| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P W Kalivas, P Duffy, L A DuMars, C Skinne. Behavioral and neurochemical effects of acute and daily cocaine administration in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:3130474. |
acute injection with cocaine was found to significantly depress dopa accumulation in the a10 region, nucleus accumbens and striatum. |
1988-06-16 |
2023-08-11 |
rat |
| P W Kalivas, P Duffy, L A DuMars, C Skinne. Behavioral and neurochemical effects of acute and daily cocaine administration in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:3130474. |
x 3 days), but remained intact in the nucleus accumbens and striatum, except after daily pretreatment with the highest dose of cocaine. |
1988-06-16 |
2023-08-11 |
rat |
| L Hernandez, B G Hoebe. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life sciences. vol 42. issue 18. 1988-06-03. PMID:3362036. |
food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. |
1988-06-03 |
2023-08-11 |
rat |
| L Hernandez, B G Hoebe. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life sciences. vol 42. issue 18. 1988-06-03. PMID:3362036. |
at the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine five-fold. |
1988-06-03 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361305. |
in contrast, the release of dopamine from the nucleus accumbens and striatum was either unaltered or slightly enhanced in rats pretreated with cocaine and morphine. |
1988-06-02 |
2023-08-11 |
rat |
| L A DuMars, L D Rodger, P W Kaliva. Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region. Behavioural brain research. vol 27. issue 1. 1988-04-05. PMID:3342116. |
the motor stimulant effect produced by cocaine and the injection of opioids onto a10 dopamine neurons is thought to be mediated by an increase in dopaminergic transmission in mesolimbic dopamine terminal fields such as the nucleus accumbens. |
1988-04-05 |
2023-08-11 |
rat |
| R A Wise, M A Bozart. Brain mechanisms of drug reward and euphoria. Psychiatric medicine. vol 3. issue 4. 1988-03-18. PMID:2893431. |
cocaine and amphetamine act at the terminals of the dopaminergic fibers to nucleus accumbens and perhaps other structures. |
1988-03-18 |
2023-08-11 |
Not clear |
| L C Einhorn, P A Johansen, F J Whit. Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339402. |
this effect was not observed with iontophoretically administered procaine iontophoresis of cocaine also significantly potentiated the inhibition of a10 da activity caused by electrical stimulation of the nucleus accumbens (nac). |
1988-03-08 |
2023-08-11 |
rat |
| M E Trulson, J C Joe, S Babb, J D Raes. Chronic cocaine administration depletes tyrosine hydroxylase immunoreactivity in the meso-limbic dopamine system in rat brain: quantitative light microscopic studies. Brain research bulletin. vol 19. issue 1. 1987-11-20. PMID:2888517. |
chronic administration of cocaine (10 mg/kg, ip, every 12 hours for 10 consecutive days) produced a large decrease in tyrosine hydroxylase staining axons and terminal boutons in the frontal cortex and nucleus accumbens in rats. |
1987-11-20 |
2023-08-11 |
rat |
| N E Goeders, M J Kuha. Chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens. Alcohol and drug research. vol 7. issue 4. 1987-05-21. PMID:2950865. |
chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens. |
1987-05-21 |
2023-08-11 |
rat |
| K A Zito, G Vickers, D C Robert. Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 23. issue 6. 1986-02-19. PMID:3936058. |
disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. |
1986-02-19 |
2023-08-11 |
rat |
| K A Zito, G Vickers, D C Robert. Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 23. issue 6. 1986-02-19. PMID:3936058. |
in previous experiments we have demonstrated that bilateral infusions of 6-hydroxydopamine (6-ohda) into the nucleus accumbens result in a drastic reduction in the rate of cocaine self-administration. |
1986-02-19 |
2023-08-11 |
rat |
| C Missale, L Castelletti, S Govoni, P F Spano, M Trabucchi, I Hanbaue. Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens. Journal of neurochemistry. vol 45. issue 1. 1985-07-17. PMID:3998732. |
moreover na+-dependent [3h]cocaine binding is not detectable in nucleus accumbens. |
1985-07-17 |
2023-08-11 |
rat |
| R A Wis. Neural mechanisms of the reinforcing action of cocaine. NIDA research monograph. vol 50. 1985-01-31. PMID:6440023. |
the action responsible for the rewarding property, and hence the abuse liability, of cocaine is an action in the dopaminergic synapse; in the rat the major set of critical dopaminergic synapses appears to be in the nucleus accumbens. |
1985-01-31 |
2023-08-12 |
human |
| H O Pettit, A Ettenberg, F E Bloom, G F Koo. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology. vol 84. issue 2. 1985-01-18. PMID:6438676. |
destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. |
1985-01-18 |
2023-08-12 |
rat |
| H O Pettit, A Ettenberg, F E Bloom, G F Koo. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology. vol 84. issue 2. 1985-01-18. PMID:6438676. |
after local destruction of the da terminals in the nucleus accumbens (nacc) with 6-hydroxydopamine (6-ohda), rats trained to self-administer cocaine and heroin on alternate days were observed for changes in their drug-seeking behaviors. |
1985-01-18 |
2023-08-12 |
rat |
| H O Pettit, A Ettenberg, F E Bloom, G F Koo. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology. vol 84. issue 2. 1985-01-18. PMID:6438676. |
thus, selective lesions of the da terminals in the nucleus accumbens significantly attenuate cocaine but not heroin self-administration. |
1985-01-18 |
2023-08-12 |
rat |
| C Missale, F Battaini, S Govoni, L Castelletti, P F Spano, M Trabucch. Chronic lead exposure differentially affects dopamine transport in rat striatum and nucleus accumbens. Toxicology. vol 33. issue 1. 1984-11-27. PMID:6495347. |
cocaine binding, that is related to the uptake system, appeared to be down-regulated in the striatum and unaffected in the nucleus accumbens. |
1984-11-27 |
2023-08-12 |
rat |
| D C Roberts, M E Corcoran, H C Fibige. On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine. Pharmacology, biochemistry, and behavior. vol 6. issue 6. 1984-06-21. PMID:122445. |
lesions of the nucleus accumbens that reduced the da content of this nucleus by 90% resulted in a significant and long-lasting (15 days) reduction in self-administration of cocaine. |
1984-06-21 |
2023-08-11 |
rat |
| A G Phillips, C L Broekkamp, H C Fibige. Strategies for studying the neurochemical substrates of drug reinforcement in rodents. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 4-6. 1984-03-08. PMID:6686695. |
intravenous self-administration of cocaine is blocked by intracerebral microinjection of spiroperidol into the nucleus accumbens but not into the caudate nucleus. |
1984-03-08 |
2023-08-12 |
Not clear |