| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Huang, L Hert. Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects. Brain research. vol 873. issue 2. 2000-09-28. PMID:10930558. |
the concentration dependence is biphasic and identical to that previously described for dexmedetomidine's effect on free cytosolic calcium concentration ([ca(2+)](i)) in astrocytes, and both effects are exerted on the alpha(2a) subtype of the alpha(2) receptor, suggesting a ca(2+)-mediated effect. |
2000-09-28 |
2023-08-12 |
mouse |
| A J Rouch, L H Kud. Role of PGE(2) in alpha(2)-induced inhibition of AVP- and cAMP-stimulated H(2)O, Na(+), and urea transport in rat IMCD. American journal of physiology. Renal physiology. vol 279. issue 2. 2000-09-12. PMID:10919849. |
indomethacin was used to inhibit endogenous prostaglandin synthesis, and the alpha(2)-agonists clonidine, oxymetazoline, and dexmedetomidine were used to test the role of pge(2) in the alpha(2)-mediated mechanism that inhibits transport. |
2000-09-12 |
2023-08-12 |
rat |
| Y Chen, Z Zhao, W E Code, L Hert. A correlation between dexmedetomidine-induced biphasic increases in free cytosolic calcium concentration and energy metabolism in astrocytes. Anesthesia and analgesia. vol 91. issue 2. 2000-08-15. PMID:10910847. |
the alpha(2)-adrenergic agonist, dexmedetomidine, increases free cytosolic calcium concentration ([ca(2+)](i)) in astrocytes, but not in neurons. |
2000-08-15 |
2023-08-12 |
mouse |
| C J Bol, J P Vogelaar, J P Tang, J W Mandem. Quantification of pharmacodynamic interactions between dexmedetomidine and midazolam in the rat. The Journal of pharmacology and experimental therapeutics. vol 294. issue 1. 2000-07-24. PMID:10871332. |
the pharmacodynamic (pd) interaction between the benzodiazepine agonist midazolam and the alpha(2)-adrenergic agonist dexmedetomidine was characterized for defined measures of anesthetic action and cardiovascular and ventilatory side effects in 33 rats. |
2000-07-24 |
2023-08-12 |
rat |
| S Dutta, R Lal, M D Karol, T Cohen, T Eber. Influence of cardiac output on dexmedetomidine pharmacokinetics. Journal of pharmaceutical sciences. vol 89. issue 4. 2000-06-21. PMID:10737913. |
dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, reduces the requirements for anesthetic, analgesic, sedative, and hypnotic drugs. |
2000-06-21 |
2023-08-12 |
human |
| Wade S Kingery, Tian Z Guo, Frances M Davies, Lee Limbird, Mervyn Maz. The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain. vol 85. issue 3. 2000-06-21. PMID:10781908. |
nerve injury enhanced the analgesic efficacy of the alpha(2) adrenoceptor agonist dexmedetomidine, and paradoxically also induced an analgesic response to alpha(2) adrenoceptor antagonists. |
2000-06-21 |
2023-08-12 |
mouse |
| S J MacLennan, P H Reynen, R S Martin, R M Eglen, G R Marti. Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes. British journal of pharmacology. vol 129. issue 7. 2000-05-25. PMID:10742288. |
in alpha(2a)-adrenoceptor transfected cells the rank order of agonist potency was a-54741 (mean pec(50)=8.96)>dexmedetomidine (8.88)>uk-14304 (8.42)>b-ht 920 (7.05)>noradrenaline (6.92). |
2000-05-25 |
2023-08-12 |
human |
| P H Reynen, G R Martin, R M Eglen, S J MacLenna. Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. British journal of pharmacology. vol 129. issue 7. 2000-05-25. PMID:10742289. |
several alpha-adrenoceptor agonists were examined including the alpha(2)-adrenoceptor agonists uk-14304, b-ht 920, dexmedetomidine and a-54741, the selective alpha(1)-adrenoceptor agonist phenylephrine and the non-selective adrenergic agonist noradrenaline. |
2000-05-25 |
2023-08-12 |
human |
| P Talke, R Chen, B Thomas, A Aggarwall, A Gottlieb, P Thorborg, S Heard, A Cheung, S L Son, A Kalli. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesthesia and analgesia. vol 90. issue 4. 2000-04-20. PMID:10735784. |
we tested dexmedetomidine, an alpha(2) agonist that decreases heart rate, blood pressure, and plasma norepinephrine concentration, for its ability to attenuate stress responses during emergence from anesthesia after major vascular operations. |
2000-04-20 |
2023-08-12 |
Not clear |
| B A Graham, D L Hammond, H K Proudfi. Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. vol 85. issue 1-2. 2000-04-11. PMID:10692612. |
synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and st-91, in two substrains of sprague-dawley rats. |
2000-04-11 |
2023-08-12 |
rat |
| B A Graham, D L Hammond, H K Proudfi. Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. vol 85. issue 1-2. 2000-04-11. PMID:10692612. |
several lines of evidence indicate that the antinociception produced by intrathecal administration of the alpha(2)-adrenoceptor agonists dexmedetomidine or st-91 is mediated by different subtypes of the alpha(2)-adrenoceptor. |
2000-04-11 |
2023-08-12 |
rat |
| B A Graham, D L Hammond, H K Proudfi. Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. vol 85. issue 1-2. 2000-04-11. PMID:10692612. |
the consistent finding that these two alpha(2)-adrenoceptor agonists interact in a supra-additive manner provides strong evidence that dexmedetomidine and st-91 produce antinociception by acting at different alpha(2)-adrenoceptor subtypes in the spinal cord. |
2000-04-11 |
2023-08-12 |
rat |
| B A Graham, D L Hammond, H K Proudfi. Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. vol 85. issue 1-2. 2000-04-11. PMID:10692612. |
this conclusion is consistent with the earlier proposal that dexmedetomidine acts predominantly at alpha(2a)-adrenoceptors whereas st-91 acts predominantly at non-alpha(2a)-adrenoceptors. |
2000-04-11 |
2023-08-12 |
rat |
| J E Hall, T D Uhrich, J A Barney, S R Arain, T J Eber. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesthesia and analgesia. vol 90. issue 3. 2000-03-16. PMID:10702460. |
implicatipns: the alpha(2) agonist, dexmedetomidine, has sedation and analgesic properties. |
2000-03-16 |
2023-08-12 |
human |
| Z P Khan, I T Munday, R M Jones, C Thornton, T G Mant, D Ami. Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: Pharmacodynamic and pharmacokinetic interactions. British journal of anaesthesia. vol 83. issue 3. 2000-02-17. PMID:10655905. |
dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist with anaesthetic-sparing effects. |
2000-02-17 |
2023-08-12 |
human |
| T S Grabow, R W Hurley, P N Banfor, D L Hammon. Supraspinal and spinal delta(2) opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha(2) adrenoceptors. Pain. vol 83. issue 1. 1999-11-16. PMID:10506671. |
the second experiment determined that intrathecal co-administration of delt with the alpha(2)-adrenoceptor agonist dexmedetomidine in a 2:1 fixed dose ratio produced a synergistic antinociception in the tail-flick test. |
1999-11-16 |
2023-08-12 |
rat |
| Y Miyazaki, T Adachi, J Kurata, J Utsumi, T Shichino, H Segaw. Dexmedetomidine reduces seizure threshold during enflurane anaesthesia in cats. British journal of anaesthesia. vol 82. issue 6. 1999-11-16. PMID:10562794. |
dexmedetomidine is an alpha 2 agonist and has been reported to have proconvulsant actions. |
1999-11-16 |
2023-08-12 |
Not clear |
| P S Pagel, L T Proctor, A Devcic, D A Hettrick, J R Kersten, J P Tessmer, N E Farber, W T Schmeling, D C Warltie. A novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs. Journal of cardiothoracic and vascular anesthesia. vol 12. issue 4. 1998-10-27. PMID:9713732. |
a novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs. |
1998-10-27 |
2023-08-12 |
Not clear |
| P S Pagel, L T Proctor, A Devcic, D A Hettrick, J R Kersten, J P Tessmer, N E Farber, W T Schmeling, D C Warltie. A novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs. Journal of cardiothoracic and vascular anesthesia. vol 12. issue 4. 1998-10-27. PMID:9713732. |
to test the hypothesis that l-659,066, a peripherally acting alpha 2-adrenoceptor agonist, will abolish the early pressor response but preserve the late depressor action of intravenous dexmedetomidine in conscious, unsedated dogs. |
1998-10-27 |
2023-08-12 |
Not clear |
| J G Richman, J W Rega. Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. The American journal of physiology. vol 274. issue 3. 1998-04-24. PMID:9530096. |
mitogen-activated protein kinase activity in the rasm cells was stimulated fivefold over basal by the alpha 2-selective agonist dexmedetomidine (dex) and was blocked by coincubation with the alpha 2-selective antagonist rauwolscine (rw) or by preincubation of the cells with the gi/g(o)-protein inhibitor pertussis toxin. |
1998-04-24 |
2023-08-12 |
rat |