| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janne Lähdesmäki, Jukka Sallinen, Ewen MacDonald, Jouni Sirviö, Mika Scheini. Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726820. |
dexmedetomidine caused profound hypothermia (up to 14.7 degrees c mean reduction in rectal temperature) and locomotor inhibition in wt mice, and inhibited the turnover of na, 5-ht and da, but increased na turnover in alpha(2a)-ko mice. |
2003-08-04 |
2023-08-12 |
mouse |
| W Caroline Lo, John Harris, Rob W Clark. Endogenous opioids support the spinal inhibitory action of an alpha 2-adrenoceptor agonist in the decerebrated, spinalised rabbit. Neuroscience letters. vol 340. issue 2. 2003-05-29. PMID:12668245. |
in rabbits decerebrated and spinalised under halothane/nitrous oxide anaesthesia, the selective alpha(2)-adrenoceptor agonist dexmedetomidine (3-30 microg intrathecal) induced significant decreases in short- and long-latency reflex responses evoked in medial gastrocnemius (mg) motoneurones by stimulation of the sural nerve. |
2003-05-29 |
2023-08-12 |
rabbit |
| Alan S Mult. Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal. Anesthesia and analgesia. vol 96. issue 4. 2003-04-24. PMID:12651659. |
dexmedetomidine, an alpha(2)-adrenoceptor agonist, is indicated for sedating patients on mechanical ventilation. |
2003-04-24 |
2023-08-12 |
Not clear |
| Jukka Puoliväli, Markus Björklund, Maya Holmberg, Jouni A Ihalainen, Mika Scheinin, Heikki Tanil. Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527480. |
we investigated the role of alpha(2c)-ars in the modulation of baseline cortical eeg activity and eeg responses to the alpha(2)-ar selective agonist, dexmedetomidine (3-300 microg/kg, s.c.), and antagonist, atipamezole (3-1000 microg/kg, s.c.), by using alpha(2c)-ar knockout (ko) and wildtype (wt) mice. |
2003-03-28 |
2023-08-12 |
mouse |
| Henriëtte M Willigers, Frits W Prinzen, Paul M Roekaerts, Simon de Lange, Marcel E Durieu. Dexmedetomidine decreases perioperative myocardial lactate release in dogs. Anesthesia and analgesia. vol 96. issue 3. 2003-03-17. PMID:12598239. |
the sympatholytic effect of the alpha(2)-adrenergic agonist dexmedetomidine may decrease emergence-related myocardial ischemic load in patients. |
2003-03-17 |
2023-08-12 |
Not clear |
| Amy C Porter, Samuel P S Svensson, W Daniel Stamer, Joseph J Bahl, Jeremy G Richman, John W Rega. Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. Life sciences. vol 72. issue 13. 2003-02-27. PMID:12535714. |
both dexmedetomidine, an alpha(2)-selective agonist, and norepinephrine, increased actin cytoskeleton organization and this increase was blocked by the alpha(2)-selective antagonist, atipamezole. |
2003-02-27 |
2023-08-12 |
rat |
| Laura E Nelson, Jun Lu, Tianzhi Guo, Clifford B Saper, Nicholas P Franks, Mervyn Maz. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. vol 98. issue 2. 2003-02-25. PMID:12552203. |
the authors investigated whether the sedative, or hypnotic, action of the general anesthetic dexmedetomidine (a selective alpha -adrenoceptor agonist) activates endogenous nonrapid eye movement (nrem) sleep-promoting pathways. |
2003-02-25 |
2023-08-12 |
Not clear |
| Kristin Engelhard, Christian Werner, Eva Eberspächer, Monika Bachl, Manfred Blobner, Eberhard Hildt, Peter Hutzler, Eberhard Koch. The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesthesia and analgesia. vol 96. issue 2. 2003-02-11. PMID:12538207. |
the effect of the alpha 2-agonist dexmedetomidine and the n-methyl-d-aspartate antagonist s(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. |
2003-02-11 |
2023-08-12 |
rat |
| M Frances Davies, Fawzi Haimor, Geoffrey Lighthall, J David Clar. Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration. Anesthesia and analgesia. vol 96. issue 1. 2003-01-21. PMID:12505952. |
the alpha(2)-adrenergic receptor agonist, dexmedetomidine (dex), is similar to opioids in that it is an analgesic that interacts with cell-surface receptors linked to the inhibition of adenylate cyclase and the modulation of ion channel activity. |
2003-01-21 |
2023-08-12 |
mouse |
| Joseph D Tobia. Controlled hypotension in children: a critical review of available agents. Paediatric drugs. vol 4. issue 7. 2002-12-31. PMID:12083972. |
when considering the pediatric-aged patient, studies have reported the use of the inhalational agent sevoflurane, the alpha(2)-adrenoceptor agonist dexmedetomidine as well as various vasodilators including sodium nitroprusside, nitroglycerin, fenoldopam, and alprostadil for controlled hypotension. |
2002-12-31 |
2023-08-12 |
Not clear |
| H Wei, E Jyväsjärvi, S Niissalo, M Hukkanen, E Waris, Y T Konttinen, A Pertovaar. The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animals. Neuroscience. vol 114. issue 3. 2002-12-20. PMID:12220567. |
for assessment of alpha(2)-adrenergic antinociception, the rats were treated systemically with two alpha(2)-adrenoceptor agonists, one of which only poorly (mpv-2426) and the other very well (dexmedetomidine) penetrates the blood-brain barrier. |
2002-12-20 |
2023-08-12 |
rat |
| Tomoyo Nishida, Masaji Nishimura, Kiyokazu Kagawa, Yukio Hayashi, Takashi Mashim. The effects of dexmedetomidine on the ventilatory response to hypercapnia in rabbits. Intensive care medicine. vol 28. issue 7. 2002-11-29. PMID:12122538. |
dexmedetomidine is a highly selective alpha(2)-adrenergic agonist that can reduce anesthetic requirements. |
2002-11-29 |
2023-08-12 |
Not clear |
| Richard C Prielipp, Michael H Wall, Joseph R Tobin, Leanne Groban, Mark A Cannon, Frederic H Fahey, H Donald Gage, David A Stump, Robert L James, Judy Bennett, John Butterwort. Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow. Anesthesia and analgesia. vol 95. issue 4. 2002-10-28. PMID:12351293. |
dexmedetomidine is a selective alpha(2)-agonist approved for sedation of critically ill patients. |
2002-10-28 |
2023-08-12 |
human |
| Robert A Whittington, Laszlo Virag, Yvonne Vulliemoz, Thomas B Cooper, Hisayo O Morishim. Dexmedetomidine increases the cocaine seizure threshold in rats. Anesthesiology. vol 97. issue 3. 2002-09-24. PMID:12218537. |
the purpose of this study was to determine if dexmedetomidine, a highly selective alpha -adrenoceptor agonist, alters the threshold for cocaine-induced seizure activity in rats. |
2002-09-24 |
2023-08-12 |
rat |
| R W Clarke, S Eves, J Harris, J E Peachey, E Stuar. Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems. Neuroscience. vol 112. issue 3. 2002-09-06. PMID:12074898. |
potentiated, and the alpha(2)-agonist dexmedetomidine (1-30 microg i.t.) |
2002-09-06 |
2023-08-12 |
rabbit |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
the alpha 2 agonist dexmedetomidine (10 nm) decreased stimulated na efflux more in c3h than in mao-a ko mice (73.3% cf. |
2002-07-26 |
2023-08-12 |
mouse |
| Junichirou Hamasaki, Isao Tsuneyoshi, Rumi Katai, Tatewaki Hidaka, Walter A Boyle, Yuichi Kanmur. Dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries. Anesthesia and analgesia. vol 94. issue 6. 2002-06-19. PMID:12032002. |
dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries. |
2002-06-19 |
2023-08-12 |
human |
| Daniel Cussac, Stéphane Schaak, Céline Gales, Christodoulos Flordellis, Colette Denis, Hervé Pari. alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. American journal of physiology. Renal physiology. vol 282. issue 5. 2002-05-17. PMID:11934705. |
in both cell types, the alpha(2b)-ar is coupled to g protein, and its stimulation by dexmedetomidine, but not by uk-14304, provoked a significant inhibition of the accumulation of camp induced by forskolin or parathyroid hormone. |
2002-05-17 |
2023-08-12 |
rat |
| Vincent Laudenbach, Jean Mantz, Hugo Lagercrantz, Jean-Marie Desmonts, Philippe Evrard, Pierre Gressen. Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. Anesthesiology. vol 96. issue 1. 2002-02-07. PMID:11753013. |
effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. |
2002-02-07 |
2023-08-12 |
Not clear |
| Carolyn A Fairbanks, Laura S Stone, Kelley F Kitto, H Oanh Nguyen, Ivan J Posthumus, George L Wilco. alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. The Journal of pharmacology and experimental therapeutics. vol 300. issue 1. 2002-01-24. PMID:11752127. |
the alpha(2a)-adrenergic receptor (ar) subtype mediates antinociception induced by the alpha(2)ar agonists clonidine, dexmedetomidine, norepinephrine, and 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamine (uk-14,304) as well as antinociceptive synergy of uk-14,304 with opioid agonists [d-ala(2),n-me-phe(4),gly(5)-ol]-enkephalin and deltorphin ii. |
2002-01-24 |
2023-08-12 |
mouse |