| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K T Kivistö, A Kallio, P J Neuvone. Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine. European journal of clinical pharmacology. vol 46. issue 4. 1994-11-30. PMID:7957520. |
dexmedetomidine is a novel alpha 2-adrenoceptor agonist that may provide beneficial effects as premedication for anesthesia. |
1994-11-30 |
2023-08-12 |
human |
| A Fale, J R Kirsch, R W McPherso. Alpha 2-adrenergic agonist effects on normocapnic and hypercapnic cerebral blood flow in the dog are anesthetic dependent. Anesthesia and analgesia. vol 79. issue 5. 1994-11-30. PMID:7978406. |
we assessed the effects of dexmedetomidine (dex), a highly selective alpha 2-adrenergic agonist, on the cerebrovascular response to hypercapnia in dogs anesthetized with either pentobarbital (pento) or isoflurane (iso), drugs which produce different levels of cbf at a similar level of cerebral oxygen consumption (cmro2). |
1994-11-30 |
2023-08-12 |
dog |
| O Erkola, K Korttila, M Aho, J Haasio, R Aantaa, A Kalli. Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy. Anesthesia and analgesia. vol 79. issue 4. 1994-11-10. PMID:7943770. |
alpha 2 agonist, dexmedetomidine (dex), and midazolam (mid) premedication. |
1994-11-10 |
2023-08-12 |
Not clear |
| A Devcic, W T Schmeling, J P Kampine, D C Warltie. Oral dexmedetomidine preserves baroreceptor function and decreases anesthetic requirements of halothane-anesthetized dogs. Anesthesiology. vol 81. issue 2. 1994-09-08. PMID:8053593. |
the alpha 2-adrenergic agonist, dexmedetomidine, alters hemodynamics by diminishing sympathetic and/or augmenting parasympathetic neurogenic tone to the heart and peripheral vasculature. |
1994-09-08 |
2023-08-12 |
Not clear |
| M T Salmenperä, F Szlam, C C Hu. Anesthetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs. Anesthesiology. vol 80. issue 4. 1994-08-04. PMID:7912911. |
anesthetic doses of dexmedetomidine (dmed), a highly selective alpha 2 agonist, are not well tolerated hemodynamically. |
1994-08-04 |
2023-08-12 |
Not clear |
| M B Sabbe, J P Penning, G T Ozaki, T L Yaks. Spinal and systemic action of the alpha 2 receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide response. Anesthesiology. vol 80. issue 5. 1994-07-28. PMID:7912480. |
spinal and systemic action of the alpha 2 receptor agonist dexmedetomidine in dogs. |
1994-07-28 |
2023-08-12 |
Not clear |
| T Seppälä, J J Idänpään-Heikkilä, C Strömberg, M J Mattil. Ethanol antagonism by atipamezole on motor performance in mice. Life sciences. vol 55. issue 3. 1994-07-19. PMID:7911966. |
the interactions of an alpha 2-adrenoceptor antagonist, atipamezole, and an alpha 2-adrenoceptor agonist, dexmedetomidine, with ethanol were studied in male nih swiss mice. |
1994-07-19 |
2023-08-12 |
mouse |
| M Bührer, A Mappes, R Lauber, D R Stanski, P O Maitr. Dexmedetomidine decreases thiopental dose requirement and alters distribution pharmacokinetics. Anesthesiology. vol 80. issue 6. 1994-07-18. PMID:7912044. |
alpha 2-adrenergic agonists such as dexmedetomidine can be used to reduce the dose requirement of intravenous and volatile anesthetics. |
1994-07-18 |
2023-08-12 |
Not clear |
| J C Eisenach, S L Shafer, B A Bucklin, C Jackson, A Kalli. Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep. Anesthesiology. vol 80. issue 6. 1994-07-18. PMID:7912045. |
this study examines antinociception, transfer to cerebrospinal fluid (csf), and csf pharmacokinetics in sheep of the selective alpha 2-adrenergic agonist dexmedetomidine, with lipophilicity 3.5 times greater than clonidine, and correlates csf concentrations to hemodynamic effects. |
1994-07-18 |
2023-08-12 |
Not clear |
| C C Jansson, A Marjamäki, K Luomala, J M Savola, M Scheinin, K E Akerma. Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells. European journal of pharmacology. vol 266. issue 2. 1994-05-13. PMID:7908883. |
for the full agonists noradrenaline, uk 14,304, and dexmedetomidine, the maximal inhibitory effect on camp production was smaller in the alpha 2b-c2 subtype (35%) than in the alpha 2a-c10 and alpha 2c-c4 subtypes (50-70%). |
1994-05-13 |
2023-08-12 |
mouse |
| G Tarkovács, C Blandizzi, E S Viz. Functional evidence that alpha 2A-adrenoceptors are responsible for antilipolysis in human abdominal fat cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 349. issue 1. 1994-04-28. PMID:7908124. |
the effects of alpha 2-adrenoceptor agonists (dexmedetomidine, oxymetazoline), alone or in combination with various alpha-adrenoceptor subtype-selective antagonists (ch-38083, idazoxan, wb4101, brl44408, arc-239, prazosin), on noradrenaline- and isoprenaline-induced lipolysis were investigated in human isolated abdominal subcutaneous fat cells. |
1994-04-28 |
2023-08-12 |
human |
| R W McPherson, R C Koehler, R J Traystma. Hypoxia, alpha 2-adrenergic, and nitric oxide-dependent interactions on canine cerebral blood flow. The American journal of physiology. vol 266. issue 2 Pt 2. 1994-04-26. PMID:7511347. |
we tested the hypothesis that no synthase inhibition with n omega-nitro-l-arginine methyl ester (l-name) and alpha 2-adrenoreceptor stimulation with dexmedetomidine (dex) decreases the cerebral blood flow (cbf) response to hypoxia. |
1994-04-26 |
2023-08-12 |
Not clear |
| M Salonen, M Maz. Implementation of a radioreceptor assay for dexmedetomidine. Pharmacology & toxicology. vol 73. issue 5. 1994-03-31. PMID:7906879. |
we have implemented a radioreceptor assay for dexmedetomidine, a novel alpha 2-adrenoceptor agonist. |
1994-03-31 |
2023-08-12 |
rat |
| K Reid, Y Hayashi, T Z Guo, C Correa-Sales, C Nacif-Coelho, M Maz. Chronic administration of an alpha 2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:7906889. |
chronic administration of an alpha 2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. |
1994-03-25 |
2023-08-12 |
rat |
| K Reid, Y Hayashi, T Z Guo, C Correa-Sales, C Nacif-Coelho, M Maz. Chronic administration of an alpha 2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:7906889. |
male sprague-dawley rats were administered dexmedetomidine, a highly selective alpha 2 adrenergic agonist, at rates varying between 1 and 10 micrograms.kg-1.h-1 via a chronically implanted sc osmotic pump. |
1994-03-25 |
2023-08-12 |
rat |
| M Matsumoto, M H Zornow, B C Rabin, M Maz. The alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain research. vol 627. issue 2. 1994-03-09. PMID:7905353. |
the alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. |
1994-03-09 |
2023-08-12 |
Not clear |
| M Matsumoto, M H Zornow, B C Rabin, M Maz. The alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain research. vol 627. issue 2. 1994-03-09. PMID:7905353. |
this study was designed to evaluate the ability of a selective alpha 2 adrenergic agonist (dexmedetomidine) to attenuate ischemia-induced increases in striatal norepinephrine, 3 methoxy-4-hydroxyphenethyleneglycol (mhpg), dopamine, and 5-hydroxyindoleacetic acid (5-hiaa). |
1994-03-09 |
2023-08-12 |
Not clear |
| M Matsumoto, M H Zornow, B C Rabin, M Maz. The alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain research. vol 627. issue 2. 1994-03-09. PMID:7905353. |
these results suggest that the alpha 2 agonist dexmedetomidine can selectively attenuate ischemia-induced increases in striatal norepinephrine concentrations. |
1994-03-09 |
2023-08-12 |
Not clear |
| B Ligier, M J Breslow, K Clarkson, H Raff, R J Traystma. Adrenal blood flow and secretory effects of adrenergic receptor stimulation. The American journal of physiology. vol 266. issue 1 Pt 2. 1994-03-09. PMID:7905716. |
to evaluate effects of adrenergic receptor stimulation on regional adrenal blood flow and secretion, pentobarbital-anesthetized dogs (n = 5-6/group) received the beta-agonist isoproterenol (group i), the alpha 1-agonist phenylephrine (group ii), or the alpha 2-agonist dexmedetomidine (group iii). |
1994-03-09 |
2023-08-12 |
Not clear |
| R W McPherson, J R Kirsch, R J Traystma. Inhibition of nitric oxide synthase does not affect alpha 2-adrenergic-mediated cerebral vasoconstriction. Anesthesia and analgesia. vol 78. issue 1. 1994-01-25. PMID:7505532. |
in control animals (n = 6), cbf (microspheres), cerebral oxygen consumption (cmro2), and electroencephalograph (eeg) were measured after 1 h of isoflurane (1.4% end-tidal) and before and 5, 10, and 20 min after injection of an alpha 2-adrenergic receptor agonist (dexmedetomidine 10 micrograms/kg, intravenous bolus). |
1994-01-25 |
2023-08-12 |
Not clear |