| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
d1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
sch23390, a selective d1 dopamine antagonist, significantly increased the self-administration of cocaine when injected into the nucleus accumbens. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
these data suggest that d1 receptors in the nucleus accumbens are important for the reinforcing properties of cocaine. |
1993-07-19 |
2023-08-12 |
rat |
| C D Striplin, P W Kaliva. Robustness of G protein changes in cocaine sensitization shown with immunoblotting. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511715. |
a significant decline in gi1 alpha was seen in the nucleus accumbens at 14 days following daily cocaine administration regardless of whether they received an acute challenge with cocaine or saline 1 hr prior to decapitation. |
1993-07-15 |
2023-08-12 |
rat |
| C D Striplin, P W Kaliva. Robustness of G protein changes in cocaine sensitization shown with immunoblotting. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511715. |
no change in g protein immunoreactivity was measured in the nucleus accumbens or ventral tegmental area of rats decapitated 1 hr after discontinuing daily cocaine. |
1993-07-15 |
2023-08-12 |
rat |
| S T Cain, D Griff, C M Joyner, E H Ellinwood, C B Nemerof. Chronic continuous or intermittent infusion of cocaine differentially alter the concentration of neurotensin-like immunoreactivity in specific rat brain regions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 3. 1993-07-12. PMID:8507352. |
twenty-four hours following a single acute injection of 40 mg/kg of cocaine, nt-li was increased in the sn and nucleus accumbens. |
1993-07-12 |
2023-08-12 |
rat |
| J I Javaid, J M Davi. Cocaine disposition in discrete regions of rat brain. Biopharmaceutics & drug disposition. vol 14. issue 4. 1993-06-30. PMID:8499585. |
in rat brain, cocaine effects on striatal and nucleus accumbens dopaminergic systems show quantitative differences. |
1993-06-30 |
2023-08-12 |
rat |
| N E Goeders, J E Smit. Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8496810. |
intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. |
1993-06-22 |
2023-08-12 |
rat |
| Y L Hurd, M Herkenha. Molecular alterations in the neostriatum of human cocaine addicts. Synapse (New York, N.Y.). vol 13. issue 4. 1993-05-25. PMID:7683144. |
the greater magnitude of changes in the dorsolateral striatum (caudate and putamen) as opposed to the ventromedial striatum (nucleus accumbens) suggests that cocaine abuse preferentially alters the biosynthetic activity of striatal systems associated with sensorimotor functioning. |
1993-05-25 |
2023-08-12 |
human |
| C W Bradberry, J B Nobiletti, J D Elsworth, B Murphy, P Jatlow, R H Rot. Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8455033. |
extracellular levels of dopamine in the nucleus accumbens were increased to approximately 400% of preinjection value by both cocaine and cocaethylene when administered intravenously. |
1993-04-19 |
2023-08-12 |
rat |
| C W Bradberry, J B Nobiletti, J D Elsworth, B Murphy, P Jatlow, R H Rot. Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8455033. |
after intraperitoneal administration, extracellular levels of dopamine in the nucleus accumbens were increased to 400% of preinjection levels by cocaine, but were only increased to 200% of preinjection levels by cocaethylene, the difference being statistically significant. |
1993-04-19 |
2023-08-12 |
rat |
| F Rougé-Pont, P V Piazza, M Kharouby, M Le Moal, H Simo. Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study. Brain research. vol 602. issue 1. 1993-04-12. PMID:8448654. |
furthermore, previous studies have shown that hr animals have a higher basal dopac/da ratio in the nucleus accumbens and higher extracellular concentrations of dopamine in this structure in response to cocaine. |
1993-04-12 |
2023-08-12 |
rat |
| G A Barr, S Wan. Peripheral and central administration of cocaine produce conditioned odor preferences in the infant rat. Brain research. vol 599. issue 2. 1993-03-30. PMID:1291029. |
to assess the development of the reinforcing properties of cocaine, 3- to 4-day-old rat pups were administered cocaine s.c (3.0-30.0 mg/kg), intracerebroventricularly (3.0-10.0 micrograms/injection), or directly to the nucleus accumbens (1-25 micrograms/injection) in the presence of a distinctive odor. |
1993-03-30 |
2023-08-11 |
rat |
| L Pulvirenti, R Maldonado-Lopez, G F Koo. NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat. Brain research. vol 594. issue 2. 1993-01-07. PMID:1360323. |
nmda receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat. |
1993-01-07 |
2023-08-11 |
rat |
| F Weiss, A Markou, M T Lorang, G F Koo. Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain research. vol 593. issue 2. 1993-01-06. PMID:1450939. |
basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. |
1993-01-06 |
2023-08-11 |
rat |
| F Weiss, A Markou, M T Lorang, G F Koo. Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain research. vol 593. issue 2. 1993-01-06. PMID:1450939. |
the effects of withdrawal from cocaine on extracellular dopamine (da) levels in the nucleus accumbens (nac) were examined by intracranial microdialysis in awake rats after periods (9.5-21.75 h) of unlimited-access, intravenous cocaine self-administration. |
1993-01-06 |
2023-08-11 |
rat |
| P A Broderic. Distinguishing effects of cocaine i.v. and SC on mesoaccumbens dopamineand serotonin release with chloral hydrate anesthesia. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1448488. |
cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (da) and serotonin [5-hydroxytryptamine (5-ht)] in the mesoaccumbens nerve terminal, the nucleus accumbens (nacc), in chloral hydrate-anesthetized, male sprague-dawley rats (rattus norvegicus) with in vivo electrochemistry (voltammetry). |
1992-12-30 |
2023-08-11 |
rat |
| F Weiss, M P Paulus, M T Lorang, G F Koo. Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 11. 1992-12-11. PMID:1432099. |
increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. |
1992-12-11 |
2023-08-11 |
rat |
| F Weiss, M P Paulus, M T Lorang, G F Koo. Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 11. 1992-12-11. PMID:1432099. |
the present study was therefore designed to investigate the effects of repeated cocaine administration on basal extracellular da concentrations in the nucleus accumbens (nac) using in vivo microdialysis procedures in halothane-anesthetized rats. |
1992-12-11 |
2023-08-11 |
rat |
| A N Gifford, K M Johnso. Comparison of the role of local anesthetic properties with dopamine uptake blockade in the inhibition of striatal and nucleus accumbens [3H]acetylcholine release by cocaine. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1359115. |
comparison of the role of local anesthetic properties with dopamine uptake blockade in the inhibition of striatal and nucleus accumbens [3h]acetylcholine release by cocaine. |
1992-12-08 |
2023-08-11 |
Not clear |