| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G F Koo. Neural mechanisms of drug reinforcement. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1632582. |
the brain substrates involved in the effect of cocaine on brain stimulation reward, in the psychomotor activation associated with cocaine, and in cocaine self-administration appear to be focused on the medial forebrain bundle and its connections with the basal forebrain, notably the nucleus accumbens. |
1992-08-17 |
2023-08-11 |
rat |
| B Hope, B Kosofsky, S E Hyman, E J Nestle. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 13. 1992-08-14. PMID:1631058. |
regulation of immediate early gene expression and ap-1 binding in the rat nucleus accumbens by chronic cocaine. |
1992-08-14 |
2023-08-11 |
rat |
| B Hope, B Kosofsky, S E Hyman, E J Nestle. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 13. 1992-08-14. PMID:1631058. |
chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus accumbens (nac), a brain region implicated in mediating the reinforcing effects of cocaine and other drugs of abuse. |
1992-08-14 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
acute cocaine administration preferentially increases extracellular dopamine levels in nucleus accumbens as compared with striatum. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
quantitative autoradiography with [3h]mazindol revealed that the affinity of the dopamine transporter for cocaine was similar in both brain areas but that the density of [3h]mazindol binding sites in nucleus accumbens was 60% lower than in dorsal striatum. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
our results suggest that a difference in dopamine uptake may explain the greater sensitivity of nucleus accumbens to cocaine as compared with dorsal striatum. |
1992-07-24 |
2023-08-11 |
rat |
| W A Cass, G A Gerhardt, R D Mayfield, P Curella, N R Zahnise. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1613502. |
furthermore, this difference may be due to fewer dopamine transporter molecules in nucleus accumbens for cocaine to inhibit, rather than to a higher affinity of the transporter for cocaine. |
1992-07-24 |
2023-08-11 |
rat |
| E E Brown, H C Fibige. Cocaine-induced conditioned locomotion: absence of associated increases in dopamine release. Neuroscience. vol 48. issue 3. 1992-07-16. PMID:1603333. |
given the large body of evidence that implicates the mesolimbic dopaminergic projection in the unconditioned behavioural properties of cocaine, the present study used in vivo microdialysis to determine whether stimuli paired with cocaine elicit increases in interstitial dopamine in the nucleus accumbens that are similar to the unconditioned effects of this drug. |
1992-07-16 |
2023-08-11 |
human |
| I M Maisonneuve, S D Glic. Interactions between ibogaine and cocaine in rats: in vivo microdialysis and motor behavior. European journal of pharmacology. vol 212. issue 2-3. 1992-07-13. PMID:1601069. |
ibogaine, administered 19 h earlier, potentiated the increase in extracellular dopamine levels in striatum and nucleus accumbens as well as the stimulated motor activity induced by cocaine. |
1992-07-13 |
2023-08-11 |
rat |
| A N Gifford, K M Johnso. Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1534415. |
effect of chronic cocaine treatment on d2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum. |
1992-06-30 |
2023-08-11 |
rat |
| A N Gifford, K M Johnso. Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1534415. |
although this pretreatment significantly enhanced behavioral response to a challenge injection of cocaine when compared with rats pretreated with saline only, no significant differences were apparent in the degree of inhibition of electrically evoked [3h]da or [14c]ach release by quinpirole in either the nucleus accumbens or striatum. |
1992-06-30 |
2023-08-11 |
rat |
| L Pulvirenti, N R Swerdlow, G F Koo. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1687766. |
nucleus accumbens nmda antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. |
1992-06-30 |
2023-08-11 |
rat |
| P A Broderic. Cocaine: on-line analysis of an accumbens amine neural basis for psychomotor behavior. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1816582. |
dose-response studies on subcutaneous cocaine were done to ascertain its effects in nucleus accumbens in dopaminergic and serotonergic neuronal circuitry in the behaving rat with in vivo voltammetry. |
1992-06-30 |
2023-08-11 |
rat |
| P A Broderic. In vivo voltammetric studies on release mechanisms for cocaine with gamma-butyrolactone. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1816583. |
the effect of cocaine (20 mg/kg sc) on presynaptic mechanisms of release for dopamine (da) and for serotonin (5-ht) was studied in nucleus accumbens of unrestrained rats (rattus norvegicus). |
1992-06-30 |
2023-08-11 |
rat |
| G F Koob, F Weis. Neuropharmacology of cocaine and ethanol dependence. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350359. |
the reinforcing actions of acute cocaine as measured by intravenous cocaine self-administration appear to be mediated by the presynaptic release of dopamine in the region of the nucleus accumbens and may preferentially involve the dopamine d-1 receptor subtype. |
1992-06-22 |
2023-08-11 |
rat |
| G F Koob, F Weis. Neuropharmacology of cocaine and ethanol dependence. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350359. |
the nucleus accumbens circuitry involved in the reinforcing actions of cocaine may include the ventral pallidum and may be modulated by serotonin. |
1992-06-22 |
2023-08-11 |
rat |
| Y L Hurd, E E Brown, J M Finlay, H C Fibiger, C R Gerfe. Cocaine self-administration differentially alters mRNA expression of striatal peptides. Brain research. Molecular brain research. vol 13. issue 1-2. 1992-06-05. PMID:1374504. |
following a 7 day period of variable free access to cocaine, dynorphin and substance p mrna levels were elevated throughout the striatum, but the increases were substantially greater in the dorsal striatum than in the nucleus accumbens. |
1992-06-05 |
2023-08-11 |
rat |
| S E Hemby, G H Jones, J B Justice, D B Neil. Conditioned locomotor activity but not conditioned place preference following intra-accumbens infusions of cocaine. Psychopharmacology. vol 106. issue 3. 1992-05-22. PMID:1570378. |
in the first experiment, the conditioned place preference (cpp) paradigm was used to examine the rewarding properties of bilateral microinfusions of cocaine hcl into the nucleus accumbens (0, 12.5, 25, 50, or 100 micrograms). |
1992-05-22 |
2023-08-11 |
rat |
| L G Sharpe, N S Pilotte, W M Mitchell, E B De Souz. Withdrawal of repeated cocaine decreases autoradiographic [3H]mazindol-labelling of dopamine transporter in rat nucleus accumbens. European journal of pharmacology. vol 203. issue 1. 1992-04-16. PMID:1797552. |
withdrawal of repeated cocaine decreases autoradiographic [3h]mazindol-labelling of dopamine transporter in rat nucleus accumbens. |
1992-04-16 |
2023-08-11 |
rat |