| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
in the present studies, we first examined if incubation of cocaine seeking was associated with aberrant dopamine transmission in the nucleus accumbens after seven days of abstinence from intermittent access to cocaine. |
2024-12-09 |
2024-12-12 |
rat |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. Neuropharmacology. 2024-12-04. PMID:39631679. |
this includes development of cocaine locomotor sensitization - or increased locomotor responses to the same doses of cocaine - which depends on nucleus accumbens (nac) neural plasticity. |
2024-12-04 |
2024-12-07 |
mouse |
| Marina E Wol. Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics. Annual review of pharmacology and toxicology. 2024-10-07. PMID:39374445. |
we have learned the most about cocaine-induced plasticity in the nucleus accumbens and its relationship to cocaine seeking, so that is the focus in this review. |
2024-10-07 |
2024-10-10 |
Not clear |
| Marina E Wol. Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics. Annual review of pharmacology and toxicology. 2024-10-07. PMID:39374445. |
a relationship between cocaine seeking and potentiated ampar transmission in nucleus accumbens is indicated by both models. |
2024-10-07 |
2024-10-10 |
Not clear |
| Philipp Mews, Yentl Van der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, Eric J Nestle. Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. Science advances. vol 10. issue 40. 2024-10-04. PMID:39365860. |
cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. |
2024-10-04 |
2024-10-07 |
Not clear |
| Philipp Mews, Yentl Van der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, Eric J Nestle. Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. Science advances. vol 10. issue 40. 2024-10-04. PMID:39365860. |
here, we describe an epigenetic mechanism whereby chronic cocaine exposure causes lasting chromatin and downstream transcriptional modifications in the nucleus accumbens (nac), a critical brain region controlling motivation. |
2024-10-04 |
2024-10-07 |
Not clear |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
here, we report that long-access cocaine self-administration followed by prolonged home cage abstinence results in decreased branching complexity of nucleus accumbens astrocytes, characterized by the loss of peripheral processes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Sophia J Weber, Alex B Kawa, Madelyn M Beutler, Hayley M Kuhn, Alana L Moutier, Jonathan G Westlake, Lara M Koyshman, Cloe D Moreno, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-19. PMID:39300272. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-09-19 |
2024-09-22 |
rat |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. bioRxiv : the preprint server for biology. 2024-09-16. PMID:39282274. |
this includes development of cocaine locomotor sensitization - or increased locomotor responses to the same doses of cocaine - which depends on nucleus accumbens (nac) neural plasticity. |
2024-09-16 |
2024-09-19 |
mouse |
| Shahid Nazir Wani, Amarjot Kaur Grewal, Heena Khan, Thakur Gurjeet Sing. Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal. Psychopharmacology. 2024-09-10. PMID:39254835. |
chronic cocaine usage leads to synchronized alterations in gene expression, causing modifications in the nucleus accumbens (nac), a vital part of the reward system of the brain. |
2024-09-10 |
2024-09-13 |
Not clear |
| Emily G Peck, Katherine M Holleran, Alyson M Curry, Kimberly M Holter, Paige M Estave, Jonathon P Sens, Jason L Locke, Olivia A Ortelli, Brianna E George, Monica H Dawes, Alyssa M West, Nancy J Alexander, Drew D Kiraly, Sean P Farris, Robert W Gould, Brian A McCool, Sara R Jone. Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211138. |
overexpression also enhanced nucleus accumbens dopamine signaling and prevented cocaine-induced deficits, suggesting a putative therapeutic role for synaptogyrin-3 in cocaine use disorder. |
2024-08-30 |
2024-09-04 |
rat |
| Daniel J Wood, Jessica L Huebschman, Dalia Martinez, Evgeny Tsvetkov, Kirsten Snyder, Raymond Tjhia, Jaswinder Kumar, Brandon W Hughes, Makoto Taniguchi, Laura N Smith, Christopher W Cowan, Rachel D Penro. The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. Genes, brain, and behavior. vol 23. issue 4. 2024-08-21. PMID:39164860. |
the activity-regulated cytoskeleton-associated protein (arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. |
2024-08-21 |
2024-08-23 |
mouse |
| Daniel J Wood, Jessica L Huebschman, Dalia Martinez, Evgeny Tsvetkov, Kirsten Snyder, Raymond Tjhia, Jaswinder Kumar, Brandon W Hughes, Makoto Taniguchi, Laura N Smith, Christopher W Cowan, Rachel D Penro. The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. Genes, brain, and behavior. vol 23. issue 4. 2024-08-21. PMID:39164860. |
in rodents, the activity-regulated cytoskeleton-associated protein (arc) can regulate glutamatergic synaptic transmission, and cocaine regulates arc expression and subcellular localization in multiple brain regions, including the nucleus accumbens (nac)-a brain region linked to cud-related behavior. |
2024-08-21 |
2024-08-23 |
mouse |
| Janay P Franklin, Anze Testen, Piotr A Mieczkowski, Austin Hepperla, Gogce Crynen, Jeremy M Simon, Jonathan D Wood, Eden V Harder, Tania J Bellinger, Emily A Witt, N LaShae Powell, Kathryn J Reissne. Investigating cocaine- and abstinence-induced effects on astrocyte gene expression in the nucleus accumbens. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149305. |
astrocytes are structurally altered following exposure to drugs of abuse; specifically, astrocytes within the nucleus accumbens (nac) exhibit significantly decreased surface area, volume, and synaptic colocalization after operant self-administration of cocaine and extinction or protracted abstinence (45 days). |
2024-08-16 |
2024-08-18 |
rat |
| Kelsey E Lucerne, Calista R Dean, Aya Osman, Katherine R Meckel, Yesha A Dave, Ava L Shipman, Dannis R Cazarez, Flurin Cathomas, Rebecca S Hofford, Drew D Kiral. Colony-stimulating factor 2 (CSF2) as a gut microbiome dependent immune factor that alters molecular and behavioral responses to cocaine in male mice. Brain, behavior, and immunity. 2024-08-04. PMID:39098439. |
on a molecular level, we find that peripheral injections of csf2 alter the transcriptional response to both acute and repeated cocaine in the nucleus accumbens. |
2024-08-04 |
2024-08-07 |
mouse |
| Freddyson J Martínez-Rivera, Yun Young Yim, Arthur Godino, Angélica Minier-Toribio, Solange Tofani, Leanne M Holt, Angélica Torres-Berrío, Rita Futamura, Caleb J Browne, Tamara Markovic, Peter J Hamilton, Rachael L Neve, Eric J Nestle. Cell-Type-Specific Regulation of Cocaine Reward by the E2F3a Transcription Factor in Nucleus Accumbens. bioRxiv : the preprint server for biology. 2024-07-19. PMID:39026727. |
cell-type-specific regulation of cocaine reward by the e2f3a transcription factor in nucleus accumbens. |
2024-07-19 |
2024-07-21 |
mouse |
| Sophia J Weber, Alex B Kawa, Alana L Moutier, Madelyn M Beutler, Lara M Koyshman, Cloe D Moreno, Jonathan G Westlake, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979157. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-07-09 |
2024-07-12 |
rat |
| Young-Jung Kim, Su Jeong Choi, Sa-Ik Hong, Jung-Cheol Park, Youyoung Lee, Shi-Xun Ma, Kwang-Hyun Hur, Young Lee, Kyeong-Man Kim, Hyung Kyu Kim, Hee Young Kim, Seok-Yong Lee, Se-Young Choi, Choon-Gon Jan. The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens. Molecular psychiatry. 2024-05-31. PMID:38822069. |
the ion channel trpa1 is a modulator of the cocaine reward circuit in the nucleus accumbens. |
2024-05-31 |
2024-06-02 |
mouse |
| Bo W Sortman, Samantha Rakela, Sarah Paprotna, Berk Cerci, Brandon L Warre. Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. Addiction biology. vol 29. issue 5. 2024-05-07. PMID:38711205. |
nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. |
2024-05-07 |
2024-05-27 |
rat |
| Bo W Sortman, Samantha Rakela, Sarah Paprotna, Berk Cerci, Brandon L Warre. Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. Addiction biology. vol 29. issue 5. 2024-05-07. PMID:38711205. |
neuronal ensembles in the medial prefrontal cortex mediate cocaine self-administration via projections to the nucleus accumbens. |
2024-05-07 |
2024-05-27 |
rat |