| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher Heard, Frederick Burrows, Kristin Johnson, Prashant Joshi, James Houck, Jerrold Lerma. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesthesia and analgesia. vol 107. issue 6. 2008-12-30. PMID:19020127. |
dexmedetomidine is an alpha(2) agonist that is currently being investigated for its suitability to provide anesthesia for children. |
2008-12-30 |
2023-08-12 |
Not clear |
| Brett S Kirby, Wyatt F Voyles, Rick E Carlson, Frank A Dinenn. Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscle. The Journal of physiology. vol 586. issue 17. 2008-12-18. PMID:18617568. |
we measured forearm blood flow (fbf; doppler ultrasound) and calculated the vascular conductance (fvc) responses to local intra-arterial infusions of phenylephrine (alpha(1)-agonist) and dexmedetomidine (alpha(2)-agonist) during moderate rhythmic handgrip exercise (15% maximum voluntary contraction), during a control non-exercise vasodilator condition (adenosine), and during atp infusion in eight young adults. |
2008-12-18 |
2023-08-12 |
human |
| F T Billings, Sean W C Chen, Mihwa Kim, Sang Won Park, Joseph H Song, Shuang Wang, Joseph Herman, Vivette D'Agati, H Thomas Le. alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. American journal of physiology. Renal physiology. vol 295. issue 3. 2008-10-27. PMID:18579700. |
utilizing a murine model, we tested the hypothesis that alpha(2)-adrenergic receptor agonists (clonidine and dexmedetomidine) protect against rcn induced with iohexol (a nonionic low-osmolar radiocontrast). |
2008-10-27 |
2023-08-12 |
mouse |
| F T Billings, Sean W C Chen, Mihwa Kim, Sang Won Park, Joseph H Song, Shuang Wang, Joseph Herman, Vivette D'Agati, H Thomas Le. alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. American journal of physiology. Renal physiology. vol 295. issue 3. 2008-10-27. PMID:18579700. |
some mice were pretreated with yohimbine (a selective alpha(2)-receptor antagonist) before saline, clonidine, or dexmedetomidine administration. |
2008-10-27 |
2023-08-12 |
mouse |
| F T Billings, Sean W C Chen, Mihwa Kim, Sang Won Park, Joseph H Song, Shuang Wang, Joseph Herman, Vivette D'Agati, H Thomas Le. alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. American journal of physiology. Renal physiology. vol 295. issue 3. 2008-10-27. PMID:18579700. |
to determine whether proximal tubular alpha(2)-adrenergic receptors mediate the cytoprotective effects, we treated cultured human proximal tubule (hk-2) cells and rat pulmonary microvascular endothelial cells with iohexol after vehicle, clonidine, or dexmedetomidine pretreatment. |
2008-10-27 |
2023-08-12 |
mouse |
| Hideaki Ishii, Tatsuro Kohno, Tomohiro Yamakura, Miho Ikoma, Hiroshi Bab. Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18554299. |
dexmedetomidine is a highly specific, potent and selective alpha(2)-adrenoceptor agonist. |
2008-10-09 |
2023-08-12 |
rat |
| Hideaki Ishii, Tatsuro Kohno, Tomohiro Yamakura, Miho Ikoma, Hiroshi Bab. Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18554299. |
the outward currents induced by dexmedetomidine were suppressed by the alpha(2)-adrenoceptor antagonist yohimbine, but not by prazosin, an alpha(1)-, alpha(2b)- and alpha(2c)-adrenoceptor antagonist. |
2008-10-09 |
2023-08-12 |
rat |
| Hideaki Ishii, Tatsuro Kohno, Tomohiro Yamakura, Miho Ikoma, Hiroshi Bab. Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18554299. |
the action of dexmedetomidine was mimicked by the alpha(2a)-adrenoceptor agonist oxymetazoline. |
2008-10-09 |
2023-08-12 |
rat |
| Hideaki Ishii, Tatsuro Kohno, Tomohiro Yamakura, Miho Ikoma, Hiroshi Bab. Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18554299. |
these findings suggest that dexmedetomidine hyperpolarizes the membrane potentials of sg neurons by g-protein-mediated activation of k+ channels through alpha(2a)- and alpha(2c)-adrenoceptors. |
2008-10-09 |
2023-08-12 |
rat |
| Hiroaki Kishikawa, Katsuya Kobayashi, Ken Takemori, Tadashi Okabe, Kimiaki Ito, Atsuhiro Sakamot. The effects of dexmedetomidine on human neutrophil apoptosis. Biomedical research (Tokyo, Japan). vol 29. issue 4. 2008-10-06. PMID:18724006. |
these results suggest that high doses of dexmedetomidine induce apoptosis without alpha(2)-adrenoceptors stimulus and inhibit superoxide production after long-term incubation. |
2008-10-06 |
2023-08-12 |
human |
| Kumiko Tanabe, Shinji Takai, Rie Matsushima-Nishiwaki, Kanefusa Kato, Shuji Dohi, Osamu Kozaw. Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells. Journal of neurochemistry. vol 106. issue 2. 2008-09-16. PMID:18384648. |
dexmedetomidine (dexmd), a potent and highly specific alpha(2) adrenoreceptor agonist, is an efficient therapeutic agent for sedation. |
2008-09-16 |
2023-08-12 |
rat |
| Martin Votava, Ladislav Hess, Miloslav Krsia. Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice. Aggressive behavior. vol 34. issue 4. 2008-08-13. PMID:18348168. |
in our recent study, dexmedetomidine, a full alpha(2)-ar agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. |
2008-08-13 |
2023-08-12 |
mouse |
| B Li, T Du, H Li, L Gu, H Zhang, J Huang, L Hertz, L Pen. Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. British journal of pharmacology. vol 154. issue 1. 2008-07-17. PMID:18311185. |
stimulation of astrocytes by the alpha(2)-adrenoceptor agonist dexmedetomidine, a neuroprotective drug, transactivates epidermal growth factor (egf) receptors. |
2008-07-17 |
2023-08-12 |
Not clear |
| Jan Höcker, Bernd Weber, Peter H Tonner, Jens Scholz, Philipp-Alexander Brand, Henning Ohnesorge, Berthold Bei. Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain. European journal of pharmacology. vol 582. issue 1-3. 2008-06-05. PMID:18234187. |
alpha(2)-adrenoceptor agonists like clonidine or dexmedetomidine increase the sedative and analgesic actions of opioids. |
2008-06-05 |
2023-08-12 |
mouse |
| Vivian M Yuen, Theresa W Hui, Michael G Irwin, Man K Yue. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial. Anesthesia and analgesia. vol 106. issue 6. 2008-06-05. PMID:18499600. |
dexmedetomidine is a more alpha(2) selective drug with more favorable pharmacokinetic properties than clonidine. |
2008-06-05 |
2023-08-12 |
Not clear |
| Burcu Tufanogullari, Paul F White, Mariana P Peixoto, Daniel Kianpour, Thomas Lacour, James Griffin, Gary Skrivanek, Amy Macaluso, Mary Shah, David A Provos. Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables. Anesthesia and analgesia. vol 106. issue 6. 2008-06-05. PMID:18499604. |
dexmedetomidine (dex), an alpha(2) agonist, has well-known anesthetic and analgesic-sparing effects. |
2008-06-05 |
2023-08-12 |
Not clear |
| S Vilo, P Rautiainen, K Kaisti, R Aantaa, M Scheinin, T Manner, K T Olkkol. Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age. British journal of anaesthesia. vol 100. issue 5. 2008-05-13. PMID:18378546. |
information has been very limited on the pharmacokinetics of the selective alpha(2)-adrenoceptor agonist dexmedetomidine in children, particularly in children <2 yr of age. |
2008-05-13 |
2023-08-12 |
Not clear |
| S Konakci, T Adanir, G Yilmaz, T Rezank. The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route. European journal of anaesthesiology. vol 25. issue 5. 2008-05-06. PMID:18088445. |
dexmedetomidine, a potent and highly selective alpha(2)-adrenoceptor agonist, is in current clinical use, particularly in the intensive care unit. |
2008-05-06 |
2023-08-12 |
Not clear |
| Souhayl Dahmani, Andrea Paris, Virginie Jannier, Lutz Hein, Danielle Rouelle, Jens Scholz, Pierre Gressens, Jean Mant. Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology. vol 108. issue 3. 2008-03-12. PMID:18292683. |
dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline i1 receptors. |
2008-03-12 |
2023-08-12 |
Not clear |
| E Huupponen, A Maksimow, P Lapinlampi, M Särkelä, A Saastamoinen, A Snapir, H Scheinin, M Scheinin, P Meriläinen, S-L Himanen, S Jääskeläine. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta anaesthesiologica Scandinavica. vol 52. issue 2. 2008-03-04. PMID:18005372. |
dexmedetomidine, a selective alpha(2)-adrenoceptor agonist, induces a unique, sleep-like state of sedation. |
2008-03-04 |
2023-08-12 |
human |