmedetomidine decreased the global alpha/beta/gamma power, whereas propofol decreased the alpha power in the occipital area and increased the global spindle/beta/gamma power. |
2018-12-26 |
2023-08-13 |
human |
| Hui Chen, Xiang Xu, Xiao-Yu Yang, Bing-Yu Ling, He-Ping Sun, Chao Liu, Yu Qiu Zhang, Hong Cao, Lan X. Systemic dexmedetomidine attenuates mechanical allodynia through extracellular sign db type 2 diabetic mice. Neuroscience letters. vol 657. 2018-05-28. PMID:28757391. |
in the present study, we investigated the effect of systemic administration dexmedetomidine (dex), a selective alpha 2 adrenergic receptor (α2ar) agonist, on mechanical allodynia and its underlying mechanism in db/db mice, an animal model of type 2 diabetes mellitus. |
2018-05-28 |
2023-08-13 |
mouse |
| Mervyn Maz. From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine. Anesthesiology. vol 125. issue 3. 2017-06-09. PMID:27348818. |
dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. |
2017-06-09 |
2023-08-13 |
rat |
| Hanan Sayed M Farghaly, Ahmed Mostafa Mahmoud, Khaled A Abdel-Sate. Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of interleukin-6 and tumor necrosis factor-α. European journal of pharmacology. vol 776. 2016-12-13. PMID:26896779. |
dexmedetomidine (dex) is a novel alpha 2-adrenoceptor agonist. |
2016-12-13 |
2023-08-13 |
rat |
| Jing Li, Ming Xiong, Pratap R Nadavaluru, Wanhong Zuo, Jiang Hong Ye, Jean D Eloy, Alex Bekke. Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure. Journal of neurosurgical anesthesiology. vol 28. issue 1. 2016-09-26. PMID:25844953. |
dexmedetomidine (dex), a selective alpha 2-adrenoreceptor agonist, has antiapoptotic properties in several brain injury models. |
2016-09-26 |
2023-08-13 |
rat |
| Xiao-Lan Qian, Wei Zhang, Ming-Zheng Liu, Yu-Bing Zhou, Jing-Min Zhang, Li Han, You-Mei Peng, Jin-hua Jiang, Qing-Duan Wan. Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice. European journal of pharmacology. vol 746. 2015-08-31. PMID:25460022. |
dexmedetomidine, a selective alpha 2 adrenal receptor agonist, was revealed anesthesia and brain protective role. |
2015-08-31 |
2023-08-13 |
mouse |
| Baran Gencer, Turan Karaca, Hasan Ali Tufan, Selçuk Kara, Sedat Arikan, Huseyin Toman, Ihsan Karaboga, Volkan Hanc. The protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in rats. Cutaneous and ocular toxicology. vol 33. issue 4. 2015-07-20. PMID:24517497. |
dexmedetomidine is an alpha 2 adrenoceptor agonist and can be used for postoperative sedation, analgesia and anesthesia-sparing properties. |
2015-07-20 |
2023-08-12 |
rat |
| Shagufta Naaz, Erum Ozai. Dexmedetomidine in current anaesthesia practice- a review. Journal of clinical and diagnostic research : JCDR. vol 8. issue 10. 2014-12-05. PMID:25478365. |
dexmedetomidine is an alpha 2 adrenergic receptor agonist, even ten times more selective than clonidine. |
2014-12-05 |
2023-08-13 |
Not clear |
| Akcan Akkaya, Umit Yasar Tekelioglu, Abdullah Demirhan, Murat Bilgi, Isa Yildiz, Tayfun Apuhan, Hasan Kocogl. [Comparison of the effects of magnesium sulphate and dexmedetomidine on surgical vision quality in endoscopic sinus surgery: randomized clinical study]. Revista brasileira de anestesiologia. vol 64. issue 6. 2014-12-02. PMID:25437697. |
the aim of this study was to compare the surgical vision quality, haemodynamic parameters, postoperative pain, and other effects of magnesium, a hypotensive agent, with that of dexmedetomidine, which was initially developed for short-term sedation in the intensive care unit but also is an alpha 2 agonist sedative. |
2014-12-02 |
2023-08-13 |
Not clear |
| Shuang-Shuang Li, Wei-Shi Zhang, Dong Ji, Ya-Lan Zhou, Hui Li, Jia-Le Yang, Yuan-Chang Xiong, Yu-Qiu Zhang, Hua X. Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI. Neuroscience letters. vol 560. 2014-09-08. PMID:24345418. |
dexmedetomidine, a selective alpha 2-adrenoceptor (α2ar) agonist, has provided significant analgesia in neuropathic pain. |
2014-09-08 |
2023-08-12 |
rat |
| Marshall T Bell, Viktor A Agoston, Kirsten A Freeman, Ferenc Puskas, Paco S Herson, Joshua Mares, David A Fullerton, T Brett Reec. Interruption of spinal cord microglial signaling by alpha-2 agonist dexmedetomidine in a murine model of delayed paraplegia. Journal of vascular surgery. vol 59. issue 4. 2014-08-19. PMID:23850057. |
the alpha 2a adrenergic receptor agonist, dexmedetomidine, has been shown to preserve neurologic function and neuronal viability in a murine model of spinal cord ischemia reperfusion, although the mechanism remains elusive. |
2014-08-19 |
2023-08-12 |
Not clear |
| Waleed A Almarakbi, Abdullah M Kak. Addition of dexmedetomidine to bupivacaine in transversus abdominis plane block potentiates post-operative pain relief among abdominal hysterectomy patients: A prospective randomized controlled trial. Saudi journal of anaesthesia. vol 8. issue 2. 2014-05-20. PMID:24843325. |
dexmedetomidine is an alpha 2 adrenergic agonist, prolongs analgesia when used in neuraxial and peripheral nerve blocks. |
2014-05-20 |
2023-08-13 |
Not clear |
| I Jurn. [Antinociceptive effects of alpha(2)-adrenoceptor agonists ("analgesic" actions in animal experiments)agonists ("analgesic" actions in animal experiments).]. Schmerz (Berlin, Germany). vol 9. issue 6. 2012-10-02. PMID:18415519. |
alpha(2)-adrenoceptor agonists like clonidine, dexmedetomidine, and st-91, inhibit nociceptive reflex activity predominantly by a spinal mode of action. |
2012-10-02 |
2023-08-12 |
Not clear |
| I Jurn. [Antinociceptive effects of alpha(2)-adrenoceptor agonists ("analgesic" actions in animal experiments)agonists ("analgesic" actions in animal experiments).]. Schmerz (Berlin, Germany). vol 9. issue 6. 2012-10-02. PMID:18415519. |
clonidine and dexmedetomidine stimulate adrenoceptors of the alpha(2a) subtype, while st-91 stimulates alpha(2b) adrenoceptors. |
2012-10-02 |
2023-08-12 |
Not clear |