| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J G Richman, J W Rega. Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. The American journal of physiology. vol 274. issue 3. 1998-04-24. PMID:9530096. |
mitogen-activated protein kinase activity in the rasm cells was stimulated fivefold over basal by the alpha 2-selective agonist dexmedetomidine (dex) and was blocked by coincubation with the alpha 2-selective antagonist rauwolscine (rw) or by preincubation of the cells with the gi/g(o)-protein inhibitor pertussis toxin. |
1998-04-24 |
2023-08-12 |
rat |
| P Riihioja, P Jaatinen, H Oksanen, A Haapalinna, E Heinonen, A Hervone. Dexmedetomidine alleviates ethanol withdrawal symptoms in the rat. Alcohol (Fayetteville, N.Y.). vol 14. issue 6. 1998-01-08. PMID:9401667. |
the effect of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on ethanol withdrawal symptoms was studied in chronically ethanol-fed rats. |
1998-01-08 |
2023-08-12 |
rat |
| A J Rouch, L H Kud. Indomethacin and staurosporine reverse alpha 2 inhibition of water transport in rat IMCD. Kidney international. vol 52. issue 5. 1997-12-01. PMID:9350658. |
these studies were conducted to determine if the prostaglandin-synthesis inhibitor indomethacin or the protein kinase c (pkc) inhibitor staurosporine affect the inhibition of osmotic water permeability (pf) by the alpha-2 (alpha 2) agonist dexmedetomidine in the rat inner medullary collecting duct (imcd). |
1997-12-01 |
2023-08-12 |
rat |
| P Riihioja, P Jaatinen, H Oksanen, A Haapalinna, E Heinonen, A Hervone. Dexmedetomidine, diazepam, and propranolol in the treatment of ethanol withdrawal symptoms in the rat. Alcoholism, clinical and experimental research. vol 21. issue 5. 1997-10-23. PMID:9267529. |
in this study, the effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on ethanol withdrawal symptoms, were compared with those of diazepam and propranolol. |
1997-10-23 |
2023-08-12 |
rat |
| C J Lawrence, F W Prinzen, S de Lang. Hemodynamic and coronary vascular effects of dexmedetomidine in the anesthetized goat. Acta anaesthesiologica Scandinavica. vol 41. issue 7. 1997-09-25. PMID:9265924. |
in phase iii trials, the hemodynamic stabilising effect of the alpha 2-adrenergic agonist dexmedetomidine (dex) is being investigated in patients with coronary artery disease, coronary vascular effects of alpha 2-agonists have been studied in dogs and pigs, but both species have a different hemodynamic response to dex than man. |
1997-09-25 |
2023-08-12 |
Not clear |
| W Klimscha, C Tong, J C Eisenac. Intrathecal alpha 2-adrenergic agonists stimulate acetylcholine and norepinephrine release from the spinal cord dorsal horn in sheep. An in vivo microdialysis study. Anesthesiology. vol 87. issue 1. 1997-08-21. PMID:9232141. |
intrathecal injection of clonidine and dexmedetomidine produce behavioral analgesia by an alpha 2-adrenergic mechanism. |
1997-08-21 |
2023-08-12 |
Not clear |
| Y Asano, R C Koehler, T Kawaguchi, R W McPherso. Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat. The American journal of physiology. vol 272. issue 6 Pt 2. 1997-08-18. PMID:9227530. |
pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat. |
1997-08-18 |
2023-08-12 |
rat |
| Y Asano, R C Koehler, T Kawaguchi, R W McPherso. Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat. The American journal of physiology. vol 272. issue 6 Pt 2. 1997-08-18. PMID:9227530. |
dexmedetomidine (dex) is an alpha 2-adrenergic agonist that decreases cerebral blood flow (cbf) when administered systemically. |
1997-08-18 |
2023-08-12 |
rat |
| B C Rabin, T Z Guo, M Maz. Dissociation of hypnotic-anesthetic actions of alpha 2 agonists from cyclic AMP in the rat. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164550. |
we have examined the alpha 2-adrenoceptor-mediated anesthetic actions of dexmedetomidine, a highly selective alpha 2-adrenergic agonist, after pretreatment of the animals with rolipram, a cyclic amp (camp)-specific phosphodiesterase inhibitor, camp accumulation and monoamine turnover were measured in the locus coeruleus (lc) and hippocampus (hc) following administration of rolipram [275 mg/kg, intraperitoneally (ip)] and dexmedetomidine (100-500 mg/kg, ip). |
1997-07-30 |
2023-08-12 |
rat |
| K Reid, Y Hayashi, J Hsu, P A Maguire, B C Rabin, T Z Guo, M Maz. Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164555. |
chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. |
1997-07-30 |
2023-08-12 |
rat |
| K Reid, Y Hayashi, J Hsu, P A Maguire, B C Rabin, T Z Guo, M Maz. Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164555. |
tolerance to the hypnotic response was induced in rats by chronically infusing dexmedetomidine, a novel alpha 2-adrenergic agonist. |
1997-07-30 |
2023-08-12 |
rat |
| K Takada, Y Hayashi, T Kamibayashi, T Mammoto, A Yamatodani, S Kitamura, I Yoshiy. The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors. British journal of pharmacology. vol 120. issue 8. 1997-06-23. PMID:9113381. |
to elucidate the possible involvement of pertussis toxin (ptx)-sensitive g proteins in the post receptor mechanism of alpha 2-adrenoceptors and imidazoline receptors, we examined the effect of pretreatment of the central nervous system with ptx on the antidysrhythmic effect of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, and rilmenidine, a selective i1-imidazoline receptor agonist on halothane-adrenaline dysrhythmias in rats. |
1997-06-23 |
2023-08-12 |
rat |
| K Takada, Y Hayashi, T Kamibayashi, T Mammoto, A Yamatodani, S Kitamura, I Yoshiy. The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors. British journal of pharmacology. vol 120. issue 8. 1997-06-23. PMID:9113381. |
), an alpha 2-adrenoceptor antagonist with low affinity for imidazoline receptors inhibited the action of dexmedetomidine (5.0 micrograms kg-1, min-1, i.v. |
1997-06-23 |
2023-08-12 |
rat |
| C W Stevens, G M Brenne. Spinal administration of adrenergic agents produces analgesia in amphibians. European journal of pharmacology. vol 316. issue 2-3. 1997-06-12. PMID:8982687. |
significant analgesic effects were noted for at least 4 h. the analgesic effect of intraspinal dexmedetomidine or epinephrine was blocked by systemic pretreatment with the alpha 2-adrenoceptor antagonists, yohimbine and atipamezole, but not with the alpha 1-adrenoceptor antagonist, prazosin. |
1997-06-12 |
2023-08-12 |
Not clear |
| Y H Hui, K C Marsh, S Menacherr. Analytical method development for the simultaneous quantitation of dexmedetomidine and three potential metabolites in plasma. Journal of chromatography. A. vol 762. issue 1-2. 1997-06-12. PMID:9098987. |
dexmedetomidine, a novel alpha 2-adrenergic receptor agonist, is being developed as an anesthetic adjunct for perioperative use. |
1997-06-12 |
2023-08-12 |
Not clear |
| R Aantaa, M L Jaakola, A Kallio, J Kant. Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine. Anesthesiology. vol 86. issue 5. 1997-06-10. PMID:9158354. |
the present study was designed to define the interaction of intravenous infusion of dexmedetomidine, an alpha 2-adrenergic agonist, and isoflurane in patients having surgery by using the minimum alveolar concentration (mac) of isoflurane as the measure of anesthetic potency. |
1997-06-10 |
2023-08-12 |
Not clear |
| T I Ala-Kokko, P Pienimäki, E Lampela, A I Hollmén, O Pelkonen, K Vähäkanga. Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta. Acta anaesthesiologica Scandinavica. vol 41. issue 2. 1997-06-03. PMID:9062619. |
the placental transfer of the alpha 2 receptor agonist clonidine, earlier used as an adjuvant in obstetric epidural analgesia, was compared with the transfer of the newer and more alpha 2-selective agonist dexmedetomidine. |
1997-06-03 |
2023-08-12 |
human |
| M T Taittonen, O A Kirvelä, R Aantaa, J H Kant. Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state. British journal of anaesthesia. vol 78. issue 4. 1997-05-13. PMID:9135361. |
we have compared the perioperative metabolic and haemodynamic effects of two alpha 2-agonists, clonidine and the more selective dexmedetomidine, in 30 asa i patients undergoing plastic surgical procedures under general anaesthesia. |
1997-05-13 |
2023-08-12 |
Not clear |
| b' S Ruotsalainen, A Haapalinna, P J Riekkinen, J Sirvi\\xc3\\xb. Dexmedetomidine reduces response tendency, but not accuracy of rats in attention and short-term memory tasks. Pharmacology, biochemistry, and behavior. vol 56. issue 1. 1997-03-28. PMID:8981606.' |
a low dose (3.0 micrograms/kg, s.c.) of dexmedetomidine, an alpha 2-adrenoceptor agonist, reduced response tendency in an attentional task and a working memory task, but it did not affect the choice accuracy of rats. |
1997-03-28 |
2023-08-12 |
rat |
| E Umeda, T Satoh, H Nagashima, P E Potter, G Tarkovács, E S Viz. alpha 2A subtype of presynaptic alpha 2-adrenoceptors modulates the release of [3H]-noradrenaline from rat spinal cord. Brain research bulletin. vol 42. issue 2. 1997-03-25. PMID:8971417. |
the alpha 2-adrenoceptor agonists, clonidine and dexmedetomidine inhibited the stimulation-evoked release of na from spinal cord slices, whereas alpha 2-adrenoceptor antagonists yohimbine and ch-38083 (7,8-(methylenedioxy)-14-alpha-hydroxyalloberbane hci), enhanced it. |
1997-03-25 |
2023-08-12 |
rat |