| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Willenbring, J A DeLeo, D W Coomb. Sciatic cryoneurolysis in rats: a model of sympathetically independent pain. Part 2: Adrenergic pharmacology. Anesthesia and analgesia. vol 81. issue 3. 1995-09-26. PMID:7653821. |
similar attenuation occurred with infusions of the alpha 2 agonist dexmedetomidine and at the lowest dose (2.0 micrograms) of the mixed alpha agonist clonidine. |
1995-09-26 |
2023-08-12 |
rat |
| B R Karlsson, E M Löberg, P A Stee. Dexmedetomidine, a potent alpha 2-agonist, does not affect neuronal damage following severe forebrain ischaemia in the rat. European journal of anaesthesiology. vol 12. issue 3. 1995-09-19. PMID:7641718. |
dexmedetomidine, a potent alpha 2-agonist, does not affect neuronal damage following severe forebrain ischaemia in the rat. |
1995-09-19 |
2023-08-12 |
rat |
| B R Karlsson, E M Löberg, P A Stee. Dexmedetomidine, a potent alpha 2-agonist, does not affect neuronal damage following severe forebrain ischaemia in the rat. European journal of anaesthesiology. vol 12. issue 3. 1995-09-19. PMID:7641718. |
we have studied the effect of dexmedetomidine, a potent alpha 2-adrenergic receptor agonist that reduces the central release of noradrenaline, on neuronal damage after 10 min of severe forebrain ischaemia in the rat. |
1995-09-19 |
2023-08-12 |
rat |
| H Bouaziz, C Hewitt, J C Eisenac. Subarachnoid neostigmine potentiation of alpha 2-adrenergic agonist analgesia. Dexmedetomidine versus Clonidine. Regional anesthesia. vol 20. issue 2. 1995-08-17. PMID:7605758. |
the authors tested whether dexmedetomidine, an alpha 2-adrenergic agonist with greater intrinsic efficacy than clonidine, would be similarly affected by neostigmine and nmla. |
1995-08-17 |
2023-08-12 |
Not clear |
| J Levänen, M L Mäkelä, H Scheini. Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. Anesthesiology. vol 82. issue 5. 1995-06-06. PMID:7741286. |
dexmedetomidine is a new potent and highly selective alpha 2-adrenoceptor agonist with sedative-hypnotic and anesthetic sparing properties. |
1995-06-06 |
2023-08-12 |
Not clear |
| M B Weinger, B L Partridge, A F Henr. Dexmedetomidine does not modify the neuromuscular blocking action of vecuronium in the anaesthetized rat. British journal of anaesthesia. vol 74. issue 4. 1995-06-05. PMID:7734268. |
dexmedetomidine is a new alpha 2 adrenergic agonist anaesthetic adjuvant. |
1995-06-05 |
2023-08-12 |
rat |
| b' P Rauhala, J J Id\\xc3\\xa4np\\xc3\\xa4\\xc3\\xa4n-Heikkil\\xc3\\xa4, A Lang, R K Tuominen, P T M\\xc3\\xa4nnist\\xc3\\xb. Cold exposure attenuates effects of secretagogues on serum prolactin and growth hormone levels in male rats. The American journal of physiology. vol 268. issue 4 Pt 1. 1995-06-01. PMID:7733277.' |
the stimulatory effect of morphine, dexmedetomidine (an alpha 2-adrenoceptor agonist), 1-(3-chlorophenyl)-piperazine (m-cpp, a 5-ht1b agonist), u-50488h (a kappa-opioid receptor agonist), pimozide (a dopamine antagonist), and restraint stress on prolactin and growth hormone (gh) secretion was compared during cold exposure (4 degrees c) and under basal conditions (30 degrees c) in male rats. |
1995-06-01 |
2023-08-12 |
rat |
| b' J J Id\\xc3\\xa4np\\xc3\\xa4\\xc3\\xa4n-Heikkil\\xc3\\xa4, M Bj\\xc3\\xb6rn, T Sepp\\xc3\\xa4l\\xc3\\xa. The effects of ethanol in combination with the alpha 2-adrenoceptor agonist dexmedetomidine and the alpha 2-adrenoceptor antagonist atipamezole on brain monoamine metabolites and motor performance of mice. European journal of pharmacology. vol 292. issue 2. 1995-05-23. PMID:7536679.' |
the effects of ethanol in combination with the alpha 2-adrenoceptor agonist dexmedetomidine and the alpha 2-adrenoceptor antagonist atipamezole on brain monoamine metabolites and motor performance of mice. |
1995-05-23 |
2023-08-12 |
mouse |
| b' J J Id\\xc3\\xa4np\\xc3\\xa4\\xc3\\xa4n-Heikkil\\xc3\\xa4, M Bj\\xc3\\xb6rn, T Sepp\\xc3\\xa4l\\xc3\\xa. The effects of ethanol in combination with the alpha 2-adrenoceptor agonist dexmedetomidine and the alpha 2-adrenoceptor antagonist atipamezole on brain monoamine metabolites and motor performance of mice. European journal of pharmacology. vol 292. issue 2. 1995-05-23. PMID:7536679.' |
the time course of the effects of ethanol alone and in combination with the selective alpha 2-adrenoceptor agonist dexmedetomidine and the alpha-adrenoceptor antagonist atipamezole was studied in nih-swiss mice. |
1995-05-23 |
2023-08-12 |
mouse |
| Y Hayashi, T Z Guo, M Maz. Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Anesthesiology. vol 82. issue 4. 1995-05-16. PMID:7717568. |
the analgesic and sedative-hypnotic utility of the alpha 2 agonists clonidine and dexmedetomidine are currently being investigated. |
1995-05-16 |
2023-08-12 |
rat |
| Y Hayashi, T Z Guo, M Maz. Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Anesthesiology. vol 82. issue 4. 1995-05-16. PMID:7717568. |
a series of studies was conducted in rats to determine (1) whether tolerance and cross-tolerance develop to the analgesic actions of clonidine or dexmedetomidine; (2) how the number of available alpha 2 adrenoceptors affects the analgesic response to dexmedetomidine and clonidine; and (3) how the number of available alpha 2 adrenoceptor affects the hypnotic response to dexmedetomidine. |
1995-05-16 |
2023-08-12 |
rat |
| G Horváth, Z Morvay, M Kovács, M Szikszay, G Benede. An ultrasonographic method for the evaluation of dexmedetomidine on micturition in intact rats. Journal of pharmacological and toxicological methods. vol 32. issue 4. 1995-04-13. PMID:7881136. |
we describe a simple, noninvasive, nontraumatic, and reproducible ultrasonographic method to determine the effect of the alpha 2-adrenoceptor agonist dexmedetomidine in anesthetic dose (300 micrograms/kg subcutaneously) on the micturition reflex in intact rats. |
1995-04-13 |
2023-08-12 |
rat |
| G Horváth, Z Morvay, M Kovács, M Szikszay, G Benede. An ultrasonographic method for the evaluation of dexmedetomidine on micturition in intact rats. Journal of pharmacological and toxicological methods. vol 32. issue 4. 1995-04-13. PMID:7881136. |
this study indicates that the alpha 2-adrenoceptor agonist dexmedetomidine inhibits the micturition reflex in intact rats. |
1995-04-13 |
2023-08-12 |
rat |
| C M Jorm, J A Stamfor. Actions of morphine on noradrenaline efflux in the rat locus coeruleus are mediated via both opioid and alpha 2 adrenoceptor mechanisms. British journal of anaesthesia. vol 74. issue 1. 1995-04-11. PMID:7880711. |
cumulatively applied morphine 10(-8)-10(-4) mol litre-1 had no effect on noradrenaline efflux evoked by pseudo-single-pulse stimulations (20 pulses at 100 hz) while the alpha 2 agonist dexmedetomidine 2 x 10(-10)-10(-7) mol litre-1 decreased efflux of noradrenaline in a concentration-dependent manner. |
1995-04-11 |
2023-08-12 |
human |
| P Talke, J Li, U Jain, J Leung, K Drasner, M Hollenberg, D T Mangan. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. vol 82. issue 3. 1995-04-05. PMID:7879930. |
dexmedetomidine, a highly selective alpha 2-adrenergic agonist, increases perioperative hemodynamic stability in healthy patients but decreases blood pressure and heart rate. |
1995-04-05 |
2023-08-12 |
Not clear |
| A F Sullivan, K Hewett, A H Dickenso. Differential modulation of alpha 2-adrenergic and opioid spinal antinociception by cholecystokinin and cholecystokinin antagonists in the rat dorsal horn: an electrophysiological study. Brain research. vol 662. issue 1-2. 1995-03-22. PMID:7859067. |
the present study examined the effect of cck and cckb antagonists on the spinal antinociception mediated by the selective alpha 2-adrenergic agonist dexmedetomidine. |
1995-03-22 |
2023-08-12 |
rat |
| M A Mirski, L A Rossell, R W McPherson, R J Traystma. Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. Anesthesiology. vol 81. issue 6. 1995-01-10. PMID:7992911. |
dexmedetomidine (dex) is a highly selective alpha 2 agonist with marked sedative and analgesic properties thought to be mediated via reduction of central noradrenergic transmission. |
1995-01-10 |
2023-08-12 |
rat |
| C Nacif-Coelho, C Correa-Sales, L L Chang, M Maz. Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Anesthesiology. vol 81. issue 6. 1995-01-10. PMID:7992922. |
perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. |
1995-01-10 |
2023-08-12 |
rat |
| O M Vainio, B C Bloo. Relation between body temperature and dexmedetomidine-induced minimum alveolar concentration and respiratory changes in isoflurane-anesthetized miniature swine. American journal of veterinary research. vol 55. issue 7. 1994-12-01. PMID:7978616. |
dexmedetomidine (dex), an alpha 2-receptor agonist, is the pharmacologically active d-isomer of medetomidine, a compound used as a sedative in veterinary medicine. |
1994-12-01 |
2023-08-12 |
Not clear |
| K T Kivistö, A Kallio, P J Neuvone. Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine. European journal of clinical pharmacology. vol 46. issue 4. 1994-11-30. PMID:7957520. |
dexmedetomidine is a novel alpha 2-adrenoceptor agonist that may provide beneficial effects as premedication for anesthesia. |
1994-11-30 |
2023-08-12 |
human |