| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nishanthan Rajakumaraswamy, Daqing Ma, Mahmuda Hossain, Robert D Sanders, Nicholas P Franks, Mervyn Maz. Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neuroscience letters. vol 409. issue 2. 2007-01-04. PMID:17052852. |
xenon, an nmda receptor antagonist and dexmedetomidine (dex), an alpha(2)-adrenoceptor agonist, both exhibit neuroprotective effects. |
2007-01-04 |
2023-08-12 |
mouse |
| Zerrin Ozkose, Figen Sunay Demir, Kutluk Pampal, Sahin Yardi. Hemodynamic and anesthetic advantages of dexmedetomidine, an alpha 2-agonist, for surgery in prone position. The Tohoku journal of experimental medicine. vol 210. issue 2. 2006-12-22. PMID:17023769. |
hemodynamic and anesthetic advantages of dexmedetomidine, an alpha 2-agonist, for surgery in prone position. |
2006-12-22 |
2023-08-12 |
Not clear |
| Aki Rovasalo, Harri Tohmo, Riku Aantaa, Eija Kettunen, Riitta Palojok. Dexmedetomidine as an adjuvant in the treatment of alcohol withdrawal delirium: a case report. General hospital psychiatry. vol 28. issue 4. 2006-12-19. PMID:16814639. |
in this case report, even a moderate dose of dexmedetomidine, a very selective alpha(2)-adrenergic agent, resulted in a rapid response to alcohol withdrawal delirium after the standard treatment. |
2006-12-19 |
2023-08-12 |
Not clear |
| Henriëtte M Willigers, Frits W Prinzen, Paul M H J Roekaert. The effects of esmolol and dexmedetomidine on myocardial oxygen consumption during sympathetic stimulation in dogs. Journal of cardiothoracic and vascular anesthesia. vol 20. issue 3. 2006-10-26. PMID:16750737. |
the purpose of this study was to compare the potential of the beta(1)-adrenergic receptor blocker esmolol and the alpha(2)-adrenergic receptor agonist dexmedetomidine to suppress the cardiovascular and neuroendocrine response to a sympathetic stimulus. |
2006-10-26 |
2023-08-12 |
Not clear |
| Anni-Maija Linden, M Isabel Aller, Elli Leppä, Olga Vekovischeva, Teemu Aitta-Aho, Emma L Veale, Alistair Mathie, Per Rosenberg, William Wisden, Esa R Korp. The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16397088. |
the in vivo contributions of task-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists. |
2006-06-09 |
2023-08-12 |
mouse |
| Anni-Maija Linden, M Isabel Aller, Elli Leppä, Olga Vekovischeva, Teemu Aitta-Aho, Emma L Veale, Alistair Mathie, Per Rosenberg, William Wisden, Esa R Korp. The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16397088. |
here, we have characterized the basal behavioral phenotype of task-1 knockout mice and tested their sensitivity to the inhalation anesthetics halothane and isoflurane, the alpha(2) adrenoreceptor agonist dexmedetomidine, and the cannabinoid agonist win55212-2 mesylate [r-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3,-de]-1,4-benzoxazinyl]-(1-naphtalenyl)methanone mesylate)]. |
2006-06-09 |
2023-08-12 |
mouse |
| E Rioja, M Santos, F Martínez Taboada, J A Ibancovichi, F J Tendill. Cardiorespiratory and minimum alveolar concentration sparing effects of a continuous intravenous infusion of dexmedetomidine in halothane or isoflurane-anaesthetized rats. Laboratory animals. vol 40. issue 1. 2006-03-02. PMID:16460585. |
dexmedetomidine (dex) is a highly selective alpha(2)-adrenoceptor agonist in both the central and peripheral nervous systems. |
2006-03-02 |
2023-08-12 |
rat |
| Andrea Paris, Jean Mantz, Peter H Tonner, Lutz Hein, Marc Brede, Pierre Gressen. The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. Anesthesia and analgesia. vol 102. issue 2. 2006-02-21. PMID:16428542. |
we performed the current study in mice lacking individual alpha2-adrenoceptor subtypes to elucidate the contribution of alpha(2)-adrenoceptor subtypes to the neuroprotective properties of dexmedetomidine in a model of perinatal excitotoxic brain injury. |
2006-02-21 |
2023-08-12 |
mouse |
| P Grille, A Biestro, G Fariña, R Miraballe. [Effects of dexmedetomidine on intracranial hemodynamics in severe head injured patients]. Neurocirugia (Asturias, Spain). vol 16. issue 5. 2005-12-30. PMID:16276449. |
dexmedetomidine, an alpha 2 adrenergic agonist, with distinctive characteristics when compared to traditional plans, namely: conscious sedation, sympatholysis and lack of respiratory depression, represents an attempt to improve the sedoanalgesia of critically ill patients. |
2005-12-30 |
2023-08-12 |
Not clear |
| A M-H Ho, S Chen, M K Karmaka. Central apnoea after balanced general anaesthesia that included dexmedetomidine. British journal of anaesthesia. vol 95. issue 6. 2005-12-21. PMID:16243902. |
dexmedetomidine is an alpha(2)-adrenoreceptor agonist that, in spite of its potent sedative, amnesic, and analgesic properties, has minimal respiratory depressant effect. |
2005-12-21 |
2023-08-12 |
Not clear |
| G Guler, A Akin, Z Tosun, E Eskitascoglu, A Mizrak, A Boyac. Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation. Acta anaesthesiologica Scandinavica. vol 49. issue 8. 2005-11-08. PMID:16095449. |
the alpha agonist dexmedetomidine, a sedative and analgesic, reduces heart rate and blood pressure dose-dependently. |
2005-11-08 |
2023-08-12 |
Not clear |
| John W Berkenbosch, Patricia C Wankum, Joseph D Tobia. Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. vol 6. issue 4. 2005-11-07. PMID:15982430. |
dexmedetomidine is a newer alpha(2)-adrenergic receptor agonist with sedative properties and minimal respiratory depression. |
2005-11-07 |
2023-08-12 |
Not clear |
| Shizue Masuki, Frank A Dinenno, Michael J Joyner, John H Eisenac. Selective alpha2-adrenergic properties of dexmedetomidine over clonidine in the human forearm. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 2. 2005-09-30. PMID:15802370. |
we tested the hypothesis that dexmedetomidine (dex) has greater alpha(2)- vs. alpha(1) selectivity than clonidine and causes more alpha(2)-selective vasoconstriction in the human forearm. |
2005-09-30 |
2023-08-12 |
human |
| Gyongyi Horvath, Gabriella Kekesi, Ildiko Dobos, Walter Klimscha, Gyorgy Benede. Long-term changes in the antinociceptive potency of morphine or dexmedetomidine after a single treatment. Anesthesia and analgesia. vol 101. issue 3. 2005-09-27. PMID:16115996. |
we investigated the long-term changes in the antinociceptive potency of morphine (10 mg/kg) injected intraperitoneally and the alpha(2)-adrenoceptor agonist dexmedetomidine (150 microg/kg intraperitoneally) on acute heat pain (tail-flick test) sensitivity and on carrageenan-induced inflammatory thermal hyperalgesia (paw withdrawal test) after a second injection 7 days later. |
2005-09-27 |
2023-08-12 |
Not clear |
| H M M Willigers, F W Prinzen, P M H J Roekaert. Comparison of the effects of dexmedetomidine and esmolol on myocardial oxygen consumption in dogs. European journal of anaesthesiology. vol 21. issue 12. 2005-07-29. PMID:15719859. |
the beta-adrenergic blocker esmolol and the alpha 2-adrenergic agonist dexmedetomidine have the potential to decrease perioperative myocardial ischaemia. |
2005-07-29 |
2023-08-12 |
Not clear |
| Sean R R Hall, Louie Wang, Brian Milne, Murray Hon. Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension. Canadian journal of anaesthesia = Journal canadien d'anesthesie. vol 51. issue 10. 2005-06-30. PMID:15574556. |
to determine if central sympathetic blockade by dexmedetomidine, a selective alpha(2) adrenergic receptor agonist, prevents cardiac dysfunction associated with intracranial hypertension (ich) in a rat model. |
2005-06-30 |
2023-08-12 |
rat |
| Joanna C Murrell, Ludo J Hellebreker. Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. Veterinary anaesthesia and analgesia. vol 32. issue 3. 2005-06-30. PMID:15877658. |
research into alpha(2) adrenoreceptor agonists and their clinical use is extensive, therefore this review focuses on the use of dexmedetomidine and medetomidine in dogs. |
2005-06-30 |
2023-08-12 |
dog |
| Krishna Baddigam, Pierantonio Russo, Joanne Russo, Joseph D Tobia. Dexmedetomidine in the treatment of withdrawal syndromes in cardiothoracic surgery patients. Journal of intensive care medicine. vol 20. issue 2. 2005-06-24. PMID:15855224. |
dexmedetomidine (precedex, abbott laboratories, abbott park, il) is an alpha 2 adrenergic agonist that possesses a high ratio of specificity for the alpha 2 versus the alpha 1 receptor. |
2005-06-24 |
2023-08-12 |
Not clear |
| Robert D Sanders, Mariangella Giombini, Daqing Ma, Yoko Ohashi, Mahmuda Hossain, Masahiko Fujinaga, Mervyn Maz. Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Anesthesia and analgesia. vol 100. issue 5. 2005-05-26. PMID:15845672. |
dexmedetomidine (dex), an alpha(2)-adrenoceptor agonist, is an effective analgesic and sedative drug in adults; however, little information is available about its efficacy in pediatric populations. |
2005-05-26 |
2023-08-12 |
rat |
| Daqing Ma, Mahmuda Hossain, Nishanthan Rajakumaraswamy, Mubarik Arshad, Robert D Sanders, Nicholas P Franks, Mervyn Maz. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. European journal of pharmacology. vol 502. issue 1-2. 2005-04-08. PMID:15464093. |
dexmedetomidine produces its neuroprotective effect via the alpha 2a-adrenoceptor subtype. |
2005-04-08 |
2023-08-12 |
mouse |