| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Freddyson J Martínez-Rivera, Leanne M Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J Browne, Philipp Mews, Li Shen, Eric J Nestle. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats. Nature communications. vol 16. issue 1. 2025-03-26. PMID:40133300. |
transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats. |
2025-03-26 |
2025-03-28 |
rat |
| Freddyson J Martínez-Rivera, Leanne M Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J Browne, Philipp Mews, Li Shen, Eric J Nestle. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats. Nature communications. vol 16. issue 1. 2025-03-26. PMID:40133300. |
cocaine use disorder (cud) exemplifies this phenomenon in which reward regions such as nucleus accumbens (nac) undergo withdrawal-associated modifications. |
2025-03-26 |
2025-03-28 |
rat |
| Conner W Wallace, Clare Y Slinkard, Rachael Shaughnessy, Katherine M Holleran, Samuel W Centanni, Christopher C Lapish, Sara R Jone. Fiber photometry analysis of spontaneous dopamine signals: The z-scored data are not the data. bioRxiv : the preprint server for biology. 2025-03-10. PMID:40060421. |
the d1-like receptor antagonist sch23390 was used to prevent dlight sensors from interacting with dopamine in the extracellular space, while cocaine was used to inhibit uptake and raclopride to increase release of dopamine in the nucleus accumbens. |
2025-03-10 |
2025-03-12 |
mouse |
| L Gordon-Fennell, R D Farero, J D Jones, L S Zweifel, P E M Phillip. Corticotropin-Releasing Factor in the Nucleus Accumbens Does Not Drive High Levels of Cocaine Consumption. bioRxiv : the preprint server for biology. 2025-03-10. PMID:40060554. |
corticotropin-releasing factor in the nucleus accumbens does not drive high levels of cocaine consumption. |
2025-03-10 |
2025-03-12 |
human |
| L Gordon-Fennell, R D Farero, J D Jones, L S Zweifel, P E M Phillip. Corticotropin-Releasing Factor in the Nucleus Accumbens Does Not Drive High Levels of Cocaine Consumption. bioRxiv : the preprint server for biology. 2025-03-10. PMID:40060554. |
employing a cocaine self-administration paradigm that induces escalation of cocaine consumption in a subset of subjects, we investigated the role of crf activity in the nucleus accumbens (nac) in cocaine-taking patterns both before and after chronic cocaine experience. |
2025-03-10 |
2025-03-12 |
human |
| Ravid Doron, Lilach Rozevich, Noa Bregman-Yemini, Gal Yadi. The influence of chronic or acute DHEA exposure on β-Endorphin levels in the Nucleus Accumbens. European journal of pharmacology. 2025-03-01. PMID:40023360. |
as drug addiction manifestation is affected by upregulation of β-endorphin levels in the nucleus accumbens (nac), which is vital for the brain's reward system and to the rewarding properties of drugs, the current study aims to determine the effects of dhea on β-endorphin levels in the nac and its implications for cocaine addiction treatment. |
2025-03-01 |
2025-03-05 |
Not clear |
| Mark D Namba, Samuel L Goldberg, Christine M Side, Abhiram Yadlapalli, Christina M Curran-Alfaro, Devin Kress, Melissa F Fogarty, Amanda L A Mohr, Jacqueline M Barke. Dissociating the incubation of appetitive and consummatory behavior in a model of oral cocaine self-administration. bioRxiv : the preprint server for biology. 2025-02-24. PMID:39990380. |
these behavioral changes were accompanied by reduced expression of the glial glutamate transporter glt-1 within the nucleus accumbens (nac) of cocaine self-administering mice, regardless of abstinence. |
2025-02-24 |
2025-02-26 |
mouse |
| Qiaowei Xie, Mark D Namba, Rohan Dasari, Lauren A Buck, Christine M Side, Samuel L Goldberg, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Chemogenetic Activation of Medial Prefrontal Cortex Projections to the Nucleus Accumbens Shell Suppresses Cocaine-Primed Reinstatement in EcoHIV Infected Mice. bioRxiv : the preprint server for biology. 2025-02-20. PMID:39975137. |
this process involves neuroadaptations within the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) shell, regions that mediate cocaine reward learning and relapse-related behavior. |
2025-02-20 |
2025-02-23 |
mouse |
| Lyonna F Parise, Sergio D Iñiguez, Brandon L Warren, Eric M Parise, Ryan K Bachtell, David M Dietz, Eric J Nestler, Carlos A Bolaños-Guzmá. ERK2 Signaling in the Nucleus Accumbens Facilitates Stress Susceptibility and Cocaine Reinstatement. Biological psychiatry global open science. vol 5. issue 2. 2025-02-03. PMID:39896237. |
erk2 signaling in the nucleus accumbens facilitates stress susceptibility and cocaine reinstatement. |
2025-02-03 |
2025-02-05 |
Not clear |
| Estefani Saint-Jour, Marie-Charlotte Allichon, Andry Andrianarivelo, Enrica Montalban, Claire Martin, Lisa Huet, Nicolas Heck, Anna M Hagenston, Aisha Ravenhorst, Mélanie Marias, Nicolas Gervasi, Faustine Arrivet, Adèle Vilette, Katleen Pinchaud, Sandrine Betuing, Thomas Lissek, Jocelyne Caboche, Hilmar Bading, Peter Vanhoutt. Nuclear calcium signaling in D1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine. Biological psychiatry. 2025-01-26. PMID:39864789. |
nuclear calcium signaling in d1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine. |
2025-01-26 |
2025-01-29 |
Not clear |
| Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L Cruz, Marian T Sepulveda-Orengo, Richard J Noe. Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats. Pharmaceuticals (Basel, Switzerland). vol 18. issue 1. 2025-01-25. PMID:39861103. |
this study investigates the relationship among nef, glutamate homeostasis, and cocaine in the nucleus accumbens (nac), a critical brain region associated with drug motivation and reward. |
2025-01-25 |
2025-01-28 |
rat |
| Hilla Pe'er-Nissan, Pnina Shirel Itzhak, Iris Gispan, Racheli Ofir, Gal Yadi. Cocaine-Induced Microglial Impairment and Its Rehabilitation by PLX-PAD Cell Therapy. International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39796091. |
the results revealed an addiction-stage and region-specific impairment in microglia following chronic cocaine exposure, with deficits observed in the nucleus accumbens (nac) during the maintenance stage and in both the nac and dentate gyrus (dg) during the extinction and reinstatement stages. |
2025-01-11 |
2025-01-14 |
Not clear |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
in the present studies, we first examined if incubation of cocaine seeking was associated with aberrant dopamine transmission in the nucleus accumbens after seven days of abstinence from intermittent access to cocaine. |
2024-12-09 |
2024-12-12 |
rat |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. Neuropharmacology. 2024-12-04. PMID:39631679. |
this includes development of cocaine locomotor sensitization - or increased locomotor responses to the same doses of cocaine - which depends on nucleus accumbens (nac) neural plasticity. |
2024-12-04 |
2024-12-07 |
mouse |
| Marina E Wol. Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics. Annual review of pharmacology and toxicology. 2024-10-07. PMID:39374445. |
we have learned the most about cocaine-induced plasticity in the nucleus accumbens and its relationship to cocaine seeking, so that is the focus in this review. |
2024-10-07 |
2024-10-10 |
Not clear |
| Marina E Wol. Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics. Annual review of pharmacology and toxicology. 2024-10-07. PMID:39374445. |
a relationship between cocaine seeking and potentiated ampar transmission in nucleus accumbens is indicated by both models. |
2024-10-07 |
2024-10-10 |
Not clear |
| Philipp Mews, Yentl Van der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, Eric J Nestle. Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. Science advances. vol 10. issue 40. 2024-10-04. PMID:39365860. |
cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. |
2024-10-04 |
2024-10-07 |
Not clear |
| Philipp Mews, Yentl Van der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, Eric J Nestle. Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. Science advances. vol 10. issue 40. 2024-10-04. PMID:39365860. |
here, we describe an epigenetic mechanism whereby chronic cocaine exposure causes lasting chromatin and downstream transcriptional modifications in the nucleus accumbens (nac), a critical brain region controlling motivation. |
2024-10-04 |
2024-10-07 |
Not clear |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
here, we report that long-access cocaine self-administration followed by prolonged home cage abstinence results in decreased branching complexity of nucleus accumbens astrocytes, characterized by the loss of peripheral processes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Sophia J Weber, Alex B Kawa, Madelyn M Beutler, Hayley M Kuhn, Alana L Moutier, Jonathan G Westlake, Lara M Koyshman, Cloe D Moreno, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-19. PMID:39300272. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-09-19 |
2024-09-22 |
rat |