| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G A Barr, S Wan. Peripheral and central administration of cocaine produce conditioned odor preferences in the infant rat. Brain research. vol 599. issue 2. 1993-03-30. PMID:1291029. |
to assess the development of the reinforcing properties of cocaine, 3- to 4-day-old rat pups were administered cocaine s.c (3.0-30.0 mg/kg), intracerebroventricularly (3.0-10.0 micrograms/injection), or directly to the nucleus accumbens (1-25 micrograms/injection) in the presence of a distinctive odor. |
1993-03-30 |
2023-08-11 |
rat |
| L Pulvirenti, R Maldonado-Lopez, G F Koo. NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat. Brain research. vol 594. issue 2. 1993-01-07. PMID:1360323. |
nmda receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat. |
1993-01-07 |
2023-08-11 |
rat |
| F Weiss, A Markou, M T Lorang, G F Koo. Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain research. vol 593. issue 2. 1993-01-06. PMID:1450939. |
basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. |
1993-01-06 |
2023-08-11 |
rat |
| F Weiss, A Markou, M T Lorang, G F Koo. Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain research. vol 593. issue 2. 1993-01-06. PMID:1450939. |
the effects of withdrawal from cocaine on extracellular dopamine (da) levels in the nucleus accumbens (nac) were examined by intracranial microdialysis in awake rats after periods (9.5-21.75 h) of unlimited-access, intravenous cocaine self-administration. |
1993-01-06 |
2023-08-11 |
rat |
| P A Broderic. Distinguishing effects of cocaine i.v. and SC on mesoaccumbens dopamineand serotonin release with chloral hydrate anesthesia. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1448488. |
cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (da) and serotonin [5-hydroxytryptamine (5-ht)] in the mesoaccumbens nerve terminal, the nucleus accumbens (nacc), in chloral hydrate-anesthetized, male sprague-dawley rats (rattus norvegicus) with in vivo electrochemistry (voltammetry). |
1992-12-30 |
2023-08-11 |
rat |
| F Weiss, M P Paulus, M T Lorang, G F Koo. Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 11. 1992-12-11. PMID:1432099. |
increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. |
1992-12-11 |
2023-08-11 |
rat |
| F Weiss, M P Paulus, M T Lorang, G F Koo. Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 11. 1992-12-11. PMID:1432099. |
the present study was therefore designed to investigate the effects of repeated cocaine administration on basal extracellular da concentrations in the nucleus accumbens (nac) using in vivo microdialysis procedures in halothane-anesthetized rats. |
1992-12-11 |
2023-08-11 |
rat |
| A N Gifford, K M Johnso. Comparison of the role of local anesthetic properties with dopamine uptake blockade in the inhibition of striatal and nucleus accumbens [3H]acetylcholine release by cocaine. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1359115. |
comparison of the role of local anesthetic properties with dopamine uptake blockade in the inhibition of striatal and nucleus accumbens [3h]acetylcholine release by cocaine. |
1992-12-08 |
2023-08-11 |
Not clear |
| A N Gifford, K M Johnso. Comparison of the role of local anesthetic properties with dopamine uptake blockade in the inhibition of striatal and nucleus accumbens [3H]acetylcholine release by cocaine. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1359115. |
in the nucleus accumbens cocaine was about 5-fold less potent at inhibiting ach release than in the striatum and sulpiride was much less effective at reversing the inhibitory effect of cocaine, suggesting that the local anesthetic effects of cocaine play a greater role in regulating ach release in this area relative to dopamine uptake blockade. |
1992-12-08 |
2023-08-11 |
Not clear |
| J M Ackerman, F J Whit. Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine. European journal of pharmacology. vol 218. issue 1. 1992-11-20. PMID:1397028. |
this decreased activity may underlie the diminished basal levels of synaptic da within the nucleus accumbens previously reported in cocaine-withdrawn rats and may account for anhedonia, anergia and cocaine craving reported by withdrawn cocaine addicts. |
1992-11-20 |
2023-08-11 |
rat |
| E E Brown, G S Robertson, H C Fibige. Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 10. 1992-11-18. PMID:1403102. |
consistent with its stimulant actions, cocaine produced an increase in locomotion that was accompanied by an increase in fos expression within specific limbic regions (cingulate cortex, claustrum, piriform cortex, lateral septal nucleus, paraventricular nucleus of the thalamus, lateral habenula, and amygdala) as well as the basal ganglia (dorsomedial striatum and nucleus accumbens). |
1992-11-18 |
2023-08-11 |
human |
| E E Brown, G S Robertson, H C Fibige. Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 10. 1992-11-18. PMID:1403102. |
although the nucleus accumbens is necessary for the reinforcing and locomotor effects of cocaine, it does not exhibit a conditional fos response, suggesting that different neural circuits are involved in the unconditioned and conditioned effects of cocaine. |
1992-11-18 |
2023-08-11 |
human |
| J Peris, M Coleman-Hardee, W J Millar. Cocaine in utero enhances the behavioral response to cocaine in adult rats. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409782. |
neither cocaine in utero nor in vivo affected d2 da receptor binding in striatum nor nucleus accumbens. |
1992-11-18 |
2023-08-11 |
rat |
| Z Sarnyai, M Vecsernyés, F Laczi, E Bíró, G Szabó, G L Kovác. Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats. Neuropeptides. vol 23. issue 1. 1992-11-06. PMID:1407414. |
the oxt levels in the basal forebrain structures (including the septum and the nucleus accumbens) were decreased by a single dose of cocaine. |
1992-11-06 |
2023-08-11 |
rat |
| R D Mayfield, G Larson, N R Zahnise. Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum. Brain research. vol 573. issue 2. 1992-09-18. PMID:1387030. |
based on electrophysiological data showing that repeated cocaine administration produces persistent enhancement of d1 dopamine (da) receptor-mediated responses in nucleus accumbens (nac), we investigated whether changes in neurochemical properties of these receptors resulted when rats were injected with cocaine (15 mg/kg) for 6 days followed by a 7-day abstinence period. |
1992-09-18 |
2023-08-11 |
rat |
| H C Fibiger, A G Phillips, E E Brow. The neurobiology of cocaine-induced reinforcement. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638924. |
the introduction of in vivo brain microdialysis as a tool with which to investigate the neurochemical correlates of motivated behaviour has provided new opportunities for investigating the role of dopamine in the nucleus accumbens in the acquisition and maintenance of cocaine self-administration. |
1992-09-03 |
2023-08-11 |
Not clear |
| N S Pilotte, W M Mitchell, L G Sharpe, E B De Souza, E M Da. Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821482. |
nt binding in the nucleus accumbens was unaffected by cocaine or its withdrawal. |
1992-08-19 |
2023-08-11 |
rat |
| M S Hooks, G H Jones, A D Smith, D B Neill, J B Justic. Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821483. |
response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. |
1992-08-19 |
2023-08-11 |
human |
| P Robledo, R Maldonado-Lopez, G F Koo. Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1385935. |
role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. |
1992-08-17 |
2023-08-11 |
Not clear |
| N R Zahniser, R D Mayfield, W A Cass, G A Gerhard. Cocaine administration: D1 dopamine receptor function and dopamine clearance/diffusion in rat striatum and nucleus accumbens. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1385936. |
cocaine administration: d1 dopamine receptor function and dopamine clearance/diffusion in rat striatum and nucleus accumbens. |
1992-08-17 |
2023-08-11 |
rat |