| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L G Sharpe, N S Pilotte, W M Mitchell, E B De Souz. Withdrawal of repeated cocaine decreases autoradiographic [3H]mazindol-labelling of dopamine transporter in rat nucleus accumbens. European journal of pharmacology. vol 203. issue 1. 1992-04-16. PMID:1797552. |
down-regulation of the dopamine transporter in the nucleus accumbens by withdrawal of chronic cocaine may be one of the mechanisms involved in cocaine's long-term abstinence effects. |
1992-04-16 |
2023-08-11 |
rat |
| L H Parsons, A D Smith, J B Justic. Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse (New York, N.Y.). vol 9. issue 1. 1992-04-08. PMID:1796352. |
basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. |
1992-04-08 |
2023-08-11 |
rat |
| L H Parsons, A D Smith, J B Justic. Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse (New York, N.Y.). vol 9. issue 1. 1992-04-08. PMID:1796352. |
after 1 day of abstinence, there was no significant difference in basal da levels in the nucleus accumbens (n acc) between cocaine treated (4.1 +/- 0.3 nm; mean +/- sem) and saline-treated (3.9 +/- 0.2 nm) groups. |
1992-04-08 |
2023-08-11 |
rat |
| L Hernandez, N A Guzman, B G Hoebe. Bidirectional microdialysis in vivo shows differential dopaminergic potency of cocaine, procaine and lidocaine in the nucleus accumbens using capillary electrophoresis for calibration of drug outward diffusion. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1796132. |
bidirectional microdialysis in vivo shows differential dopaminergic potency of cocaine, procaine and lidocaine in the nucleus accumbens using capillary electrophoresis for calibration of drug outward diffusion. |
1992-04-07 |
2023-08-11 |
rat |
| L Hernandez, N A Guzman, B G Hoebe. Bidirectional microdialysis in vivo shows differential dopaminergic potency of cocaine, procaine and lidocaine in the nucleus accumbens using capillary electrophoresis for calibration of drug outward diffusion. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1796132. |
cocaine and two other local anesthetics were applied directly into the nucleus accumbens for 20 min by diffusion from a 4 mm microdialysis probe in freely moving rats. |
1992-04-07 |
2023-08-11 |
rat |
| L Hernandez, N A Guzman, B G Hoebe. Bidirectional microdialysis in vivo shows differential dopaminergic potency of cocaine, procaine and lidocaine in the nucleus accumbens using capillary electrophoresis for calibration of drug outward diffusion. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1796132. |
this suggests that in vivo about 68 nmol cocaine diffused into the nucleus accumbens (nac) during the 20 min. |
1992-04-07 |
2023-08-11 |
rat |
| B A Sorg, P W Kaliva. Effects of cocaine and footshock stress on extracellular dopamine levels in the ventral striatum. Brain research. vol 559. issue 1. 1992-03-19. PMID:1782559. |
the effects of stress and cocaine on extracellular levels of dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva), were measured by in vivo microdialysis in the rostral ventral striatum, including the nucleus accumbens. |
1992-03-19 |
2023-08-11 |
rat |
| S Izenwasser, J G Rosenberger, B M Co. Inhibition of [3H]dopamine and [3H]serotonin uptake by cocaine: comparison between chopped tissue slices and synaptosomes. Life sciences. vol 50. issue 8. 1992-03-12. PMID:1736024. |
cocaine inhibits both [3h]dopamine and [3h]serotonin uptake in rat striatum and nucleus accumbens. |
1992-03-12 |
2023-08-11 |
rat |
| N E Goeder. Cocaine differentially affects benzodiazepine receptors in discrete regions of the rat brain: persistence and potential mechanisms mediating these effects. The Journal of pharmacology and experimental therapeutics. vol 259. issue 2. 1991-12-24. PMID:1658304. |
bzd receptor binding was increased significantly in the caudate nucleus and decreased in the substantia nigra for up to 2 days after the final injection, whereas binding was decreased in the nucleus accumbens and medial prefrontal cortex and increased in the ventral tegmental area after daily injections of cocaine for 15 days. |
1991-12-24 |
2023-08-11 |
rat |
| D J Henry, F J Whit. Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1890623. |
repeated cocaine administration causes persistent enhancement of d1 dopamine receptor sensitivity within the rat nucleus accumbens. |
1991-10-17 |
2023-08-11 |
rat |
| D J Henry, F J Whit. Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1890623. |
the rewarding effects of cocaine are mediated primarily by the mesoaccumbens dopamine (da) system, which projects from a10 da cell bodies within the ventral tegmental area to the nucleus accumbens (nac). |
1991-10-17 |
2023-08-11 |
rat |
| R Kuczenski, D S Segal, M L Aizenstei. Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 9. 1991-10-03. PMID:1715389. |
using in vivo microdialysis, the caudate and nucleus accumbens dopamine (da) responses to the psychomotor stimulants amphetamine (amph), cocaine (coc), and fencamfamine (fcf) were evaluated in rats concurrent with characterization of their behavioral response profiles. |
1991-10-03 |
2023-08-11 |
rat |
| L Hernandez, N A Guzman, B G Hoebe. Differential dopaminergic potency of cocaine, procaine and lidocaine infused locally in the nucleus accumbens in vivo with calibration by capillary electrophoresis in vitro. NIDA research monograph. vol 105. 1991-09-20. PMID:1678870. |
differential dopaminergic potency of cocaine, procaine and lidocaine infused locally in the nucleus accumbens in vivo with calibration by capillary electrophoresis in vitro. |
1991-09-20 |
2023-08-11 |
Not clear |
| J D Steketee, C D Striplin, T F Murray, P W Kaliva. Possible role for G-proteins in behavioral sensitization to cocaine. Brain research. vol 545. issue 1-2. 1991-08-30. PMID:1907213. |
the capacity of acute cocaine to increase motor activity and dopamine release in the nucleus accumbens was significantly augmented in rats pretreated 14 days earlier with ptx. |
1991-08-30 |
2023-08-11 |
rat |
| D Beitner-Johnson, E J Nestle. Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. Journal of neurochemistry. vol 57. issue 1. 1991-07-23. PMID:1675665. |
we studied levels of tyrosine hydroxylase immunoreactivity and phosphorylation state in the ventral tegmental area (vta) and nucleus accumbens (nac) in an effort to understand better the mechanisms by which these brain reward regions are influenced by opiates and cocaine. |
1991-07-23 |
2023-08-11 |
Not clear |
| P Jatlow, J D Elsworth, C W Bradberry, G Winger, J R Taylor, R Russell, R H Rot. Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion. Life sciences. vol 48. issue 18. 1991-05-30. PMID:2020260. |
ec was equipotent to cocaine with respect to inhibition of binding of [3h]gbr 12935 to the dopamine reuptake complex, inhibition of [3h]dopamine uptake into synaptosomes and in its ability to increase extracellular dopamine concentration in the nucleus accumbens following its systemic administration to rats. |
1991-05-30 |
2023-08-11 |
rat |
| H O Pettit, J B Justic. Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain research. vol 539. issue 1. 1991-05-22. PMID:2015506. |
effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. |
1991-05-22 |
2023-08-11 |
Not clear |
| H O Pettit, J B Justic. Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain research. vol 539. issue 1. 1991-05-22. PMID:2015506. |
the reinforcing properties of cocaine are thought to be primarily mediated by the release of dopamine (da) in the nucleus accumbens (n acc). |
1991-05-22 |
2023-08-11 |
Not clear |
| M W Robertson, C A Leslie, J P Bennet. Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment. Brain research. vol 538. issue 2. 1991-05-16. PMID:2012975. |
the effects on motor behavior and forebrain dopamine (da) synaptic function of withdrawal from chronic cocaine treatment were examined with simultaneous activity monitoring and microdialysis in nucleus accumbens. |
1991-05-16 |
2023-08-11 |
rat |
| J P Ng, G W Hubert, J B Justic. Increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltammetry. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:2013751. |
increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltammetry. |
1991-05-16 |
2023-08-11 |
rat |