| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H K Kim, M H Zornow, M A Strnat, M Maz. Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit. Journal of neurosurgical anesthesiology. vol 8. issue 3. 1997-03-20. PMID:8803836. |
this study was designed to evaluate the ability of dexmedetomidine, an alpha 2-adrenergic agonist, to attenuate increases in the hippocampal concentration of extracellular glutamate and glycine that result from episodes of transient global cerebral ischemia. |
1997-03-20 |
2023-08-12 |
rabbit |
| J Jalonen, M Hynynen, A Kuitunen, H Heikkilä, J Perttilä, M Salmenperä, M Valtonen, R Aantaa, A Kalli. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology. vol 86. issue 2. 1997-03-13. PMID:9054252. |
the effects of dexmedetomidine, a highly specific alpha 2-adrenergic agonist, on these responses have not been reported in patients undergoing coronary artery bypass grafting. |
1997-03-13 |
2023-08-12 |
Not clear |
| M Heesen, G V Dietrich, O Detsch, J Drevermann, J Boldt, G Hempelman. [The in vitro effect of alpha-2 agonists on thrombocyte function and density of thrombocyte alpha-2 receptors]. Der Anaesthesist. vol 45. issue 3. 1997-03-07. PMID:8919899. |
the present study examined whether in vitro incubation of blood with the alpha 2-agonists clonidine and dexmedetomidine decreases alpha 2-receptor density and hereby influences platelet aggregation. |
1997-03-07 |
2023-08-12 |
Not clear |
| J Sallinen, R E Link, A Haapalinna, T Viitamaa, M Kulatunga, B Sjöholm, E Macdonald, M Pelto-Huikko, T Leino, G S Barsh, B K Kobilka, M Scheini. Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Molecular pharmacology. vol 51. issue 1. 1997-02-27. PMID:9016344. |
genetic alteration of alpha 2c-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. |
1997-02-27 |
2023-08-12 |
mouse |
| J Sallinen, R E Link, A Haapalinna, T Viitamaa, M Kulatunga, B Sjöholm, E Macdonald, M Pelto-Huikko, T Leino, G S Barsh, B K Kobilka, M Scheini. Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Molecular pharmacology. vol 51. issue 1. 1997-02-27. PMID:9016344. |
the effects of dexmedetomidine, a subtype-nonselective alpha 2-ar agonist, on monoamine turnover in brain and on locomotor activity were similar in mice with targeted inactivation of the alpha 2c-ar gene and in their controls, but the hypothermic effect of the alpha 2-ar agonist was significantly attenuated by the receptor gene inactivation. |
1997-02-27 |
2023-08-12 |
mouse |
| J Sallinen, R E Link, A Haapalinna, T Viitamaa, M Kulatunga, B Sjöholm, E Macdonald, M Pelto-Huikko, T Leino, G S Barsh, B K Kobilka, M Scheini. Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Molecular pharmacology. vol 51. issue 1. 1997-02-27. PMID:9016344. |
correspondingly, another strain of transgenic mice with 3-fold overexpression of alpha 2c-ar in striatum and other brain regions expressing alpha 2c-ar showed normal reductions in brain monoamine metabolism and locomotor activity after dexmedetomidine, but their hypothermic response to the alpha 2c-ar agonists was significantly accentuated. |
1997-02-27 |
2023-08-12 |
mouse |
| P Dowlatshahi, T L Yaks. Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesthesia and analgesia. vol 84. issue 1. 1997-01-29. PMID:8989014. |
differential effects of two intraventricularly injected alpha 2 agonists, st-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. |
1997-01-29 |
2023-08-12 |
rat |
| P Dowlatshahi, T L Yaks. Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesthesia and analgesia. vol 84. issue 1. 1997-01-29. PMID:8989014. |
recent observations suggest that the investigational compound st-91 and dexmedetomidine (dmet) may interact with distinct alpha 2 subclasses at spinal sites. |
1997-01-29 |
2023-08-12 |
rat |
| C J Lawrence, F W Prinzen, S de Lang. The effect of dexmedetomidine on nutrient organ blood flow. Anesthesia and analgesia. vol 83. issue 6. 1996-12-30. PMID:8942579. |
the alpha 2-adrenergic agonist dexmedetomidine decreases not only heart rate, myocardial contractility, and oxygen demand, but also cardiac output (q). |
1996-12-30 |
2023-08-12 |
Not clear |
| B C Rabin, T Z Guo, K Gregg, M Maz. Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813614. |
role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. |
1996-12-18 |
2023-08-12 |
rat |
| B C Rabin, T Z Guo, K Gregg, M Maz. Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813614. |
in conclusion, these findings suggest that the hypnotic effect of the alpha 2-adrenoceptor agonist, dexmedetomidine, is not mediated solely by changes in noradrenergic neurtransmission, but instead is strongly associated with a decrease in serotonergic neurotransmission and correspondingly diminished by stimulation of 5-ht2 receptors. |
1996-12-18 |
2023-08-12 |
rat |
| M K Savola, J M Savol. [3H]dexmedetomidine, an alpha 2-adrenoceptor agonist, detects a novel imidazole binding site in adult rat spinal cord. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813646. |
[3h]dexmedetomidine, an alpha 2-adrenoceptor agonist, detects a novel imidazole binding site in adult rat spinal cord. |
1996-12-18 |
2023-08-12 |
rat |
| M K Savola, J M Savol. [3H]dexmedetomidine, an alpha 2-adrenoceptor agonist, detects a novel imidazole binding site in adult rat spinal cord. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813646. |
binding properties of [3h]dexmedetomidine [(+)-(s)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole] as an agonist-type radioligand for alpha 2-adrenoceptors were characterised for the first time in tissues relevant to its analgesic (spinal cord from neonatal or adult rats) and behavioural (rat cerebral cortex) actions. |
1996-12-18 |
2023-08-12 |
rat |
| M K Savola, J M Savol. [3H]dexmedetomidine, an alpha 2-adrenoceptor agonist, detects a novel imidazole binding site in adult rat spinal cord. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813646. |
in conclusion, [3h]dexmedetomidine shows very complex binding characteristics that limit its use as an agonist-type radioligand for alpha 2-adrenoceptors but it may be a useful tool for imidazoline receptor characterisation. |
1996-12-18 |
2023-08-12 |
rat |
| b' J J Id\\xc3\\xa4np\\xc3\\xa4\\xc3\\xa4n-Heikkil\\xc3\\xa4, P Rauhala, P T M\\xc3\\xa4nnist\\xc3\\xb. Neuroendocrine effects of dexmedetomidine: evidence of cross-tolerance between a mu-opioid agonist and an alpha 2-adrenoceptor agonist in growth hormone secretion of the male rat. Pharmacology & toxicology. vol 78. issue 3. 1996-12-16. PMID:8882345.' |
neuroendocrine effects of dexmedetomidine: evidence of cross-tolerance between a mu-opioid agonist and an alpha 2-adrenoceptor agonist in growth hormone secretion of the male rat. |
1996-12-16 |
2023-08-12 |
rat |
| b' J J Id\\xc3\\xa4np\\xc3\\xa4\\xc3\\xa4n-Heikkil\\xc3\\xa4, P Rauhala, P T M\\xc3\\xa4nnist\\xc3\\xb. Neuroendocrine effects of dexmedetomidine: evidence of cross-tolerance between a mu-opioid agonist and an alpha 2-adrenoceptor agonist in growth hormone secretion of the male rat. Pharmacology & toxicology. vol 78. issue 3. 1996-12-16. PMID:8882345.' |
the interplay between opiates and alpha 2-adrenergic drugs in the acute secretion of growth hormone and prolactin, as well as the possible cross-tolerance between morphine (mu-opioid receptor agonist) and dexmedetomidine (alpha 2-adrenoceptor agonist) in growth hormone secretion were also evaluated. |
1996-12-16 |
2023-08-12 |
rat |
| P Talke, P E Bickle. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology. vol 85. issue 3. 1996-11-07. PMID:8853085. |
the selective alpha(2) agonist dexmedetomidine may improve neurologic outcome after incomplete ischemia in animals when it is administered either before or after the start of the ischemic insult. |
1996-11-07 |
2023-08-12 |
Not clear |
| P Talke, P E Bickle. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology. vol 85. issue 3. 1996-11-07. PMID:8853085. |
to clarify further the mechanisms by which alpha(2) agonists may provide neuroprotective effects, the authors tested the hypotheses that dexmedetomidine decreases synaptic and extrasynaptic glutamate release stimulated by potassium chloride or hypoxia, and decreases postsynaptic glutamate receptor activity during aerobic or hypoxic conditions. |
1996-11-07 |
2023-08-12 |
Not clear |
| B C Rabin, K Reid, T Z Guo, E Gustafsson, C Zhang, M Maz. Sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective alpha(2)-adrenergic agonist. Anesthesiology. vol 85. issue 3. 1996-11-07. PMID:8853087. |
sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective alpha(2)-adrenergic agonist. |
1996-11-07 |
2023-08-12 |
rat |
| B C Rabin, K Reid, T Z Guo, E Gustafsson, C Zhang, M Maz. Sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective alpha(2)-adrenergic agonist. Anesthesiology. vol 85. issue 3. 1996-11-07. PMID:8853087. |
the development of tolerance to the sympatholytic and anesthetic-reducing effects of alpha(2) agonists after prolonged administration of dexmedetomidine and how the number of available alpha(2) adrenoceptors affects these dexmedetomidine-induced responses was studied. |
1996-11-07 |
2023-08-12 |
rat |