| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Trulson, J C Joe, S Babb, J D Raes. Chronic cocaine administration depletes tyrosine hydroxylase immunoreactivity in the meso-limbic dopamine system in rat brain: quantitative light microscopic studies. Brain research bulletin. vol 19. issue 1. 1987-11-20. PMID:2888517. |
chronic administration of cocaine (10 mg/kg, ip, every 12 hours for 10 consecutive days) produced a large decrease in tyrosine hydroxylase staining axons and terminal boutons in the frontal cortex and nucleus accumbens in rats. |
1987-11-20 |
2023-08-11 |
rat |
| N E Goeders, M J Kuha. Chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens. Alcohol and drug research. vol 7. issue 4. 1987-05-21. PMID:2950865. |
chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens. |
1987-05-21 |
2023-08-11 |
rat |
| K A Zito, G Vickers, D C Robert. Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 23. issue 6. 1986-02-19. PMID:3936058. |
disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. |
1986-02-19 |
2023-08-11 |
rat |
| K A Zito, G Vickers, D C Robert. Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 23. issue 6. 1986-02-19. PMID:3936058. |
in previous experiments we have demonstrated that bilateral infusions of 6-hydroxydopamine (6-ohda) into the nucleus accumbens result in a drastic reduction in the rate of cocaine self-administration. |
1986-02-19 |
2023-08-11 |
rat |
| C Missale, L Castelletti, S Govoni, P F Spano, M Trabucchi, I Hanbaue. Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens. Journal of neurochemistry. vol 45. issue 1. 1985-07-17. PMID:3998732. |
moreover na+-dependent [3h]cocaine binding is not detectable in nucleus accumbens. |
1985-07-17 |
2023-08-11 |
rat |
| R A Wis. Neural mechanisms of the reinforcing action of cocaine. NIDA research monograph. vol 50. 1985-01-31. PMID:6440023. |
the action responsible for the rewarding property, and hence the abuse liability, of cocaine is an action in the dopaminergic synapse; in the rat the major set of critical dopaminergic synapses appears to be in the nucleus accumbens. |
1985-01-31 |
2023-08-12 |
human |
| H O Pettit, A Ettenberg, F E Bloom, G F Koo. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology. vol 84. issue 2. 1985-01-18. PMID:6438676. |
destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. |
1985-01-18 |
2023-08-12 |
rat |
| H O Pettit, A Ettenberg, F E Bloom, G F Koo. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology. vol 84. issue 2. 1985-01-18. PMID:6438676. |
after local destruction of the da terminals in the nucleus accumbens (nacc) with 6-hydroxydopamine (6-ohda), rats trained to self-administer cocaine and heroin on alternate days were observed for changes in their drug-seeking behaviors. |
1985-01-18 |
2023-08-12 |
rat |
| H O Pettit, A Ettenberg, F E Bloom, G F Koo. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology. vol 84. issue 2. 1985-01-18. PMID:6438676. |
thus, selective lesions of the da terminals in the nucleus accumbens significantly attenuate cocaine but not heroin self-administration. |
1985-01-18 |
2023-08-12 |
rat |
| C Missale, F Battaini, S Govoni, L Castelletti, P F Spano, M Trabucch. Chronic lead exposure differentially affects dopamine transport in rat striatum and nucleus accumbens. Toxicology. vol 33. issue 1. 1984-11-27. PMID:6495347. |
cocaine binding, that is related to the uptake system, appeared to be down-regulated in the striatum and unaffected in the nucleus accumbens. |
1984-11-27 |
2023-08-12 |
rat |
| D C Roberts, M E Corcoran, H C Fibige. On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine. Pharmacology, biochemistry, and behavior. vol 6. issue 6. 1984-06-21. PMID:122445. |
lesions of the nucleus accumbens that reduced the da content of this nucleus by 90% resulted in a significant and long-lasting (15 days) reduction in self-administration of cocaine. |
1984-06-21 |
2023-08-11 |
rat |
| A G Phillips, C L Broekkamp, H C Fibige. Strategies for studying the neurochemical substrates of drug reinforcement in rodents. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 4-6. 1984-03-08. PMID:6686695. |
intravenous self-administration of cocaine is blocked by intracerebral microinjection of spiroperidol into the nucleus accumbens but not into the caudate nucleus. |
1984-03-08 |
2023-08-12 |
Not clear |
| J A Nielsen, D S Chapin, K E Moor. Differential effects of d-amphetamine, beta-phenylethylamine, cocaine and methylphenidate on the rate of dopamine synthesis in terminals of nigrostriatal and mesolimbic neurons and on the efflux of dopamine metabolites into cerebroventricular perfusates of rats. Life sciences. vol 33. issue 19. 1984-01-27. PMID:6645784. |
the in vivo effects of four psychomotor stimulants (d-amphetamine, beta-phenylethylamine, cocaine and methylphenidate) were determined on: 1) the rate of dopamine (da) synthesis, as measured by the accumulation of dihydroxyphenylalanine (dopa) after aromatic l-amino acid decarboxylase inhibition, in the striatum (terminals of nigrostriatal neurons) and in the nucleus accumbens and olfactory tubercle (terminals of mesolimbic neurons) and 2) the efflux of the da metabolite 3,4-dihydroxyphenylacetic acid (dopac) into cerebroventricular perfusates of conscious, freely-moving rats. |
1984-01-27 |
2023-08-12 |
rat |
| D C Roberts, G F Koo. Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats. Pharmacology, biochemistry, and behavior. vol 17. issue 5. 1983-02-25. PMID:6817350. |
6-hydroxydopamine-induced destruction of dopaminergic terminals in the nucleus accumbens have been shown previously to disrupt cocaine and amphetamine self-administration. |
1983-02-25 |
2023-08-12 |
rat |
| D C Roberts, G F Koob, P Klonoff, H C Fibige. Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 12. issue 5. 1980-09-28. PMID:7393973. |
extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. |
1980-09-28 |
2023-08-12 |
Not clear |