| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junhua Yang, Jianan Chen, Yongqing Liu, Kevin Hong Chen, Jay M Baraban, Zhaozhu Qi. Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. Neuron. 2023-01-21. PMID:36681074. |
repeated cocaine exposure potentiates astrocytic tonic gaba release through volume-regulated anion channels (vracs) and augments tonic inhibition of vta gaba neurons, thus downregulating their activities and disinhibiting nucleus accumbens (nac) projecting da neurons. |
2023-01-21 |
2023-08-14 |
mouse |
| Kelle E Nett, Alexa R Zimbelman, Matthew S McGregor, Vanessa Alizo Vera, Molly Harris, Ryan T LaLumier. Infralimbic projections to the nucleus accumbens shell and amygdala regulate the encoding of cocaine extinction learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-01-19. PMID:36657972. |
prior evidence indicates that the infralimbic cortex (il) mediates the ongoing inhibition of cocaine seeking following self-administration and extinction training in rats, specifically through projections to the nucleus accumbens (na) shell. |
2023-01-19 |
2023-08-14 |
rat |
| Xiao-Xing Liu, Fang-Lin Liu, Xin Li, Tang-Sheng Lu, Yi-Xiao Luo, Min Jian, Kai Yuan, Shi-Qiu Meng, Yan-Ping Bao, Jie Shi, Lin Lu, Ying Ha. Novel role of AMPK in cocaine reinforcement via regulating CRTC1. Translational psychiatry. vol 12. issue 1. 2022-12-31. PMID:36587026. |
repeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (nac), a region that mediates reinforcing effects of drugs. |
2022-12-31 |
2023-08-14 |
rat |
| Shane A Perrine, Walid F Alsharif, Arman Harutyunyan, Swatabdi Kamal, Nerissa T Viola, Juri G Gelovan. Low- and high-cocaine intake affects the spatial and temporal dynamics of class IIa HDAC expression-activity in the nucleus accumbens and hippocampus of male rats as measured by [18F]TFAHA PET/CT neuroimaging. Addiction neuroscience. vol 4. 2022-12-21. PMID:36540409. |
repeated cocaine alters neuronal function in the nucleus accumbens (nac), a brain region involved in cocaine taking, and in hippocampus (hc), known for contextual and associative learning. |
2022-12-21 |
2023-08-14 |
rat |
| Sarah E Swinford-Jackson, Phillip J Huffman, Melissa C Knouse, Arthur S Thomas, Matthew T Rich, Sharvari Mankame, Samantha J Worobey, Mateo Sarmiento, Ayanna Coleman, R Christopher Pierc. High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-11-29. PMID:36446928. |
high frequency dbs-like optogenetic stimulation of nucleus accumbens dopamine d2 receptor-containing neurons attenuates cocaine reinstatement in male rats. |
2022-11-29 |
2023-08-14 |
rat |
| He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan L. Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. Frontiers in cellular neuroscience. vol 16. 2022-11-21. PMID:36406750. |
the nucleus accumbens (nac) is involved in the expression of cocaine addictive phenotypes, including acquisition, extinction, and reinstatement. |
2022-11-21 |
2023-08-14 |
Not clear |
| Subhash C Gupta, Ali Ghobbeh, Rebecca J Taugher-Hebl, Rong Fan, Jason B Hardie, Ryan T LaLumiere, John A Wemmi. Carbonic anhydrase 4 disruption decreases synaptic and behavioral adaptations induced by cocaine withdrawal. Science advances. vol 8. issue 46. 2022-11-16. PMID:36383659. |
cocaine use followed by withdrawal induces synaptic changes in nucleus accumbens (nac), which are thought to underlie subsequent drug-seeking behaviors and relapse. |
2022-11-16 |
2023-08-14 |
mouse |
| Aram Parsegian, M Julia García-Fuster, Elaine Hebda-Bauer, Stanley J Watson, Shelly B Flagel, Huda Aki. Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes. Frontiers in psychiatry. vol 13. 2022-10-31. PMID:36311521. |
in bhrs, decreased h3k9me3 and increased ach3k9 in the nucleus accumbens (nac) core associated with cocaine sensitization. |
2022-10-31 |
2023-08-14 |
rat |
| María P Avalos, Andrea S Guzman, Constanza Garcia-Keller, Bethania Mongi-Bragato, María A Esparza, Daiana Rigoni, Marianela A Sanchez, Gastón D Calfa, Flavia A Bollati, Liliana M Cancel. Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091376. |
the present study explores the neurobiological mechanisms underpinning the sensitized response to the psychomotor-stimulating effects of cocaine following chronic restraint stress (crs), emphasizing the differential contribution of both subcompartments of the nucleus accumbens (na), the core (nacore) and shell (nashell), to this phenomenon. |
2022-09-12 |
2023-08-14 |
rat |
| Megan A McWain, Rachel L Pace, Patricia A Nalan, Deranda B Leste. Age-dependent effects of social isolation on mesolimbic dopamine release. Experimental brain research. 2022-09-03. PMID:36057752. |
mice were socially isolated for 6 weeks during these developmental stages, then in vivo fixed potential amperometry with recording electrodes in the nucleus accumbens was used to measure stimulation-evoked dopamine release, the synaptic half-life of dopamine, dopamine autoreceptor functioning, and the dopaminergic response to cocaine. |
2022-09-03 |
2023-08-14 |
mouse |
| Kenneth Blum, Mark S Gold, Jean L Cadet, David Baron, Abdalla Bowirrat, Panayotis K Thanos, Raymond Brewer, Rajendra D Badgaiyan, Marjorie C Gondré-Lewi. Dopaminylation in Psychostimulant Use Disorder Protects Against Psychostimulant Seeking Behavior by Normalizing Nucleus Accumbens (NAc) Dopamine Expression. Current psychopharmacology. vol 11. issue 1. 2022-09-01. PMID:36046837. |
repeated cocaine administration changes histone acetylation and methylation on lys residues and deoxyribonucleic acid (dna) within the nucleus accumbens (nac). |
2022-09-01 |
2023-08-14 |
Not clear |
| Sierra M Webb, Arianne D Sacramento, Megan A McCloskey, Melissa G Wroten, Kyle L Ploense, Tod E Kippin, Osnat Ben-Shahar, Karen K Szumlinsk. The incubation of cocaine craving is dissociated from changes in glial cell markers within prefrontal cortex and nucleus accumbens of rats. Addiction neuroscience. vol 3. 2022-08-29. PMID:36034166. |
the incubation of cocaine craving is dissociated from changes in glial cell markers within prefrontal cortex and nucleus accumbens of rats. |
2022-08-29 |
2023-08-14 |
rat |
| Laura Domingo-Rodriguez, Judit Cabana-Domínguez, Noèlia Fernàndez-Castillo, Bru Cormand, Elena Martín-García, Rafael Maldonad. Differential expression of miR-1249-3p and miR-34b-5p between vulnerable and resilient phenotypes of cocaine addiction. Addiction biology. vol 27. issue 5. 2022-08-24. PMID:36001423. |
we found that mmu-mir-34b-5p was downregulated in the nucleus accumbens of vulnerable mice with high motivation for cocaine. |
2022-08-24 |
2023-08-14 |
mouse |
| Ronald Kim, Anze Testen, Eden V Harder, Natalie E Brown, Emily A Witt, Tania J Bellinger, Janay P Franklin, Kathryn J Reissne. Abstinence-dependent effects of long-access cocaine self-administration on nucleus accumbens astrocytes are observed in male, but not female rats. eNeuro. 2022-08-22. PMID:35995558. |
abstinence-dependent effects of long-access cocaine self-administration on nucleus accumbens astrocytes are observed in male, but not female rats. |
2022-08-22 |
2023-08-14 |
rat |
| Ronald Kim, Anze Testen, Eden V Harder, Natalie E Brown, Emily A Witt, Tania J Bellinger, Janay P Franklin, Kathryn J Reissne. Abstinence-dependent effects of long-access cocaine self-administration on nucleus accumbens astrocytes are observed in male, but not female rats. eNeuro. 2022-08-22. PMID:35995558. |
for example, reductions in structural features and synaptic colocalization of male rat nucleus accumbens (nac) astrocytes are observed following short-access (sha, 2 hours/day) self-administration and extinction from cocaine, methamphetamine, and heroin. |
2022-08-22 |
2023-08-14 |
rat |
| Linda D Simmler, Yue Li, Lotfi C Hadjas, Agnès Hiver, Ruud van Zessen, Christian Lüsche. Dual action of ketamine confines addiction liability. Nature. 2022-07-27. PMID:35896744. |
addictive drugs such as cocaine increase the levels of dopamine in the nucleus accumbens. |
2022-07-27 |
2023-08-14 |
Not clear |
| Alex B Kawa, Eun-Kyung Hwang, Jonathan R Funke, Hongyi Zhou, Mauro Costa-Mattioli, Marina E Wol. Positive Allosteric Modulation of mGlu Biological psychiatry. 2022-07-23. PMID:35871097. |
expression of incubated cocaine craving depends on elevated calcium-permeable ampa receptors (cp-ampars) on medium spiny neurons in the nucleus accumbens (nac) core. |
2022-07-23 |
2023-08-14 |
Not clear |
| Gajanan P Shelkar, Pauravi J Gandhi, Jinxu Liu, Shashank M Dravi. Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens. Science advances. vol 8. issue 29. 2022-07-22. PMID:35867797. |
cocaine preference and neuroadaptations are maintained by astrocytic nmda receptors in the nucleus accumbens. |
2022-07-22 |
2023-08-14 |
mouse |
| Gajanan P Shelkar, Pauravi J Gandhi, Jinxu Liu, Shashank M Dravi. Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens. Science advances. vol 8. issue 29. 2022-07-22. PMID:35867797. |
selective ablation of glun1 subunit from astrocytes in the nucleus accumbens enhanced extinction of cocaine preference memory but did not affect cocaine conditioning or reinstatement. |
2022-07-22 |
2023-08-14 |
mouse |
| Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L K Goh, Yingjie Zhu, Fanglin Guan, Teng Che. A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects. Molecular psychiatry. 2022-06-17. PMID:35715487. |
its expression is consistently downregulated in the nucleus accumbens (nac) of mice when exposed to meth and cocaine, whereas significant alterations in novel-m009c expression were not observed in the nac of mice subjected to other rewarding and psychiatric stimuli, such as sucrose, morphine and mk-801. |
2022-06-17 |
2023-08-14 |
mouse |