| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N E Goeder. Cocaine differentially affects benzodiazepine receptors in discrete regions of the rat brain: persistence and potential mechanisms mediating these effects. The Journal of pharmacology and experimental therapeutics. vol 259. issue 2. 1991-12-24. PMID:1658304. |
bzd receptor binding was increased significantly in the caudate nucleus and decreased in the substantia nigra for up to 2 days after the final injection, whereas binding was decreased in the nucleus accumbens and medial prefrontal cortex and increased in the ventral tegmental area after daily injections of cocaine for 15 days. |
1991-12-24 |
2023-08-11 |
rat |
| D J Henry, F J Whit. Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1890623. |
repeated cocaine administration causes persistent enhancement of d1 dopamine receptor sensitivity within the rat nucleus accumbens. |
1991-10-17 |
2023-08-11 |
rat |
| D J Henry, F J Whit. Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1890623. |
the rewarding effects of cocaine are mediated primarily by the mesoaccumbens dopamine (da) system, which projects from a10 da cell bodies within the ventral tegmental area to the nucleus accumbens (nac). |
1991-10-17 |
2023-08-11 |
rat |
| R Kuczenski, D S Segal, M L Aizenstei. Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 9. 1991-10-03. PMID:1715389. |
using in vivo microdialysis, the caudate and nucleus accumbens dopamine (da) responses to the psychomotor stimulants amphetamine (amph), cocaine (coc), and fencamfamine (fcf) were evaluated in rats concurrent with characterization of their behavioral response profiles. |
1991-10-03 |
2023-08-11 |
rat |
| L Hernandez, N A Guzman, B G Hoebe. Differential dopaminergic potency of cocaine, procaine and lidocaine infused locally in the nucleus accumbens in vivo with calibration by capillary electrophoresis in vitro. NIDA research monograph. vol 105. 1991-09-20. PMID:1678870. |
differential dopaminergic potency of cocaine, procaine and lidocaine infused locally in the nucleus accumbens in vivo with calibration by capillary electrophoresis in vitro. |
1991-09-20 |
2023-08-11 |
Not clear |
| J D Steketee, C D Striplin, T F Murray, P W Kaliva. Possible role for G-proteins in behavioral sensitization to cocaine. Brain research. vol 545. issue 1-2. 1991-08-30. PMID:1907213. |
the capacity of acute cocaine to increase motor activity and dopamine release in the nucleus accumbens was significantly augmented in rats pretreated 14 days earlier with ptx. |
1991-08-30 |
2023-08-11 |
rat |
| D Beitner-Johnson, E J Nestle. Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. Journal of neurochemistry. vol 57. issue 1. 1991-07-23. PMID:1675665. |
we studied levels of tyrosine hydroxylase immunoreactivity and phosphorylation state in the ventral tegmental area (vta) and nucleus accumbens (nac) in an effort to understand better the mechanisms by which these brain reward regions are influenced by opiates and cocaine. |
1991-07-23 |
2023-08-11 |
Not clear |
| P Jatlow, J D Elsworth, C W Bradberry, G Winger, J R Taylor, R Russell, R H Rot. Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion. Life sciences. vol 48. issue 18. 1991-05-30. PMID:2020260. |
ec was equipotent to cocaine with respect to inhibition of binding of [3h]gbr 12935 to the dopamine reuptake complex, inhibition of [3h]dopamine uptake into synaptosomes and in its ability to increase extracellular dopamine concentration in the nucleus accumbens following its systemic administration to rats. |
1991-05-30 |
2023-08-11 |
rat |
| H O Pettit, J B Justic. Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain research. vol 539. issue 1. 1991-05-22. PMID:2015506. |
effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. |
1991-05-22 |
2023-08-11 |
Not clear |
| H O Pettit, J B Justic. Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain research. vol 539. issue 1. 1991-05-22. PMID:2015506. |
the reinforcing properties of cocaine are thought to be primarily mediated by the release of dopamine (da) in the nucleus accumbens (n acc). |
1991-05-22 |
2023-08-11 |
Not clear |
| M W Robertson, C A Leslie, J P Bennet. Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment. Brain research. vol 538. issue 2. 1991-05-16. PMID:2012975. |
the effects on motor behavior and forebrain dopamine (da) synaptic function of withdrawal from chronic cocaine treatment were examined with simultaneous activity monitoring and microdialysis in nucleus accumbens. |
1991-05-16 |
2023-08-11 |
rat |
| J P Ng, G W Hubert, J B Justic. Increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltammetry. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:2013751. |
increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltammetry. |
1991-05-16 |
2023-08-11 |
rat |
| J P Ng, G W Hubert, J B Justic. Increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltammetry. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:2013751. |
electrically stimulated dopamine (da) release (overflow) and uptake were measured with in vivo voltammetry in the nucleus accumbens (n acc) of anesthetized rats that had previously received repeated cocaine treatments. |
1991-05-16 |
2023-08-11 |
rat |
| C Wahlestedt, F Karoum, G Jaskiw, R J Wyatt, D Larhammar, R Ekman, D J Rei. Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 6. 1991-04-25. PMID:2006146. |
repeated administration of cocaine elicits substantial, long-lasting, but reversible reductions in neuropeptide y (npy) and npy mrna in the rat cerebral cortex and nucleus accumbens. |
1991-04-25 |
2023-08-11 |
rat |
| D W Clow, R P Hamme. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 4. issue 1. 1991-04-22. PMID:2003868. |
cocaine abstinence following chronic treatment significantly reduced lcgu in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (nac). |
1991-04-22 |
2023-08-11 |
rat |
| J W Brock, J P Ng, J B Justic. Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2127087. |
effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with nsd-1015. |
1991-04-01 |
2023-08-11 |
rat |
| J W Brock, J P Ng, J B Justic. Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2127087. |
reduced steady state formation of dihydroxyphenylalanine (dopa) (47%) was found in the nucleus accumbens (n. acc) of rats treated with ten days of repeated cocaine (10 mg/kg, i.p.) |
1991-04-01 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2289133. |
daily cocaine treatment produces a persistent reduction of [3h]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. |
1991-04-01 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2289133. |
furthermore, cocaine was a more potent inhibitor of [3h]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline. |
1991-04-01 |
2023-08-11 |
rat |
| M S Kleven, B D Perry, W L Woolverton, L S Seide. Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain. Brain research. vol 532. issue 1-2. 1991-03-21. PMID:2149299. |
in contrast to these effects on d1 binding sites, d2 binding sites were decreased in striatum and frontal cortex and increased in the nucleus accumbens 20 min after repeated cocaine, but were unaffected 2 weeks after repeated cocaine. |
1991-03-21 |
2023-08-11 |
rat |