| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rabie Nasr Soliman, Amira Refaie Hassan, Amr Madih Rashwan, Ahmed Mohamed Oma. Prospective, randomized study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia. Middle East journal of anaesthesiology. vol 21. issue 3. 2012-04-10. PMID:22428485. |
dexmedetomidine, alpha 2 adrenoceptor agonist used as adjuvant to anaesthetic agents. |
2012-04-10 |
2023-08-12 |
Not clear |
| Rabie Nasr Soliman, Amira Refaie Hassan, Amr Madih Rashwan, Ahmed Mohamed Oma. Prospective, randomized study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia. Middle East journal of anaesthesiology. vol 21. issue 3. 2012-04-10. PMID:22428485. |
relatively recent studies have shown that dexmedetomidine is able to decrease circulating plasma norepinephrine and epinephrine concentration in approximately 50%, decreases brain blood flow by directly acting on post-synaptic alpha 2 receptors, decreases csf pressure without ischemic suffering and effectively decrease brain metabolism and intracranial pressure and also, able to decrease injury caused by focal ischemia. |
2012-04-10 |
2023-08-12 |
Not clear |
| Sinan Gursoy, Ercan Ozdemir, Ihsan Bagcivan, Ahmet Altun, Nedim Durmu. Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats. Upsala journal of medical sciences. vol 116. issue 4. 2012-03-01. PMID:21919812. |
effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats. |
2012-03-01 |
2023-08-12 |
rat |
| J M Honkavaara, F Restitutti, M R Raekallio, E K Kuusela, O M Vaini. The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. Journal of veterinary pharmacology and therapeutics. vol 34. issue 4. 2012-01-25. PMID:20969603. |
the effects of increasing doses of mk-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. |
2012-01-25 |
2023-08-12 |
Not clear |
| J M Honkavaara, F Restitutti, M R Raekallio, E K Kuusela, O M Vaini. The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. Journal of veterinary pharmacology and therapeutics. vol 34. issue 4. 2012-01-25. PMID:20969603. |
different doses of mk-467, a peripheral alpha(2)-adrenergic receptor antagonist, with or without dexmedetomidine were compared in conscious dogs. |
2012-01-25 |
2023-08-12 |
Not clear |
| Bertrand J Brown, Sammy Zakhary, Lindsay Rogers, Cynthia Ellis-Stoll, Dennis Gable, Michael A E Ramsa. Use of dexmedetomidine versus general anesthesia for endovascular repair of abdominal aortic aneurysms. Proceedings (Baylor University. Medical Center). vol 19. issue 3. 2011-11-10. PMID:17252035. |
a sedation technique using dexmedetomidine, an alpha 2-adrenoreceptor agonist, was developed for this procedure. |
2011-11-10 |
2023-08-12 |
Not clear |
| Waleed M Abdelmageed, Kaled M Elquesny, Ramadn I Shabana, Hossam M Abushama, Ahmad M Nassa. Analgesic properties of a dexmedetomidine infusion after uvulopalatopharyngoplasty in patients with obstructive sleep apnea. Saudi journal of anaesthesia. vol 5. issue 2. 2011-11-10. PMID:21804794. |
dexmedetomidine is an alpha(2) -adrenergic agonist with sedative and analgesic properties. |
2011-11-10 |
2023-08-12 |
Not clear |
| Rabie Nasr Soliman, Amira Refaie Hassan, Amr Madih Rashwan, Ahmed Mohamed Oma. Prospective, randomized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia. Middle East journal of anaesthesiology. vol 21. issue 1. 2011-10-25. PMID:21991729. |
dexmedetomidine, alpha 2 adrenoceptor agonist, is used as adjuvant to anesthetic agents. |
2011-10-25 |
2023-08-12 |
Not clear |
| Rabie Nasr Soliman, Amira Refaie Hassan, Amr Madih Rashwan, Ahmed Mohamed Oma. Prospective, randomized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia. Middle East journal of anaesthesiology. vol 21. issue 1. 2011-10-25. PMID:21991729. |
relatively recent studies have shown that dexmedetomidine is able to decrease circulating plasma norepinephrine and epinephrine concentration in approximately 50%, decreases brain blood flow by directly acting on post-synaptic alpha 2 receptors, decreases csf pressure without ischemic suffering and effectively decreases brain metabolism and intracranial pressure and also, able to decrease injury caused by focal ischemia. |
2011-10-25 |
2023-08-12 |
Not clear |
| C W Cheung, K F J Ng, J Liu, M Y V Yuen, M H A Ho, M G Irwi. Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. British journal of anaesthesia. vol 107. issue 3. 2011-10-13. PMID:21685111. |
dexmedetomidine (dex) is an alpha 2-adrenoreceptor agonist, which induces sedation and analgesia. |
2011-10-13 |
2023-08-12 |
Not clear |
| Shinji Tamagaki, Takahiro Suzuki, Satoshi Hagihira, Yukio Hayashi, Takashi Mashim. Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up-regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn. The Journal of pharmacy and pharmacology. vol 62. issue 12. 2011-05-11. PMID:21054403. |
systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up-regulation of alpha 2 adrenergic receptor subtypes a, b and c in dorsal root ganglion and dorsal horn. |
2011-05-11 |
2023-08-12 |
mouse |
| Sharanya Nama, Daniel R Meenan, William T Frit. The use of sub-anesthetic intravenous ketamine and adjuvant dexmedetomidine when treating acute pain from CRPS. Pain physician. vol 13. issue 4. 2011-03-14. PMID:20648205. |
dexmedetomidine is an alpha 2 agonist similar to clonidine with analgesic properties that can be used in combination with ketamine to provide additional analgesia in crps. |
2011-03-14 |
2023-08-12 |
Not clear |
| Emily S W Wong, Ricky Y K Man, Paul M Vanhoutte, Kwok F J N. Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. The Journal of pharmacology and experimental therapeutics. vol 335. issue 3. 2011-02-03. PMID:20837990. |
dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. |
2011-02-03 |
2023-08-12 |
rat |
| Liang Peng, Baoman Li, Ting Du, Ebenezer K C Kong, Xiaoling Hu, Shiquen Zhang, Xiaolei Shan, Meixia Zhan. Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling. Neurochemistry international. vol 57. issue 4. 2010-12-22. PMID:20450946. |
using primary cell cultures we have found that dexmedetomidine, a specific alpha(2)-adrenergic receptor, induced shedding of hb-egf from astrocytes, which in turn transactivated egf receptors and stimulated astrocytic c-fos and fosb expression. |
2010-12-22 |
2023-08-12 |
Not clear |
| Toshifumi Kosugi, Kotaro Mizuta, Tsugumi Fujita, Mikio Nakashima, Eiichi Kumamot. High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. British journal of pharmacology. vol 160. issue 7. 2010-11-30. PMID:20649570. |
high concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. |
2010-11-30 |
2023-08-12 |
Not clear |
| Toshifumi Kosugi, Kotaro Mizuta, Tsugumi Fujita, Mikio Nakashima, Eiichi Kumamot. High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. British journal of pharmacology. vol 160. issue 7. 2010-11-30. PMID:20649570. |
dexmedetomidine, an alpha(2)-adrenoceptor agonist, exhibits anti-nociceptive actions at the spinal cord and enhances the effect of local anaesthetics in the peripheral nervous system. |
2010-11-30 |
2023-08-12 |
Not clear |
| Marianne D David, Lorenzo De March. Dexmedetomidine sedation for awake tracheotomy: case report and literature review. Journal of clinical anesthesia. vol 22. issue 5. 2010-11-08. PMID:20650383. |
the safe administration of conscious sedation in a patient with a critical airway who underwent awake tracheotomy using dexmedetomidine, a selective alpha(2)-agonist with sympatholytic, anxiolytic, analgesic, and sedative properties, is presented. |
2010-11-08 |
2023-08-12 |
Not clear |
| Tina M Grof, Kathleen A Bledso. Evaluating the use of dexmedetomidine in neurocritical care patients. Neurocritical care. vol 12. issue 3. 2010-08-03. PMID:20217277. |
dexmedetomidine is a highly selective alpha(2)-adrenoreceptor agonist that produces dose-dependent sedation, anxiolysis, and analgesia without respiratory depression. |
2010-08-03 |
2023-08-12 |
Not clear |
| Bo Xu, Wei-shi Zhang, Jia-le Yang, Hua Xu, Xiao-ming Deng, Yu-qiu Zhan. Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis. Acta pharmacologica Sinica. vol 31. issue 5. 2010-06-28. PMID:20364156. |
to investigate the effect of systemic administration dexmedetomidine, a selective alpha 2 adrenergic receptor (alpha(2)ar) agonist, on thermal hyperalgesia and spinal glial activation evoked by monoarthritis (ma). |
2010-06-28 |
2023-08-12 |
rat |
| Marijke C Laarakker, Jeroen R van Raai, Hein A van Lith, Frauke Oh. The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour. Psychoneuroendocrinology. vol 35. issue 4. 2010-06-17. PMID:19766405. |
we investigated if this pathway could possibly be involved in avoidance/arousal susceptibility by applying an agonist (dexmedetomidine) and an antagonist (atipamezole) of the alpha 2a-adrenoceptor to male mice from a consomic strain (c57bl/6j-chr 19(a)/naj, abbreviated to css19=anxious), and the corresponding donor (a/j=anxious) and host (b6=non-anxious) strains. |
2010-06-17 |
2023-08-12 |
mouse |