| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Kersten, P S Pagel, J P Tessmer, D L Roerig, W T Schmeling, D C Warltie. Dexmedetomidine alters the hemodynamic effects of desflurane and isoflurane in chronically instrumented dogs. Anesthesiology. vol 79. issue 5. 1993-12-10. PMID:7902030. |
this investigation examined the cardiovascular effects of desflurane and isoflurane in the presence or absence of dexmedetomidine, a highly selective alpha 2-adrenergic agonist that may be clinically useful as a premedicant or anesthetic adjuvant. |
1993-12-10 |
2023-08-12 |
Not clear |
| W E Hoffman, V L Baughman, R F Albrech. Interaction of catecholamines and nitrous oxide ventilation during incomplete brain ischemia in rats. Anesthesia and analgesia. vol 77. issue 5. 1993-11-18. PMID:8105726. |
group 3 (n = 10) received 25 micrograms.kg-1 x h-1 of fentanyl and 70% n2o ventilation and 100 micrograms/kg of dexmedetomidine, an alpha 2-adrenergic receptor agonist that decreases sympathetic activity. |
1993-11-18 |
2023-08-12 |
rat |
| C M Jorm, J A Stamfor. Actions of the hypnotic anaesthetic, dexmedetomidine, on noradrenaline release and cell firing in rat locus coeruleus slices. British journal of anaesthesia. vol 71. issue 3. 1993-11-01. PMID:8104450. |
we have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus. |
1993-11-01 |
2023-08-12 |
rat |
| C M Jorm, J A Stamfor. Actions of the hypnotic anaesthetic, dexmedetomidine, on noradrenaline release and cell firing in rat locus coeruleus slices. British journal of anaesthesia. vol 71. issue 3. 1993-11-01. PMID:8104450. |
these results suggest that cell firing and noradrenaline release are under alpha 2 receptor control and that dexmedetomidine potently stimulates these receptors. |
1993-11-01 |
2023-08-12 |
rat |
| F Bari, G Horváth, G Benede. Dexmedetomidine-induced decrease in cerebral blood flow is attenuated by verapamil in rats: a laser Doppler study. Canadian journal of anaesthesia = Journal canadien d'anesthesie. vol 40. issue 8. 1993-10-28. PMID:8104728. |
this study was performed to examine the changes in local cortical blood flow (cobf) after simultaneous administration of an alpha 2 adrenergic agonist (dexmedetomidine) and a calcium channel antagonist (verapamil) to urethane-anaesthetized rats. |
1993-10-28 |
2023-08-12 |
rat |
| A D Rakovsk. Functional and neurochemical evidence that neurotensin-induced release of acetylcholine from Auerbach's plexus of guinea-pig ileum is presynaptically controlled via alpha 2-adrenoceptors. Neurochemical research. vol 18. issue 7. 1993-10-04. PMID:8103576. |
this effect of neurotensin was inhibited by stimulation of alpha 2-adrenoceptors: noradrenaline, clonidine, xylazine or dexmedetomidine (alpha 2-adrenoceptor agonists) inhibited neurotensin-induced release of acetycholine (ach) as well as the contractions, while ch-38083 or yohimbine (alpha 2-adrenoceptor antagonist) prevented this inhibitory effect. |
1993-10-04 |
2023-08-12 |
Not clear |
| E MacDonald, J Vartiainen, K Jäsberg, L Vuorilehto, J S Salonen, A Urtt. Systemic absorption and systemic effects of ocularly administered dexmedetomidine in rabbits. Current eye research. vol 12. issue 5. 1993-09-07. PMID:8102091. |
dexmedetomidine is a selective alpha 2-adrenoceptor agonist which has previously been shown to reduce the ocular pressure of normotensive rabbits as well as those with pressures artificially elevated by laser irradiation. |
1993-09-07 |
2023-08-12 |
Not clear |
| C Maier, G K Steinberg, G H Sun, G T Zhi, M Maz. Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology. vol 79. issue 2. 1993-08-31. PMID:8102042. |
neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. |
1993-08-31 |
2023-08-12 |
Not clear |
| C Maier, G K Steinberg, G H Sun, G T Zhi, M Maz. Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology. vol 79. issue 2. 1993-08-31. PMID:8102042. |
dexmedetomidine, a highly selective alpha 2-adrenoreceptor agonist, decreases central sympathetic activity and reduces the anesthetic requirement of halothane. |
1993-08-31 |
2023-08-12 |
Not clear |
| J A Schultz, W E Hoffman, R F Albrech. Sympathetic stimulation with physostigmine worsens outcome from incomplete brain ischemia in rats. Anesthesiology. vol 79. issue 1. 1993-08-30. PMID:8102038. |
this study evaluated whether physostigmine may increase plasma epinephrine and norepinephrine during carotid occlusion with hypotension and worsen ischemic outcome in rats and if this effect could be reversed by dexmedetomidine, an alpha 2-adrenergic agonist. |
1993-08-30 |
2023-08-12 |
rat |
| M Virkkilä, T Ali-Melkkilä, J Kanto, J Turunen, H Scheini. Dexmedetomidine as intramuscular premedication in outpatient cataract surgery. A placebo-controlled dose-ranging study. Anaesthesia. vol 48. issue 6. 1993-08-03. PMID:8100688. |
we studied the effects of dexmedetomidine, a new alpha 2 agonist, on intra-ocular pressure, haemodynamic parameters, sedation, anxiolysis and dryness of mouth in 35 (asa physical status 1-3) patients undergoing day-case cataract surgery under peri-ocular anaesthesia. |
1993-08-03 |
2023-08-12 |
Not clear |
| M J Puke, Z Wiesenfeld-Halli. The differential effects of morphine and the alpha 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesthesia and analgesia. vol 77. issue 1. 1993-07-27. PMID:8100405. |
the differential effects of morphine and the alpha 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. |
1993-07-27 |
2023-08-12 |
rat |
| M J Puke, Z Wiesenfeld-Halli. The differential effects of morphine and the alpha 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesthesia and analgesia. vol 77. issue 1. 1993-07-27. PMID:8100405. |
the effect of intrathecal morphine (mo) and the alpha 2-adrenoceptor agonists clonidine (clon) and dexmedetomidine on self-mutilation (autotomy), a behavior that may indicate the presence of neuropathic pain, has been examined in rats. |
1993-07-27 |
2023-08-12 |
rat |
| M J Puke, Z Wiesenfeld-Halli. The differential effects of morphine and the alpha 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesthesia and analgesia. vol 77. issue 1. 1993-07-27. PMID:8100405. |
in a third experiment, mo (10 micrograms), clon (10 micrograms), and dexmedetomidine (1 microgram), an alpha 2-agonist with higher affinity for the alpha 2-receptor than clon, or sal were injected intrathecally twice daily for 21 days starting 24 h after axotomy. |
1993-07-27 |
2023-08-12 |
rat |
| H Scheinin, M L Jaakola, S Sjövall, T Ali-Melkkilä, S Kaukinen, J Turunen, J Kant. Intramuscular dexmedetomidine as premedication for general anesthesia. A comparative multicenter study. Anesthesiology. vol 78. issue 6. 1993-07-12. PMID:8512099. |
dexmedetomidine is a new potent and selective alpha 2-agonist that might prove useful as a preanesthetic agent. |
1993-07-12 |
2023-08-12 |
Not clear |
| D J Detweiler, J C Eisenach, C Tong, C Jackso. A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8098758. |
the highly lipid-soluble alpha 2 adrenergic agonists dexmedetomidine and clonidine produced antinociception, whereas the poorly lipid-soluble st-91 (2,[2,6-diethylphenylamino]-2-imidazoline) produced antinociception only at much larger doses and did not affect cerebrospinal fluid levels of acetylcholine. |
1993-06-22 |
2023-08-12 |
human |
| J B Dyck, M Maze, C Haack, L Vuorilehto, S L Shafe. The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology. vol 78. issue 5. 1993-06-10. PMID:8098190. |
dexmedetomidine is an alpha 2 agonist with potential utility in clinical anesthesia for both its sedative and sympatholytic properties. |
1993-06-10 |
2023-08-12 |
human |
| M Takano, Y Takano, T L Yaks. Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha 2 agonists. Peptides. vol 14. issue 2. 1993-05-28. PMID:7683402. |
addition of dexmedetomidine (10 microm), an alpha 2-adrenergic agonist, did not change the baseline release of either cgrp or sp, but significantly decreased the cap-evoked release of both peptides. |
1993-05-28 |
2023-08-12 |
rat |
| M Takano, Y Takano, T L Yaks. Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha 2 agonists. Peptides. vol 14. issue 2. 1993-05-28. PMID:7683402. |
the common sensitivity of the agonists to yohimbine and the differential effects of atipamezole and prazosin are consistent with the hypothesis that dexmedetomidine and st-91 may interact with different subpopulations of spinal alpha 2 receptors, both of which may modulate afferent terminal release. |
1993-05-28 |
2023-08-12 |
rat |
| G Horváth, M Kovács, M Szikszay, G Benede. Drugs acting at calcium channels can influence the hypnotic-anesthetic effect of dexmedetomidine. Acta biochimica et biophysica Hungarica. vol 26. issue 1-4. 1993-05-25. PMID:1688240. |
the effects of chronic administration of the calcium channel antagonist verapamil on the anesthetic effects of a novel specific alpha 2-receptor agonist (dexmedetomidine) were studied in rats. |
1993-05-25 |
2023-08-11 |
rat |