| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A N Gifford, K M Johnso. Comparison of the role of local anesthetic properties with dopamine uptake blockade in the inhibition of striatal and nucleus accumbens [3H]acetylcholine release by cocaine. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1359115. |
in the nucleus accumbens cocaine was about 5-fold less potent at inhibiting ach release than in the striatum and sulpiride was much less effective at reversing the inhibitory effect of cocaine, suggesting that the local anesthetic effects of cocaine play a greater role in regulating ach release in this area relative to dopamine uptake blockade. |
1992-12-08 |
2023-08-11 |
Not clear |
| J M Ackerman, F J Whit. Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine. European journal of pharmacology. vol 218. issue 1. 1992-11-20. PMID:1397028. |
this decreased activity may underlie the diminished basal levels of synaptic da within the nucleus accumbens previously reported in cocaine-withdrawn rats and may account for anhedonia, anergia and cocaine craving reported by withdrawn cocaine addicts. |
1992-11-20 |
2023-08-11 |
rat |
| E E Brown, G S Robertson, H C Fibige. Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 10. 1992-11-18. PMID:1403102. |
consistent with its stimulant actions, cocaine produced an increase in locomotion that was accompanied by an increase in fos expression within specific limbic regions (cingulate cortex, claustrum, piriform cortex, lateral septal nucleus, paraventricular nucleus of the thalamus, lateral habenula, and amygdala) as well as the basal ganglia (dorsomedial striatum and nucleus accumbens). |
1992-11-18 |
2023-08-11 |
human |
| E E Brown, G S Robertson, H C Fibige. Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 10. 1992-11-18. PMID:1403102. |
although the nucleus accumbens is necessary for the reinforcing and locomotor effects of cocaine, it does not exhibit a conditional fos response, suggesting that different neural circuits are involved in the unconditioned and conditioned effects of cocaine. |
1992-11-18 |
2023-08-11 |
human |
| J Peris, M Coleman-Hardee, W J Millar. Cocaine in utero enhances the behavioral response to cocaine in adult rats. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409782. |
neither cocaine in utero nor in vivo affected d2 da receptor binding in striatum nor nucleus accumbens. |
1992-11-18 |
2023-08-11 |
rat |
| Z Sarnyai, M Vecsernyés, F Laczi, E Bíró, G Szabó, G L Kovác. Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats. Neuropeptides. vol 23. issue 1. 1992-11-06. PMID:1407414. |
the oxt levels in the basal forebrain structures (including the septum and the nucleus accumbens) were decreased by a single dose of cocaine. |
1992-11-06 |
2023-08-11 |
rat |
| R D Mayfield, G Larson, N R Zahnise. Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum. Brain research. vol 573. issue 2. 1992-09-18. PMID:1387030. |
based on electrophysiological data showing that repeated cocaine administration produces persistent enhancement of d1 dopamine (da) receptor-mediated responses in nucleus accumbens (nac), we investigated whether changes in neurochemical properties of these receptors resulted when rats were injected with cocaine (15 mg/kg) for 6 days followed by a 7-day abstinence period. |
1992-09-18 |
2023-08-11 |
rat |
| H C Fibiger, A G Phillips, E E Brow. The neurobiology of cocaine-induced reinforcement. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638924. |
the introduction of in vivo brain microdialysis as a tool with which to investigate the neurochemical correlates of motivated behaviour has provided new opportunities for investigating the role of dopamine in the nucleus accumbens in the acquisition and maintenance of cocaine self-administration. |
1992-09-03 |
2023-08-11 |
Not clear |
| N S Pilotte, W M Mitchell, L G Sharpe, E B De Souza, E M Da. Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821482. |
nt binding in the nucleus accumbens was unaffected by cocaine or its withdrawal. |
1992-08-19 |
2023-08-11 |
rat |
| M S Hooks, G H Jones, A D Smith, D B Neill, J B Justic. Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821483. |
response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. |
1992-08-19 |
2023-08-11 |
human |
| P Robledo, R Maldonado-Lopez, G F Koo. Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1385935. |
role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. |
1992-08-17 |
2023-08-11 |
Not clear |
| N R Zahniser, R D Mayfield, W A Cass, G A Gerhard. Cocaine administration: D1 dopamine receptor function and dopamine clearance/diffusion in rat striatum and nucleus accumbens. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1385936. |
cocaine administration: d1 dopamine receptor function and dopamine clearance/diffusion in rat striatum and nucleus accumbens. |
1992-08-17 |
2023-08-11 |
rat |
| G F Koo. Neural mechanisms of drug reinforcement. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1632582. |
the brain substrates involved in the effect of cocaine on brain stimulation reward, in the psychomotor activation associated with cocaine, and in cocaine self-administration appear to be focused on the medial forebrain bundle and its connections with the basal forebrain, notably the nucleus accumbens. |
1992-08-17 |
2023-08-11 |
rat |
| B Hope, B Kosofsky, S E Hyman, E J Nestle. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 13. 1992-08-14. PMID:1631058. |
regulation of immediate early gene expression and ap-1 binding in the rat nucleus accumbens by chronic cocaine. |
1992-08-14 |
2023-08-11 |
rat |
| B Hope, B Kosofsky, S E Hyman, E J Nestle. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 13. 1992-08-14. PMID:1631058. |
chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus accumbens (nac), a brain region implicated in mediating the reinforcing effects of cocaine and other drugs of abuse. |
1992-08-14 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
acute cocaine administration preferentially increases extracellular dopamine levels in nucleus accumbens as compared with striatum. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
quantitative autoradiography with [3h]mazindol revealed that the affinity of the dopamine transporter for cocaine was similar in both brain areas but that the density of [3h]mazindol binding sites in nucleus accumbens was 60% lower than in dorsal striatum. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
our results suggest that a difference in dopamine uptake may explain the greater sensitivity of nucleus accumbens to cocaine as compared with dorsal striatum. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
furthermore, this difference may be due to fewer dopamine transporter molecules in nucleus accumbens for cocaine to inhibit, rather than to a higher affinity of the transporter for cocaine. |
1992-07-24 |
2023-08-11 |
rat |