| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Whittington, L Virag, H O Morishima, Y Vulliemo. Dexmedetomidine decreases extracellular dopamine concentrations in the rat nucleus accumbens. Brain research. vol 919. issue 1. 2002-01-03. PMID:11689170. |
the effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (da) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using hplc with electrochemical detection. |
2002-01-03 |
2023-08-12 |
rat |
| S E Hopwood, J A Stamfor. Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors. Neuropharmacology. vol 41. issue 4. 2001-11-01. PMID:11543763. |
on short stimulus trains (10 pulses, 200 hz), the alpha(2)-selective agonist dexmedetomidine (10nm) decreased evoked 5-ht release in drn and mrn (to 44+/-3 and 43+/-7% of pre-drug values, respectively, at minimum). |
2001-11-01 |
2023-08-12 |
rat |
| S E Hopwood, J A Stamfor. Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors. Neuropharmacology. vol 41. issue 4. 2001-11-01. PMID:11543763. |
in both nuclei, this response was antagonised by the selective alpha(2a)-antagonist brl 44408 (1 microm: p<0.001 vs. dexmedetomidine) but not by the selective alpha(2b/c)-adrenoceptor antagonist arc 239 (500 nm), the selective 5-ht(1a) antagonist way 100635 (100 nm) or the alpha(1)-selective antagonist prazosin (1 microm), suggesting that the effect of dexmedetomidine is wholly attributable to alpha(2a)-receptor activation. |
2001-11-01 |
2023-08-12 |
rat |
| S E Hopwood, J A Stamfor. Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors. Neuropharmacology. vol 41. issue 4. 2001-11-01. PMID:11543763. |
since the effect of dexmedetomidine was not antagonised by prazosin, we suggest that its effect was mediated directly, possibly through alpha(2a) receptors located on 5-ht cell elements, and not transduced indirectly through alpha(1)-adrenoceptor activation, as previously suggested by others. |
2001-11-01 |
2023-08-12 |
rat |
| T L. Dexmedetomidine, a novel alpha 2-adrenergic agonist for short-term sedation in the intensive care unit. Connecticut medicine. vol 65. issue 5. 2001-07-26. PMID:11402470. |
dexmedetomidine, a novel alpha 2-adrenergic agonist for short-term sedation in the intensive care unit. |
2001-07-26 |
2023-08-12 |
Not clear |
| A B Malmberg, L R Hedley, J R Jasper, J C Hunter, A I Basbau. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309255. |
contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. |
2001-07-19 |
2023-08-12 |
mouse |
| A B Malmberg, L R Hedley, J R Jasper, J C Hunter, A I Basbau. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309255. |
we also examined the antinociceptive effect produced by the alpha(2) ar agonist dexmedetomidine in nerve-injured mice. |
2001-07-19 |
2023-08-12 |
mouse |
| A B Malmberg, L R Hedley, J R Jasper, J C Hunter, A I Basbau. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309255. |
dexmedetomidine reversed the allodynia at a low dose (3 microg kg(-1), s.c.) and produced antinociceptive effects at higher doses (10 - 30 microg kg(-1)) in all groups except in alpha(2a) ar mutant mice. |
2001-07-19 |
2023-08-12 |
mouse |
| A B Malmberg, L R Hedley, J R Jasper, J C Hunter, A I Basbau. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309255. |
the effect of dexmedetomidine was reversed by intrathecal, but not systemic, injection of the alpha(2) ar antagonist rs 42206. |
2001-07-19 |
2023-08-12 |
mouse |
| A B Malmberg, L R Hedley, J R Jasper, J C Hunter, A I Basbau. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. British journal of pharmacology. vol 132. issue 8. 2001-07-19. PMID:11309255. |
these results suggest that neither alpha(2a), alpha(2b) nor alpha(2c) ar is required for the development of neuropathic pain after peripheral nerve injury, however, the spinal alpha(2a) ar is essential for the antinociceptive effects of dexmedetomidine. |
2001-07-19 |
2023-08-12 |
mouse |
| P Kortesuo, M Ahola, M Kangas, A Yli-Urpo, J Kiesvaara, M Marvol. In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters. International journal of pharmaceutics. vol 221. issue 1-2. 2001-07-12. PMID:11397572. |
dexmedetomidine, an alpha 2-agonist, was incorporated as a hydrochloride salt into silica xerogel in order to evaluate the effect of sol-gel synthesis parameters: ph of the sol, water/alkoxide molar ratio, drug concentration and size of the device on the drug release rate and degradation rate of the matrix. |
2001-07-12 |
2023-08-12 |
Not clear |
| M Taoda, Y U Adachi, Y Uchihashi, K Watanabe, T Satoh, E S Viz. Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137626. |
the alpha(2)-adrenoceptor agonist, dexmedetomidine inhibited the stimulation-evoked release of na from kidney slices in a concentration-dependent manner, whereas alpha(2)-adrenoceptor antagonist ch-38083 (7,8-methyenedioxy-14-alpha-hydroxyalloberbane hcl), an alpha(2)-adrenoceptor antagonists, enhanced it. |
2001-05-31 |
2023-08-12 |
rat |
| M Taoda, Y U Adachi, Y Uchihashi, K Watanabe, T Satoh, E S Viz. Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137626. |
when dexmedetomidine and brl-44408, a selective alpha(2a) antagonist, were added together, the effect of dexmedetomidine was significantly antagonized. |
2001-05-31 |
2023-08-12 |
rat |
| M Taoda, Y U Adachi, Y Uchihashi, K Watanabe, T Satoh, E S Viz. Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137626. |
in contrast, arc-239 (2-(2,4-(o-piperazine-1-yl)-ethyl-4,4-dimethyl-1,3-(2h, 4h)disoguinolinedione chloride), a selective alpha(2b)-antagonist, had no effect on the release and failed to prevent the effect of dexmedetomidine. |
2001-05-31 |
2023-08-12 |
rat |
| M Taoda, Y U Adachi, Y Uchihashi, K Watanabe, T Satoh, E S Viz. Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137626. |
it is therefore suggested that there is a negative feedback modulation of na release at the sympathetic innervation of kidney cortex, and dexmedetomidine, a clinically used anesthetic adjunct inhibits the release via activation of alpha(2c)-adrenoceptors. |
2001-05-31 |
2023-08-12 |
rat |
| R Ben-Abraham, D Ogorek, A A Weinbrou. Dexmedetomidine: a promising agent for anesthesia and perioperative care. The Israel Medical Association journal : IMAJ. vol 2. issue 10. 2001-05-31. PMID:11344741. |
dexmedetomidine is a relatively new, highly selective, short-acting central alpha 2 agonist. |
2001-05-31 |
2023-08-12 |
Not clear |
| C Vayssettes-Courchay, C Ragonnet, A A Cordi, T J Verbeure. In vivo analysis of adrenergic and serotoninergic constrictions of the rabbit saphenous vein. European journal of pharmacology. vol 408. issue 3. 2001-02-22. PMID:11090645. |
dose-related constrictions of rabbit veins were obtained with l-phenylephrine and the alpha(2)-adrenoceptor agonist dexmedetomidine. |
2001-02-22 |
2023-08-12 |
rabbit |
| M J Millan, A Dekeyne, A Newman-Tancredi, D Cussac, V Audinot, G Milligan, D Duqueyroix, S Girardon, J Mullot, J A Boutin, J P Nicolas, A Renouard-Try, J M Lacoste, A Cord. S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082457. |
s18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: i. receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. |
2000-12-20 |
2023-08-12 |
human |
| M J Millan, A Dekeyne, A Newman-Tancredi, D Cussac, V Audinot, G Milligan, D Duqueyroix, S Girardon, J Mullot, J A Boutin, J P Nicolas, A Renouard-Try, J M Lacoste, A Cord. S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082457. |
although the affinity of dexmedetomidine at alpha(2)-ars was lower than s18616; it displayed a similar receptor and functional profile. |
2000-12-20 |
2023-08-12 |
human |
| R Huang, L Hert. Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects. Brain research. vol 873. issue 2. 2000-09-28. PMID:10930558. |
dexmedetomidine, a selective alpha(2)-adrenergic agonist, increases accumulation of [14c]glutamine and its labeled metabolites in primary cultures of mouse astrocytes. |
2000-09-28 |
2023-08-12 |
mouse |