| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Kurnik, Mordechai Muszkat, Gbenga G Sofowora, Eitan A Friedman, William D Dupont, Mika Scheinin, Alastair J J Wood, C Michael Stei. Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. Hypertension (Dallas, Tex. : 1979). vol 51. issue 2. 2008-02-26. PMID:18071056. |
we examined the hypothesis that there are ethnic differences in the responses to the highly selective alpha(2)-agonist, dexmedetomidine, and that these genetic variants contribute to interindividual variability in drug responses. |
2008-02-26 |
2023-08-12 |
human |
| Daniel Kurnik, Mordechai Muszkat, Gbenga G Sofowora, Eitan A Friedman, William D Dupont, Mika Scheinin, Alastair J J Wood, C Michael Stei. Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. Hypertension (Dallas, Tex. : 1979). vol 51. issue 2. 2008-02-26. PMID:18071056. |
there is large interindividual variability in response to the selective alpha(2)-ar agonist dexmedetomidine, and neither ethnicity nor adra2c and gnb3 genotypes contribute to it. |
2008-02-26 |
2023-08-12 |
human |
| Maria Konstandi, Matti A Lang, Dimitris Kostakis, Elizabeth O Johnson, Marios Marselo. Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic & clinical pharmacology & toxicology. vol 102. issue 1. 2008-01-17. PMID:17973897. |
either blockade or stimulation of alpha(2)-adrenoceptors with atipamezole and dexmedetomidine respectively, eliminated the up-regulating effect of stress on cyp1a2 benzo(alpha)pyrene-induced expression, while it enhanced mrod activity. |
2008-01-17 |
2023-08-12 |
rat |
| Basem Abdelmalak, Laila Makary, Jeremy Hoban, D John Doyl. Dexmedetomidine as sole sedative for awake intubation in management of the critical airway. Journal of clinical anesthesia. vol 19. issue 5. 2007-12-27. PMID:17869990. |
we report a series of successful awake fiberoptic intubations in patients with critical (unstable, difficult) airways using the alpha(2)-agonist, dexmedetomidine. |
2007-12-27 |
2023-08-12 |
Not clear |
| M Kalyanaraman, J L Costello, J P Star. Use of dexmedetomidine in patients with trisomy 21 after cardiac surgery. Pediatric cardiology. vol 28. issue 5. 2007-12-20. PMID:17607500. |
dexmedetomidine is an alpha(2)-adrenergic receptor agonist that has sedative, analgesic, and anxiolytic properties. |
2007-12-20 |
2023-08-12 |
Not clear |
| S M Walker, M Fitzgeral. Characterization of spinal alpha-adrenergic modulation of nociceptive transmission and hyperalgesia throughout postnatal development in rats. British journal of pharmacology. vol 151. issue 8. 2007-10-31. PMID:17533423. |
the selective alpha(2)-adrenergic agonist dexmedetomidine is used clinically for analgesia and sedation, but effects in early life are not well characterized. |
2007-10-31 |
2023-08-12 |
rat |
| Atsushi Takizuka, Kouichiro Minami, Yasuhito Uezono, Takafumi Horishita, Toru Yokoyama, Munehiro Shiraishi, Takeshi Sakurai, Akio Shigematsu, Yoichi Uet. Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 375. issue 5. 2007-10-04. PMID:17563882. |
dexmedetomidine, an alpha(2)-adrenoceptor agonist, has been approved for clinical use, although the mechanism of dexmedetomidine action has not been fully elucidated. |
2007-10-04 |
2023-08-12 |
rat |
| Atsushi Takizuka, Kouichiro Minami, Yasuhito Uezono, Takafumi Horishita, Toru Yokoyama, Munehiro Shiraishi, Takeshi Sakurai, Akio Shigematsu, Yoichi Uet. Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 375. issue 5. 2007-10-04. PMID:17563882. |
therefore, it is of interest to determine whether dexmedetomidine affects the function of gpcrs other than the alpha(2)-adrenoceptor. |
2007-10-04 |
2023-08-12 |
rat |
| Atsushi Takizuka, Kouichiro Minami, Yasuhito Uezono, Takafumi Horishita, Toru Yokoyama, Munehiro Shiraishi, Takeshi Sakurai, Akio Shigematsu, Yoichi Uet. Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 375. issue 5. 2007-10-04. PMID:17563882. |
dexmedetomidine inhibits the function of m(3) receptors, in addition to its agonistic effects on alpha(2)-adrenoceptors, which provides further insight into the pharmacological properties of dexmedetomidine. |
2007-10-04 |
2023-08-12 |
rat |
| Neusa Maria H Bulow, Nilda Vargas Barbosa, Joao Batista Teixeira Roch. Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery. Journal of clinical anesthesia. vol 19. issue 4. 2007-08-21. PMID:17572323. |
to evaluate the capacity of dexmedetomidine (dex), an alpha(2) adrenergic agonist drug, as a substitute for remifentanil (rem), a potent opioid, in total intravenous anesthesia (tiva), in patient undergoing gynecologic videolaparoscopy. |
2007-08-21 |
2023-08-12 |
Not clear |
| Julia C Finkel, Zenaide M N Quezad. Hypothermia-induced bradycardia in a neonate receiving dexmedetomidine. Journal of clinical anesthesia. vol 19. issue 4. 2007-08-21. PMID:17572325. |
dexmedetomidine, an alpha(2)-adrenergic agonist, decreases lipolysis and thus prevents nonshivering thermogenesis in infants. |
2007-08-21 |
2023-08-12 |
Not clear |
| M Durmus, A K But, Z Dogan, A Yucel, M C Miman, M O Erso. Effect of dexmedetomidine on bleeding during tympanoplasty or septorhinoplasty. European journal of anaesthesiology. vol 24. issue 5. 2007-07-26. PMID:17241505. |
the aim of this study was to evaluate the efficacy of dexmedetomidine, an alpha(2)-adrenoceptor agonist, on intraoperative bleeding, anaesthetic drug requirement and postoperative pain. |
2007-07-26 |
2023-08-12 |
Not clear |
| R Blaine Easley, Kenneth M Brady, Joseph D Tobia. Dexmedetomidine for the treatment of postanesthesia shivering in children. Paediatric anaesthesia. vol 17. issue 4. 2007-06-29. PMID:17359402. |
dexmedetomidine, a centrally acting alpha(2)-adrenergic agonist, has been used as a sedative agent and is known to reduce the shivering threshold. |
2007-06-29 |
2023-08-12 |
Not clear |
| H Smith, J Elliot. Alpha(2) receptors and agonists in pain management. Current opinion in anaesthesiology. vol 14. issue 5. 2007-06-19. PMID:17019139. |
the alpha(2) agonists that are currently employed in anesthesia and pain management include clonidine, tizanidine, and dexmedetomidine. |
2007-06-19 |
2023-08-12 |
Not clear |
| Baris Karadas, Tijen Kaya, Sefa Gulturk, Ahmet Parlak, Sinan Gursoy, Ali Cetin, Ihsan Bagciva. Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17126828. |
dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, is an extremely potent antinociceptive agent. |
2007-04-05 |
2023-08-12 |
rat |
| Baris Karadas, Tijen Kaya, Sefa Gulturk, Ahmet Parlak, Sinan Gursoy, Ali Cetin, Ihsan Bagciva. Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17126828. |
the antinociceptive effect of dexmedetomidine was blocked by systemic pretreatment of selective alpha(2)-adrenoceptor antagonist, atipamezole. |
2007-04-05 |
2023-08-12 |
rat |
| Baris Karadas, Tijen Kaya, Sefa Gulturk, Ahmet Parlak, Sinan Gursoy, Ali Cetin, Ihsan Bagciva. Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17126828. |
this suggests that antinociceptive effects of dexmedetomidine involve alpha(2)-adrenoceptors. |
2007-04-05 |
2023-08-12 |
rat |
| A Maksimow, A Snapir, M Särkelä, E Kentala, J Koskenvuo, J Posti, S K Jääskeläinen, S Hinkka-Yli-Salomäki, M Scheinin, H Scheini. Assessing the depth of dexmedetomidine-induced sedation with electroencephalogram (EEG)-based spectral entropy. Acta anaesthesiologica Scandinavica. vol 51. issue 1. 2007-03-27. PMID:17073855. |
dexmedetomidine, a selective alpha(2)-adrenoceptor agonist, has recently been introduced for the sedation of icu patients. |
2007-03-27 |
2023-08-12 |
Not clear |
| Fatima C Fernandes, Halina C Ferreira, Viviane R Cagido, Giovanna M C Carvalho, Leonel S Pereira, Debora S Faffe, Walter A Zin, Patricia R M Rocc. Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats. Respiratory physiology & neurobiology. vol 154. issue 3. 2007-02-16. PMID:16527548. |
dexmedetomidine is a highly selective and specific alpha(2)-adrenergic agonist, with sedative, analgesic, and sympatholytic activities. |
2007-02-16 |
2023-08-12 |
rat |
| Nishanthan Rajakumaraswamy, Daqing Ma, Mahmuda Hossain, Robert D Sanders, Nicholas P Franks, Mervyn Maz. Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neuroscience letters. vol 409. issue 2. 2007-01-04. PMID:17052852. |
xenon, an nmda receptor antagonist and dexmedetomidine (dex), an alpha(2)-adrenoceptor agonist, both exhibit neuroprotective effects. |
2007-01-04 |
2023-08-12 |
mouse |