| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Ng, G W Hubert, J B Justic. Increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltammetry. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:2013751. |
electrically stimulated dopamine (da) release (overflow) and uptake were measured with in vivo voltammetry in the nucleus accumbens (n acc) of anesthetized rats that had previously received repeated cocaine treatments. |
1991-05-16 |
2023-08-11 |
rat |
| C Wahlestedt, F Karoum, G Jaskiw, R J Wyatt, D Larhammar, R Ekman, D J Rei. Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 6. 1991-04-25. PMID:2006146. |
repeated administration of cocaine elicits substantial, long-lasting, but reversible reductions in neuropeptide y (npy) and npy mrna in the rat cerebral cortex and nucleus accumbens. |
1991-04-25 |
2023-08-11 |
rat |
| D W Clow, R P Hamme. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 4. issue 1. 1991-04-22. PMID:2003868. |
cocaine abstinence following chronic treatment significantly reduced lcgu in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (nac). |
1991-04-22 |
2023-08-11 |
rat |
| J W Brock, J P Ng, J B Justic. Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2127087. |
effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with nsd-1015. |
1991-04-01 |
2023-08-11 |
rat |
| J W Brock, J P Ng, J B Justic. Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2127087. |
reduced steady state formation of dihydroxyphenylalanine (dopa) (47%) was found in the nucleus accumbens (n. acc) of rats treated with ten days of repeated cocaine (10 mg/kg, i.p.) |
1991-04-01 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2289133. |
daily cocaine treatment produces a persistent reduction of [3h]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. |
1991-04-01 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2289133. |
furthermore, cocaine was a more potent inhibitor of [3h]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline. |
1991-04-01 |
2023-08-11 |
rat |
| M S Kleven, B D Perry, W L Woolverton, L S Seide. Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain. Brain research. vol 532. issue 1-2. 1991-03-21. PMID:2149299. |
in contrast to these effects on d1 binding sites, d2 binding sites were decreased in striatum and frontal cortex and increased in the nucleus accumbens 20 min after repeated cocaine, but were unaffected 2 weeks after repeated cocaine. |
1991-03-21 |
2023-08-11 |
rat |
| M S Kleven, B D Perry, W L Woolverton, L S Seide. Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain. Brain research. vol 532. issue 1-2. 1991-03-21. PMID:2149299. |
furthermore, cocaine caused opposite, transient effects on d1 and d2 site density in nucleus accumbens. |
1991-03-21 |
2023-08-11 |
rat |
| F Karoum, R L Suddath, R J Wyat. Chronic cocaine and rat brain catecholamines: long-term reduction in hypothalamic and frontal cortex dopamine metabolism. European journal of pharmacology. vol 186. issue 1. 1991-03-15. PMID:2282931. |
the short-term reductions in da metabolism observed in the striatum and nucleus accumbens disappeared within one week of termination of cocaine treatment. |
1991-03-15 |
2023-08-11 |
rat |
| S Izenwasser, L L Werling, B M Co. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2145054. |
cocaine, gbr 12909, amfonelic acid, and methylphenidate each biphasically inhibited uptake in the striatum, nucleus accumbens and olfactory tubercle with gbr 12909 and amfonelic acid being approximately 50-fold more potent than cocaine or methylphenidate. |
1990-11-14 |
2023-08-11 |
rat |
| Z J Yu, D K Lim, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: I. Levels of dopamine and metabolites. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215853. |
effects of acute and subacute cocaine administration on dopamine (da) and its metabolites in striata and nucleus accumbens of nine week-old wistar-kyoto and spontaneously hypertensive rats were studied. |
1990-11-01 |
2023-08-11 |
rat |
| Z J Yu, D K Lim, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: I. Levels of dopamine and metabolites. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215853. |
however, only wky treated subacutely with cocaine showed significantly increased hva either with or without changes in dopac in nucleus accumbens and striatum, respectively. |
1990-11-01 |
2023-08-11 |
rat |
| Z J Yu, D K Lim, B Hoskins, R W Rockhold, I K H. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: I. Levels of dopamine and metabolites. Neurochemical research. vol 15. issue 6. 1990-11-01. PMID:2215853. |
these results suggest that subacute cocaine administration affects da levels in striata and nucleus accumbens differently between wky and shr. |
1990-11-01 |
2023-08-11 |
rat |
| W J Freed, H E Cannon-Spoo. A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects. Psychopharmacology. vol 101. issue 4. 1990-09-27. PMID:1975105. |
gdee, an antagonist of the aa2 or quisqualic acid category of excitatory amino acid receptor, decreases behavioral activity and locomotor stimulation induced by cocaine and amphetamine when locally injected into the nucleus accumbens. |
1990-09-27 |
2023-08-11 |
Not clear |
| E J Nestler, R Z Terwilliger, J R Walker, K A Sevarino, R S Duma. Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain. Journal of neurochemistry. vol 55. issue 3. 1990-09-17. PMID:2117048. |
chronic cocaine also had no effect on levels of gs alpha or g beta immunoreactivity in the ventral tegmental area and nucleus accumbens. |
1990-09-17 |
2023-08-11 |
rat |
| H O Pettit, H T Pan, L H Parsons, J B Justic. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. Journal of neurochemistry. vol 55. issue 3. 1990-09-17. PMID:2384752. |
in vivo microdialysis procedures were used to monitor extracellular dopamine (da) and cocaine concentrations in the nucleus accumbens (n acc) and cocaine concentrations in plasma of animals that received chronic or acute cocaine treatments. |
1990-09-17 |
2023-08-11 |
Not clear |
| N Uchimura, R A Nort. Actions of cocaine on rat nucleus accumbens neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2193689. |
actions of cocaine on rat nucleus accumbens neurones in vitro. |
1990-08-08 |
2023-08-11 |
rat |
| N Uchimura, R A Nort. Actions of cocaine on rat nucleus accumbens neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2193689. |
it is concluded that cocaine acts to inhibit the uptake of dopamine and 5-hydroxytryptamine in slices of rat nucleus accumbens; lower concentrations of cocaine (0.3 to 1 microm) are particularly effective in potentiating the action of 5-hydroxytryptamine. |
1990-08-08 |
2023-08-11 |
rat |
| P Berger, J D Elsworth, J Arroyo, R H Rot. Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens. European journal of pharmacology. vol 177. issue 1-2. 1990-06-28. PMID:1967129. |
although some behavioral effects of cocaine are hypothesized to be due to blockade of dopamine uptake in nucleus accumbens, it has been reported that in nucleus accumbens there are no specific cocaine binding sites and that cocaine is a weak inhibitor of dopamine uptake. |
1990-06-28 |
2023-08-11 |
Not clear |