| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Felice Su, Susan C Nicolson, Marc R Gastonguay, Jeffrey S Barrett, Peter C Adamson, David S Kang, Rodolfo I Godinez, Athena F Zupp. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesthesia and analgesia. vol 110. issue 5. 2010-05-13. PMID:20418300. |
dexmedetomidine is a highly selective alpha(2)-agonist with hypnotic, analgesic, and anxiolytic properties. |
2010-05-13 |
2023-08-12 |
Not clear |
| Tiina Leino, Timo Viitamaa, Antti Haapalinna, Jyrki Lehtimäki, Raimo Virtane. Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 6. 2010-03-30. PMID:19826791. |
the present experiments compared the peripheral and central pharmacological effects of three alpha(2)-adrenoceptor agonists: fadolmidine, clonidine, and dexmedetomidine after single intrathecal bolus injections at analgesic dose level in rats. |
2010-03-30 |
2023-08-12 |
rat |
| Hugo van Oostrom, Peter J Stienen, Arie Doornenbal, Ludo J Hellebreker. The alpha(2)-adrenoceptor agonist dexmedetomidine suppresses memory formation only at doses attenuating the perception of sensory input. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:19958768. |
the alpha(2)-adrenoceptor agonist dexmedetomidine suppresses memory formation only at doses attenuating the perception of sensory input. |
2010-03-30 |
2023-08-12 |
rat |
| Hugo van Oostrom, Peter J Stienen, Arie Doornenbal, Ludo J Hellebreker. The alpha(2)-adrenoceptor agonist dexmedetomidine suppresses memory formation only at doses attenuating the perception of sensory input. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:19958768. |
it was investigated whether continuous rate infusion of the alpha(2)-adrenoceptor agonist dexmedetomidine can suppress memory formation by mechanisms other than reducing perception of sensory input in a fear-conditioning paradigm. |
2010-03-30 |
2023-08-12 |
rat |
| Anthony T Gerlach, Claire V Murph. Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literature. Pharmacotherapy. vol 29. issue 12. 2010-02-02. PMID:19947809. |
dexmedetomidine is an alpha(2)-agonist indicated for sedation in critically ill patients and procedural sedation in nonintubated patients. |
2010-02-02 |
2023-08-12 |
Not clear |
| Hee-Jin Kim, Ju-Tae Sohn, Young-Seok Jeong, Man Seok Cho, Hye Jung Kim, Ki Churl Chang, Mi-Kyung Shin, Chang-Shin Park, Young-Kyun Chun. Direct effect of dexmedetomidine on rat isolated aorta involves endothelial nitric oxide synthesis and activation of the lipoxygenase pathway. Clinical and experimental pharmacology & physiology. vol 36. issue 4. 2009-11-24. PMID:19018801. |
taken together, the results indicate that dexmedetomidine-induced contraction of aortic rings involves activation of the lipoxygenase and cyclo-oxygenase pathways and is attenuated by increased no production following stimulation of endothelial alpha(2)-adrenoceptors by dexmedetomidine. |
2009-11-24 |
2023-08-12 |
human |
| A Arcangeli, C D'Alò, R Gaspar. Dexmedetomidine use in general anaesthesia. Current drug targets. vol 10. issue 8. 2009-11-09. PMID:19702517. |
dexmedetomidine is a potent and highly selective alpha(2)-adrenoreceptor agonist currently utilized for continuous infusion for sedation/analgesia in the intensive care unit (icu). |
2009-11-09 |
2023-08-12 |
Not clear |
| E Congedo, M Sgreccia, G De Cosm. New drugs for epidural analgesia. Current drug targets. vol 10. issue 8. 2009-11-09. PMID:19702518. |
other categories of agents have been investigated for epidural administration, such as alpha(2)-adrenergic agonists clonidine and dexmedetomidine. |
2009-11-09 |
2023-08-12 |
Not clear |
| Eric A Stone, Yan Lin, Yasmeen Sarfraz, David Quartermai. Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist. Brain research. vol 1291. 2009-11-04. PMID:19632210. |
infusion of selective antagonists of alpha(1)- (terazosin) or alpha(2)- (atipamezole) receptors or of either the partial alpha(1)-agonist, phenylephrine, or full alpha(2)-agonist, dexmedetomidine, indicated that the behavioral effects of 6fne were due largely due to activation of lc alpha(1)-receptors consistent with the known greater density of alpha(1)- than alpha(2)-adrenoreceptors in the mouse nucleus. |
2009-11-04 |
2023-08-12 |
mouse |
| Robert D Sanders, Tracy Hussell, Mervyn Maz. Sedation & immunomodulation. Critical care clinics. vol 25. issue 3. 2009-10-19. PMID:19576530. |
benzodiazepines, opioids, and possibly even propofol worsen outcome in animal models of infection, whereas preliminary evidence suggests that the alpha(2)-adrenoceptor agonist, dexmedetomidine, may improve outcomes in the setting of infection. |
2009-10-19 |
2023-08-12 |
Not clear |
| A Palanisamy, R J Klickovich, M Ramsay, D W Ouyang, L C Tse. Intravenous dexmedetomidine as an adjunct for labor analgesia and cesarean delivery anesthesia in a parturient with a tethered spinal cord. International journal of obstetric anesthesia. vol 18. issue 3. 2009-09-14. PMID:19188060. |
dexmedetomidine, a highly selective alpha(2) agonist with negligible placental transfer, may be a valuable adjunct to ivpca by providing additional analgesia without the respiratory depression associated with increasing opioid usage. |
2009-09-14 |
2023-08-12 |
Not clear |
| Carolyn A Fairbanks, Laura S Stone, George L Wilco. Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis. Pharmacology & therapeutics. vol 123. issue 2. 2009-09-14. PMID:19393691. |
targeting these spinal alpha(2)ars with one of five selective therapeutic agonists, clonidine, dexmedetomidine, brimonidine, st91 and moxonidine, produces significant antinociception that can work in concert with opioid agonists to yield synergistic antinociception. |
2009-09-14 |
2023-08-12 |
mouse |
| Mahmoud M Al-Mustafa, Izdiad Z Badran, Hamdi M Abu-Ali, Bassam A Al-Barazangi, Isalm M Massad, Subhi M Al-Ghane. Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia. Middle East journal of anaesthesiology. vol 20. issue 2. 2009-08-04. PMID:19583070. |
the new alpha 2 agonist, dexmedetomidine has been proved to prolong the spinal anesthesia through the intrathecal route. |
2009-08-04 |
2023-08-12 |
Not clear |
| Kyle Ludwig, Matthew Sorrell, Peter Li. Severe rash associated with dexmedetomidine use during mechanical ventilation. Pharmacotherapy. vol 29. issue 4. 2009-06-09. PMID:19323624. |
dexmedetomidine, a sedative administered by continuous infusion, is used to facilitate mechanical ventilation through alpha(2)-receptor activation. |
2009-06-09 |
2023-08-12 |
Not clear |
| I Saadawy, A Boker, M A Elshahawy, A Almazrooa, S Melibary, A A Abdellatif, W Afif. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics. Acta anaesthesiologica Scandinavica. vol 53. issue 2. 2009-03-26. PMID:19076110. |
dexmedetomidine (dex) is a highly selective alpha(2)-adrenoceptor agonist that has been used increasingly in children. |
2009-03-26 |
2023-08-12 |
Not clear |
| Nkanyezi E Ngwenyama, John Anderson, Daniel G Hoernschemeyer, Joseph D Tobia. Effects of dexmedetomidine on propofol and remifentanil infusion rates during total intravenous anesthesia for spine surgery in adolescents. Paediatric anaesthesia. vol 18. issue 12. 2009-03-12. PMID:19076573. |
the current study investigated the propofol-sparing effects of the concomitant administration of the alpha(2)-adrenergic agonist, dexmedetomidine, during spinal fusion surgery in adolescents. |
2009-03-12 |
2023-08-12 |
Not clear |
| Richard R Riker, Yahya Shehabi, Paula M Bokesch, Daniel Ceraso, Wayne Wisemandle, Firas Koura, Patrick Whitten, Benjamin D Margolis, Daniel W Byrne, E Wesley Ely, Marcelo G Roch. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. vol 301. issue 5. 2009-02-09. PMID:19188334. |
gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (icu) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages. |
2009-02-09 |
2023-08-12 |
Not clear |
| Gwen Erkonen, Fred Lamb, Joseph D Tobia. High-dose dexmedetomidine-induced hypertension in a child with traumatic brain injury. Neurocritical care. vol 9. issue 3. 2009-01-27. PMID:18491236. |
dexmedetomidine is a centrally acting alpha(2)-adrenergic agonist which is currently fda-approved for the short-term (less than 24 h) sedation of adults during mechanical ventilation. |
2009-01-27 |
2023-08-12 |
Not clear |
| A Snapir, P Talke, J Posti, M Huiku, E Kentala, M Scheini. Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. British journal of anaesthesia. vol 102. issue 1. 2009-01-07. PMID:18987056. |
this study aimed to assess the contribution of endothelial nitric oxide synthesis to the net responses of human peripheral blood vessels in vivo to the selective alpha(2)-adrenoceptor agonist dexmedetomidine. |
2009-01-07 |
2023-08-12 |
human |
| Christopher Heard, Frederick Burrows, Kristin Johnson, Prashant Joshi, James Houck, Jerrold Lerma. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesthesia and analgesia. vol 107. issue 6. 2008-12-30. PMID:19020127. |
dexmedetomidine is an alpha(2) agonist that is currently being investigated for its suitability to provide anesthesia for children. |
2008-12-30 |
2023-08-12 |
Not clear |